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지예섭,정호근,오민구,하동엽,박성동 동국대학교 의학연구소 2006 東國醫學 Vol.13 No.2
담낭 염전은 담낭과 간 사이의 해부학적 이상에 의해 발생되는 드문 질환으로 아직도 정확한 원인은 밝혀지지 않았다. 그리고 담낭 염전에 관한 인식 부족과 함께 비특이적인 증상과 임상 검사로 인해 수술 전 진단이 어려운 현실이다. 본 저자들은 2004년 4월 우상복부 통증을 주소로 내원한 83세 여자 환자를 수술중 담낭염전으로 진단하여 성공적으로 치료하였기에 증례 보고와 함께 담낭 염전의 문헌 고찰을 보고하는 바이다. Gall bladder volvulus is a rare disease that arises from the anatomical anomaly of gall bladder and liver, yet the etiology has not been revealed. Since Wendel et al. first reported the case, about 400 cases were reported outside the country, however 12 cases were reported in Korea since 1969. Because of lack of recognition of gall bladder volvulus and its atypical symptoms and clinical examinations, an accurate preoperative diagnosis has not yet done. Along with the review of gall bladder volvulus, we propose a case of 83-year old female who was admitted for right upper quadrant pain on April, 2004, intraoperatively diagnosed as gall bladder volvulus, and successfully treated.
지예섭,Tae Jung Jang,Ki Hoon Jung 대한의학회 2012 Journal of Korean medical science Vol.27 No.9
Inflammation is closely related to the progression of cancer as well as tumorigenesis. Here,we investigated the effect of prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) on E-cadherin expression in SNU719 gastric cancer cells. E-cadherin expression decreased as the dose or exposure time of PGE2 and IL-1β increased, whereas Snail expression increased with dose or time of PGE2 and IL-1β. E-cadherin expression reduced by PGE2 treatment increased after the transfection of Snail siRNA. Neutralization of IL-1β using anti-IL-1βantibody blocked the expression pattern of E-cadherin and Snail occurred by IL-1βtreatment. However, there was no synergic effect of IL-1β and PGE2 on the expression pattern of E-cadherin and Snail. In conclusion, inflammatory mediators reduced E-cadherin expression by enhancing Snail expression in gastric cancer cells. Inflammationinduced transcriptional regulation of E-cadherin in gastric cancer has implications for targeted chemoprevention and therapy.
다발성 외상 환자에서 발생되는 급성 호흡 곤란 증후군의 예측 인자로서 혈청 페리틴의 의의
지예섭 ( Yae Sub Ji ),김낙희 ( Nak Hee Kim ),정호근 ( Ho Geun Jung ),하동엽 ( Dong Yeup Ha ),정기훈 ( Ki Hoon Jung ) 대한외상학회 2007 大韓外傷學會誌 Vol.20 No.2
Purpose: Clinically, acute respiratory distress syndrome (ARDS) occurs within 72 hours after acute exposure of risk factors. Because of its high fatality rate once ARDS progresses, early detection and management are essential to reduce the mortality rate. Accordingly, studies on early changes of ARDS were started, and serum ferritin, as well the as injury severity score (ISS), which has been addressed in previous studies, thought to be an early predictive indicator for ARDS Methods: From March 2003 to March 2005, we investigated 50 trauma patients who were admitted to the intensive care unit in Dongguk University Medical Center, Gyeongju. The patients were characterized according to age, sex, ISS, onset of ARDS, time onset of ARDS, serum ferritin level (posttraumatic 1st & 2nd day), amount of transfused blood, and death. Abdominal computed topography was performed as an early diagnostic tool to evaluate the onset of ARDS according to its diagnostic criteria. The serum ferritin was measured by using a VIDAS(R) Ferritin (bioMeriux, Marcy-1` Etoile, France) kit with an enzyme-linked fluorescent assay method. For statistical analysis, Windows SPSS 13.0 and MedCalc were used to confirm the probability of obtaining a predictive measure from the receiver operating characteristics (ROC) curve. Results: The ISS varied from 14 to 66 (mean: 33.8) whereas the onset of ARDS could be predicted with the score above 30 (sensitivity: 90.0%, specificity: 60.0%, p<0.05). On the posttraumatic 1st day, the serum ferritin levels were measured to be from 31 mg/dL to 1,200 mg/dL (mean: 456 mg/dL), and the onset of ARDS could be predicted when the value was over 340 mg/dL (sensitivity: 80.0%, specificity: 65.0%, p<0.05). On the posttraumatic 2nd day, the serum ferritin levels were measured to be from 73 mg/dL to 1,200 mg/dL (mean: 404 mg/dL), and the onset of ARDS could be predicted when the value was over 627 mg/dL (sensitivity: 60.0%, specificity: 92.5%, p<0.05). The serum ferritin levels and the ISS were significantly higher on the posttraumatic 1st and 2nd day in the ARDS group, suggesting that they are suitable indices predicting the onset of ARDS, however relationship between the serum ferritin levels and the ISS was not statistically significant. Conclusion: In this study, we discovered increasing serum ferritin levels in multiple- trauma patients on the posttraumatic 1st & 2nd day and concluded that both the serum ferritin level and the ISS were good predictors of ARDS. Although they do not show statistically significant relationship to each other, they can be used as independent predictive measures for ARDS. Since ARDS causes high mortality, further studies, including the types of surgery and the methods of anesthesia on a large number of patients are essential to predict the chance of ARDS earlier and to reduce the incidence of death. (J Korean Soc Traumatol 2007;20:57-64)
Decreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas
장태정,지예섭,정기훈 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.6
Purpose: Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often overexpressed in gastric carcinomas and during gastric carcinogenesis. However, little is known about the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for the biological inactivation of PG, in gastric carcinomas. Materials and Methods: We investigated the expression of 15-PGDH in 28 cases of advanced gastric carcinomas by Western blot analysis and also the relation between its expression and the gene promoter methylation. Results: 15-PGDH expression was significantly decreased in gastric carcinomas compared to corresponding non-neoplastic tissues and inversely correlated with the expression of proliferating cell nuclear antigen in gastric carcinomas. However, there was no correlation between 15-PGDH expression and pathological findings such as nodal metastasis and vascular invasion. Promoter hypermethylation of 15-PGDH gene was not detected in carcinomas, with only a negligible expression of the enzyme. Conclusion: Our results suggested that 15- PGDH has tumor suppressor activity in gastric carcinomas.