제 3 회 신약개발 연구발표회 초록집 ( 1994 . 4 . 15 ~ 16 ) : 포스터발표 제 2 분과 ( 생명공학 , 약효검색 , 약리대사 ) ; PHOSPHODIESTERASE 억제제 (PDE-1) , SODIUM NITROPRUSSIDE , AMITRIPTYLINE , 및 CHLORPROMAZINE 의 항 - 혈소판작용

전보권,안상건,최상현,신경호,이민수,천연숙 한국응용약물학회 1994 학술대회 Vol.1994 No.1

CCl₄에 依한 肝病變과 Norepinephrine代謝의 變動에 미치는 粗人蔘 saponin의 影響

全普權 고려대학교 의과대학 1981 고려대 의대 잡지 Vol.18 No.1

Calvert and Brody (1958) formulated the hypothesis that CCl₄ acted on the central nervous system to produce and intensify sympathetic discharge which resulted in anoxic necrosis of the liver. But Recknagel(1967) suggesred that the essential feature of CCl₄ hepatotoxicity depended on the cleavage of it to CCl₃·(free radical) and the peroxidative decomposition of cytoplasmic membrane lipids. Brekhman(1969) reported that the main effect of ginseng is its adaptogenic activity to promote nonspecific biological resistance, and Han et al. reported that the methanolic extracts of Korean ginseng showed up anti-oxidant property with the free radical quenching activity. This present study was undertaken to evaluate the influence of Korean ginseng on the CCl₄ hepatotoxicity and the change induced by CCl₄ of brain and liver norepinephrine turnover. The results obtained were summarized as follows; 1. Influence of crude ginseng saponin on the changes induced by CCL₄ of hepatic total lipid, glycogen, and lipid peroxide contents and serum lactic dehydrogenase (LDH) activity in mice. a. CCl₄ increased hepatic total lipid and lipid peroxide contents and serum LDH activity and decreased hepatic glycogen content. b. The increased or decrease induced by CCl₄ showed up the maximum values within 24 hours after CCl₄ injection and after that, gradually returned to the normal values. c. Crude ginseng saponin (20㎎/㎏/day for 3 days) did not affect on the hepatic contents and the serum LDH activity. d. The increase or decrease induced by CCl₄(5㎖/㎏) were not affected by the pretreatment of crude ginseng saponin(20㎎/㎏/day for 3 days), but the increase induced by CCl₄ (5㎖/㎏/day for 3 days)were significantly suppressed by the post-treatment of crude ginseng saponin(20㎎/㎏×2) 30 minutes and 6 hours after the last CCl₄ administration. And the decrease of hepatic glycogen induced by CCl₄ was not affected by the pre-or post-treatment of crude ginseng saponin. 2. Influence of crude ginseng saponin on the change of brain and liver norepinephrine turnover induced by CCl₄ in rats. a. CCl₄ (5㎖/㎏ or 5㎖/㎏/day for 3 days) moderately increased brain norepinephrine turnover rate, and CCl₄ (5㎖/㎏/day for 3 days) significantly decreased brain norepinephring content. b. CCl₄ (5㎖/㎏) moderately increased liver norepinephrine turnover rate, but CCl₄ (5㎖/㎏/day for 3 days) rather slightly decreased the rate. c. Crude ginseng saponin (20㎎/㎏/day for 3 days) slightly decreased brain norepinephrine content, but it did not affect on liver norepinephrine content. And the rates of brain and liver norepinephrine turnover were not affected by the saponin regimen. d. The increase of brain and liver norepinephrine turnover rates induced by CCl₄ (5㎖/㎏) were suppressed by the pretreatment of crude ginseng saponin (20㎎/㎏/day for 3 days). And the increase of brain norepinephrine turnover rate and the slight decrease of liver noreohrine turnover rate, induced CCl₄ (5㎖/㎏/day for 3 days), were slightly suppressed by the post-treatment of crude ginseng saponin(20㎎/㎏) 5 minutes after the last CCl₄ administration.

8명의 한국인 남자 학생들에서 Sodium Valproate의 생체이용률 연구를 위한 HPLC 분석 방법의 개발

전보권,정운원,이승관,이창규 高麗大學校 倂設 保健大學 保健科學硏究所 2003 保健科學論集 Vol.29 No.2

Sodium Valproate levels are frequently monitored in clinical laboratories to assess compliance in epileptic patients and to optimize theraphy. In this study, a simple and accurate high performance liquid chromato-graphic method for valproic acid in plasma was developed to be applicable for the studies on the bioavailability of sodium valproate tablets and the therpeutic drug monitoring of plasma valproic acid level. All plasma samples were added with an internal standard, zinc sulfate solution, and acetonitrile, followed by centrifugation. The supernatants were added with 4-bromophenacyl bromide and were heated at 70℃ for 15min. The derivatization products were extracted with hexane, and the hexane extraction solutions were evaporated to dryness and redissolved in mobile phase. The solution was analyzed using HPLC system. The inter-Day and the intra-Day coefficients of variation ranged from 1.8% to 4.9%, and 3.0% to 4.2%. The simple and accurate HPLC method of analysis of plasma valproic acid seems to be adequate for the studies of bioavailability of sodium valproate tablets and therapeutic drug monitoring of plasma valproic acid level.

Ephedrine의 血糖增加作用에 미치는 交感神經遮斷藥의 影響

全普權 고려대학교 의과대학 1978 고려대학교 의과대학 잡지 Vol.15 No.2

Ephedrine의 血糖增加作用에 미치는 交感神經遮斷藥의 影響

全普權,申明湜,申萬鍊 고려대학교 의과대학 1978 고려대 의대 잡지 Vol.15 No.2

Ephedrine which is an alkaloid with direct and indirect sympathomimetic property has been will known as a tachyphylactic drug, but few studies were reported for the metabolic effect of it. In this paper, the change of the hyperglycemic action of ephedrine which was occurred by increase of ephedrine dosage or repeated injection of it in rabbits respectively and the influences of several adrenergic blocking drugs on the hyperglycemic action of ephedrine were investigated. The results obtained were as follows: 1. The increase of blood sugar induced by triple injection of ephedrine 10 ㎎/㎏ (repeat interval: 10 min) was much less than that induced by each injection of ephedrine 10 ㎎/㎏ and 30㎎/㎏ respectively. 2. The increase of blood sugar induced by ephedrine was significantly inhibited by reserpine pretreatment. 3. The blood sugar concentration was not increased by dibenamine 2 ㎎/㎏ but increased by dibenamine 10 ㎎/㎏. and the increase of blood sugar induced by ephedrine was significantly potentiated by dibenamine pretreatment of both dosages. 4. The blood sugar concentration was slightly increased by ergotamine 0.1 ㎎/㎏, but after ergotamine pretreatment, the concentration was not increased by ephedrine, and rather decreased below the normal level 5. The increase of blood sugar induced by ephedrine and the increase by ephedrine which was potentiated by dibenamine pretreatment were significantly inhibited by propranolol.

Picrotoxin의 과혈당작용(過血糖作用)과 그에 대(對)한 몇 약물(藥物)의 영향(影響)

전보권,Chun, Boe-Gwun 대한약리학회 1978 대한약리학잡지 Vol.14 No.1

Ban formulated the concept of 'sympathetic center' and 'parasympathetic center' in the central nervous system, and Folkow et al. reported that the electric stimulation of the posterior part of hypothalamus induced the marked liberation of catecholamines from the adrenal medulla. Tatum reported that the hyperglycemic action of picrotoxin is contributed to the cathecholamines liberation from adrenal medulla by the excitation of hypothalamus via splanchnic nervous plexus. In this paper, the relationship between the convulsive action and the hyperglycemic effect of picrotoxin was investigated, with references to the influences of several drugs related with adrenergic function and two intravenous anesthetics on the picrotoxin hyperglycemia. The results obtained were summarized as follows; 1) There was no difference between the convulsive dose(1. 5mg/kg) and the subconvulsive dose (0.75mg/kg) of picrotoxin in its hyperglycemic effect that was not affected with the phenobarbital pretreatment, but the efficacy of its hyperglycemic action was more prominent than that of strychnine. 2) The hyperglycemic effect of picrotoxin was markedly suppressed by the pretreatment of thiopental or ketamine. 3) The hyperglycemic effect was not affected by the reserpine pretreatment, but the effect was markedly suppressed by the pretreatment of iproniazid or chlorpromazine. 4) The hyperglycemic effect of picrotoxin was significantly suppressed by the pretreatment of hexamethonium, propranolol or guanethidine, and the order of those suppressing efficacy was propranolol> hexamethonium> guanethidine.

약물상호작용의 원리와 의의

전보권,Chun, Boe-Gwun 대한생물정신의학회 2000 생물정신의학 Vol.7 No.1

There is nothing that is harmless ; the dose alone decides that something is no poison(Paracelsus, 1493-1541). So, in a point of view to maximize the therapeutic efficacy of drug therapy in a way that minimize the drug toxicity, the knowledges of the drug-ineractions as well as the pharmacokinetic and pharmacodynamic principles of every therapeutic drug used in the medical clinic cannot be emphasized too much. Many drug interactions can be predicted if the pharmacokinetic properties, pharmacodynamic mechanisms of action of the interacting drugs are known, and most adverse interactions can be avoided. In this paper, the clinical importance, classification, and general principles of clinical drug-interactions are presentated with a few explanatory examples.

Tyramine 및 epinephrine에 依한 血中 二·三 代謝中間物質의 變動에 미치는 Ca 및 Mg의 影響

全普權 고려대학교 의과대학 1977 고려대 의대 잡지 Vol.14 No.1

Sutherland and his colleagues formulated the concept of cyclic AMP as a second messenger in the actions of epinephrine, and many studies agree with early work showing an inhibition of adenyl cyclase by excess calcium. Titus et al. reported that the neuronal uptake of norepinephrine was enhanced by addition of Ca and Mg. In this paper, the influences of Ca and Mg on the changes of blood sugar, plasma nonesterified fatty acid and serm in tyraorganic phosphorus levls of rabbits which were induced by tyramine and epinephrine injection were investigated. The results obtained were summarized as follows; 1. The increase of blood sugar induced by tyramine and epinephrine injection was inhibited by Ca or Mg pretreatment, and especially, the blood sugar level of rabbits pretreated with Ca was decereased below the normal value by tyramine injection. 2. The increase of plasma nonesterified fatty acid induced by tyramine injection was not affected by Ca of Mg pretreatment, but the increase by epinephrine was inhibited by Ca of Mg pretreatment. 3. The transient decrease of serum inorganic phosphorus induced by tyramine injection was prolonged by Ca pretreatment, but inhibited by Mg pretreatment. And the marked decrease of serum inorganic phosphorus induced by epinephrine injection was not affected by Ca of Mg pretreatment.

설파劑의 藥力學的 特性

全普權 藥業新聞社 1985 (月刊) 醫藥情報 Vol.1985 No.7

알코올의 약리작용

全普權 대한의사협회 1998 대한의사협회지 Vol.41 No.1