헬스케어산업 관점에서 본 린스타트업 적용 사례연구: (주)휴메딕스 사례를 중심으로

임성훈,김용태,Lim, Sung-Hoon,Kim, Yong-Tae 한국벤처창업학회 2015 벤처창업연구 Vol.10 No.3

최근 해외뿐만 아니라 국내에서도 헬스케어 산업에 대한 투자가 지속적으로 증가하고 있다. 그러나 시간과 비용이 많이 들어가는 헬스케어 산업의 특성은 창업 활성화 및 투자에 제약이 되고 있다. 이 때문에 IT산업 분야의 스타트업 기업에 적용되어 효용성을 인정받고 있는 린스타트업 방법론이 헬스케어 산업 분야의 스타트업에도 적용 가능한지를 살펴보는 것은 중요한 의미를 갖는다고 하겠다. 본 연구에서는 헬스케어 산업분야에서 기술력을 바탕으로 창업하여 벤처캐피탈 투자유치 및 코스닥 상장까지 이룬 기업의 사례를 통해서 IT 산업분야 초기 창업기업에 적용되어 왔던 린스타트업(Lean Startup)이론의 응용 가능성을 모색하고자 하였다. 헬스케어 산업분야의 특성 및 린스타트업 관점의 접근을 통한 사례연구의 함의는 다음과 같다. 첫째, 시제품의 테스트가 법으로 엄격히 규제되어 있는 헬스케어 산업분야의 기술창업일수록 린스타트업 이론에 의한 최소요건제품(MVP, Minimum Viable Product) 개발을 통한 가설검증이 중요하다. 둘째, 헬스케어 산업과 같이 전임상(pre-clinical study), 임상 시험 등 인허가 과정이 길고, 비용이 많이 들어가는 산업일수록 연구조직을 스타트업(Startup) 조직으로 구성하고 연구원의 기업가정신(Entrepreneurship)을 함양해야 된다. 셋째, 젊은 엔지니어의 기술창업을 활성화하기 위해서는 기업가정신 함양과 같은 응용인문학 교육과 더불어 린 스타트업과 같은 스타트업을 위한 차별화된 경영기법이 요구된다. The investment in healthcare industry has recently increased not only for global ventures but also for the domestic ventures. However, there has been hardship of founding and investment caused by healthcare startups characteristics that are costly and time consuming. In this study, the applicability of 'Lean Startup' theory to healthcare ventures was explored through the case of a domestic startup which accomplished funding from VC and KOSDAQ after establishing based on its technology in healthcare industry. There have been numerous case studies that applied 'Lean Startup' to IT industry. However, this case study that applied 'Lean Startup' to healthcare industry have some implications as follow: First, it is critical to conduct a hypothesis testing at initial research stage through R&D of 'MVP' (Minimum Viable Product) as the prototype testing is strictly prohibited in healthcare industry. Second, healthcare R&D teams ought to be well organized as startup teams and all researchers should be equipped with entrepreneurship as the licensing process in healthcare industry is time-consuming and costly due to issues like clinical studies. Lastly, management skills as smart and light as 'Lean Startup' are required in order to encourage young engineers' technology startups.

PLT buffer층의 삽입에 따른 강유전 PZT박막의 특성 향상

임성훈,이은선,정현우,전경아,이상렬,Lim, Sung-Hoon,Lee, Eun-Sun,Chung, Hyun-Woo,Jeon, Kyung-Ah,Lee, Sang-Yeol 한국전기전자재료학회 2005 전기전자재료학회논문지 Vol.18 No.2

The Pb(Zr,Ti)O$_3$ thin films were fabricated with Pb(La,Ti)O$_3$ buffers in-situ onto Pt/Ti/SiO$_2$/Si substrates by pulsed laser deposition method. We have observed the increase of the remanent polarization using PLT buffers. The remanent polarization value of 33.4 $\mu$C/$\textrm{cm}^2$ and the coercive field value of 66.4 kV/cm were obtained when the PLT tufter was deposited for 15 seconds. Enhancement of the polarization is resulted from the enhanced orientation of PZT thin film because of the PLT buffet layer.

탄소나노튜브 밀도의 변화에 따른 전자방출 안정성 연구

임성훈,윤현식,유제황,문종현,박규창,장진,문병연,Lim Sung Hoon,Yun Hyun Sik,Ryu Je Hwang,Moon Jong Hyun,Park Kyu Chang,Jang Jin,Moon Byeong Yeon 한국진공학회 2005 Applied Science and Convergence Technology Vol.14 No.4

본 연구는 실리콘 질화막 박막을 덮개층으로 사용하여 탄소나노튜브를 성장하고, 성장된 나노튜브의 전자방출특성을 조사하였다. 탄소 나노튜브는 triode PE-CVD 장치에 의해 성장되었으며, 탄소나노튜브의 밀도는 실리콘 질화막의 두께에 따라 크게 변하였다. 탄소 나노튜브의 밀도가 $10^{4}$/$cm^{2}$에서 전자방출 특성이 가장 우수하였으며, 이때 전자방출특성은 문턱전계 1.2 V/$\mu$m, 전류밀도는 3.6 V/$\mu$n의 전기장에서 0.17 mA/$cm^{2}$으로 측정 되었다. 또한, 진공 챔버에서 질소($N_{2}$) 분위기 하에서 전자방출 안정성을 조사하였으며, 탄소나노튜브의 밀도가 감소함에 따라 전자방출 안정성이 향상되었고, 탄소나노튜브의 밀도가 $10^{4}$/$cm^{2}$ 인 경우 $1\times10^{-4}$ A/$cm^{2}$ 이상의 전류가 흐르는 특성을 보였으며, 이 경우 $1\times$$10^{-5}$ Torr의 압력하에서 방출 전류의 안정도는 최소인 $2\%$를 유지하였다. We report on the field emission properties from vertically aligned carbon nanotubes (CNTs) produced by a triode PECVD with a SiNx capping layer on metal catalyst. It is found that the CNTs density can be controlled by the capping layer thickness and decreases with increasing SiNx thickness. The CNT density of $\~$ 104/$cm^{2}$ exhibited highest electron emission characteristics, the threshold field of 1.2 V/$\mu$m and the current density of 0.17 mA/$cm^{2}$ at 3.6 V/$\mu$m. We have carried out investigation of electron emission stability under ambient gas of N2. The electron emission stability was improved with decreasing CNT density. Under $1\times$$10^{-5}$ Torr ambient pressure, the CNTs in 5 $\mu$m hole show electron emission current higher than $1\times$$10^{-4}$ A/cm2 and it's electron emission uniformity has $2\%$.

무기체계의 효과분석과 의사결정을 위한 다기준분석 방법론의 연구

임성훈,조기홍,박승,Lim, Sung-Hoon,Cho, Ki-Hong,Park, Seung 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.5

Weapon system currently considers the research about effect analysis including cost effectiveness methodology for a budget management and an achievement of the military strategy goal. So that, this study considers the theoretical background, strength and weakness of several Multi-Criteria Decision Making, and an effect analysis of weapon system. And AHP(Analytic Hierarchy Process) is selected for the best effect analysis methodology of weapon system. Therefore, we applied AHP to the case study of the new generation Multiple Launcher Rocket System, performing the analysis of cost effectiveness methodology. Using AHP and cost effectiveness methodology, we propose the actual and proper decision making result.

투자유치기관 지배구조와 외국인투자 유치성과간 연관성에 관한 실증연구

임성훈 ( Sung Hoon Lim ) 한국국제통상학회 2010 국제통상연구 Vol.15 No.4

외국인투자유치정책 수립 메커니즘과 각국 사례연구 - 영국, 싱가포르, 말레이시아, 아일랜드, 한국의 투자유치정책 사례를 중심으로 -

임성훈 ( Sung Hoon Lim ),김학민 ( Hag Min Kim ) 국제지역학회 2004 국제지역연구 Vol.8 No.2

해외직접투자이론 전개과정에서 스테판 하이머의 이론적 공헌

임성훈(Sung Hoon Lim) 건국대학교 경제경영연구소 2009 商經硏究 Vol.34 No.1

Stephen Herbert Hymer was born in 1934, and died in a car accident 40 years later. In his short life, he made a seminal figure to the theory of the multinational corporation and foreign direct investment(FDI). This article focuses on Hymer’ evolving analytical framework, and assesses it in terms of modern FDI theories such as Dunning’s Eclectic paradigm (i.e., ownership advantage, internalization advantage, locational advantage), oligopolistic structure approach introduced by Raymon Vernon, Federick Knickerbocker, Edward Graham, John Cantwell etc., and Aharoni’s Behavior process approach. This paper concludes by questioning his predictions on a MNC’s activity in terms of FDI economic effect into host countries and policy regulation.

흰쥐의 치아 맹출과 치간 이개 과정에서 수종의 치주인대 단백질 발현의 변화에관한 면역 조직화학적 연구

임성훈(Sung-Hoon Lim),박형수(Hyung-Soo Park),윤영주(Young-Jooh Yoon),김광원(Kwang-Won Kim),김흥중(Heung-Joong Kim),정문진(Moon-Jin Jeong),박주철(Joo-Cheol Park) 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.1

치아의 맹출 과정과 치간이개로 유도된 치아 및 치조골의 흡수 과정에서 치주인대 세포와 치주인대 단백질의 기능을 알아보기 위하여, 발육 중인 흰쥐를 치근 형성 전, 치근 형성 시작과 치근 형성 및 맹출 시기로 구분하여 표본을 제작하고, 또한 성장 중인 흰쥐를 2주간 치간 이개시켜 조직표본을 제작하였다. 치주인대 섬유모세포에서 특이적으로 발현되며 치주인대의 분화와 성숙에 관여하는 PDLs22 단백질과 치아와 치조골의 파괴와 흡수를 조절하는 것으로 알려진 RANKL과 OPG의 발현을 면역 조직화학적으로 연구하였다. PDLs22 단백질은 치근 형성이 시작되면서부터 치낭세포와 골모세포에서 발현되어, 치아가 맹출하는 과정에서도 그 발현이 계속 유지되었으나, 치간이개에 의하여 치주인대가 개조되는 부위에서는 발현이 감소하였다. RANKL은 치근 형성 과정에서는 미약한 발현을 나타내었으나, 치아가 맹출하면서 발현이 증대되었으며, 치간이개에 의한 치근과 치조골 흡수과정에서는 치주인대세포, 골모세포, 치수세포 및 파치세포에서 발현이 증대 되었다. OPG는 치근이 형성되는 시기에는 강한 발현을 보였으나, 치아가 맹출하면서 발현이 현저히 감소하였ㄱ, 치아와 치조골의 흡수가 진행됨에 따라서 발현이 다소 감소하였다. In this study, we attempt to investigate the mechanisms by which PDL cells regulate osteoclast formation and also tc know whether PDL retained their characteristic phenotype during tooth eruption and interdental separation. Rats were prepared at developmental days 21 (pre-root formation), 27 (root development), 34 (advanced root formation/ eruption) and at later times(adult rats). To induce severe resorption state of alveolar bone and tooth root, interdental separation with brass wire was performed between the lower first and second molars for 2 weeks in adult rats. Rat mandibles were dernineralized and embedded in paraffin, and horizontal and frontal section were prepared for immunohistochenucal analysis using PDL-specific protein 22 (PDLs22), receptor activator of NFKB ligand (RANKL) and ostei protegerin (OPG) antibodies. 1. Root formation and eruption stage of tooth development. 1) PDLs22 immunolocalization was observed in tooth folliclelPDL cells and osteoblasts throught out the root formation and eruption stages of tooth development 2) RANKL expression became stronger at eruption stage than root formation stage of tooth development. 3) Strong expression of OPG was detected in follice/PDL cells of root formation stage but it was decreased with tooth eruption. 2. Interdental separation between lower first and second molar. 1) Con parared to normal animal, multinucleated osteoclasts and odontoclasts were markedly induced in the alveolar bone and tooth root with PDL remodeling in hematoxylin-eosin section. 2) PDLs22 expression was decreased with interdental separation. 3) RANKL expression was increased with interdental separation in PDL fibroblasts, osteoblasts, odontoclasts and it lacunae, resorbing dentin, cementum and bone matrix. 4) OPG expression was slightly decreased in the PDL cells adjacent to the alveolar bone and root surface with interdental separation. These results suggested that during tooth eruption and tooth movement, RANKL and OPG in the periodontal tissues are important determinants regulating balanced alveolar bone and tooth root resorption. And it is also suggested that PDL cells retained their characteristic phenotype during tooth eruption and interdental separation except for the short period of PDL remodeling.

미니-임플랜트를 이용한 3급 부정교합 치료

임성훈 ( Sung Hoon Lim ) 조선대학교 치의학연구원 2010 Oral Biology Research (Oral Biol Res) Vol.34 No.1

To improve molar relation of Class III malocclusion or to resolve mandibular crowding by non-extraction treatment, the distalization of mandibular posterior teeth is needed. However, the distalization of mandibular posterior teeth is known to difficult to achieve. In the past, mandibular headgear, lip bumper, distal extension lingual arch were introduced for distalization of mandibular posterior teeth, but there were problems like loss of anchor, uncontrolled movement, and need of patient compliance. To avoid these problems, skeletal anchorage can be used for distalization of mnadibular posterior teeth. Mini-implants can be placed at the interdental area and retromolar pad area. The mini-implant placed in the interdental area can hinder distalization of posterior teeth and the mini-implant placed in the retromolar area will be buried in the soft tissue arid may cause soft tisse irritation. To minimize soft tissue irritation, mini-implant can be placed in the distobuecal side of mandibular 2nd molar where muscle attachement is minimal. In this case reports, Class III molar relation was successfully corrected using mini-implants placed in the distobuccal side of mandibular 2nd molar.

임베디드 SoC 기반의 적응적 부스팅을 이용한 실시간 번호판 인식 시스템

임성훈(Sung-Hoon Lim),박병주(Byeong-Ju Park),이재흥(Jae-Heung Lee) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6