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3차 의료기관의 소화기 전문의에게 의뢰된 기능서 위장질환의 양상
함기백,김종수,이광재,김진홍,조성원 대한소화기기능성질환·운동학회 2004 Journal of Neurogastroenterology and Motility (JNM Vol.10 No.2
목적: 위장관 증상으로 3차 의료기관에 의뢰된 환자에서 위장관 증상의 빈도, 로마기준 II에 의해 진단된 기능성 위장질환의 종류 및 양상을 알아보고자 하였다. 대상 및 방법: 2004년 1월부터 동년 3월까지 아주대학교병원 소화기내과에 위장관 증상을 주소로 내원한 초진 환자 476명을 대상으로 하였으며, 간담췌질환이 원인인 경우는 연구대상에서 제외하였고, 로마기준 II에 따른 기능성 위장질환의 분류가 가능하도록 고안된 설문지를 통하여 전향적으로 조사하였다. 결과: 대상환자 중 기질적 질환이 90명(19%), 기능성 위장질환으로 진단된 경우가 332명(70%) 이었으며, 54명(11%)의 환자에서는 기질적 원인을 찾을 수 없었으나 로마기준 II를 만족시키지 못 하는 환자였다. 기능성 위장질환은 기질적인 질환에 비해 여자에서 더 흔하게 나타났다. 환자가 호소하는 증상으로 상부 위장관에서는 소화불량(33%)이, 하부 위장관에서는 복통/복부 불쾌감(27%)이 가장 많았다. 기능성 위장질환 중에는 기능성 소화불량증(37%)과 과민성 장 증후군(18%)이 가장 많았으나 그 외에도 다양한 종류의 기능성 위장질환이 관찰되었다. 기능성 위장질환으로 진단된 환자들 중 20%에서 2가지 종류 이상의 기능성 위장질환을 갖고 있었으며, 기능성 소화불량증과 과민성 장 증후군이 중복된 경우가 가장 많았다. 결론: 기능성 위장질환은 3차 의료기관의 소화기 전문의에게 의뢰되는 가장 흔한 질환이며, 특히 기능성 소화불량증과 과민성 장 증후군이 가장 많은 군을 차지한다. 여러 부위의 다양한 기능성 위장질환이 나타날 수 있으므로 보다 효과적인 진단 및 치료를 위한 신뢰성 있는 분류가 필요하다.
각종 간질환 환자에서 혈중 lipoprotein ( a ) 농도의 변화
함기백,김원호,한광협,전재윤,강진경,박인서,최홍재 ( Ki Baik Hahm,Won Ho Kim,Kwang Hyub Han,Chae Yoon Chon,Jin Kyung Kang,In Suh Park,Heung Jai Choi ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2
Lipoprotein (a) [Lp (a)] is a LDL-like lipoprotein whose concentrations in plasma are significantly are correlated with atherosclerosis. The characteristic protein compoment of Lp (a) is apoliporotein (a) which is linked to apolipoprotein B-100 by disulfide bonds. Although Lp (a) might play an important role in the development of premature atherosclerotic vascular lesions, only scarse information about the metabolism of this lipoprotein is available. The major site of synthesis of Lp (a) appers to be the liver because it was found that a complete conversion of the Lp (a) phenotype of thc receipient to that of the donor occurs after liver transplantation and presence of apo (a) mRNA in human liver and hepatoma cell line. Until the present time, little information is available about determining the influence of liver disease on Lp (a) concentration. This study was designed to find out the changes of Lp (a) concentrations in 88 patients with various liver diseases, diagnosed histologically through the peritoneoscopic liver biopsy. The Lp (a) concentrations were checked by the method of radioimmunoassay. The mean Lp (a) concentrations of CAH with LC (6.1+4.8 mg/ml) and LC group (4.1+2,2 mg/ml) were significantly lower than those of normal control (24.4+19.1 mg/ml), CPH (25.4+18.5mg/ml), and CAH group (16.6+13.7 mg/ml). The Lp (a) concentrations were significantly correlated with serum albumin concentrations (r=0.54 p<0.05) and prothrombin time (r=0.62, p<0.01). There was a significant difference in mean Lp (a) coincentration between the cases with serum albumin above and below 3.0 g/ml in patients with liver cirrhosis. These data suggest that lipoprotein (a) may be secreted frorn the liver in accordance with the capability of liver to synthesize the protein and we find out that as the liver diseases progressed and deteriorated, the levels of Lp (a) concentrations were significantly decreased.
알코올에 의한 간손상시 적혈구막 지질 과산화현상의 역할
함기백,김원호,전재윤,문영명,강진경,박인서,최홍재,장학철,김한수,백승운,신용운 ( Ki Baik Hahm,Won Ho Kim,Chae Yoon Chon,Young Myung Moon,Jin Kyung Kang,In Suh Park,Heung Jai Choi,Hak Chul Jang,Han Soo Kim,Seung Woon Paik,Yong Woon Shin 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2
The question of whether or not ethanol-induced liver injury is related to or accompanied by lipid peroxidation has been a subject of controversy. Short-term ethanol administration was shown by some to produce hepatic lipid peroxidation in rats, but very large doses of ethaol had to be used. Furthermore, some investigators failed to confirm these effects of ethanol. Fewer studies have explored the relationship between alcohol consumption and lipid peroxidation. In order to study this question and clarify the role of oxygen derived free radicals and lipid peroxidation of the RBC in inducing the alcoholic liver diseases, we measured the thiobarbituric acid reactivities in normal controls and patients with alcoholic liver disease. The subjects were divided into three groups according to the liver function tests and the amounts of alcohol drinking: group I-normal controls, group II-cases showing normal liver function test in spite of frequent alcohol drinking over 3 days per week and 45 g alcohol per one time, group III-patients with alcoholic liver disaesae, drinking alcohol over 4 times per week. The thiobarbituric acid reactive substances were measured as a marker of lipid peroxidation by the method of Uchiyama and Mihara. The colorimetric method was used by a measurment of malonyldialdehyde [MDA, nmole/ml (packed cells)] concentration. The results were as follows; (continue...)
Cysteamine 이 백서의 십이지장궤양 형성시 미치는 영향
함기백,이상인,임대순,김원호,전재윤,문영명,강진경,박인서,최홍재,박형우 ( Ki Baik Hahm,Sang In Lee,Dae Soon Yim,Won Ho Kim,Chae Yoon Chon,Young Myung Moon,Jin Kyung Kang,In Suh Park,Heung Jai Choi,Hyung Woo Park ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.4
The administration of cysteamine is koown to produce duodenal ulcer in rat. Mucosal damage starts to appear in the duodenal bulb after a delay of 4-8 hous after administration of cysteamine, but despite of several studies, the pathogenesis is not fully understood yet. The aim of the present study was to investigate the role of the various factors such as acid, motility, GABA, and primary afferent neuron on cysteamine-induced duodenal ulcer through the experiments using the Sprague-Dawley rats. (continue...)