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Amino-Functionalized Mesoporous Silica Particles for Ocular Delivery of Brimonidine
Kim, Se-Na,Ko, Song Ah,Park, Chun Gwon,Lee, Seung Ho,Huh, Beom Kang,Park, Yoh Han,Kim, Young Kook,Ha, Ahnul,Park, Ki Ho,Choy, Young Bin American Chemical Society 2018 MOLECULAR PHARMACEUTICS Vol.15 No.8
<P>To treat glaucoma, conventional eye drops are often prescribed. However, the eye drops have limited effectiveness as a result of low drug bioavailability due to their rapid clearance from the preocular space. To resolve this, we proposed amino-functionalized mesoporous silica (AMS) particles as delivery carriers of the glaucoma drug, brimonidine. Because of the presence of mesopores, brimonidine (BMD) could be encapsulated in the AMS with a loading amount of 41.73 μg/mg (i.e., drug loading capacity of about 4.17%) to give the BMD-AMS, which could release the drug in a sustained manner over 8 h. BMD-AMS was also shown to be mucoadhesive due to the presence of both hydroxyl and amino groups in the surface, allowing for formation of hydrogen bonds and an ionic complex with the mucin, respectively. Therefore, when topically administered to rabbit eyes in vivo, BMD-AMS could reside in the preocular space for up to 12 h because of its adherence to the mucous layer. To assess in vivo efficacy, we examined the variance in intraocular pressure (IOP) and brimonidine concentration in the aqueous humor (AH) after applying BMD-AMS to the eye, which was compared with that induced by Alphagan P, the marketed brimonidine eye drops. For BMD-AMS, the duration in the decrease in IOP and the area under the drug concentration in the AH-time curve (AUC) were 12 h and 2.68 μg·h/mL, respectively, which were about twice as large as those obtained with Alphagan P; this finding indicated enhanced ocular bioavailability of brimonidine with BMD-AMS.</P> [FIG OMISSION]</BR>
고완태,김영아,장동원 전주교육대학교 1995 論文集 Vol.31 No.-
The main goal of this article is to show principal problems to be primarily solved in teachers' society and explore soving methods about them for educational competitive force's enhancement. Recently, Korea and pricipal advanced countries of the world which recognized that the criterion of national development exists in educational development are making efforts, to educational reforms for improving educationl quality. Such a educational quality and education's success or failure directly relate to teachers' problems, so they should be primarily solved. They are as follows. First, insufficent incentives to secure well-qualified teacher candidates. Second, teachers' low morale, reduced effort and lower job satisfaction because of poor economic compensation, low social status, noninstructional duties, and inadeqate teaching environment and so on. Third, lack of teachers' professionalism, (e. g., poor professional development opportunities, teachers' professional quality about their charged subjects and job. Fourth, intricate coflicts among teachers, (e. g., poor administrative leadership, that is, principls's authoritative leadership style and low staff collegiality) To these problems, First, increasing dramatically teacher's salary up to adequate level according to their careers and professionalism, Teanher's salary should be given to elevate their moral and commitment to education because it has finally influence upon educational effectiveness. Second, improving teacher's working environment. The school's commitment to provide a safe and attractive working environment is a key indicator of whether it is a good place to work.(e. g., an efficent heatingand cooling system, a cmfortable faculty lounge, an ample parking area, adequate -sized office or workplace) Third, preparing various and attractive incentive system for securing well-qualified teacher to be. (e. g., expanding a variety of scholarship for good candidates for teaching, a good teaching physical working conditions descrived above, and various fringe benefits and so forth) Finally, upgrading the degree of social recognition of teachers' society to recover self-respect and pride of teachers, (e. g., enacting a positive, powerful, and special law to gurantee teacher's social, economic status)
Estradiol에 의한 흰쥐-자궁의 수축 기능과 Polyamine 대사의 변동에 관한 연구
이명아,고재홍,이영재,신경호,전보권,천연숙 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.3
The polyamines have been postulated to be essential in most processes associated with both hypertrophy and hyperplasia. The effects of estrogen on uterine contractility vary with animal species, and most reports have shown that in vitro contractility of rat uterus is decreased after estrogen treatment, but estrogen increases polyamine contents in castrated rat uterus. This study was carried out to investigate whether the regulation of polyamine metabolism may be instrumental in the contractile response of castrated nonpregnant uterus of female SD rats to electrical field stimulation (40 V, 100 μsec : EFS). Estradiol (E2) increased uterine contents of putrescine (PT), spermidine (SPD), and spermine (SPM). These E2 effects were inhibited by tamoxifen or DFMO, but E2-incuced increase of uterine SPM content was enhanced by aminoguanidine. E2 decreased the amplitude of force developed in the rhythmic spontaneous contraction of rat uterus, but it exaggerated the increase of uterine contraction force in response to EFS. The E2-dependent exaggeration was inhibited by tamoxifen, DFMO, or indomethacin, but was significantly enhanced by aminoguanidine. The synergism between E2 and aminoguanidine on uterine contractility was little affected by indomethacin. These results suggest that E2-dependent increase of uterine contractility may be ascribed partly to increase of uterus polyamines.
문형남,고태성,박영서,박윤아,홍창희 울산대학교 의과대학 1994 울산의대학술지 Vol.3 No.1
From May to July 1993, we observed an epidemic of aseptic meningitis. We performed clinical and virological studies on 174 children with aseptic meningitis who had been admitted to the Department of Pediatrics, Asan Medical Center, from May to July, 1993 The results were as follows; 1) This epidemic of aseptic meningitis was most prevalent in June 1993. The most of the patients were 3 to 6 years old and male to female ratio was 1.6 : 1. 2) The most patients suffered from fever, vomiting, headache, and abdominal pain was noticed in 36% of patients, characteristically. 3) In 7 cases among 10 randomly sampled cases, enterovirus was cultured. Among them, we performed serotyping in 3 cases and Echovirus 9 was isolated.
Inoculation Methods for Sclerotinia Rot-Resistance Screening in Perilla Germplasm
Young Ah Jeon(전영아),Jung Sook Sung(성정숙),Hyung Jin Baek(백형진),On Sook Hur(허온숙),Na Young Ro(노나영),Ju Hee Lee(이주희),Hyun Choong Ok(옥현충),Ho Cheol Ko(고호철),Awraris Derbie Assefa(아와리스 더비 아세파) 한국약용작물학회 2017 한국약용작물학회 학술대회논문집 Vol.2017 No.2
Young-Yi Lee,Gyu-Taek Cho,Ho-Cheol Ko,Ho-Sun Lee,Young-Ah Jeon,Jung-Sook Sung,Sok-Young Lee,Chang-Yung Kim,Yeon-Gyu Kim 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
The world-wide capacity of genebanks for ex-situ conservation of crop genetic resources has increased greatly since the 1970s, improving the access of crop breeders to landraces, and wild relatives (Wright, 1997). In south Korea, systematic seed germplasm management was begun at the Rural Development Administration (RDA) in 1985 and consequently genebank system was established in 1988. The RDA genebank, National Agrobiodiversity Center (NAC) of south Korea, preserve 173,217 accessions of plant seed germplasm and 10.7% (18,509 accessions) of whole preserved germplasm is occupied by horticultral PGR by 2011. Horticultural PGR preserved in NAC is composed with 67 genera of crops including pepper (3,817 accessions), tomato (2,040 accessions), cabbages (1,690 accessions) and etc. According to horticultural plant sub-group, fruit-vegetable is the biggest group with 60% of accession share and leafy vegetable (19%), root vegetable (10%), bulb vegetable (8%), and ornamental (3%) follow subsequently. In aspect of PGR status, landrace is dominant part of conserved accession and then developed cultivar, wild relatives, cultivated material, wild, and weedy type follow subsequently. Recently characterization and evaluation of horticultural PGR have been activated for 3 years in NAC, which are useful for breeders and users focused on disease-resistance or active ingredient. It will promote utilization of horticultural PGR and development of horticultural crop breeding program for both human being and sustainable agriculture in near future.