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김동훈,김민경,채승완,이경분,한은미,강성희,손진희,Kim, Dong-Hoon,Kim, Min-Kyung,Chae, Seoung-Wan,Lee, Kyoung-Bun,Han, Eun Mee,Kang, Sung-Hee,Sohn, Jin-Hee The Korean Society for Cytopathology 2007 대한세포병리학회지 Vol.18 No.2
Sono-guided fine needle aspiration (FNA) of the thyroid is widely used, but the aspirated samples are typically not well preserved and low cellularity makes diagnosis difficult in many cases. The object of the current study is to evaluate the adequacy and diagnostic accuracy of the use of $SurePath^{TM}$ liquid-based cytology (SP-LBC) in the sonoguided fine needle aspiration of the thyroid nodule and to compare its use with that of the use of a conventional smear (CS). A total of 172 sono-guided FNAs of thyroid nodules from April to June, 2006 were prepared by the use of the split method with either SP-LBC or CS; the samples were stained with the use of hematoxylin-eosin (H&E) and Papanicolaou (Pap) stains. A cyto-histological correlation was performed in 69 (30 SP and 39 CS) cases that had been histologically confirmed. The rate of producing unsatisfactory slides by the use of the SP-LBC method (9.3%) was less than that of the use of the CS method (20.9%). The diagnostic accuracy of the SP method (93.3%) was better than that of the CS method (85.3%). The sensitivity and specificity of the SP method (94.4% and 92.3%) was better than that of the CS method (83.3% and 70%), respectively (p < 0.05). The CS of sono-guided aspirated specimens had some unavoidable limitations related to inadequate sampling such as a bloody background, low cellularity and an indication that some clinicians smeared many useless slides (averaging four to ten slides), and that most slides showed only blood that included few follicular cells. The SP method resulted in more thinly smeared slides and showed cleaner background and greater cellularity than the use of the CS method. Each follicular cell shows superior nuclear detail, and more distinct cytoplasmic features than with the use of the CS method. SP-LBC appears to be an easy, highly accurate, and reliable cytological method for employ for a diagnostic approach of thyroid disease and thyroid nodules. The SP-LBC method is a suitable alternative to the CS method to overcome diagnostic difficulties.
측경부 림프절 전이를 동반한 갑상선 유두상암의 임상 양상과 면역조직화학적 특성
이선욱(Seon Uk Lee),진성민(Sung Min Jin),이상혁(Sang Hyuk Lee),손진희(Jin Hee Sohn),채승완(Seung Wan Chae),김동훈(Dong Hoon Kim) 대한두경부종양학회 2011 대한두경부 종양학회지 Vol.27 No.1
Background and Objectives:Papillary thyroid carcinoma(PTC) frequently metastasize to the regional neck, however, lateral neck lymph node metastasis is less common. The aim of this study is to investigate clinical and immunohistochemical features of PTC with lateral LN metastasis, and determine the predictive factors for lateral LN metastases. Material and Methods:We undertook a retrospective study of 83 patients treated between January 2007 and December 2009 for PTC by thyroidectomy with or without lateral neck dis-section. The following criteria were used to study the clinical predictive value of lateral LN. metastases : sex, age, tumor size, multifocality, extracapsular spread(ECS) and lymphovascular emboli. Immunohistochemical staining for VEGF-A, VEGF-C, Bax, Bcl-2, Cyclin D1, Cyclin E, p27 kip1 and p57 kip2 was performed, and quantified blindly by three pathologists who had no clinical information of the patients. Immunohistochemical expression was scored as high(>50% of cells stained) or low(0-49%). Results:With use of univariate and multivariate analysis, tumor size(>2cm) and ECS were independent correlates of lateral LN metastasis in PTC. Expression of VEGF-C, Bax, and Cyclin D1 in the PTC with lateral LN metastasis was scored higher than in PTC without lateral LN metastasis(p<0.05). Conclusion:The important risk factors for lateral LN metastasis in PTC are primary tumor size and the presence of ECS. And expression of VEGF-C, Bax and cy-clin D1 may be considered of lateral LN metastatic potential in PTC.
방기배 ( Ki Bae Bang ),조용균 ( Yong Kyun Cho ),이상혁 ( Sang Hyuk Lee ),박은혜 ( Eun Hye Park ),설지수 ( Ji Soo Seol ),채승완 ( Seoung Wan Chae ),조상원 ( Sang Won Jo ) 대한내과학회 2013 대한내과학회지 Vol.84 No.2
영아 간혈관내피종은 양성 혈관 질환으로 성인에서 진단되는 경우는 매우 드물다. 저자들은 일반적인 종양의 자연경과와 달리 69세 성인에서 진단된 영아 간혈관내피종을 경험 하였으며 이에 대한 국내보고가 없어 문헌고찰과 함께 보고 하는 바이다. Infantile hepatic hemangioendothelioma is a rare disorder. It is a benign entity and usually resolves spontaneously. Most patients present in infancy and early childhood. Because of its natural course and symptom onset, most cases are discovered during childhood. We experienced a rare case of infantile hepatic hemangioendothelioma in an adult. (Korean J Med 2013;84:259-264)
갑상샘의 소포샘종과 소포암종의 세포 소견: 세침흡인 세포 진단의 가능성에 대한 연구
박희대,박운선,김선희,최석현,조영혜,강성희,이경분,김민경,김동훈,채승완,손진희,Park, Hee-Dae,Park, Woon-Sun,Kim, Sun-Hee,Choi, Seock-Hyun,Cho, Young-Hye,Kang, Sung-Hee,Lee, Kyung-Bun,Kim, Min-Gyeong,Kim, Dong-Hoon,Chae, Seoung-Wan,Shon 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2
Fine-needle aspiration cytology (FNAC) cannot differentiate follicular adenoma from follicular carcinoma since this distinction can only be based on the presence of capsular or vascular invasion, and this can¬not be detected on a cytologic smear. The goal of this study was to define the diagnostic cytologic findings of follicular neoplasm and the possibility of diagnosing follicular neoplasm by performing FNAC. The cases of histologically diagnosed follicular adenoma and follicular carcinoma on the thyroidectomy specimens were retrieved. Among them, the cases with preoperative FNAC that was done within 3 months of the operation were finally selected. Then we reviewed the FNAC and histologic slides of 19 cases: 9 follicular adenomas and 10 follicular carcinomas. Our results suggest that for cases of follicular neoplasm, the aspirates show high or abundant cellularity, frequent follicle formation and occasional cellular atypism of the follicular cells. However, the atypism is more pronounced and more frequently noticed in the cases of follicular carcinoma, which reveals more higher anisocytosis (7/10, 70%), nuclear pleomorphism (9/10, 90%), coarse clumping of chromatin (8/10, 80%) and cellular overlapping (8/10, 80%).
김종재,김용일,김우호,지제근,채승완,팽성숙,최기영 대한소화기학회 2000 대한소화기학회지 Vol.35 No.4
Background/Aims: The solid-pseudopapillary tumor of the pancreas occurs predominantly in young women, and most of them seem to be benign. The histogenesis of this tumor remains unclear. In this study, we reviewed the clinicopathologic findings and immunohistochemical staining pattern of eleven cases of solid-pseudopapillary tumor of the pancreas. Methods: Eleven cases of solid-pseudopapillary tumor of the pancreas were reviewed and immunohistochemistry with 12 antibodies was performed. Two cases were examined by electron microscopy. Results: All of the cases were female with a mean age of 27.9 years. Grossly, tumors were well demarcated multinodular mass with solid, cystic and hemorrhagic pattern and the mean diameter was 7.7 cm. Histologic examination showed that uniform cells formed solid sheets, and loss of cohesion produced pseudopapillae. Immunohistochemically, the all cases were reactive for vimentin and neuron specific enolase. Three cases expressed progesteron receptor, two cases expressed cytokeratin, and one case expressed alpha-1 antitrypsin. None of the cases showed expression of estrogen receptor, chromogranin, synaptophysin, lipase, epithelial membrane antigen, carcinoembryonic antigen or p53 protein. Conclusions: The solid-pseudopapillary tumor of the pancreas is possibly originated from pluripotent stem cells, but lacks definite evidences of endocrine or exocrine differentiation.