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박인석 ( In Seok Park ),한세환 ( Se Hwan Han ),김기환 ( Ki Whan Kim ),배병노 ( Byung Noe Bae ),양근호 ( Keun Ho Yang ),곽금희 ( Geum Hee Gwak ),조현진 ( Hyun Jin Cho ),박경미 ( Kyeong Mee Park ),김지영 ( Ji Young Kim ),박성진 ( Su 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.1
목적: 유방암 환자에서 국소구역 재발은 환자의 사망률을 증가시키는 요인이다. 본 연구는 유방 보존술을 받은 환자를 대상으로 국소구역 재발에 영향을 주는 인자를 알아보고자 진행 되었다. 방법: 단일 기관에서 유방 보존술을 받은 302명의 환자를 대상으로 후향적으로 의무 기록 및 조직 병리 보고서를 검토하여 국소구역 재발과 연관 있는 인자들을 분석 하였다. 결과: 302명의 환자 중 26명(8.6%)이 국소구역 재발을 보였고 중간 추적관찰기간 35.5개월 동안 18명(5.9%)이 국소재발을, 6명(2.0%)이 구역재발을, 그리고 2명(0.7%)이 국소구역 재발을 하였다. 각각의 인자들에 대한 단변량 분석에서 절제연 상태, HER2/neu 발현 양성, 광범위 관내상피 병소, 다발성 병변이 통계학적 유의한 인자였고 다변량 분석에서는 절제연 상태, HER2/neu 발현 양성, 다발성 병변이 유의한 인자였다. 결론: 침습 유방암에서 유방 보존술 후 국소구역 재발율을 낮추기 위해서는 수술 시 음성 절제연을 확보하고 보조 항암화학요법 및 방사선 치료를 고려해야 한다. 특히 다발성 병변을 가지고 있거나 HER2/neu 양성인 유방암은 국소 재발율이 높으므로 보조치료 후 국소 재발을 발견하기 위한 적극적 추적관찰이 필요 할 것으로 사료된다. Purpose: Significant proportion of breast cancer patients with locoregional recurrence eventually die of their disease. This study was performed to investigate the risk factors associated with locoregional recurrence of breast cancer after breast conserving surgery. Methods: We reviewed the medical records of 302 patients with breast cancer who underwent breast conserving surgery and analyzed the association between locoregional recurrences and clinico-pathological factors of each patients. Results: The 26 of 302 patients (8.6%) developed locoregional recurrence during a median follow-up of 35.5 months. 18 patients (5.9%) had local recurrence, 6 patients (2.0%) had regional recurrence and 2 patients (0.7%) had locoregional recurrence. On univariate analysis, positive margin (p<0.0001), HER2/neu positive, extensive intraductal component, multiplicity were statistically significant risk factors for locoregional recurrence of breast cancer. On multivariate analysis, positive margin status, HER2/neu positivity and multiplicity were significantly associated with locoregional recurrence after breast conserving surgery. Conclusion: Our study showed that adequate resection margin is the most important to reduce locoregional recurrence of breast cancer after breast conserving surgery. In addition, HER2/neu amplification or multiplicity increased the locoregional recurrence rate in breast cancer.
강동원,곽금희,양근호,배병노,김기환,한세환,김홍주,김영덕,최명재,Kang, Dong-Won,Gwak, Geum-Hee,Yang, Keun-Ho,Bae, Byung-Noe,Kim, Ki-Hwan,Han, Se-Whan,Kim, Hong-Joo,Kim, Young-Duk,Choi, Myeung-Jae 대한소아외과학회 2008 소아외과 Vol.14 No.2
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in the neonatal population. The aim of this study is to evaluate surgical indication and prognostic factors of NEC. Clinical data of seventy patients, diagnosed as NEC between January 2000 & January 2007, were reviewed retrospectively. Fifty-seven patients had medical treatment and 7 of them died. Thirteen patients who presented with pneumoperitoneum on plain abdominal film or were refractory to medical treatment received surgical treatment, and 5 of them died. All the expired 12 patients weighed less than 2500 g. Twenty out of seventy patients showed thrombocytopenia, and 11 patients of them died. The finding of pneumoperitoneum and thrombocytopenia could be the most important surgical indication. Prematurity, low birth weight and thrombocytopenia were related to a bad prognosis. NEC patients who presents with these findings must be considered for close observation and intensive care.
정현석 ( Hyeon Seok Jeoung ),곽금희 ( Geum Hee Gwak ),한세환 ( Se Hwan Han ),김영덕 ( Young Duk Kim ),김홍주 ( Hong Ju Kim ),김기환 ( Ki Whan Kim ),배병노 ( Byung Noe Bae ),양근호 ( Keun Ho Yang ),김홍용 ( Hong Yong Kim ),박성진 ( 대한임상종양학회 2010 Korean Journal of Clinical Oncology Vol.6 No.2
목적: 내시경적 갑상선 수술은 양성 갑상선 질환뿐만 아니라 갑상선 암에서도 널리 시행되고 있다. 본 연구자들은 갑상선 암의 내시경적 수술이 기존의 경부절개를 통한 갑상선 수술의 결과와 비교하고자 하였다. 대상과 방법: 2008년 6월부터 2010년 5월까지 유두상 갑상선 암으로 갑상선 전 절제술, 아전절제술, 혹은 엽절제술을 시행한 환자들을 대상으로 경부 절개 갑상선 절제술과 내시경 갑상선 절제술의 단기 임상 결과를 비교 분석하였다. 결과: 내시경 갑상선 절제 군은 22예, 경부절개 갑상선 절제 군은 79 예였다. 내시경적 갑상선 수술을 받았던 환자 군에서 나이가 40.1±09.1세 (25-57세)로 경부 절개 군의 51.1 ± 9.9세 (33-73세) 보다 적었고(p<0.00001) 종양의 크기도 0.64 ± 0.28 cm로 1.06±0.72 cm 보다 더 적었다(p<0.009). 수술시간은 내시경 군에서 231.8분으로 경부절개 군의 147.9보다 80분 정도 더 걸렸다(p<0.0001). 하지만 수술 후 입원기간이나 장액종, 제거 술이 필요할 정도로 증상을 야기한 혈종, 일시적인 저칼슘혈증, 영구적인 저칼슘혈증, 회귀 후두신경 손상, 식도 손상, 기도 손상 등과 같은 합병증의 발생률은 경부 절개 군이나 내시경적 수술 군 사이에 통계학적으로 차이가 나지 않았다. 결론: 내시경 갑상선 절제술은 최소한의 수술적 위험도로 크기가 적은 유두상 갑상선 암에서 안전하게 시행할 수 있는 수술법이었다.
위암환자의 예후인자로서 cyclin D1의 유용성에 관한 연구
류석용,김홍용,한세환,배병노 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1
■ Objectives This study was conducted to evaluate the clinical implication of cyclin D1 expression in human gastric cancer. In addition, clinical utility of cyclin D1 as a prognostic marker in human gastric cancer was also evaluated. ■ Methods and materials Medical records and archival pathology tissues from 76 primary gastric cancer patients who underwent curative gastric resection and same postoperative adjuvant chemotherapy were evaluated. Correlation between cyclin D1 expression and clinicopathological parameters was investigated. ■ Results Expression of cyclin D1 was observed in 22 of 76(28.9%) gastric cancer tissues. Expression of cyclin D1 did not correlate with depth of tumor infiltration(p=0.15), lymph node metastasis (p=0.54) and pathologic stage of the disease(p=0.45). Cyclin D1 expression slightly increased in intestinal type tumors. but there was not significant correlation between cyclin D1 expression and Lauren's classification(p=0.50). Increased expression of cyclin D1 was observed more frequently in the tumors with high levels of S-phase fraction but there was not a sign ficant correlation between expression of cyclin D1 and S-phase(p=0.14). Cyclin D1 expression increased in diploid cancers but the result showed no statistical significance(p=0.47). In the analysis for prognostic significance of cyclin D1 in gastric cancer, there was not significant correlation between clinical outcome of the patients and cyclin D1 expression (p=0.39). ■ Conclusions Cyclin D1 expression was not significant correlation with clinicopathologic characteristics, cell growth and differentiation in human gastric cancer and expression of cyclin D1 did not have prognostic significance. Additional study seems to be necessary to elucidate the clinical utility of cyclin D1 as a useful prognostic marker in human gastric cancer.
칼만증후군 (Kallmann s Syndrome) 2예
김선주,오도연,허갑범,이현철,조용욱,황성규,한세환 대한내분비학회 1990 Endocrinology and metabolism Vol.5 No.4
Kallmann's syndrome is congenital, often familial, defect in GnRH secretion involving both sexes and can be associated with midline cranio-facial defects. The mode inheritance has not been fully elucidated, and the defect in patients with Kallmann's syndrome occurs at a suprapituitary level involving mechanisms that regulate GnRH synthesis or release. The successful stimulation of spermatogenesis and fertility are enabled to administration of gonadotropin or pulsatile GnRH. We have experienced 2 patients with Kallmann's syndrome and presented cases with the review of the literature (J Kor Soc Endocrinol 5:308 313, 1990).