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소아에서 엡스타인-바 바이러스 감염과 관련한 막성 신병증 1례
이은희,임동희,임형은,유기환,원남희,홍영숙,이주원,Lee, Eun-Hee,Lim, Dong-Hee,Yim, Hyung-Eun,Yoo, Kee-Hwan,Won, Nam-Hee,Hong, Young-Sook,Lee, Joo-Won 대한소아신장학회 2008 Childhood kidney diseases Vol.12 No.1
Infection of Epstein-Barr virus(EBV) gives rise to a broad spectrum of clinical manifestations in children. Although renal involvement is rare, diverse renal manifestations are known from hematuria to acute renal failure. Secondary membranous nephropathy(MN) associated with systemic EBV infection is an uncommon renal pathology and only two cases have been reported. We are adding another case of MN associated with EBV infection in a child. An 8-year-old girl was admitted for renal biopsy. She had been followed up for microscopic hematuria and intermittent proteinuria for 5 months. There had been no specific findings in serology and radiology. Tonsil biopsy had been done due to exudative tonsillar hypertrophy and enlarged multiple cervical lymph nodes. And it showed EBV-associated lymphoproliferative findings. Serologic tests for EBV showed positive evidence of recent infection; viral capsid antigen(VCA) IgM was borderline positive, VCA IgG and early antigen IgG were positive, and EB nuclear antigen IgG was negative. In Situ Hybridization of tonsil for EBV mRNA was positive. Because her proteinuria and hematuria were aggravated at that time(protein 3 +, RBC >60/HPF), renal biopsy was done. Renal biopsy showed the findings of MN, characterized by thickened capillary walls with epimembranous spikes on light microscopy and subepithelial, mesangial and subendothelial electron dense deposits on electron microscopy. On immunofluorescence microscopy, IgG, C1q, kappa and lambda chains were positive. After steroid administration, proteinuria and hematuria resolved gradually within 6 months. 막성 신병증은 성인에 비해 소아에서는 드문 신병증으로 감염, 자가면역, 종양에 의한 이차성 신병증이 알려져 있다. 그 중에서도 엡스타인-바 바이러스 감염과의 관련은 잘 알려지지 않아, 최근 1개 보고에서 면역기능이 저하된 2례를 소개한 바 있을 뿐이다. 이에 저자들은 면역기능이 정상으로 보이는 소아에서 엡스타인-바 바이러스 감염과 관련한 막성 신병증 1례를 경험하였기에 보고하는 바이다.
고려시대 목조건축물의 상록하단(上綠下丹) 단청기법 수용
이은희,Lee, Eun-Hee 한국건축역사학회 2016 건축역사연구 Vol.25 No.5
The color that painted on the ground of Dancheong becomes Gachil(basecoat)-Dancheong and underpainting of Moro-Dancheong or Geum-Dancheong. So, the color of underpainting is the most important element that determines impression of the building. Thus, the architecture after using "Sangrokhadan" has different characters from what it had been. In the existing perception toward the background color of Dancheong, it was considered the characters of Korean Dancheong so-called "Sangrokhadan" that paint vertical elements like columns red and upper part of the columns green. But this study examined the color of Dancheong according to the era and region before and after Goryeo Dynasty era, then it reveals that Sangrokhadan technique was applied from the 14th century in the late Goryeo Dynasty. One of the Goryeo architecture, Geungnakjeon Hall of Bongjeongsa Temple is thought to be a previous style that is not applied "Sangrokhadan" technique because old elements are painted red pigment.
신경독성물질에 의한 신경계장애 조기발견을 위한 색각검사의 활용가능성
이은희,최경호,채홍재,백도명,Lee, Eun-Hee,Choi, Kyung-Ho,Chae, Hong-Jae,Paek, Do-Myung 대한예방의학회 2008 예방의학회지 Vol.41 No.6
This paper reviews the published literature that is concerned with color vision impairment from industrial and environmental exposure to neurotoxic substances, and we evaluated whether testing for color vision impairment could be an affordable procedure for assessing these neurotoxic effects. In general, most cases of congenital color vision impairment are red-green, and blue-yellow impairment is extremely rare. However, most of the acquired color vision impairment that is related to age, alcohol or environmental factors is blue-yellow impairment. Therefore, many studies have been performed to identify this relationship between exposure to neurotoxic substances, such as organic solvents and heavy metals, and the prevalence of blue-yellow color vision impairment. The test for color vision impairment is known to be very sensitive to the early signs of nervous system dysfunction and this can be useful for making the early diagnosis of neurotoxic effects from exposure to very low concentrations of toxic substances.
사람 융모 성선 자극 호르몬에 의한 복강 대식세로로부터 산화질소의 발생
이은희,신태용,김형민,Lee, Eun-Hee,Shin, Tae-Yong,Kim, Hyung-Min 대한약학회 1997 약학회지 Vol.41 No.3
Human chorionic gonadotropin (hCG) is a placental hormone and is involved in maintenance of the corpus luteum during pregnancy. In the present study, effect of hCG on nitiric ox ide (NO) generation from peritoneal macrophage was examined. hCG ahd no effect on NO generation by itself, whereas recombinant interferon- ${\gamma}$ (rIFN-${\gamma}$) alone had modest activity. When hCG was used in combination with rIFN-${\gamma}$, there was a marked cooperative induction of NO generation in a dose-dependent manner. The optimal effect of hCG on NO generation was shown at 6 hr after treatment with rIFN-${\gamma}$. Furthermore, northern blot analysis of showed that hCG increased the expression of inducible NO synthase(iNOS) gene. These results suggest that hCG induces NO generation from macrophages by increasing the expression of iNOS gene.
하이퍼써미아 응용을 위한 하이브리드 에어로젤 내 분산된 마그네타이트 나노입자
이은희,좌용호,김창열,Lee, Eun-Hee,Choa, Yong-Ho,Kim, Chang-Yeoul 한국재료학회 2012 한국재료학회지 Vol.22 No.7
Magnetite nanoparticles(NPs) have been the subject of much interest by researchers owing to their potential use as magnetic carriers in drug targeting and as a tumor treatment in cases of hyperthermia. However, magnetite nanoparticles with 10 nm in diameter easily aggregate and thus create large secondary particles. To disperse magnetite nanoparticles, this study proposes the infiltration of magnetite nanoparticles into hybrid silica aerogels. The feasible dispersion of magnetite is necessary to target tumor cells and to treat hyperthermia. Magnetite NPs have been synthesized by coprecipitation, hydrothermal and thermal decomposition methods. In particular, monodisperse magnetite NPs are known to be produced by the thermal decomposition of iron oleate. In this study, we thermally decomposed iron acetylacetonate in the presence of oleic acid, oleylamine and 1,2 hexadecanediol. We also attempted to disperse magnetite NPs within a mesoporous aerogels. Methyltriethoxysilicate(MTEOS)-based hybrid silica aerogels were synthesized by a supercritical drying method. To incorporate the magnetite nanoparticles into the hybrid aerogels, we devised two methods: adding the synthesized aerogel into a magnetite precursor solution followed by nucleation and crystal growth within the pores of the aerogels, and the infiltration of magnetite nanoparticles synthesized beforehand into aerogel matrices by immersing the aerogels in a magnetite nanoparticle colloid solution. An analysis using a vibrating sample magnetometer showed that approximately 20% of the magnetite nanoparticles were well dispersed in the aerogels. The composite samples showed that heating under an inductive magnetic field to a temperature of $45^{\circ}C$ is possible.
재미한인 노인들을 위한 너싱홈의 물리적 주거환경에 관한 사례연구 - 재미한인 노인 거주자 관점을 중심으로 -
이은희,Lee, Eun-Hee 한국주거학회 2011 한국주거학회 논문집 Vol.22 No.5
The purpose of this study was to describe the overall physical environment's features of nursing homes for Korean American elders in the United States. This investigation was conducted in Korean American nursing homes on the East Coast and in the Midwest with multiple qualitative data collection methods, such as interviews, observations, document review, and field notes. The findings of this study are as follows: 1) Although almost all respondents were unable to speak and understand English at all, most written materials in nursing homes were in only English; 2) The nursing homes were placed near or within the Korean communities; thus, it contributed to close ties with religious Korean American groups and other groups in the ethnic communities; 3) Whether the facility's physical features looked like those of a hospital or a home, many residents did not consider a nursing homes as a real home; 4) A fenced garden in the nursing home in the Midwest was the residents' favorite public space; 5) Due to being forced to room with residents who had dementia and were bedridden, they were more likely to have conflicts with their roommates and feel uncomfortable living in their room; and 6) The facilities seemed to be designed without consideration to protect residents' privacy.