갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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여수국가산업단지 인근 지역 대기오염물질 농도에 영향을 미치는 요인분석

김민영,변정훈,이영훈,이건영,한지은,이예림,임지현,장봉기 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

Eight monitoring stations in the Yeosu National Industrial Complex will determine the concentration of air pollutants measured every hour in 2019, analyze what factors affect them, and how they correlate with the air pollutant measurements. Six air pollutants (SO2, NO2, O3, CO, PM-10 and PM-2.5) measured at eight monitoring stations around Yeosu National Industrial Complex (Seogang-dong, Wolnae-dong, Munsu-dong, Yeocheon-dong, Deokchung-dong, Hwayang-myeon, Yulchon-myeon, Samil-dong) the measurement data for each hour of the year were downloaded to analyze the concentration by weather condition, time zone, season, separation distance from Yeosu Industrial Complex, and separation distance from Gwangyang Industrial Complex. SO2, NO2, and CO concentrations were significantly higher in winter, significantly lower in summer, and O3, PM-10, and PM-2.5 concentrations were significantly higher in spring. SO2, CO, PM-10, and PM-2.5 concentrations were significantly higher between 10 a.m. and 12 p.m., NO2 concentrations were significantly higher between 7 a.m. and 9 a.m., and O3 concentrations were significantly higher between 13 p.m. and 15 p.m.(p<0.001). The concentration of air pollutants (SO2, NO2, CO, PM-10, PM-2.5) excluding O3 was found to have a negative (-) correlation with weather condition, and in the case of O3, it was found to have a positive (+) correlation with PM-10, PM-2.5, temperature and wind speed. It was confirmed that the concentration of air pollutants emitted from the Yeosu National Industrial Complex differs depending on the season, time and distance to the industrial complex. This study aims to establish measures to minimize health damage to residents living relatively close to the industrial complex and contribute to the establishment of management and response measures according to the properties of substances to reduce the concentration of air pollutants in the future.

수종 한약재가 백혈병 세포에 미치는 영향에 대한 연구

崔湖榮,金澤,柳志昌,卞德市,盧昇鉉 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

I am reporting here a syntematic in vitro examination for specificity of anti-cancer effect of several oriental herbs, which have been used frequently for cancer pateints(therapy), on Molt-4 LCL(Lymphoblastoid Cell Line) Leukemic cells in relation to its density and time of incubation. 1. ErOH extract of Jujubae Fructus reduced Molt-4 cell's survival rate effectively after 48 hours' treatment at 1000㎍/㎖'s density and it reduced survival rate of LCL effectively after 12 hours' treatment at 1000㎍/㎖'s density. 2. EtOH extract of Cordyceps reduced LCL's survival rate effectively after 36 hour's treatment at 1000㎍/㎖'s density. 2. EtOH extract of Fici Fructus reduced LCL's survival rate effectively after 36 hours' treatment at 1000㎍/㎖'s density. 4. EtOH extract of Trionycis reduced Molt-4 cell's survival rate even at 500㎍/㎖ density and further effective at 1000㎍/㎖ density after 24 hours treatment and it killed the cells completely at 1000㎍/㎖ density after 48 hours treatment, It also Killed LCL completely after 12 hours and 36 hours' treatment at 1000㎍/㎖'s density. 5. EtOH extract of Biotae Cacumen reduced LCL's survival rate effectively after 12 hours' treatment at 1000㎍/㎖'s density, and after 36 hours treatment it reduced LCL's survival time very effectively. 6. EtOH extract of Psoraleae Fructus reduced Molt-4 cell's survival rate very effectively after 24 hours' treatment at 500㎍/㎖ and 1000㎍/㎖'s density, and after 48 hours' treatment at 250㎍/㎖'s density it reduced effectively and it killed the cell completely at 500㎍/㎖ and 1000㎍/㎖'s density. It also killed LCL completely after 12 hours and 36 hours' treatment at 1000㎍/㎖'s density. I hope to proceed with more advanced experiment in vivo and clinically as for the two kinds of oriental herbs and another herbs effective for leukemia.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

난원공 개존을 통한 우심방에서 좌심방으로의 단락 진단에 있어 경흉부 심초음파 하모닉 영상의 유용성

신미승,강석민,장길진,변기현,하종원,정남식,허지회,이병인 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Leaner Perspectives toward Collaborative Writing Projects Using SNSs in an EFL College Context

Ji-Hyun Byun 한국언어연구학회 2015 언어학연구 Vol.20 No.3

The ultimate goal of this study is to explore how EFL learners react to collaborative writing projects in an EFL context using online mode. Also, the study aims to explore learners’ general perspectives about collaboration. According to the data, the participants of the present study showed positive attitudes toward using Kakaotalk and Google Plus in their collaborations. However, they also recognized the importance of including offline discussion as well. In terms of learners’ general perspectives toward a collaborative writing project, the participants in general reported positive attitudes toward it.

Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition

( Hyun Jung Byun ),( Kyung Jin Kang ),( Mi Kyung Park ),( Hye Ja Lee ),( June Hee Kang ),( Eun Ji Lee ),( You Ri Kim ),( Hyun Ji Kim ),( Young Woo Kim ),( Kyung Chae Jung ),( Soo Youl Kim ),( Chang Ho 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.5

Sphingosylphosphorylcholine (SPC) is signifi cantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) fi laments in PANC-1 cells. The reorganization contributes to the viscoelasticity of metastatic cancer cells resulting in increased migration. Recently, we reported that transglutaminase-2 (Tgase-2) is involved in SPC-induced K8 phosphorylation and reorganization. However, effects of Tgase-2 inhibitors on SPC-induced K8 phosphorylation and reorganization were not clearly studied. We found that ethacrynic acid (ECA) concentration-dependently inhibited Tgase-2. Therefore, we examined the effects of ECA on SPC-induced K8 phosphorylation and reorganization. ECA concentration-dependently suppressed the SPC-induced phosphorylation and perinuclear reorganization of K8. ECA also suppressed the SPC-induced migration and invasion. SPC induced JNK activation through Tgase-2 expression and ECA suppressed the activation and expression of JNK in PANC-1 cells. These results suggested that ECA might be useful to control Tgase-2 dependent metastasis of cancer cells such as pancreatic cancer and lung cancers.

The Effects of Different Foreign Language Learning on Levels of Foreign Language Anxiety

Byun, Ji-Hyun(변지현),Jee, Min Jung(지민정) 한양대학교 교육공학연구소 2012 학습과학연구 Vol.6 No.2

본 연구는 외국어의 종류가 학습자의 외국어 학습 불안에 미치는 영향에 대해서 알아보았다. 대상은 스페인어, 일본어, 중국어, 영어를 제 2외국어로 선택하고 있는 외국어 고등학교 1학년 학습자들이었다. 데이터의 분석 결과 네 반의 외국어 학습 불안감 평균이 통계적으로 유의미한 차이를 보이지 않았지만 기술통계 측면에서 관찰했을 때 평균에서 적당한 수준의 외국어 학습 두려움 차이가 나타났다. 4개의 외국어 그룹 중 스페인어 반 학생들에게서 가장 높은 외국어 학습 불안이 나타난 반면 영어반 학생들에게서는 가장 낮은 외국어 학습 불안이 나타났다. 또한 영어와 중국어 반 학생들은 성적이 높을수록 외국어 학습 불안이 높았지만, 스페인어 반 학생들은 중간 정도의 성적을 가진 학생들이 가장 높은 외국어 학습 불안을 보였다. 일본어 반에서는 성적인 낮은 학생들이 중간 정도의 성적을 가진 학생들보다 더 높은 외국어 학습 불안감을 보였다. The main aim of the present paper is to investigate how different foreign languages influence learners" anxiety levels. The data were collected from high school student who were placed in the following four different foreign language learning groups-Spanish, Japanese, Chinese, and English. The data showed no significant differences, but showed a moderate level of mean score of foreign language anxiety. More specifically, among those four groups, the Spanish learners showed the highest level of anxiety whereas the English major learners yielded the lowest level of anxiety. Student in the English and Chinese classes showed similar patterns of anxiety : the higher the scores were, the higher the anxiety level was. However, students in the Spanish class, mid-achievement group had the highest anxiety level, and in the Japanese class, the low-achievement group had a higher anxiety level than the mid-achievement group.

An ESL Teacher's Perspective on Recasts: A Qualitative Exploration of "When" and "How"?

Byun, Ji-Hyun,Kayi-Aydar, Hayriye The English Teachers Association in Korea 2010 영어어문교육 Vol.16 No.4

Recasts, which are defined as implicit types of corrective feedback, have been the focus of numerous SLA researchers for more than a decade. A range of classroom-based observational and experimental research studies have explored how and when language teachers provide recasts to learners' ill-formed utterances and aimed to understand the role of recasts in language acquisition or learning. On the basis of previous studies on recasts, our study investigated when an ESL teacher provided recasts and how recasts were provided in his class. The research questions were as follows: (1) When does an ESL teacher provide recasts? (2) How does the teacher provide recasts? The data came from observations of one ESL classroom as well as consecutive-semi structured interviews with the teacher. The data analysis included transcriptions of teacher-student interactions in the target setting and categories of recasts according to the linguistic phenomena, which prompted recasting. Based on the findings, practical suggestions for ESL teachers were provided. [156 words].

A Case Study of the Perspectives of ESL Teachers and Learners on Recasts

Ji-Hyun Byun 한국응용언어학회 2011 응용 언어학 Vol.27 No.2

The purpose of this qualitative study is to explore the perspectives of ESL learners and teachers toward recasts. Also, this study attempts to capture when and how ESL teachers offer recasts in language classrooms. The findings indicate that recasts were provided to grammatical errors, incomplete sentences, phonological errors, and lexical items. Among them, grammatical errors received most recasts. Regarding the teachers’ perspectives, they tended to see it necessary to offer recasts to learners’ ill-formed utterances. They further emphasized the importance of offering self-repair opportunities to learners. Similar to the teachers, learners also recognized the crucial role of recasts in their language development process. At the same time, language learners placed strong emphasis on language teachers’ explicit alert when recast feedback was underway.