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황일란(Il Ran Hwang),김정원(Jung Won Kim),박선미(Sun Mi Park),김해련(Hae Ryun Kim),민영일(Young Il Min) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
N/A Background/Aims: Primary gastric non-Hodgkins lymphoma is rare and represents a minority of 1-7% of all gastric malignancy. Prognosis and early diagnosis remains important. Methods: We analysed clinical and endoscopic findings in 27 patients with primary gastric non-Hodgkins lymphoma between June 1989 and July 1994 at the Asan Medical Center. Results: The prevalence of primary gastric lymphoma occupied 1.2% of all gastric cancers. The most frequent chief complaint was epigastric pain(74%), followed by postprandia] epigastric discomfort (19%), abdominal mass(15%) and gastrointestinal bleeding(11%). Initial endoscopic findings suggested gastric lyrnphoma in 6 cases(22%), advanced gastric cancer in 14 cases(52%) and benign gastric ulcer in 2 cases(7%). The macroscopic type of 15 cases(56%) was ulcerative, while 5(19%) were superficial, 5(19%) giant mucosal fold, and 2(6%) polypoid. Pathologic findings of initial endoscopic biopsy specimens in 18 operated cases were gastric lymphoma in 7 cases, atypical lymphocyte infiltration in 3 cases, adenocarcinoma in 4 cases and ulcer or erosion in 3 cases. Conclusions: A definite diagnosis of primary gastric non-Hodgkins lymphoma was difficu]t to be confirmed by endoscopic examination and biopsy. Recognition of specific endoscopic findings with a high index of suspicions is essential for early diagnosis, and multiple biopsies with/without submucosa are required. (Korean J Gastroenterol 1996;28: 11 - 18)
소화기질환에서 cDNA microarray 연구의 응용 및 전망
황일란 ( Il Ran Hwang ),조성원 ( Sung Won Cho ),함기백 ( Ki Baik Hahm ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.4
The human genome project has afforded huge amounts of DNA sequence data. A future challenge will be to determine how genes or their products actually interact with each other and response to many chemical or biological stimuli. They would respond by specifically changing in gene expression patterns. Altered expression patterns of genes are expected to accompany many or all human diseases. Such functional genomics will lead to understanding complex disease pathways and biological processes. cDNA microarray is emerging as a powerful tool to measure simultaneously the level of steady-state mRNA for every gene in human genome. It is applied to the study of functional genomics. In contrast to the traditional approach by studying a single gene, they permit massive parallel data of gene expression patterns in a single reaction based on hybridization. Now bioinformatics is capable of managing the high-throughput data with the great advance in computer science. The success of microarray depends on how we analyze and visualize data. This article reviews the methodology involved in cDNA microarray and its clinical application. Microarray is becoming increasingly useful in understanding pathogenesis in digestive diseases and also in refining patients` management in terms of disease prognosis and diagnosis, individual disease susceptibility, drug discovery, and toxicology. (Korean J Gastroenterol 2003;41:241-249)
위암 환자에서의 Helicobacter pylori IgG 항체 양성률과 혈청 Pepsinogen 1 및 2 농도
황일란(Il Ran Hwang),이상인(Sang In Lee),박효진(Hyo Jin Park),민영일(Young Il Min) 대한내과학회 1995 대한내과학회지 Vol.49 No.4
N/A Objectives: Helicobacter pylori(H. pylori) infection, thought to causally related to peptic ulcer and chronic antral gastritis, may also be associated with gastric cancer. A considerable number of normal subjects in Korea were infected with H. pylori infection. In gastric carcinogensis serum pepsinogen I and II levels may be indicator of precancerous lesions such as atrophic gastritis and intestinal metaplasia, which were known to associated with gastric cancer and may be induced by H, pylori infection. Methods: The levels of serum H. pylori IgG antibody were measured using enzyme-linked immunosorbent assay and the levels of serum pepsinogen I and II using immunoradiometric assay in 174 gastric cancer patients and 165 controls. Results: There was no statistically significant difference between the positive incidence of H. pylori infection in gastric cancer patient (60.3%) and in control group (70.9%). Antibodies to H. pylori were detected in 64.8% of non-cardiac gastric cancer patients but in only 12.5% of cardiac gastric cancer patients (p<0.05). The positive incidences of H, pylori infection in intestinal and diffuse histologic type of gastric cancer were similar. Serum pepsinogen I and II levels were higher in H. pylori-infected controls than in uninfected controls (p<0.05). Serum pepsinogen I levels was lower in gastric cancer patients than control group (p<0.05). However, there was no difference in serum pepsinogen I and II levels between H. pylori-infected and uninfected gastric cancer patients. Conclusion: The positive incidence of H. pylori infection in gastric cancer was similar to that in controls and there was no evidence of the direct relationship between H, pylori infection and gastric carcinogensis.