하천 만곡률과 홍수량에 따른 수면경사도 산정

최한규,이문희,백효선 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.A

In this research, we made a one and two-dimensional analysis of numerical data collected from the bend curvature of a bended river section. According to the result from the numerical analysis, the inflow & output angle caused a water level deviation which increased with an increase of the flood discharge. From the water level deviation of our two- dimensional numerical model, we obtained the maximum slope of 6,67% when the inflow and output angle was 105 degrees and the flood discharge was 500 CMS. As for the right side, the differences with the one-dimensional numerical model were reduced when the angle was more than 90˚. As for the left side the differences were reduced when the angle was more than 105˚. For a river with more than 90 degrees bend curvature, a hydraulic experiment would be more appropriate than a numerical analysis.

다변량 분석법을 이용한 소양강댐 상류 유역의 하천 수질 평가

최한규,백효선,허준영 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A

The object of this study is to evaluate the factors affecting the water quality and to propose the influence of dominant factor quantitatively. The correlation analysis was performed to know the correlationship among the water quality items. As a result of partial correlation analysis, it was shown that the water quality items are affected by the rainfall item directly. The factor analysis was performed to grasp some number of factors on each point for deducing the items of similar variable characteristics. The four points were divided into different factor groups. It was grasped that NH_3-N and NO_3-N items have different variable characteristics after comparing the items. The Multiple regression analysis can decrease the number of observation. In the deduced multiple regression formula, it was shown that the rate of T-N, NH_3-N and NO_3-N in the independent variable took about 60% among all the regression formulas.

春川댐 放流時 橋梁의 安定性 檢討를 위한 水理模型實驗 硏究

최한규,백효선,최상순 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

In The case of the bridge which is located in the downstream of the dam, effect of the running water and stability of the bridge is studing by using the Hydraulic model test. 1. The water level change of `Seosang1 bridge' along Chunchon dam spill occurred through this experiment more greatly than a numerical conspiracy. 2. Bight is the spot where a difference occurs in located bridge piers(p18-p28) greatly, and an influence of Chunchon dam occurs in greatly.

유입량에 따른 빈도별 저수용량 결정에 관한 연구

최한규,최용묵,전광제 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

A past monthly data is not faithful so much for a short term. But, the stochastic generation technique was provide of a long-term data. Thus this study is used a data which generated a monthly inflow amounts data by Thomas-Fiering model. This model is needed a certain process which determination of distribution, decision of continuous durability, etc. It was generated a inflow data every one month as Thomas-Fiering method. The generated inflow data was used input data for a monthly cumulative analysis. This analysis obtained a storage capacities which would be required during droughts having various return periods. It was presented a equation of fitting regression that carried out regression analysis of 5,10, 20, 50 years period.

다시마 식이가 흰쥐에서 글리피지드의 체내동태에 미치는 영향

최한곤,장보현,이종달,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Drug interactions with food, on occasion, lead to serious nutritional and functional changes in the body as well as alternations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increase risk of micovascular, macrovascurlar, and neuropathic complications. However, the precise mechanixm of diabetes mellitus remains unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo- or hyperglycemia and preventing complications. The purpose of this study was to investigate the effect of Laminaria japonica diet on the absorption, distribution, metabolism and excretion of glipizide which are frequently used in the treatment of diabetes. Diabetic rats induced by streptozotocin were employed in this study. Blood concentrations of oral hypoglycemic agents were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_a, t_1/2, C_max, t_max, and AUC. Administration of glipzide in normal rats treated with Laminaria japonica diet showed significant increase in AUC, k_a, t_1/2, t_max and decrease in C_max, compared to those without Laminaria japonica diet. This might result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption. Administration of glipizide in diabetic rats treated with Laminaria japonica diet showed significant increase in t_1/2 and t_max, and decrease in C_max, compared to those without Laminaria japonica diet. This might also result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption and flattened blood concentration of glipizide. The oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of glipizide caused by long-term Laminaria japonica diet.

계란의 음향진동 모드분석

최완규,조한근 충북대학교 농업과학기술연구소 2001 農業科學硏究 Vol.18 No.-

Surface crack detection is an important aspect in the quality control process of egg markets. The acoustic vibration of an egg could be used as a critical factor in evaluating the eggshell quality. The mode shape indicates the egg vibration behavior at different locations with respect to the input impulse and provides important information for the optimum sensor location to obtain the desired acoustic measurements. Theoretical analysis and experimental measurements were conducted to determine the acoustic vibration modes in eggs. The resonant frequencies of the first and second resonance mode of intact eggs were found to be distributed between 2kHz and 7kHz range. The measured mode shapes of an egg were similar to theoretical shapes of homogeneous, elastic spheres. An elliptical deformation at the equator ring of the egg was observed. The frequency peak of this mode was dominantly present in the frequency spectrum of an intact egg impacted at its sharp position. The mode shapes related to the first resonant frequency of an egg showed that the optimum location for the measuring sensor was the 180 degrees position. A optimum location for the egg support was found to be the 90 degrees position having the smallest vibration magnitude.

횡문근융해증과 급성 신부전 및 범발성 혈관내 응고장애를 동반한 열사병 1예

최대은,박수진,권오경,이한규,이영모,이상주,나기량,이강욱,신영태 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Heat stroke is a life-threatening illness characterized by an elevated core body temperature that rises above 40% and central nervous system dysfunctions that results in delirium, convulsions, or coma. Heat stroke is subdivided into two forms, classic and exertional. Since strenuous exercise is one of the major exacerbating and precipitating factors, the incidence of exertional heat stroke is high among young adult, especially military personnel undergoing military training. Exertional heat stroke commonly causes rhabdomyolysis, lactic acidosis, acute renal failure, shock and pulmonary edema. We report a case of heat stroke with rhabdomyolysis, acute renal failure, disseminated intravascular coagulopathy(DIC) after strenuous exercise. A 18 year old man was admitted to the hospital because of loss of consciousness. He was a wrestler and he had tried to lose 6kg in weight by jogging and strenuous exercise on that summer day with hot temperature. The development of this illness was favoured by much clothes inappropriate for that environmental condition with a purpose to enhance sweating, and by restricted intake of water and food. On admission, the blood pressure was 80/50mmHg, and body temperature was 39.4℃ with stuporous mentality. Laboratory finding were as follows : in complete blood cell count, hemoglobin was 16.7g/dL and platelet count was 158,000/ mm³. In blood chemistry, AST 1061U/L, ALT 201U/L, BUN 30mg/dL, Cr 2.2mg/dL, LDH 941IU/L, CK 696IU/L were resulted. In arterial blood gas analysis, pH 7.39, pCO₂ 30mmHg pO₂ 86mmHg, HCO₃ 18.4mEq/L, O₂ saturation 96.7% were resulted. In urinalysis, specific gravity 1.025, protein 3+, erythrocyte 2+ were resulted. In brain imaging study, brain CT finding was normal. After appropriate treatments with rapid cooling, hydration and supportive care, he improved with alert mental status. On 2nd hospital day, in laboratory result, thrombocytopenia and coagulopathy were appeared and renal insufficiency was aggravated. So he was treated with platelet concentrate and fresh frosen plasma for DIC, and enough hydration for appropriate urine volume preservation. After all, On 22nd hospital day, he fully recovered and discharged. Nowadays, with followed for some duration, he is wellbeing with no complications.

섬유아세포 동종이식을 이용한 당뇨족부 궤양의 치료

최규진,한승규,김우경 大韓成形外科學會 2004 Archives of Plastic Surgery Vol.31 No.2

프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성

최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1

Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.

일련연속교각, 다중연속교각, 말뚝군의 세굴특성에 관한 실험적 연구

최한규,김인호,최용묵 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

As materials on the river bed have been changing through erosion, transportation and accumulation, so does the waterway's section. So many bridges have nowadays been constructed to the same direction as water flows. However further researches are still needed on the scours of succession row piers and multiple row piers. Analyzing them through hydraulic stimulation experiments, this study deals with the scour character with the change of diameters in row piers which have been built in the identical direction of water flow and also the part-scour change in multiple row piers.