한국인 정신분열병 환자에서 Endothelial Nitric Oxide Synthase 유전자의 다형성

최명수,정상근,조광현,김달식,황익근 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.1

급성 ST 분절 상승 심근경색증의 표준진료지침 설계

권선옥,김우식,오명기,나종천,이홍기,조욱현,최석구 인제대학교 2006 仁濟醫學 Vol.27 No.-

The use of critical pathways for a variety of clinical conditions has grown rapidly in recent years, particularly pathways for patients with acute myocardial infarction. We intend to determine the impact of a clinical pathway on ST-elevation myocardial infarction (STEMI) and to evaluate the efficacy and safety of facilitated percutaneous coronary intervention (PCI) compared with primary PCI. Low risk STEMI patients (ST elevation >0.1mV in more than 2 limb leads or ST elevation >0.2mV in contiguous precordial lead, chest pain lasting more than 30 min without response to nitroglycerin) will be included. All patients will be also treated medically according to critical pathway. STEMI is one of the common diseases in emergency medicine and so it is necessary to establish realistic treatment guidelines. The use of critical pathways will improve the quality of care.

한국형 출혈열의 심전도학적 고찰

조명찬,주인종,김대중,이병직,정형배,이명묵,박영배,최윤식,서정돈,이영우 대한내과학회 1990 대한내과학회지 Vol.38 No.3

We reviewed 549 electrocardiograms obtained from 95 patients with Korean hemorrhagic fever to investigate the incidence and electrocardiographic characteristics, observe evolutional changes in those findings during the course of illness, identify the correlations with clinical findings, and then suggest pathophysiologic mechanisms in the development of abnormal electrocardiographic findings. The overall incidence of electrocardiographic abnormalites was 95.7%, and the frequency of each phase was 87.8% in the febrile phase, 91.3% in the hypotensive phase, 86.5% in the oliguric phase, 76.4% in the diuretic phase and 43.0% in the convalescent phase. The cardinal electrocardiographic findings were QT prolongation(82.1%), sinus bradycardia(73.7%), prominent U wave(53.7%), tall and peaked T wave(51.6%), ST-T changes(41.1 %) and sinus tachycardia(35.8%). The most frequently observed electrocardiographic findings of each phase were sinus tachycardia in the febrile and hypotensive phase, QT prolongation in the oliguric phase, sinus bradycardia in the diuretic phase and prominent U wave in the convalescent phase. The occurrence of abnormal electrocardiograms increased in patients with high serum creatinine levels during the oliguric and diuretic phases. The electrocardiographic abnormalities that persisted to the convalescent phase were QT prologation(seven cases), prominent U wave(seven cases), sinus bradycardia(five cases), and tall and peaked T wave(four cases). Even though almost all of the electrocardiographic abnormalities were mild and recovered shortly after the convalescent phase and there were no diagnostic electrocardiograms, we observed noteworthy electrocardiographic characteristics and evolutional changes during the course of illness and suggested the primary electrocardiographic changes in Korean hemorrhagic fever.

Regulation of Endothelial Cell and Endothelial Progenitor Cell Survival and Vasculogenesis by Integrin-Linked Kinase

Cho, Hyun-Jai,Youn, Seock-Won,Cheon, Soo-In,Kim, Tae-Youn,Hur, Jin,Zhang, Shu-Ying,Lee, Seung Pyo,Park, Kyung-Woo,Lee, Myoung-Mook,Choi, Yun-Shik,Park, Young-Bae,Kim, Hyo-Soo Ovid Technologies Wolters Kluwer -American Heart A 2005 Arteriosclerosis, thrombosis, and vascular biology Vol.25 No.6

<P>OBJECTIVE: New vessel formation is a dynamic process of attachment, detachment, and reattachment of endothelial cells (ECs) and endothelial progenitor cells (EPCs) with each other and with the extracellular matrix (ECM). Integrin-linked kinase (ILK) plays a pivotal role in ECM-mediated signaling. Therefore, we investigated the role of ILK in ECs and EPCs during neovascularization. METHODS AND RESULTS: In human umbilical cord vein ECs and EPCs, endogenous ILK expression, along with subsequent cell survival signals phospho-Akt and phospho-glycogen synthase kinase 3beta, was reduced after anchorage or nutrient deprivation. Even brief anchorage deprivation resulted in retarded capillary tube formation by ECs. Adenoviral ILK gene transfer in ECs and EPCs reversed the decrease in cell survival signals after anchorage or nutrient deprivation, leading to enhanced survival, reduced apoptosis, and significantly accelerated the functional recovery after reattachment. And ILK overexpressing EPCs significantly improved blood flow recovery and prevented limb loss in nude mice hindlimb ischemia model. Furthermore, the efficacy of systemic delivery was equivalent to local injection of ILK-EPCs. CONCLUSIONS: ILK overexpression protects ECs and EPCs from anchorage- or nutrient-deprived stress and enhances neovascularization, suggesting that ILK is an optimal target gene for genetically modified cell-based therapy. Neovascularization is a dynamic process of detachment and reattachment of ECs and EPCs. Endogenous ILK expression was decreased in various stress conditions, and the gene transfer of ILK protected ECs and EPCs from temporary anchorage or nutrient deprivation. Furthermore, ILK gene transfer in EPCs significantly enhanced neovascularization in vivo.</P>

巨大輸尿管을 同伴한 先天性 二重尿管 1例

曺昌周,金俊泰,金明淑,李琦寧,陣東植,李景植,鄭承和 中央醫學社 1972 中央醫學 Vol.22 No.1

A congenital double ureter with megaureter is of interest because of its rarity and difficulty in diagnosis. This one year old female was admitted with the chief problems of high fever, marked 'abdominal distension and vomiting for five days duration. After confirming the diagnosis by exploratory laparotomy, a nephroureterectomy of the left side was performed. The pathological findings showed a chronic nonspecific inflammation with marked congestion and cystic dilatation of the left kidney and megaureter. We presented a case of congenital double ureter with megaureter and. reviewed the literatures.

정신분열병 환자를 위한 인지재활훈련 프로그램의 개발 : Korean-Cognitive Differentiation Program 한국형 인지분화훈련 프로그램

현명호,안석균,이만홍,조현상,최충식,이연희,송선미,유계준,김장우,김태용,이희상 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구배경 : 정신분열병 환자들은 인지장애를 보이는바, 저자들은 이들을 대상으로 한국형 인지분화훈련 프로그램을 개발하여 정신분열병 환자들을 대상으로 인지재활훈련을 실시한 후 환자들의 인지기능, 정신병리 및 문제해결기술에 미치는 효과를 조사하였다. 방 법 : 28명의 정신분열병 환자를 훈련군(n=14)과 대조군(n=14)으로 나누어 훈련군에게 한국형 인지분화훈련 프로그램을 1회 60분씩, 주당 2회씩, 11주간 총 22회를 실시하였다. 환자들의 인지기능은 K-WAIS의 산수, 빠진곳찾기, 어휘, 공통점찾기 소검사로 측정하였고 정신병리는 양성 및 음성증상 척도로 측정하였으며 문제해결기술은 사회문제해결척도로 평가하였다. 인지재활훈련의 효과를 평가하기 위해 훈련 전후의 인지기능, 정신병리 및 문제해결기술의 변화를 종속변수로 하고 훈련 유무를 독립변수로 하여 반복측정에 의한 변량분석으로 자료를 분석하였다. 결 과 : 한국형 인지분화훈련이 시간에 따른 인지기능검사 중 산수 소검사, 문제해결기술 중 시회문제해결척도의 전체 점수와 문제해결기술 소척도의 점수의 변화에 유의한 영향을 미쳤으나, 시각적 주의력, 개념화 능력 및 정신병리의 점수의 변화에 유의한 영향을 미치지 않았다. 결 론 : 한국형 인지분화훈련 프로그램은 정신분열병 환자에서 청각적 주의력 및 문제해결기술의 호전을 꾀할 가능성이 있음을 시사한다. Objectives : The purpose of this study was to investigate the effects of cognitive differentiation training program- Korean version(a training program of attention and conceptual abilities) on cognitive function, psychopathology and problem solving skills in patients with schizophrenia. Methods : A total of patients diagnosed as schizophrenia using DSM-Ⅳ were randomly assigned to 2 groups. The training group went through a total of 22 sessions of cognitive differentiation training(60 min/ session×2 sessions/wk×11 wks). The attention-placebo control group received psychoeducation program during the same period. Arithmetic, vocabulary, similarities, picture completion of Wechsler Adult Intelligence Scale-Korean version, Positive and Negative Syndrome Scale, and Social Problem Solving Scales were administered to all patients, both before and after the training program. Results : In the arithmetic scores(F=6.35, af=1, p=0.018) of Wechsler Adult Intelligence Scale-Korean version, and total scores(F=6.35, af=1, p=0.018) and problem solving skill scale scores(F=4.88, af=1, p=0.036) of social problem solving scale, interaction effects of training was significant. Conclusion : Our findings suggest that cognitive differentiation training program-Korean version is effective on improving auditory attention and problem solving skills in patients with schizophrenia.

Synthesis and characterization of germane/stannane-capped polysiloles for the fabrication of luminescent OLED.

Kim, Myoung-Hee,Woo, Hee-Gweon,Kim, Whan Gi,Cho, Myong-Shik American Scientific Publishers 2009 Journal of Nanoscience and Nanotechnology Vol.9 No.12

<P>Dehydropolymerization (with various inorganic hydrides) and subsequent germane/stannane-capping (with Me2GeHCI and Ph2SnHCI) of 1,1-dihydrotetraphenylsilole (1) give electroluminescent germane/stannane-capped polysiloles (2) in high yield. The polymerization yield and molecular weight with Selectride increase in the order L-Selectride < N-Selectride < K-Selectride. The molecular weights increase in the order Red-Al < K-Selectride < Super Hydride. The germane/stannane-capped polysiloles 2 emit at 521 nm and are electroluminescent at 522 nm. The fluorescence quantum yield of 2 in toluene is (1.66 +/- 0.26) x 10(-2). The emission color is green and the maximum brightness of the device is 2,800 cd/m2 with a luminous efficiency of 0.68 lm/W. The type of end group exhibited no appreciable effect on the luminescent properties of polysilole backbone. Thus, the germane/stannane-capped polysiloles are found to be a good material for OLED fabrication.</P>

사각형 외팔보에서의 일대일 공진

김명구(Myoung-Gu Kim),박철희(Chul-Hui Pak),조종두(Chong-Du Cho),이흥식(Heung-Shik Lee) 한국소음진동공학회 2005 한국소음진동공학회 학술대회논문집 Vol.2005 No.5

배경 복잡도에 따른 위장 패턴 평가

조운정(WoonJung Cho),안원미(Wonmi Ahn),박지예(Jeeyea Park),김명식(Myoung Shik Kim),한광희(Kwang-Hee Han) 한국HCI학회 2011 한국HCI학회 학술대회 Vol.2011 No.1

최근 들어서 다양한 주변 상황의 변화에 따라 최적으로 위장할 수 있는 위장패턴을 찾아내는 것이 중요하게 부각되고 있다. 이에 본 연구는 환경의 복잡도에 따라 제안하는 위장 패턴의 효과성을 비교하였다. 연구 방식은 배경 이미지에서 위장 타깃을 찾는 방식으로 포토시뮬레이션 기법을 통해 연구실 환경에서 진행되었다. 그 결과, 복잡도에 따라 위장 패턴의 효과가 달라짐을 확인하였다. 우선 기존의 위장 패턴보다 제안하는 2 가지 위장 패턴의 위장성이 높았으며, 환경의 복잡도에 따라 위장 패턴들의 탐색 시간이 유의미하게 높아짐을 확인하였다. 이는 추후 패턴 개발에서 환경의 복잡도가 주요 고려 요소임을 지지하는 연구결과이다. 즉 주위 환경의 조건변화에 따라 위장성 차이가 존재하므로, 전투맥락 및 환경변화의 영향에 대한 고려가 위장패턴 개발 단계에서부터 요구된다. The recent trend in camouflage research emphasizes the need to find the optimal adaptive camouflage pattern in dynamic circumstances of various real environment conditions. Our research compared the effectiveness of camouflage patterns according to the environmental complexity. Participants in the lab experiment were asked to perform the visual search tasks using a photo simulation and then to find camouflaged targets. The resulting effect of camouflage patterns varied in accordance with image complexity. Two of the newly developed patterns that are proposed had predominant camouflage abilities than the previous pattern. Analytical search time was significantly longer with the complexity of the background environment. The results support that environmental complexity is a major concern for designing future patterns. Since there is a camouflage ability difference with the change of the environment, the consideration of battle context and effect of the environment change should be required in the stage of developing camouflage pattern.

지주막하출혈에 의해 발생한 Takotsubo 심근병증의 1예

김선영,김우식,박종혁,오명기,권선옥,나종천,조욱현,최석구 인제대학교 2007 仁濟醫學 Vol.28 No.-

A 64-years-old man was admitted to emergency department with symptom of chest pain. The characteristic of symptom was squeezing pain at substernal area. The patient had a history of hypertension and diabetes mellitus. His electrocardiogram(ECG) showed ST elevation in lead Ⅰ, Ⅱ, V3-6 and his laboratory results revealed mild increase in cardiac enzymes. And his echocardiogram showed apical hypokinesis. Based on the suspicious symptoms and results for acute anterior myocardial infarction, we decided to take a coronary angiogram for further evaluation. However, coronary angiogram revealed normal epicardial coronary arteries. He was admitted at Intensive Care Unit for monitoring and treatment of heart failure. After 3 days of hospitalization, his mental status was changed. His brain computed tomography revealed subarachnoid hemorrhage. After 5 days, hypokinesis of apex was improved to nearly normal on echocardiogram. This is a case of transient left ventricular apical ballooning or takotsubo cardiomyopathy associated with subarachnoid hemorrhage.