정상 교합자의 비인두와 Adenoid 성장에 관한 누년적 연구

지명주,박경덕,성재현 대한치과교정학회 1996 대한치과교정학회지 Vol.26 No.4

본 연구는 비인두와 adenoid의 성장발육 양상을 조사하여 부정교합자의 진단에 있어 비호흡 기능 평가시 유용한 기준을 얻기 위하여 시행되었다. 남자 19명, 여자 14명, 총 33명의 정상 교합자를 대상으로 8.5세부터 18.5세까지 촬영된 10년간의 누년적 측모 두부 X선 규격사진을 연구 자료로 비인두와 adenoid 부위의 거리와 면적 및 상대적 기도 비율을 계측 분석하여 다음과 같은 결론을 얻었다. 1. 각 연령(8.5세-18.5세)에서 남녀별 각 계측항목의 평균과 표준 편차를 얻었다. 2. 비인두의 height와 depth는 남자에서 14.5세까지, 여자에서 12.5세까지 성장하였다(p<0.05). 3. 비기도의 상대적 면적은 8.5세에 최소치를 나타내었고 남자는 10.5세부터 12.5세 사이에, 여자는 12.5세부터 14.5세 사이에 유의한 증가를 나타내었다(p<0.05). 4. 비기도의 상대적 면적과 비기도 관련 계측항목 간의 상관분석에서 Ad2-PNS, Ad2-PNS/Ho'-PNS 및 Upper pharynx가 남녀 모두 전 연령구간에서 비기도의 상대적 면적과 상관성이 있었다(p<0.01). The purpose of this study was to evaluate the growth pattern of nasopharyx and adenoid and to obtain useful measurements for evaluating the fuction of the nasal breathing. The biennial serial cephalometric radiographs of 33 samples(19 male, 14 female) with normal occlusion from 8.5 years to 18.5 years of age were used in this study. The distances, areas and ratios on nasopharynx and adenoid were measured and analyzed in each age and sex. The results of this study might be summarized as follows; 1. The mean value and standard deviation of each measurement was obtained in each age and sex. 2. The nasopharyngeal height and the nasopharyngeal depth increased significantly by 14.5 years of age in male and 12.5 years of age in female(p<0.05). 3. The relative nasal airway area showed the minimal value at 8.5 years of age and showed significant increase from 10.5 years to 12.5 years of age in male and from 12.5 years to 14.5 years of age in female(p<0.05). 4. In the correlation analysis between the measurements on the nasal airway and the measurement of relative nasal airway area, the measurements of Ad2-PNS, Ad2-PNS/Ho'-PNS and Upper pharynx appeared significant correlation with the measurement of relative nasal airway area(p<0.01).

만성정신분열증의 정량화 뇌파검사 소견

지재현,설현욱,조경형 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.1

본 연구는 만성 정신분열증 환자 30명과 정상대조군 21명의 뇌파 중 델타파와 쎄타파를 분석해 봄으로써 만성 정신분열증 환자의 국소뇌파 소견과 유병기간, 약물투여량 및 투여기간, 양성증상과 음성증상에 따른 뇌파소견을 보고자하였다. 연구결과는 다음과 같다. 첫째, 만성 정신분열증 환자와 정상대조군간에 델타파와 쎄타파의 국소뇌파량을 t 검증한 결과 델타파에는 유의한 차이가 없으나, 쎄타파는 전 부위에서 유의한 차이를 보였다. 둘째, 만성정신분열증 환자의 델타파 및 쎄타파는 유병기간에 따른 유의한 차이가 없고, 투약기간이 길어질수록 F7, T3, C3, C4의 델타가 감소하는 경향을 보이고, 항정신병약물 투여량이 많을수록 P3, P4, C4, T5, T6, O1, O2의 쎄타가 증가하는 경향을 보였다. 셋째, 양성증상의 유무에 따라 Fp2의 델타에 유의한 차이를 보이고, 음성증상의 유무에 따라서는 Fp2, T3, C3, P3, O1의 델타에 유의한 차이를 보였다. 넷째, 판별분석을 시행한 결과 qEEG의 델타파와 쎄타파의 국소 뇌파량만으로 만성정신분열증 환자 30명중 29명을 (96.7%) 만성 정신분열증으로 판별할 수 있었다. 이상에서 만성정신분열병 환자의 서파가 정상대조군과는 유의한 차이를 보이며 유병기간에 따른 차이는 없으나 투약기간과 투여량에 따른 차이를 보이고 음성 증상을 가진 환자에서 좌측 대뇌반구의 기능저하를 추측케한다. Electroencephalographic recordings in 30 medicated patients fulfilling the DSM-Ⅲ-R criteria for chronic schizophrenia and 21 normal healthy controls was studied, using computerized electroencephalography. The delta activity and theta activity were compared between the patients and the normal healthy controls, then the differences in delta activity and theta activity of the patients were analyzed according to duration of illness, duration of medication, dosage of medication, and the presence of positive and negative symptoms. In the comparison study of chronic schizophrenic patients and the normal healthy controls, the theta activity showed a significant difference in all regions, and a significant difference in abnormal electroencephalographic activity appearance rate. In the analysis of the delta and theta activities of the chronic schizophrenic patients, duration of illness had no significant influence, the delta activity in F7, T4, C3, and C4 regions showed a tendency to decrease as duration of medication increased, the theta activity in P3, P4, C4, T5, T6, O1, O2 regions showed a tendency to increased with the increment of dosage of neuroleptics. The delta activity in Fp2, T3, C3, P3, O1 regions showed a significant difference between those patients with and without negative symptoms. In summary, the theta activity of the chronic schizophrenic patients showed a significant difference in comparison with that of the normal controls. In chronic schizophrenic patients, no difference in electroencephalograph was apparent regarding the duration of illness, but significant differences were shown when analyzed regarding the duration and dosage of medication. According to the results of this study, dysfunction of left cerebral hemisphere could be presumed to be present in patients with negative symptoms.

모체혈액내 태아 유핵적혈구의 분리후PCR과 FISH에 의한 Y 염색체 검출의 임상적 유용성

정재현 ( Jae Hyun Chung ),지관자 ( Kwan Ja Ji ),양순하 ( Soon Ha Yang ),오정미 ( Jung Mi Oh ),노정래 ( Cheong Rae Roh ),문영규 ( Young Kyu Moon ),김승욱 ( Syng Wook Kim ),이제호 ( Je Ho Lee ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12

Background: Fetal cells in maternal circulation offer a potential source of fetal material for non-invasive prenatal diagnosis. The presence of fetal cells in maternal blood can be confirmed by detecting Y-chromosome of male fetus by polymerase chain reaction(PCR) or fluorescence in situ hybridization(FISH). The current investigations, however, have not yet reached the accuracy for clinical application in detecting Y-chromosome by PCR or FISH because of tiny number of fetal cells in maternal blood. Therefore, if PCR and FISH were applied simultaneously on the same materials for detecting Y-chromosome, the diagnostic accuracy would be improved. Objective: The purpose of this study was to determine the clinical applicability of combined use of PCR and FISH in the detection of Y-chromosome from isolated fetal cells in maternal blood. Study Design: Peripheral blood was obtained from 43 pregnant women at 11~20 weeks `gestation. Fetal nucleated red blood cells(nRBCs) were discriminated by centrifugation under triple density gradient and by magnetic-activated cell sorter using CD 45 monoclonal antibody. The samples were resorted using CD 71 and GPA monoclonal antibodies. The PCR and FISH were performed simultaneously for the detection of Y-chromosome in each sample. Results: The diagnostic indices of PCR in the detection of Y-chromosome from fetal nRBC in maternal blood were sensitivity 70%(14/20), specificity 83%(19/23), positive predictive value 78%(14/18), and negative predictive value 76%(19/25). Those of FISH were 85%(17/20), 87%(20/23), 85%(17/20), and 87%(20/23), respectively. When PCR and FISH were concomittently applied for detecting Y-chromosome, sensitivity was 65%(13/20), specificity was 96%(22/23), positive predictive value was 93%(13/14), and negative predictive value was 76%(22/29). When PCR detected Y-chromosome and FISH did not or vice versa, it was interpreted as male. In that case, the sensitivity was 90%(18/20), the specificity was 74%(17/23), the positive predictive value was 75%(18/24), and the negative predictive value was 89%(17/19). Conclusions: When PCR and FISH were applied simultaneously, the specificity and positive predictive value in the detection of Y-chromosome from fetal cells in maternal blood were improved. However, the overall diagnostic indicies were not enough for clinical application as prenatal diagnostic technique.

임산부 혈액에서 추출된 태아세포에서 PCR가 FISH를 이용한 태아의 Sex-determination

정재현,지관자,문영규,지일운,양순하,노정래,김승욱,이제호 대한산부인과학회 1996 대한산부인과학회 학술대회 Vol.78 No.-

Status of HPV vaccination among HPV-infected women aged 20–60 years with abnormal cervical cytology in South Korea: a multicenter, retrospective study

성재현,류상미,Myeongsu Yoo,이정규,김기순,지영미,조치흠,김석모,홍성란,정대훈,이원철,박종섭,김태진,Mee Kyung Kee 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.1

Objectives: Since 2007, human papillomavirus (HPV) vaccines have been administered for the prevention of cervical cancer in Korea. We investigated the status of HPV vaccination among HPV-infected adult women with abnormal cervical cytology before the introduction of National Immunization Program. Methods: From 2010 to 2016, HPV-positive women (age, 20–60 years) with atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion (LSIL) were enrolled from five hospitals across Korea. Their HPV genotype, epidemiologic, and clinical data, including HPV vaccination history, were obtained. We compared the epidemiological characteristics and prevalence of HPV-16/18 genotypes between vaccinated and unvaccinated women. Results: Among the 1,300 women, approximately 26% had a history of vaccination. Vaccinated patients were significantly younger, unmarried, and had a higher education level than unvaccinated women. For HPV-vaccinated individuals by vaccine dose, there was a significant younger age at vaccination initiation (p=0.025), longer duration from HPV vaccination to Pap test date (p=0.001), and lower proportion of HPV-16/18 (p=0.028) in the women with three doses. There was a significantly lower prevalence of HPV-16/18 genotypes in women who were vaccinated at least 12 months prior than in unvaccinated women (adjusted prevalence ratio [aPR]=0.51; 95% confidence interval [CI]=0.29–0.88). For women with LSIL, the prevalence of the HPV-16/18 genotypes was significantly lower in women who were vaccinated more than 12 months prior than in unvaccinated women (aPR=0.35; 95% CI=0.13–0.96). Conclusion: This study highlighted the status of HPV vaccination and the prevalence of HPV-16/18 genotypes among HPV-infected women with abnormal cervical cytology according to HPV vaccination. It provides preliminary information regarding the status of HPV vaccination among Korean adult women.

특허 정보와 오픈소스 텍스트 마이닝 도구를 이용한 잠재적 기술수요 발굴 방안

지상태,최재현,신용태 한국IT정책경영학회 2016 한국IT정책경영학회 논문지 Vol.8 No.1

Recently, technology marketing, one of the important step to create a high value for technology transfer, comes into the spotlight in economy based knowledge. Even though a role to forecast technology demand in technology marketing is the core part in marketing procedure, clearly figuring out potential demand is still a hard part except a few conglomerates engaged in internet technology field. The objective of this study is to extract technology keywords from sample firms‘ patent information by text-mining for technology marketing analysis and match between the information and potetial technology demand.

모체혈액에서 분리한 태아세포의 FISH를 이용한 분석

문영규,정재현,지일운,지관자,김석찬,김구련 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5

The isolation of fetal cells from maternal circulation has the potential to allow relatively self prenatal diagosis for all pregnant women. The present technology, however, has not reached the accuracy required for clinical diagnosis because of maternal cell contamination. So we published a new method for enrichment of nRBC in a fetal cell isolation(1996). In this study, attempted to FISH analysis of nRBC which was isolated by our own methods. We evaluated the efficiency of FISH. As the results, we have successfully used FISH on enriched nRBC. We were able to identified 2 abnormal fetus which were confirmed by conventional cytogenentic study as Down syndrome(Fig.1) and Klinefeltre syndrome(Fig.2). And the sensitivity and specificity for FISH was 86%(49/57) and 92.3%(36/39), respectively. According to our results, fetal cell analysis by FISH can be reliable used for prenatal aneuploidy diagnosis. However, the problems of enrichment of the fetal cell and FISH probe or condition should be over come before analyze.

서울대학교 에너지 및 환경유동 연구실의 연구 현황

백승찬(Seungchan Baek),지창은(Changeun Ji),유재현(Jaehyun Ryu),선구원(Guwon Seon),황원태(Wontae Hwang) 한국유체기계학회 2020 한국유체기계학회 학술대회 논문집 Vol.2020 No.8