http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이유라(You-Ra Lee),신정호(Jong-Ho Shin),민성호(Seong-Ho Min),김태희(Tae-Hui Kim),김민혁(Min-Hyuck Kim),장형민(Hyung-Min Chang),박기창(Ki-Chang Park),안정숙(Joung-Sook Ah),전영안(Yong-An Jeon),장지숙(Jee-Sook Jang) 한국중독정신의학회 2005 중독정신의학 Vol.9 No.1
Objectives:This study was designed to find out the changes of alcohol use behavior and it’s attributing factors through two surveys conducted in 1998 and 2004 in a rural community. Methods:We selected 116 problem drinkers and 116 matched non-problem drinkers among 480 men of the first survey. We surveyed basic epidemiologic data and alcohol use behavior with several questionnaires. Results:The results were as follows : 1) Drinking amount and frequency decreased with increasing age. 2) More than half among previous problem drinkers did not show any significant change in their alcohol use behavior. 3) Most of previous non-problem drinkers maintained their past alcohol use behavior. 4) Continuous problem drinkers had larger amount of past alcohol drinking than no more problem drinkers. They had lower scores on awareness of negative consequence, higher scores on drinking for coping strategy of Alcohol Effects Questionnaire (AEQ) and higher scores on drinking urge to relieve hangover of the Severity of Alcohol Dependence Questionnaire (SADQ) than no more problem drinkers. 5) Continuous problem drinkers showed more smoking and earlier drinking than continuous non-problem drinkers. 6) Continuous problem drinkers became poorer than no more problem drinkers. Conclusions: Continuous problem drinking pattern was associated with larger amount of past alcohol drinking, higher drinking frequency, higher drinking urge to relieve hangover, higher use of drinking for coping strategy and less awareness of negative consequence.
嚴泰燮,張楨娥,成大東 東亞大學校附設基礎科學硏究所 1993 基礎科學硏究論文集 Vol.10 No.1
전자결핍 구조를 갖는 다면체 붕소화합물은 붕소원자의 전자결핍성 때문에 붕소원자에 친핵적 삽입반응(nucleophilic insertion)이 용이하게 일어난다. 최근에 Reynolds 등은 다면체 붕소화합물의 전자 결핍 구조를 갖는 decaborane에 니트릴기를 갖는 pertanoate 유도체들을 반응시켜 ortho-carboranyl pyrimidine 유도체를 합성하여 보고하였다.
Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages
Kim Minji,An Jangeun,Shin Seong-Ah,Moon Sun Young,Kim Moonsu,Choi Seyeon,Kim Huiji,Phi Kim-Hoa,Lee Jun Hyuck,Youn Ui Joung,Park Hyun Ho,Lee Chang Sup 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-
Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the patho physiology of several chronic diseases. Although anti‑inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activi ties, including anti‑inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti‑inflammatory effects and molecular mechanisms of 2,5,6‑trimethoxy‑p‑terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS‑stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro‑inflammatory cytokines (IL‑1β, TNF‑α, IL‑6) and the mRNA and protein levels of the pro‑inflammatory enzymes (inducible nitric oxide synthase and cyclooxyge nase‑2). Moreover, TP1 suppressed lipopolysaccharide‑induced phosphorylation of the NF‑κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by sup pressing the expression of pro‑inflammatory cytokines, making it a potential anti‑inflammatory drug for the treatment of severe inflammatory diseases.
손호정 ( Son Ho-jung ),이정아 ( Lee Joung-ah ),한창평 ( Han Chang-pyung ),이성연 ( Lee Seong-yeun ),양성환 ( Yang Seong-hwan ),한천구 ( Han Cheon-goo ) 한국구조물진단유지관리공학회 2008 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.12 No.2
This research analyzed the heat resistant characteristics of high strength concrete by varied thicknesses of CFT steel plate for 300×300×600 mm RC column member, and has shown the following results. As for the characteristics of unhardened concrete, the air amount and slump flow did not show any difference whether fiber is mixed, however both were shown to satisfy the target range. On the characteristics of hardened concrete, the compression strength by the ages, which is over 83.9 MPa, showed high strength range, and the case where NY+PP(0.05) fiber is mixed in showed a tendency to increase minutely compared to plane where fiber is not mixed in. As for heat resistant characteristics, the cases of 3.0 mm, 4.5 mm and 6.0 mm CFT thicknesses where fiber is not mixed in showed slight improvement of heat resistance as steel plate became thicker, but showed fracture phenomenon, and 6.0 mm thickness CFT where NY+PP(0.05) fiber is mixed in maintained the original look of test body, implying sound condition, which in turn signifies the importance of organic fiber mix-in in CFT structure as well. At this time, main bar highest temperature, 520.8℃, showed relatively good temperature history.
DB3 from Antarctic lichen inhibits the growth of B16F10 melanoma cells in vitro and in vivo
Choi Seyeon,Kim Huiji,Shin Seong-Ah,Kim Moonsu,Moon Sun Young,Kim Minji,Lee Seulah,Lee Jun Hyuck,Park Hyun Ho,Youn Ui Joung,Lee Chang Sup 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
Malignant melanoma is a fatal disease with an increasing global incidence. Despite numerous studies focused on anti-cancer drugs, a variety of side effects of cancer treatment remain challenging. Thus, there is a pressing need to identify novel anti-cancer agents with minimal cytotoxicity and side effects. DB3 (1,3,7,9-tetrahydroxy-2,8-dimethyl-4,6-di[ethanoyl]dibenzofuran) is a member of the dibenzofuran family and is extracted from Ramalina terebrata (Antarctic lichen). We investigated if DB3 exerted an antitumor effect on B16F10 melanoma cells. The results revealed that DB3 exerted time- and dose-dependent reduction of cell viability by inducing apoptosis and significantly suppressing cell proliferation through cell cycle arrest in the G0/G1 phase in B16F10 melanoma cells. Additionally, DB3 impeded the migration and invasiveness of B16F10 cells. Subsequently, we observed that DB3 decreased the expression levels of Cdk4/Cyclin D1 and the phosphorylation of p38, JNK, ERK, and AKT. Furthermore, DB3 decreased melanoma tumor growth in a mouse tumor syngraft model. Based on these findings, we propose that DB3 possesses potential for use as an anti-cancer agent for melanoma treatment.