도파민 길항제에 치료 불응성인 기능성 소화불량증 환자에서 시사프리드의 효과

이상인(Sang In Lee),서원태(Won Tae Seo),박인서(In Suh Park),이용찬(Yong Chan Lee),이동기(Dong Gi Lee),이광재(Kwang Jae Lee),김도영(Do Young Kim),신용운(Yong Woon Shin),김영수(Young Soo Kijm),김범수(Pum Soo Kim),김동기(Dong Kee Kim) 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.2

N/A Background/Aims : Prokinetics are commonly used for the treatment of functional dyspesia, but their methods of action are different. First, we compared the efficacy and safety of the dopamine receptor antagonists, which were domperidone maleate and levosulpiride, in a 2 week treatment in functional dyspepsia, then investigated the efficacy and safety of cisapride tartrate in a 2 week treatment in those who were resistant to domperidone maleate or levosulpiride. Methods : One hundred Forty-nine patients, who were diagnosed with functional dyspepsia, were selected. The subjects were randomly divided into two groups, domperidone maleate (75) and levosupiride (74). Daily they took 30mg of domperidone maleate (DOM) or 75mg of levosulpiride (LEV) for 2 weeks. Then the subjects who didn't respond to these treatments took 30mg of cisapride tartrate for the following 2 weeks. Results : At week 0, the total symptom scores of the DOM group and LEV group were 8.01±2.57 and 8.14±2.65 respectively, which were not statistically different. At week 2, the total symptom scores of the DOM and LEV groups were significantly reduced to 4.28±3.30 and 4.85±3.53(p=0.0001). The efficacy rates of the DOM and LEV groups at week 2 were 50.8% vs. 44.1%. The rate of adverse events in the LEV groups was much higher than in the DOM group(17.7% vs. 8.0%). In addition the rate of change from normal to abnomal in prolactin level was markedly higher in the LEV than that of the DOM group(80.0% vs. 8.3%). After 2 weeks of treatment with cisapride tartrate, the total symptom score was significantly reduced to 3.77±2.49(p=0.0001), and the efficacy rate was 75.0%. The satisfaction of the resistant subjects in efficacy of cisapride compared with the previous treatment was 73.3%. The rate of adverse events of cisapride tartrate was 5.0%. Conclusions: Considering efficacy and safety of domperidone maleate and levosulpiride, domperidone maleate was the safer drug for the treatment of functional dyspepsia, and cisapride tartrate can be a useful drug in those patients who are resistant to dopamine antagonists like domperidone maleate and levosulpiride.

오령산 및 가미오령산이 가토이뇨작용에 미치는 영향

이상인(Sang-In Lee) 한국생약학회 1981 생약학회지 Vol.12 No.1

In order to determine the effect of Oryeongsan reputed to have diuretic action since Han Dynasty and possible synergetic action of Dianthi Semen, Polygonum avicularis Herba, Kochiae Fructus and Akebiae Lignum, herbs with similar reputation, when added to the above prescription, their decoction powders were solved into distilled water and injected into rabbits through the ear vein. Upon the treatment, the excretion of sodium, potassium and chloride ion together with urine volume was kinetically determined. At the same time the clearance of plasma creatinine and sodium ion was determined and the following results were obtained. Every experimental group demonstrated diuretic action, though feable, of relatively long duration. The diuretic mechanism in the case of Oryeongsan made up by mixing the seperate extracts of individual components and Oryeongsan(A) plus Dianthi Semen was found to be inhibitory effect of renal tubular reabsorption in contrast to the case of Oryeongsan (A) plus Polygonum avicularis Herba, Kochiae Fructus or Akebiae Lignum in which case the diuretic mechanism was found to be glomerular vascular dilatation. The urinary excretion of potassium ion was increased in the case of Oryeongsan (A) plus Dianthi Semen, Kochiae Fructus of Akebiae Lignum whereas in the other cases no similar change was registered. The diuretic action was most remarkable in the case of Oryeongsan (A) plus Polygonum avicularis Herba followed by Oryeongsan (A) plus Kochiae Fructus, Oryeongsan (A) plus Dianthi Semen, extract mixture of individual component of Oryeongsan, Oryeongsan(A) and Oryeongsan(A) plus Akebiae Lignum decreasing order. The duration of diuretic action was found to be 90 minutes in the case of Oryeongsan and mixture of individual component of Oryeongsan, and 60 minutes in the case of Oryeongsan(A) plus Dianthi Semen, Kochiae Fructus or Akebiae Lignum in contrast to the case of Oryeongsan(A) plus Polygonum avicularis Herba which lasted up to 120 minutes.

Monascus Pilosus로 발효시킨 검정콩 첨가 식이가 고지방식이 마우스의 체중과 혈청 지방함량 및 간 조직 항산화계 효소활성에 미치는 영향

이상일(Lee, Sang-Il),김순동(Kim, Soon-Dong),이예경(Lee, Ye-Kyung),김미정(Kim, Mee-Jung),이인애(Lee, In-Ae),최종근(Choi, Jongkeun),서주원(Suh, Joo-Won) 한국영양학회 2013 Journal of Nutrition and Health Vol.46 No.1

The anti-obesity effects of fermented black bean were tested with mice fed a high fat diet for seven weeks. Body weight gain and feed efficiency ratio (FER) in the high fat diet control (HC) group were markedly higher, compared with those of the normal control (NC) group, but were significantly lower in the 2% black bean powder supplemented high fat diet (BB) group and 2% black bean powder fermented by M. pilosus supplemented high fat diet (BBM) group, compared with those of the HC group. Food intake in the HC and BB groups was significantly lower than that of the NC and BBM groups. Water intake in the HC group was significantly lower than that of the NC group, but was higher in the BB and BBM groups, compared with that of the HC group. On the other hand, relative liver and kidney weight in the HC group was lower than that of the NC group, but was higher in the BB and BBM groups, compared with that of the HC group. In addition, whereas epididymal fat weight in the HC group was markedly higher than that of the NC group, it was significantly lower in the BB and BBM groups, compared with that of the HC group. Meanwhile, hepatic GSH in the HC group was significantly lower than that of the NC group, but was slightly higher in the BB and BBM groups, compared with that of the HC group. Although hepatic LPO in the HC group was dramatically higher than that of the NC group, it was significantly lower in the BB and BBM groups, compared with that of the HC group. In addition, serum TG, total cholesterol, and LDL-cholesterol in the HC group was significantly higher than that of the NC group, but was significantly lower in the BB and BBM groups, compared with that of the HC group. On the contrary, HDL-cholesterol in the HC group was significantly lower than that of the NC group, but was higher in the BB and BBM groups, compared with that of the HC group. In addition, activity of XOR D type in the HC group was lower than that of the NC group, but was slightly higher in the BB and BBM groups, compared with that of the NC group. Activities of ROS scavenging enzymes, such as SOD, GPX, and GST in the HC group were significantly lower than those of the NC group, but were significantly higher in the BB and BBM groups, compared with those of the HC group. In addition, serum ALT activity in the HC and BB groups was higher than that of the NC group, but was significantly lower in the BB and BBM groups, compared with that of the HC group. In histopathological findings, hepatic fat accumulation in the HC group was higher than that of the NC group, but was lower in the BBM group, compared with that of the HC and BB groups. In particular, antiobese, hypolipidemic, and antifatty liver effect of black bean powder fermented by M. pilosus was specifically higher than that of non-fermented steamed black bean. In conclusion, the constituents of black bean fermented by Monascus pilosus have been proven to not only inhibit obesity and hyperlipidemia but also decrease hepatic fat accumulation in high fat diet-induced obese mice. (Korean J Nutr 2013; 46(1): 5 ~ 14)

오령산 및 가미오령산이 가토 이뇨작용에 미치는 영향

Sang-In Lee(이상인) 한국생약학회 1981 생약학회지 Vol.12 No.1

In order to determine the effect of Oryeongsan reputed to have diuretic action since Han Dynasty and possible synergetic action of Dianthi Semen, Polygonum avicularis Herba, Kochiae Fructus and Akebiae Lignum, herbs with similar reputation, when added to the above prescription, their decoction powders were solved into distilled water and injected into rabbits through the ear vein. Upon the treatment, the excretion of sodium, potassium and chloride ion together with urine volume was kinetically determined. At the same time the clearance of plasma creatinine and sodium ion was determined and the following results were obtained. Every experimental group demonstrated diuretic action, though feable, of relatively long duration. The diuretic mechanism in the case of Oryeongsan made up by mixing the seperate extracts of individual components and Oryeongsan(A) plus Dianthi Semen was found to be inhibitory effect of renal tubular reabsorption in contrast to the case of Oryeongsan (A) plus Polygonum avicularis Herba, Kochiae Fructus or Akebiae Lignum in which case the diuretic mechanism was found to be glomerular vascular dilatation. The urinary excretion of potassium ion was increased in the case of Oryeongsan (A) plus Dianthi Semen, Kochiae Fructus of Akebiae Lignum whereas in the other cases no similar change was registered. The diuretic action was most remarkable in the case of Oryeongsan (A) plus Polygonum avicularis Herba followed by Oryeongsan (A) plus Kochiae Fructus, Oryeongsan (A) plus Dianthi Semen, extract mixture of individual component of Oryeongsan, Oryeongsan(A) and Oryeongsan(A) plus Akebiae Lignum decreasing order. The duration of diuretic action was found to be 90 minutes in the case of Oryeongsan and mixture of individual component of Oryeongsan, and 60 minutes in the case of Oryeongsan(A) plus Dianthi Semen, Kochiae Fructus or Akebiae Lignum in contrast to the case of Oryeongsan(A) plus Polygonum avicularis Herba which lasted up to 120 minutes.

당뇨병환자에서 식도운동에 관한 연구

이상인(Sang In Lee),이관우(Kwan Woo Lee),임승길(Seung Kil Lim),이현철(Hyun Chul Lee),문영명(Young Myoung Moon),최흥재(Heung Jai Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.3

N/A Esophageal manometry was performed in 10 diabetics with neuropathy, 11 diabetics without neuropathy and 11 healthy controls using low compliance pneumohydraulic capillary infusion system before and after infusion of edrophonium (80 ㎍/kg) and atropine (3 ㎍/kg). The results were summarized as follows: 1) Basal lower esophageal sphincter pressure and relaxation in diabetics were similar to that of healthy controls. 2) There were no significant differences in the amplitude, duration and velocity of peristaltic wave between diabetics and controls. 3) Multipeaked peristaltic waves were observed in 9 of 10 diabetic patients with neuropathy and more than quadriple peaked waves were 30%. Multipeaked peristaltic pressure complexes in control differed from those present in diabetics with neuropathy by their low incidence and by a tendency to be limited to the distal esophagus. In conclusion, multipeaked peristaltic pressure waves were the significant manmometric finding in diabetics with neuropathy and phamacologic response to edrophonium and atropine suggested the increased cholinergic tone.

2015 개정 국어과 교육과정 적용 현황 분석 연구: 초등학교 1~2학년 한글 교육을 중심으로

이상아(Lee Sang Ah),이인화(Lee In Wha) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.12

이 연구의 목적은 2015 개정 국어과 교육과정이 가장 먼저 적용되고 있는 초등학교 1~2학년의 현황을 파악하여 개정 교육과정의 현장 안착 방안을 마련하는 것이다. 초등학교 1~2학년의 적용 현황을 분석하기 위하여, 확대된 한글교육 시수 운영과 한글 교육 실태라는 두 가지 측면에 주목하고 이에 대해 교사, 학생, 학부모의 의견을 다각적으로 수렴하였다. 의견 수렴은 개정 교육과정에 대한 교사들의 인식 및 실행 실태를 설문조사하고, 다양한 교육적 현상과 그 원인에 대한 질적 분석을 면담을 통해 수행하는 방식으로 이루어졌다. 그 결과, 교사, 학생, 학부모는 한글 교육 시수 확대의 적절성에 공감하고 학년별 교과서 수준도 적절하다고 판단하였으나, 국어과의 한글 사용 수준이 수학이나 통합교과에 비해 낮다고 인식하고 있었다. 또한 교과서에 구현된 한글 교육 방향에 대해서는 긍정적으로 평가하였으나 학생간 한글 학습 수준 차이가 문제로 인식되고 있었다. 의견 수렴에서 제시된 문제점의 해소 방안으로는 창의적 체험활동에 포함되어 있는 학기 초 적응활동 시간을 활용한 한글 교육의 시행과 한글 학습 지원을 위한 다양한 수업 운영 자료의 개발및 보급을 들 수 있다. The purpose of this study is to identify the current status of the 2015 revised Korean language curriculum applied to elementary school 1st and 2nd graders and to prepare a way for the revised curriculum to settle in the field. In this study, attention was paid to expansion of Hangeul education and Korean language education in order to analyze the application status of elementary school 1st and 2nd graders. In order to understand whether the Hangeul education is smoothly performed in these two aspects, opinions of teachers, students, and parents were collected variously. The questionnaire survey was conducted on teachers perception and implementation of the revised curriculum, and the qualitative analysis of various educational phenomena and their causes was conducted through interviews. As a result, teachers, students, and parents agreed with the appropriateness of expanding Hangeul education hours and judged that the grade level textbooks were appropriate. However, it was recognized that the use level of Hangeul in Korean language was lower than that of mathematics or integrated subject. In addition, although the direction of the Hangeul education implemented in the responding textbook was evaluated positively, it was recognized that the difference of the level of the Hangeul learning was a problem. In order to solve the problems of unequal distribution of the achievement criteria and hierarchy setting, the following alternatives can be sought. First, it concentrates on Hangeul education using the adaptation activity time included in the creative experiential activities. Hangeul learning can enhance learning efficiency because it is the foundation of other subject learning. Second, it is necessary to develop and disseminate a variety of instructional materials for Hangeul education.

알레르기성 비염 흰쥐모델에서 理中湯合敗毒散이 비염치료에 미치는 영향

이상문,최인화,Lee, Sang-Moon,Choi, In-Hwa 대한한의진단학회 2004 大韓韓醫診斷學會誌 Vol.17 No.2

Background and Objectives: Recently the incidence of allergic rhinitis has increased but treatment in most cases has only dealt with the symptoms. Medicine has been developed that shows fewer side effects. However, some side effects and the psychological stress over taking medicine have remained. There have been no studies so far performed on the effect of Lizhongtang plus Baidusan Extract. This study aimed to find out the therapeutic effects of its exclusive use in rats with Allergic Rhinitis. Materials and Methods : Thirty Sprague-Dawley rats were divided into three groups: the control group, the cetirizine HCI group and the sample group. To induce allergic rhinitis in the control group, the cetirizine HCI group and the sample group, rats were sensitized intraperitoneally with 0.1$\%$ ovalumin solution 3 times at an interval of I week. Then intranasal sensitization was performed by diffusing 0.1$\%$ ovalumin solution 3 times at an interval of 2 days. After that time, rats of the cetirizine HCI group were orally administered with cetirizine HCI. Rats of the sample group were treated with Lizhongtang plus Baidusan Ex. for 28 days. We observed changes in nasal mucosa and submucosa. Also we found changes in the segment of neutrophil and lympocyte in Leukocyte. We used the statistical methods of ANOVA test(p 〈0.05). Results: The loss of the cilium and the secretion of mucus in the treated group was rare when compared to control group. Effects of Lizhongtang plus Baidusan Ex. on the liver function were also studied in rats. Treatment of Lizhongtang plus Baidusan Ex. did not affect AST and ALT. The segment of neutrophil was significantly increased in the treated group when compared with the control group and the cetirizine HCI group(p 〈0.05). The segment of lympocyte was significantly decreased in the treated group when compared with the control group and the cetirizine HCI group(p 〈0.05). Conclusion: This study shows that Lizhongtang plus Baidusan Ex. decreases the inflammatory response in rats with Allergic Rhinitis.

염증성 대장질환의 질환 활성도 측정방법으로서 99m Tc-HMPAO-SPECT의 의의

이상인(Sang In Lee),김영수(Young Soo Kim),조성원(Sung Won Cho),문영수(Young Soo Moon),김진홍(Jin Hong Kim),함기백(Ki Baik Hahm),이광재(Kwang Jae Lee),지훈(Hoon Ji),홍사준(Sa Joon Hong),박찬희(Chan Hee Park) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.1

N/A Background/Aims: Exact deterrnination of the extent of bowel involvement in inflammatry bowel disease is essential for the evaluation of disease severity and for the planning of approapriate therapy. The aim of the study was to detemine the accuracy of TC-HMPAO(Hexamethyl Propylene Amine Oxime) labelled leukocyte-SPECT(Single Photon Emission Computerized Tomography) in the assessment of disease extent and disease activity in inflammatory bowel disease. Methods: Using a scintigraphy with autologous leukocytes labelled by Tc-HMPAO was performed in 32 cases. In 15 patients with 9 ulcerative colitis, 6 Crohns disease, the clinical, endoscopic and histologic disease activities were compared with SPECT activity index, respectively. Results: 1. 'Tc HMPAO labelled leukocyte SPECT revealed 92.6% sensitivity, 100% specificity and 93.8% accuracy to detect of active inflammation of the colon. 2. The correlation between clinical activity index(Rachmilewiltz), and HMPAO SPECT activity index was very high significant(r=0.91; p0.001), less significant(r=0.69; p0.01) between endoscopy and scan activity index and highly significant(r=0.89; p(0.001) between histologic activity index and scan activity index. Conclusions: Tc-HMPAO labelled leukocyte SPECT is a reliable method to determine the extent of the bowel inflammation and disease activity in inflammatory bowel disease. (Korean J Gastroenterol 1997; 30:48 - 57)

간질환 환자의 갑상선 기능

이상인(Sang In Lee),조준구(Jun Koo Cho),전재윤(Chae Yoon Chon),함기백(Ki Baek Ham),정재복(Jae Bock Chung),최흥재(Heung Jai Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.3

N/A The liver has been recognized as an important site in the peripheral metabolism of thyroid homone, particularly in the mondeiodination of thyroxine to triiodothyronine. It is also the source of serum T, binding proteins. As is to be expected, disease of the liver has marked effects on serum thyroid hormone concentrations and bindings. In order to evaluate the change of thyroid hormones in various liver diseases and to elucidate the relationship between thyroid hormone status and severity of liver diseases, both thyroid hormones and liver functions were measured and analyzed in 110 patients with various liver diseases who were admitted to Yonsei University Severance Hospital during the period from April 1986 to October 1986. The results were as follows: 1) In various liver disease, acute hepatitis, fatty liver, chronic persistent hepatitis and chronic active hepatitis showed no significant difference in serum T3; T4, FT4, TSH and T3/T4 compared to normal controls. 2) The serum T3, T4 and FT4 of liver cirrhosis were signficantly lower than those of control group. but serum TSH, T3/T4 were within normal limits in liver cirrhosis. 3) The serum T3 and T4 and of hepatoma was significantly lower than those of control group, but mean serum FTTSH and T3/T4 showed no significant difference between hepatoma and control group. 4) The mean serum T3 level of seven patients with Child's class A was 100.73±25.44ng/dl, thirteen patients with class B 76.42±14.40ng/dl, and eighteen patients of class C 65.18±23.19ng/dl. There was a significant statistical difference among Child's class A, B and C. 5) There was no significant correlation between serum T3 and liver functions in Child's class A of liver cirrhosis. Serum T3 was significantly correlated with-total protein and albumin in Child's class B, with total protein, albumin and prothrombin time in Child class's C. 6) In liver cirrhosis, low serum T3 group (T3 <80 ng/dl) had a significant decrease in total protein, albumin and prolonged prothrombin time than normal serum T3 group (80 ng/dl < T3 < 220 ng/dl). 7) Serum T3 decreased significanlty in liver cirrhosis with ascites than in those without ascites. In conclusion, in liver cirrhosis and hepatoma, significant decrease in serum T3 and T4 level were observed and particularly serum T3 level may be useful in assessing the severity of hepato-cellular damage in liver cirrhosis.

대망에 발생한 원발성 평활근육종

이상인(Sang In Lee),김기황(Ki Hwang Kim),남수연(Su Youn Nam),박효진(Hyo Jin Pack),이희대(Hee Dai Lee),정우희(Woo Hee Jung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5

Although the greater omentum is frequently the site of metastatic neoplasm, primary omental tumors are exeedingly rare. The authors report here, a case of primary omental leiomyosarcoma presented initially as a palpable abdominal mass and epigastic discomfort for one year in a 66 year-old rnale patient. At laparotomy, 21*15*2.5 cm rnass weighing 600 gram was found in the omentum which was adherent to the anterior wall of the lower body of the stomach and liver surface. In the histologic findings presence of tumor necrosis, increased cellularity, cellular atypia and pleomorphism as well as large size of mass were indicative of leiomyosarcoma. Surg cal resection has been known to be the principle treatment for this disease, In this case, excision of the tumor with omentectomy, radical subtotal gastrectomy and wedge resection of the liver were performed. Eight months later, a recurrence was detected and chemotherapy with doxorubicin, dacarhazine, vincris- tine, and cyclophosphamide was done.