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단기간의 조영제 노출에 따른 Ioxithalamate와 Iopromide의 담낭 상피 세포의 독성 비교
주영민,이성구,김명환,서동완,이상수,차재명,최은광,정석원 대한소화기내시경학회 2006 Clinical Endoscopy Vol.32 No.2
Background/Aims: In a previous study examining long- term exposure to contrast media, high-osmolar ionic contrast media were reported to be more cytotoxic to gallbladder epithelial cells than low-osmolar nonionic contrast media. However, biliary epithelial cells are rarely exposed to contrast media for such long periods in clinical practice. This study compared the cytotoxicity of two types of contrast media to gallbladder epithelial cells exposed for a short-term. Methods: Ioxithalamate and iopromide were tested, and dog gallbladder epithelial cells were used as the test cells. The cells were exposed to the two contrast agents with increasing iodine concentration and osmolality for 30 minutes. The number of cells, aneuploidy and supernatant LDH activities were measured each day. Results: The growth of cells exposed to the two contrast media was significantly reduced but there was no difference between the two contrast media at the same iodine concentration. The level of cell lysis measured by the supernatant LDH activities before the triton X-100 treatment was similar with the two contrast media. No aneuploidy fraction was detected in any of the cell groups treated with the two contrast media for 5 days. Conclusions: In contrast to previous results, high-osmolar ionic and low-osmolar nonionic contrast media with short- term exposure were found to have a similar cytotoxicity to biliary epithelial cells. (Korean J Gastrointest Endosc 2006;32:101-108) 목적: 방사선 조영제는 크게 저 삼투압 비이온 조영제와 고 삼투압 이온 조영제로 나누어진다. 대부분의 방사선 영역에서는 부작용이 적은 저 삼투압 비이온 조영제가 사용되고 있으나 내시경 역행성 담췌관 조영술 (endoscopic retrograde cholangiopancreatography, ERCP)에서는 여전히 고 삼투압 이온 조영제가 널리 사용되고 있다. 48시간의 장기간 조영제 노출 시에 고 삼투압 이온 조영제가 저 삼투압 비이온 조영제보다 담도 상피 세포 독성이 더 심하다는 것은 이미 보고된 바 있다. 그러나 실제 ERCP 검사에서는 담도 상피 세포의 조영제 노출 시간이 짧아서 본 연구에서는 단기간의 조영제 노출에 따른 담도 상피 세포 독성을 비교하고자 하였다. 대상 및 방법: 개의 담낭 상피 세포를 배양하여 고 삼투압 이온 조영제인 ioxithalamate (1,500 mOsm/kg H2O)와 저 삼투압 비이온 조영제인 iopromide (586 mOsm/kg H2O)을 처리하였다. 담낭 상피 세포를 2배, 3배, 4배로 희석된 각각의 조영제 혼합액에 30분간 노출시키고 조영제 노출 이후 세포 수의 변화, triton X-100 처리 전후의 세포 상층액의 LDH 활성도의 차이를 확인하고 flow cytometry를 이용하여 aneuploidy의 출현을 확인하였다. 결과: 세포 수의 변화에 있어서 iopromide 364 mOsm/kg H2O 세포군을 제외하고 모든 세포군에서 정상 대조군과 비교하여 유의한 수준의 감소를 보였으나 동일한 요오드 함량을 가진 ioxithalmate와 iopromide의 세포군의 비교에서는 차이를 보이지 않았다. 세포 배양 상층액의 LDH 활성도로 확인한 cell detachment의 결과에서도 iopromide 364 mOsm/kg H2O 세포군을 제외하고 모든 세포군에서 유의한 수준의 cell detachment가 발생하였으나 동일한 요오드 함량을 가진 ioxithalamate와 iopromide의 세포군의 비교에서는 차이를 보이지 않았다. 염색체 손상의 지표로 확인한 aneuploidy는 어떤 세포군에서도 발현되지 않았다. 결론: 단기간의 조영제 노출에도 담도 상피 세포 독성이 유발된다는 것을 알 수 있었고 이전 연구 결과와 달리 두 조영제 간의 담도 상피 세포 독성에는 차이가 없음을 알 수 있었다.
주영민,박상준,김태현,최정섭,Ju, Young-Min,Park, Sang-Jun,Kim, Tae-Hyun,Choi, Jeong-Seob 대한기관식도과학회 2000 大韓氣管食道科學會誌 Vol.6 No.1
A lymphangioma is a benign lesion characterized by proliferation of lymphatic vessels. Occurrence in the oral cavity and oropharynx is rare and is extremely rare in the palatine tonsil. Recently, we experienced a case of lymphagioma on palatine tonsil, so we report this rare case with the review of literatures.
주영민,최진호,서주태 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.5
Purpose: We compared the efficacy and safety of two minimally invasive sling procedures used to treat female stress urinary incontinence (SUI), tension-free vaginal tape (TVT) SECUR® and CureMesh®, and assessed the 1-year surgical outcomes. Materials and Methods: Sixty women with SUI were assigned to undergo either the TVT SECUR (n=38) or CureMesh (n=22) procedures between April 2007 and June 2008. Patients were monitored via outpatient visits at 1 month, 3 months, and 1 year after surgery. The efficacy of these procedures was evaluated by the cough test or by a urodynamic study. At these postoperative visits, the patients also completed several questionnaires, including incontinence quality of life, patient’s perception of urgency severity, the scored form of the Bristol Female Lower Urinary Tract Symptoms, visual analog scale, and questions about perceived benefit, satisfaction, and willingness to undergo the same operation again. The objective cure rate was defined as no leakage during the cough test with a full bladder. The subjective cure rate was evaluated by self-assessment of goal achievement performed 1 year postoperatively. Results: The two groups were similar in preoperative characteristics and urodynamic parameters. The objective cure rates were similar between TVT SECUR and CureMesh (68.4% vs. 77.3%). All respondents reported improvement after surgery. There were no intra-operative complications. Conclusions: Our results showed that the TVT SECUR and CureMesh procedures are both safe and simple to perform and have no significant differences in efficacy. Comparative studies with long-term follow-up are warranted to determine the true efficacy of these procedures. Purpose: We compared the efficacy and safety of two minimally invasive sling procedures used to treat female stress urinary incontinence (SUI), tension-free vaginal tape (TVT) SECUR® and CureMesh®, and assessed the 1-year surgical outcomes. Materials and Methods: Sixty women with SUI were assigned to undergo either the TVT SECUR (n=38) or CureMesh (n=22) procedures between April 2007 and June 2008. Patients were monitored via outpatient visits at 1 month, 3 months, and 1 year after surgery. The efficacy of these procedures was evaluated by the cough test or by a urodynamic study. At these postoperative visits, the patients also completed several questionnaires, including incontinence quality of life, patient’s perception of urgency severity, the scored form of the Bristol Female Lower Urinary Tract Symptoms, visual analog scale, and questions about perceived benefit, satisfaction, and willingness to undergo the same operation again. The objective cure rate was defined as no leakage during the cough test with a full bladder. The subjective cure rate was evaluated by self-assessment of goal achievement performed 1 year postoperatively. Results: The two groups were similar in preoperative characteristics and urodynamic parameters. The objective cure rates were similar between TVT SECUR and CureMesh (68.4% vs. 77.3%). All respondents reported improvement after surgery. There were no intra-operative complications. Conclusions: Our results showed that the TVT SECUR and CureMesh procedures are both safe and simple to perform and have no significant differences in efficacy. Comparative studies with long-term follow-up are warranted to determine the true efficacy of these procedures.