http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
홍승재,양형인,윤휘중,이명수,강효종,김완욱,이상헌,조철수,김호연,Hong, Seung-Jae,Yang, Hyung-In,Yoon, Hwi-Joong,Lee, Myoung-Soo,Kang, Hyo-Jong,Kim, Wan-Uk,Lee, Sang-Heon,Cho, Chul-Soo,Kim, Ho-Youn 대한면역학회 2003 Immune Network Vol.3 No.1
Background: Celecoxib, a COX-2 specific inhibitor, has recently been used for the treatment of rheumatoid arthritis. However, the molecular and cellular mechanisms of celecoxib against RA inflammation remain to be defined. To elucidate the action mechanism of celecoxib on inflammatory cells, we investigated the effect of celecoxib on the production of two important mediators of inflammation, nitric oxide and PGE2 Methods: RAW 264.7 cells stimulated with LPS were preincubated with various concentrations of celecoxib (from $10^{-8}$ to $10^{-5}$ M) and $10{\mu}M$ hydrocortisone, respectively. The production of NO and PGE2, the end products of iNOS and COX-2 genes, were estimated in culture supernatants by Greiss method and EIA, respectively. The expression of iNOS gene, COX-2 gene, $NF-{\kappa}B$, and $I-{\kappa}B$ were determined by RT-PCR and western blot analysis. Results: Celecoxib and hydrocortisone inhibited the production of NO and PGE2 in dose dependent manner, when RAW 264.7 cells were stimulated with LPS. The expression of iNOS was also down-regulated by celecoxib and hydrocortisone. Interestingly, COX-2 gene differentially expressed according to the dose of celecoxib, a decrease with lower dose ($10^{-8}$ M) but an increase with higher dose ($10^{-5}$ M). $NF-{\kappa}B$ binding activity was decreased by lower dose of celecoxib, whereas was not affected by higher dose of it. The expression of $I-{\kappa}B$ was suppressed by higher dose of celecoxib. Conclusion: The celecoxib strongly suppressed the production of NO and PGE2 in LPS-stimulated RAW264.7 cells. The decrease of NO seems to be linked to the inhibition of iNOS by celecoxib. The lower and higher dose of celecoxib differentially regulated the COX-2 expression and $NF-{\kappa}B$ activity.
한국인 무릎 골 관절염 환자들의 임상 양상과 Apo-1/Fas (CD95) 유전자 다형성과의 상관관계에 관한 연구
홍승재,양형인,임성빈,정주호,정영옥,김호연,Hong, Seung-Jae,Yang, Hyung-In,Yim, Sung-Vin,Chung, Joo-Ho,Jung, Young-Ok,Kim, Ho-Youn 대한면역학회 2003 Immune Network Vol.3 No.2
Background: Apoptosis has been implicated in pathogenesis of various disease. Apo-1/Fas (CD95) is one of the main pathway of apoptosis. To examine the possible relationship between Apo-1/Fas (CD95) and primary knee osteoarthritis, MvaI restriction length polymorphism (RFLP) in human Apo-1/Fas (CD95) gene was assessed. Methods: Genotype and allele frequencies in promoter region in the Apo-1/Fas (CD95) gene were studied by PCR-RFLP in 226 Korean controls and 148 Korean patients with primary knee osteoarthritis. Results: No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the knee oateoarthritis patients. But in the severe grade (grade 3, 4) Kellgren-Lawrence score patients, the frequency of $MvaI^*1$ (G) allele was significantly decreased (P=0.0392) and the of $MvaI^*2$ (A) allele frequency was significantly increased (P=0.0473) compared to the normal controls. Conclusion: Apo-1/Fas (CD95) gene polymorphism is a part a determinant factor of severity in knee osteoarthritis, the patients with $MvaI^*2$ (A) allele is more severe radiologic progression. Further substantiation studies are needed in larger patient samples and various other apoptosis related genes to elucidate the mechanism of osteoarthritis, including the Fas ligand gene analysis.
홍승재(Seung Jae Hong),권선희(Sun Hee Kwon),김효종(Hyo Jong Kim),동석호(Seok Ho Dong),김병호(Byung Ho Kim),이정일(Joung Il Lee),장영운(Young Woon Chang),장린(Rin Chang) 대한내과학회 1996 대한내과학회지 Vol.51 No.6
Cronkhite-Canada Syndrome is one of the generalized gastrointestinal polyposes, whose cardinal features are the presence of hamartomatous polyps of the juvenile (retention) type throughout the stomach and intestines, adult onset, the absence of a family history of polyposis, ectodermal changes consisting of alopecia, onychodystrophy and hyperpigmentation, the eventual development of diarrhea and weight loss. Management is symptomatic treatment for abdominal pain and diarrhea as well as dietary supplementation with oral and intravenous fluids, electrolytes, vitamins, amino acids, albumin, lipids, etc, Other a variety of medical and surgical approaches has being tried. We experienced a case of 67-years-old female who intermittent epigastric pain and bloody diarrhea, alopecia, nail dystrophy, hyperpigmentation, and reported with the review of literature.
유은미,홍승재,Yu, Eun-Mi,Hong, Seung-Jae 한국주거학회 2006 한국주거학회 논문집 Vol.17 No.6
Ham-ra is a village that belongs to Ham-yuel Ri, Ik-san city and also known as the village where 4 millionaire modem age rich farmer households are residing in the center of the village. Originally, central point of the village was Gaeksa and Hyanggyo that is in Suodong, but early 1900s, rich farmers found new Places beside Suodong and built large-scale houses and around it, houses of tenant and commercial places were formed and became the new center of the village. Therefore, Ham-ra village shows well about the changes of the traditional village in the end of Chosun Dynasty aspect that of existent village space according to rich farmer's growth. Especially, the large scaled Korean traditional houses which were built newly in the year between 1917 to 1939 shows main road and Natural stream surrounding the village which are not found in any other village. 3 rich farmers (Lee Bae-won, Jo Hae-young, Kim An-gyun house) and Lee Jib-cheon's houses built a large scaled Sarang-chae and An-chae to compete and to show off there wealth. This residing imitated High-classe house yet accommodated social changes and through a voluntary experiment, is expressing modernity of Han-ok very well. Similarity and creativity in residing form appears well in buildings similar time and village. This research analyzed space composition change of the village and characteristic of Architecture who appear at modern process of typical farmer houses which make a strong resolution to Ham-ra hereupon.
류마티스 관절염 병인에서 제2형 콜라겐에 대한 면역반응의 역할
정영옥,홍승재,김호연,Jung, Young Ok,Hong, Seung-Jae,Kim, Ho-Youn 대한면역학회 2003 Immune Network Vol.3 No.1
Type II collagen (CII), major component of hyaline cartilage, has been considered as an auto-antigen in rheumatoid arthritis (RA). However, the clinical and biological significances with regard to the CII autoimmunity need to be clarified in human RA. The presence of antibodies to CII has been identified in sera, synovial fluid, and cartilage of patients with RA. In our study, the increased titer of IgG anti-CII in sera was well correlated with C-reactive protein, suggesting that this antibody may reflect the inflammatory status of RA. The titer of anti-CII antibodies (anti-CII Abs) tended to be higher in early stages of diseases. In our extending study, among 997 patients with RA, 269 (27.0%) were positive for circulatory IgG antibody to CII, those levels were fluctuated over time. It is hard to assess the significant amount of T cell responses to CII and CII (255~274) in RA. By using a sensitive method of antigen specific mixed lymphocyte culture, we can detect the presence of CII-reactive T cells in peripheral blood mononuclear cells of RA patients. Sixty seven (46.9%) of 143 patients showed positive CII reactive T cell responses to CII or CII (255~274). The frequencies of CII reactive T cells were more prominent in inflamed synovial fluid (SF) than in peripheral blood. These T cells could be clonally expanded after consecutive stimulation of CII with feeding of autologous irradiated antigen presenting cells (APC). Moreover, the production of Th1-related cytokine, such as IFN-${\gamma}$, was strongly up-regulated by CII reactive T cells. These data suggest that T cells responding to CII, which are probably presenting the IFN-${\gamma}$ producing cells, may play an important role in the perpetuation of inflammatory process in RA. To evaluate the effector function of CII reactive T cells, we investigated the effect of CII reactive T cells and fibroblasts-like synoviocytes (FLS) interaction on the production of pro-inflammatory cytokines. When the CII reactive T cells were co-cultured with FLS, the production of IL-15 and TNF-${\alpha}$ from FLS were significantly increased (2 to 3 fold increase) and this increase was clearly presented in accord to the expansion of CII reactive T cells. In addition, the production of IFN-${\gamma}$ and IL-17, T cell derived cytokines, were also increased by the co-incubation of CII reactive T cells with FLS. We also examined the impact of CII reactive T cells on chemokines production. When FLS were co-cultured with CII stimulated T cells, the production of IL-8, MCP-1, and MIP-1${\alpha}$ were significantly enhanced. The increased production of these chemokines was strongly correlated with increase the frequency of CII reactive T cells. Conclusively, immune response to CII was frequently found in RA. Activated T cells in response to CII contributed to increase the production of proinflammatory cytokines and chemokines, which were critical for inflammatory responses in RA. The interaction of CII-reactive T cells with FLS further augmented this phenomenon. Taken together, our recent studies have suggested that autoimmunity to CII could play a crucial role not only in the initiation but amplification/perpetuation of inflammatory process in human RA.
무작위 대조 이중맹검 시험을 통한 봉독 약침의 류마티스 관절염 치료 효과 연구
이상훈,홍승재,김수영,양형인,이재동,최도영,이두익,이윤호,Lee, Sang-hoon,Hong, Seung-jae,Kim, Su-young,Yang, Hyung-in,Lee, Jae-dong,Choi, Do-young,Lee, Doo-ik,Lee, Yun-ho 대한침구의학회 2003 대한침구의학회지 Vol.20 No.6
Objective : This study was performed in order to evaluate the effect of bee venom therapy on rheumatoid arthritis by randomized controlled double blind method. Methods : RA patients were recruited and divided into an experiment group and a control group by random selection. As a double blind test, the experiment group was treated with bee venom injection on acupoints, and the control group was treated with normal saline injection on acupoints twice a week for 8 weeks. Tender joint count, swollen joint count, morning stiffness, pain, health assessment questionnaire, ESR, and CRP were estimated and analyzed at baseline, and at 1 month and 2 months after bee venom therapy. Results : Compared to the control group, the experiment group showed significant decrease in tender joint count, swollen joint count, morning stiffness, and health assessment questionnaire after 2 months. Pain, ESR and CRP showed significant decrease in the experiment group after 1 & 2 months. Conclusions : These results suggests that bee venom therapy could be an effective method in the treatment of patients with rheumatoid arthritis.
박재현 ( Jae Hyun Park ),오원택 ( Won Taek Oh ),이연아 ( Yeon Ah Lee ),이상훈 ( Sang Hoon Lee ),양형인 ( Hyung In Yang ),이선 ( Sun Lee ),홍승재 ( Seung Jae Hong ) 대한내과학회 2008 대한내과학회지 Vol.75 No.4
Relapsing polychondritis is a rare condition of unknown etiology in which recurrent episodes of inflammation are followed by the destruction of cartilaginous structures, which predominantly include the nose, ears, and tracheobronchial tree. Although many autoimmune disorders, such as systemic vasculitis, rheumatoid arthritis, lupus erythematosus, Sjogren`s syndrome, and Behcet`s disease, are commonly found in patients with relapsing polychondritis, ankylosing spondylitis is rarely associated with this disease. We report a case of relapsing polychondritis with ankylosing spondylitis in the same patient. (Korean J Med 75:467-470, 2008)
고려시대 사찰 주불전의 평면 구성에 관한 연구 - 정면 5칸 불전을 중심으로 -
서지은(Seo Ji-Eun),홍승재(Hong Seung-jae) 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
This study is about the formation of plan in 5 Kan Buddhist sanctums of the Koryeo Period. Due to the excavation investigation of Koryeo temples, the constructive phase of the sanctum built in the Koryeo Period are being gradually discovered. The plan style of Buddhist sanctums founded in the Koryeo Period and the disposition structure of temples are relatively various. The plan formation (style) was examined in regard to the religious contents and Buddhist consciousness at that time. Also, based on the plan structure, it was estimated whether they were single-storied or multiple-storied. For this, they were analyzed by comparing with the existing buildings of the Choseon Period.