Human Paraoxonase 1(PON1)의 유전자 다형성에 따른 중풍환자의 습담 변증과의 상관성 연구

임지혜,고미미,이정섭,방옥선,차민호,Lim, Ji-Hye,Ko, Mi-Mi,Lee, Jung-Sup,Bang, Ok-Sun,Cha, Min-Ho 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4

Objective : In the present study, we investigated genetic distribution of eight single nucleotide polymorphisms of PON1 between Dampness and Phlegm and non Dampness and Phlegm pattern identification(PI) among Korean stroke patients. Materials and Methods : One hundred forty stroke subject without Dampness and Phlegm and fifty eight stroke subjects with Dampness and Phlegm were participated in this study. After informed consents, eight single nucleotide polymorphisms(SNPs) in PON1 of each subjects were identified by DNA sequencing and primer extension method and statistical analysis was performed to determine the significant difference between Dampness and Phlegm and non Dampness and Phlegm groups. Results : Among anthropometric characteristics and blood parameters, waist circumference and total cholesterol were significantly higher in Dampness and Phlegm. Among 8 SNPs of PON1, frequency of M allele and subjects with M allele in L55M SNP were significantly higher in Dampness and Phlegm group (p=0.0032 and p=0.0053, respectively) but subjects with T allele in C-2033T SNP were lower in Dampness and Phlegm group(p=0.0302). Effect of L55M and C-2033T on Dampness and Phlegm were 3.07% and 1.75%, respectively. Conclusion : Our results suggest that L55M SNP in exon and C-2033T in promoter region of PON1 maybe affect to Dampness and Phlegm pattern identification. However, further study should be carried out to find out the detailed mechanism how L55M and C-2033T can affect Dampness and Phlegm stroke patients.

보육시설에서의 실내공기질을 위한 관리방안 - 국내외 사례중심으로 -

임지혜,Im, Ji-Hye 한국공기청정협회 2010 空氣淸淨技術 Vol.23 No.4

선형가속기의 다엽콜리메이터 형태에 따른 치료계획 비교 평가

임지혜,장남준,석진용,정윤주,원희수,정해윤,최병돈,Lim, Ji Hye,Chang, Nam Joon,Seok, Jin Yong,Jung, Yun Ju,Won, Hui Su,Jung, Hae Youn,Choi, Byeong Don 대한방사선치료학회 2018 대한방사선치료학회지 Vol.30 No.1

목 적 : 임상적으로 많이 시행하는 치료부위에 고차원 치료기법 적용 시 선형가속기에 장착된 다엽콜리메이터(Multi leaf collimator, MLC)의 형태가 치료계획에 미치는 영향을 연구해 보고자 한다. 대상 및 방법 : 본원에서 척추암, 폐암 정위적체부방사선치료(Stereotactic body radiation therapy, SBRT)를 받은 환자와 전립선암, 폐암, 두경부암, 전골반암, 유방암의 용적변조회전치료(Volumetric modulated arc therapy, VMAT)를 시행한 환자들을 부위별로 10명씩 총 70명 선정하였다. Truebeam STx(Varian Medical system, Palo Alto, CA)의 high definition MLC(HD MLC)와 Vitalbeam(Varian Medical system, Palo Alto, CA)에 장착된 millenium MLC(M MLC)를 사용하였고, 치료계획은 Eclipse(Version 13.7, Varian Palo Alto USA, CA)를 이용하여 동일한 조건으로 환자마다 각각 2개씩 수립하였다. MLC의 형태에 따른 치료계획을 평가하기 위해 PTV coverage, conformity index(CI), homogeneity index(HI)를 비교하였고, 정상조직은 각 부위별로 임상에서 사용하는 평가 지표를 분석하였으며, 정상조직에서 저 선량 영역을 비교하기 위하여 $V_{30%}$을 평가하였다. 추가적으로 각 부위별로 치료표적의 길이 및 체적을 조사하였다. 결 과 : PTV coverage는 HD MLC를 적용한 폐암 SBRT에서 평균선량이 0.52 %, 척추암 SBRT에서 평균 선량과 최대선량이 각각 0.68 %, 1.13 %로 M MLC에 비해 감소하였다. CI와 HI는 척추암 SBRT 치료계획에서 HD MLC가 1.144, 1.079로 M MLC의 1.160, 1.092 보다 낮은 수치를 나타냈다(p<0.05). 결정장기의 선량 평가는 폐암 SBRT 치료계획에서 치료받는 쪽 폐의 평균선량이 HD MLC에서 1.48 %로 낮아졌다. 전립선암 VMAT은 HD MLC를 적용한 치료계획에서 방광의 $V_{30}$과 평균선량이 0.53 %, 1.42 %, 직장의 $V_{25}$와 평균선량이 0.97 %, 0.69 %로 감소하였다(p<0.05). 유방암 VMAT은 오히려 HD MLC를 사용한 치료계획에서 심장의 평균선량이 0.83 %로 높아졌다. 다른 치료부위 평가지표들은 두 MLC를 적용한 치료계획 사이에 큰 차이를 보이지 않았다(p>0.05). 결 론 : 본 연구 결과 SBRT나 전립선암 VMAT과 같이 치료표적의 길이가 짧고 크기가 작은 경우 HD MLC를 사용하는 것이 PTV coverage 및 정상조직 보호 효과 면에서 다소 이점이 있는 것으로 나타났으나, 그 외 상대적으로 길고, 큰 폐암, 두경부암, 전골반암, 유방암 VMAT에서는 MLC의 형태가 치료계획에 미치는 영향은 크지 않았다. Purpose : An aim of this study was to compare the effect of multi leaf collimator(MLC) types for high dimension radiotherapy in treatment sites used clinically. Material and Method : 70 patients with lung cancer, spine cancer, prostate cancer, whole pelvis, head and neck, breast cancer were included in this study. High definition(HD) MLC of TrueBeam STx (Varian Medical system, Palo Alto, CA) and millenium(M) MLC of VitalBeam (Varian Medical system, Palo Alto, CA) were used. Radiotherapy plans were performed for each patient under same treatment goals with Eclipse (Version 13.7, Varian Palo Alto USA, CA). To compare the indicators of the radiotherapy plans, planning target volume(PTV) coverage, conformity index(CI), homogeneity index(HI), and clinical indicators for each treatment sites in normal tissues were evaluated. To evaluate low dose distribution, $V_{30%}$ values were compared according to MLC types. Additionally, length and volume of targets for each treatment sites were investigated. Result : In stereotatictic body radiotherapy(SBRT) plan for lung, the average value of PTV coverage was reduced by 0.52 % with HD MLC. With SBRT plan using HD MLC for spine, the average value of PTV coverage decreased by 0.63 % and maximum dose decreased by 1.13 %. In the test of CI and HI, the values in SBRT plan with HD MLC for spine were 1.144, 1.079 and the values using M MLC were 1.160, 1.092 in SBRT plan for lung, The dose evaluation of critical organ was reduced by 1.48 % in the ipsilateral lung mean dose with HD MLC. In prostate cancer volumetric modulated arc therapy(VMAT) with HD MLC, the mean dose and the $V_{30}$ of bladder and the mean dose and the $V_{25}$ of rectum were reduced by 0.53 %, 1.42 %, 0.97 %, and 0.69 %, respectively (p<0.05). The average value of heart mean dose was reduced by 0.83 % in breast cancer VMAT with M MLC. Other assessment indices for treatment sites showed no significant difference between treatment plans with two types of MLC. Conclusion : Using HD MLC had a positive impact on the PTV coverage and normal tissue sparing in usually short or small targets such as lung and spine SBRT and prostate VMAT. But, there was no significant difference in targets with long and large such as lung, head and neck, and whole pelvis for VMAT.

지르코니아 기반 전부도재관을 이용한 상악 전치의 수복

임지혜,손서진,양미영,장석우,유현미,박동성,오태석,Im, Ji-Hye,Son, Seo-Jin,Yang, Mi-Yeong,Jang, Seok-U,Yu, Hyeon-Mi,Park, Dong-Seong,O, Tae-Seok 대한심미치과학회 2010 Journal of the Korean Academy of Esthetic Dentistr Vol.19 No.1

보육시설의 건축 및 유지관리 현황에 대한 영향인자와 오염물질 농도분포 특성 평가

임지혜(Ji-Hye Lim),손장열(Jang-Yeul Sohn) 한국생활환경학회 2010 한국생활환경학회지 Vol.17 No.5

It is important for child care centers to investigate characteristic of indoor air quality (IAQ) because they perform education and day care for children who usually have weak immunity. Nevertheless, there is insufficient research being done, given its importance. This study aims to investigate the characteristics of indoor pollutants' concentration according to the architecture and management methods in child care center. Also it aims to secure data which can be used for further researches. Measurements were performed for air temperature, relative humidity, carbon dioxide, fine particle mass, formaldehyde and volatile organic compounds. Temperature, humidity and CO₂ were measured 30 times (1 min/time) and PM10 was measured 10 times (3 min/time). Formaldehyde and volatile organic compounds were measured and analyzed based on The Indoor Air Quality Official Test Method. Architecture and management factors can effects on IAQ were corrected. The results show that the CO₂ was found to be the main pollutants as its concentration exceeded the IAQ standard. The PM10 concentration tended to be higher as building completion year longer and concentrations of HCHO and TVOC tended to be lower as refurbishment date longer. All indoor air pollutants were higher in small occupancy room than than in large occupancy room, were low in operating air purifier rooms.

실존적 정신분석의 임상철학적 의의

임지혜 ( Rim Ji-hye ) 한국하이데거학회 2014 존재론 연구 Vol.34 No.-

이 논문의 목적은 사르트르가 제시하는 실존적 정신분석의 임상철학적 의의를 탐구하고 그것의 실제적인 적용의 단초를 찾는 것이다. 이를 위해 『존재와 무』에서 다루고 있는 실존적 정신분석의 내용들을 살펴보고, 이것을 『상상계』에서 분석되고 있는 구체적인 병리적 정신현상들과 관련하여 고찰해볼 것이다. 사르트르는 그의 주저 『존재와 무』에서 정신분석학을 비판하고 실존적 정신분석이 나아가야 할 방향을 제시한다. 여기에서 사르트르는 정신분석학의 한계를 짚어봄으로써 실존적 정신분석의 과제를 점검하며 이론적 토대를 마련한다. 그에 따르면, 실존적 정신분석은 인간의 경험적인 행위를 해독하는 것을 통해서 분석대상의 환원불가능한 존재선택으로 거슬러 올라간다. 이것은 실존적 정신분석이 전적으로 그의 존재론적 관점에서 진행된다는 것을 의미한다. 또한 『상상계』에서 사르트르는 의식의 통일성과 자발성에 기초하여 환각과 강박관념에 대한 분석을 시도한다. The purpose of this paper is to explore the significance of clinical philosophy in existential psychoanalysis presented by Sartre, and to find the clue to its practical applications. For this, I will try to look into the contents of existential psychoanalysis in L’être et le neant, and study them in relation to the analysis of specific pathological mental phenomena in L’imaginaire. In his major work L’être et le neant, Sartre criticizes psychoanalysis and suggests a direction for existential psychoanalysis. In this work, Sartre takes a look at the challenges of existential psychoanalysis and sets the theoretical foundation by pointing out the limitations of psychoanalysis. According to Sartre, the existential psychoanalysis goes back to the choice of irreducible Human Being, through deciphering his empirical acts. This is means that his existential psychoanalysis proceeds from the ontological point of view. Also in L’imaginaire, Sartre tries to analyze obsessions and hallucinations on the basis of spontaneity and unity of consciousness.

배 ‘원황’의 재배지대에 따른 생육특성 및 수분공급시기에 따른 수액이동 특성비교

임지혜(Ji-hye Yim),김상백(Sang-baek Kim),진재홍(Jae-hong Jin),최동근(Dong Geun Choi) 한국원예학회 2012 한국원예학회 학술발표요지 Vol.2012 No.10

팬을 부착한 이중외피의 이론적 검토 및 적용성에 대한 실험 연구

임지혜(Ji Hye Lim),손장열(Jang Yeul Sohn) 대한설비공학회 2010 설비공학 논문집 Vol.22 No.9

Double skin facade(DSF) ventilated by fans consists of a normal external and an internal envelope. In this glass layer, the installed fan replaces an air inlet for the control of air flow through the cavity. The purpose of this paper is to investigate physical theory and to analyze the applicability of fans installed in a DSF. The experiment was conducted in 2 rooms. One room has a DSF with installed fans and the other one has a typical window. The room ventilated through a DSF which fans are installed was always kept warmer than the other room, ventilated directly from the outdoors. The average increase of the supplied air temperature through the DSF ventilated by fans was 6.54℃ at 78CMH, 6.2℃ at 95CMH, and 3.7℃ at 120CMH. As a result, the DSF with installed fans was appropriate for installation in rooms. It supplies outdoor fresh air heated through a cavity and ventilates a constant air volume.

생육기 바람에 의한 낙엽이 사과, 배, 포도, 복숭아의 저장양분과 익년 개화율에 미치는 영향

임지혜(Ji-hye Yim),김상백(Sang-baek Kim),진재홍(Jae-Hong Jin),최동근(Dong Geun Choi) 한국원예학회 2012 한국원예학회 학술발표요지 Vol.2012 No.10

지역 마케팅 홍보물에 나타난 지역 정체성 연구

임지혜(Lim Ji-hye),윤희진(Yun Hee-jin) 한국문화산업학회 2010 문화산업연구 Vol.10 No.2

Region began to be regarded as a target of Business management. This phenomenon is that a region considered as the product. This has provoked a new movement as the place marketing. In this study, as a regional communications strategy, I analyzed local marketing promotions for place identity, Comparingregional characteristics, I identified the relationship between it and the regional policy. Regional policies and regional promotions, if the information matches, Regional identity has been properly implemented, will be able to see. For this purpose, collected in 2009 in Incheon International Trade fair, promotions, and compare the contents of the policy areas. In terms of regional identity, local promotions and local policies did not match. Each region must try to maintain a consistent identity in the areas of policy and administration and marketing. Region began to be regarded as a target of Business management. This phenomenon is that a region considered as the product. This has provoked a new movement as the place marketing. In this study, as a regional communications strategy, I analyzed local marketing promotions for place identity, Comparingregional characteristics, I identified the relationship between it and the regional policy. Regional policies and regional promotions, if the information matches, Regional identity has been properly implemented, will be able to see. For this purpose, collected in 2009 in Incheon International Trade fair, promotions, and compare the contents of the policy areas. In terms of regional identity, local promotions and local policies did not match. Each region must try to maintain a consistent identity in the areas of policy and administration and marketing.