두경부암 환자 방사선 치료 시 BinkieRT^TM(구강용 고정장치)에 대한 유용성 평가

이경진,손상준,임경달,김찬용,이제희,GyeongJin Lee,SangJun Son,GyeongDal Lim,ChanYong Kim,JeHee Lee 대한방사선치료학회 2022 대한방사선치료학회지 Vol.34 No.-

Purpose: The purpose of this study is to evaluate the effectiveness of oral positioning stent, the BinkieRT^TM in radiation treatment for head and neck cancer patients in terms of tongue positions reproducibility, tongue doses and material properties. Materials and Methods: 24 cases using BinkieRT^TM during radiation treatments were enrolled. The tongue was contoured on planning CT and CBCT images taken every 3 days during treatment, and then the DSC and center of tongue shift values were analyzed to evaluate the reproducibility of the tongue. The tongue dose was compared in terms of dose distribution when using BinkieRT^TM and different type of oral stents (mouthpiece, paraffin wax). Randomly selected respective 10 patients were measured tongue doses of initial treatment plan for nasal cavity and unilateral parotid cancer. Finally, In terms of material evaluation, HU and relative electron density were identified in RTPS. Results: As a result of DSC analysis, it was 0.8 ± 0.07, skewness -0.8, kurtosis 0.61, and 95% CI was 0.79~0.82. To analyze the deviation of the central tongue shift during the treatment period, a 95% confidence interval for shift in the LR, SI, and AP directions were indicated, and a one-sample t-test for 0, which is an ideal value in the deviation(n=144). As a result of the t-test, the mean and SD in the LR and SI directions were 0.01 ± 0.14 cm (p→.05), 0.03 ± 0.25 cm (p→.05), and -0.08 ± 0.25 cm (p ←.05) in the AP direction. In the case of unilateral parotid cancer patients, the Dmean to the tongue of patients using BinkieRT^TM was 16.92% ± 3.58% compared to the prescribed dose, and 23.99% ± 10.86% of patients with Paraffin Wax, indicating that the tongue dose was relatively lower when using BinkieRT^TM (p←.05). On the other hand, among nasal cavity cancer patients, the Dmean of tongue dose for patients who used BinkieRT^TM was 4.4% ± 5.6%, and for those who used mouthpiece, 5.9% ± 6.8%, but it was not statistically significant (p→.05). The relative electron density of Paraffin Wax, BinkieRT^TM and Putty is 0.94, 0.99, 1.26 and the mass density is 0.95, 0.99 and 1.32 (g/cc), Transmission Factor is 0.99, 0.98, 0.96 respectively. Conclusion: The result of the tongue DSC analysis over the treatment period was about 0.8 and Deviation of the center of tongue shifts were within 0.2 cm, the reproducibility was more likely excellent. In the case of unilateral head and neck cancer patients, it was found that the use of BinkieRT^TM rather than Paraffin Wax or Putty can reduce the unnecessary dose irradiated to the tongue. This study might be useful to understand of BinkieRT^TM's properties and advantages. And also it could be another considered option as oral stent to keep the reproducibility of tongue and reducing dose during head and neck radiation treatments.

제2회 건강생활실천 성공사례 수상작품

이경진,Lee, Gyeong-Jin 한국건강관리협회 2004 건강소식 Vol.28 No.3

건설시험소의 견해

이경진,Lee, Gyeong-Jin 한국화재보험협회 1986 防災와 保險 Vol.29 No.-

파킨슨환자의 자기공명영상과 미세전극기록을 이용한 담창구 파괴술

이경진,손형선,박성찬,조경근,박해관,최창락,Lee, Kyung Jin,Son, Hyung Sun,Park, Sung Chan,Cho, Kyung Keun,Park, Hae Kwan,Choi, Chang Rak 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

Objective : The exact position of the lesion during the pallidotomy is critical to obtain the clinical improvement of parkinson's disease without damage to surrounding structure. Ventriculogrphy, CT(computed tomograpy) or MRI(magnetic resonance imaging) have been used to determine the initial coordinates of stereotactic target for pallidotomy. The goal of this study was to determine whether microelectrode recording significantly improves the neurophysiologic localization of the target obtained from MRI. Methods : Twenty patients were studied. They underwent a unilateral pallidotomy. Leksell frame was applied and T1 axial images parallel to the AC-PC(anterior commissure-posterior commissure) plane using a 1.5 Tesla MRI with 3mm slice thickness were obtained. Anteroposterior coordinate of target was chosen at 2mm in front of the midcommissural point and lateral coordinate between 19 and 22mm from the midline. The vertical coordinate was calculated on coronal slice using a fast spin echo inversion recovery sequence(FSEIR) related to the position of the choroidal fissure and ranged over 4-5mm below the AC-PC plane. Confirmation of the anatomical target was done on axial slices using the same FSEIR sequence . Microrecording was done at the pallidum contralateral to the symptomatic side using an electrode with a tip diameter of $1{{\mu}m}$ diameter tip and 1.1-1.4 mOhm impedance at 1000Hz. Electrophysiologic localization of the target was also confirmed intraoperatively by macrostimulation. Results : Microrecording techniques were reliable to define the transition from the base of the pallidum which was characterized by the disappearance of spike activity and by the change of the audible background activity. Signals from high amplitude neurons firing at 200-400Hz were recorded in the pallidal base. X, Y and Z coordinates of target obtained from the MRI were within 1mm from the X, Y, Z coordinates obtained with microrecording in 16 patients (80%), 15 patients(75%), 10 patients(50%) respectively. The difference of Y coordinate between on MRI and on microrecording was 4mm in only one patient. Conclusion : The MRI was accurate to localize the target within 1mm of the error from microrecording target in 70% of the patients. 4mm discrepancy was observed only once. We conclude that MRI alone can be used to determine the target for pallidotomy in most patients. However, microrecording technique can still be extremely valuable in patents with aberrant anatomy or unusual MRI coordinates. We also consider physiologic confirmation of the target using macrostimulation to be mandatory in all cases.

망 이동성 지원 기술 및 표준화 동향 분석

이경진,박정수,김형준,Lee, K.J.,Park, J.S.,Kim, H.J. 한국전자통신연구원 2003 전자통신동향분석 Vol.18 No.5

IETF NEMO 워킹그룹에서는 IPv6 이동 네트워크에서의 이동성 지원을 위한 여러 가지 방법들이 제안되었다. 특히, 최근 결성된 디자인 팀에서는 기존에 제안된 여러 방법들을 접목하여 NEMO Basic Support 프로토콜을 제안하였고, 워킹 드래프트로 채택되었다. 본 고에서는 기존에 제안되었던 여러 가지 망 이동성 지원 방법들을 분석하고, 현 표준화 동향에 대해서 기술한다.

환경중 방사성 스트론튬 분석 방법 연구

이경진,황정래,정운관,Lee, Goung-Jin,Hwang, Jung-Lae,Chung, Woon-Kwan 대한방사선방어학회 1999 방사선방어학회지 Vol.24 No.3

환경 중에는 핵실험 및 원자력 발전소에서 방출되는 여러 가지 방사성 핵종들과 천연방사성 핵종들이 존재한다. 이 중에서 원자력발전소 운영과 관련하여, 환경 중의 인공방사성 핵종에 대한 관심이 높아지고 있다. 핵실험이나 원자력발전소와 관련된 인공방사선 핵종들은 주로 핵분열 생성물들로서, 그 수가 200여종에 이른다. 이 중에서도 $^{90}Sr$과 $^{137}Cs$은 선량특성상 특히 주목되어 왔다. 본 논문에서는 환경준위의 $^{90}Sr$ 정량 분석 방법에 대한 연구를 수행하였다. 환경 중의 $^{90}Sr$은 저준위이며, 특성 감마선과는 달리 연속 스팩트럼의 베타선원으로, $^{89}Sr$, $^{90}Y$ 및 다른 방사성 핵종들과 혼합되어 있기 때문에 정량적인 분석이 매우 어렵다. 저준위 방사성 스트론튬 분석을 위해서는 농축 과정 및 분석에 영향을 주는 타 방사성 핵종과의 화학적 분리과정이 필요하다. 그 동안 국내 여러 기관에서 공통적으로 스트론튬 회수율 산정을 위해 중량법을 사용하였고, 화학분리절차도 중량법을 사용하기에 적합하도록 개발하여 사용하였다. 최근 분석기기의 발달로 인해서, ppm 이나 ppb 단위의 안정원소 분석을 쉽게 할 수 있다는 점에 근거하여, 원자분광분석기기(ICP : Inductively Coupled atomic Plasma emission spectrophotometer)를 사용한 회수율 산정 및 그에 적합한 절차를 개발하였다. 개발된 절차는 기존의 중량법에 비해서 화학적 처리절차가 훨씬 간편하면서도 정확도가 높아서, 환경방사성 스트론튬의 정량분석에 적절히 사용될 수 있다. In the natural, there exist several kinds of radioactive isotopes. From atmospheric weapon tests and then some isotopes are naturally radioactivity above all things, nuclear power plant operation and man-made radioactive isotopes concern steadily growing in the environment. During the fission process of nuclear weapon tests and nuclear power plant operation, more than 200 radioactive isotopes are generated. Among them, $^{90}Sr$ and $^{137}Cs$ has been regarded as very important isotopes due to characteristics. In this paper, a quantitative analysis method of environment low level $^{90}Sr$ is studied. Radioactivity level of the environmental $^{90}Sr$ is very low, and it emits continuous beta spectrum, and $^{90}Sr$ exists together with $^{89}Sr$, $^{90}Y$ and other radioactive isotopes. It very difficult to make the quantitative analysis of $^{90}Sr$. For the analysis of low level radioactive strontium, enrich and chemical separation of strontium from the other radioactive isotopes are needed. For the estimation of strontium recovery ratio, so called SGAT(Strontium Gravimetric Analysis Technique) was generally used among the domestic research groups, and chemical procedures were developed appropriation for the SGAT, Recently, by using ICP(Inductively Coupled atomic Plasma emission spectrophotometer), amounts of stable atoms can be measured easily and accurately to the extend of ppm or ppb. In this paper, new chemical procedures are developed to exploits the ICP technique. New developed method has simpler chemical treatment procedures and then it gives more accurate results compared with the traditional SGAT.

체외수정시술시 배아이식 후 배아이식도관 말단부에서의 미세균주 배양율과 임상적 임신율과의 관계

이경진,배상욱,김정연,김진영,이병석,박기현,조동제,송찬호,Lee, Kyoung-Jin,Bai, Sang-Wook,Kim, Jeong-Yeon,Kim, Jin-Young,Lee, Byung-Seok,Park, Ki-Hyun,Cho, Dong-Jae,Song, Chan-Ho 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3

Objective: To evaluate incidence of microbial growth from the tip of the embryo transfer catheter after embryo transfer in relation to clinical pregnancy rate following in-vitro fertilization and embryo transfer. Method: This study was performed prospectively at the time of transcervical embryo transfer following conventional in-vitro fertilization and intracytoplasmic sperm injection procedures. Sixty three patients were enrolled in this study. Microbiological cultures were performed on endocervical swabs and embryo transfer catheter tips. Results: Positive microbial growths were observed from endocervical swabs in 45 (71.4%) women and from catheter tips in 30 (47.6%) women. There was no statistically significant difference seen in the mean number of oocytes fertilized or number and grade of embryos transferred between the group of patients without growth and the group of patients with positive microbial growth from catheter tips. The clinical pregnancy rate were 30.3% in the group of patients without growth and 13.3% in the group with positive microbial growth from catheter tips. This difference in clinical pregnancy rates was statistically significant. Conclusion: Our finding is that microbial contamination at embryo transfer may influence implantation rates. The major questions arising from our finding are whether eradication of endocervical micro-organisms is possible and whether their eradication will improve implantation rates.

강판콘크리트 구조 이질접합부의 면외 휨/면내 전단하중 특성에 관한 실험연구

이경진,황경민,함경원,김우범,Lee, Kyung-Jin,Hwang, Kyeong-Min,Hahm, Kyung-Won,Kim, Woo-Bum 한국강구조학회 2012 韓國鋼構造學會 論文集 Vol.24 No.2

본 연구는 L형, I형 실험체에 강판 콘크리트 구조와 철근콘크리트 구조를 적용하여 이질접합부를 만들고, 실험체에 반복하중을 파괴 시 까지 가력하여 면외 휨 내력 및 면내 전단 내력을 평가하고 구조특성을 검토하기 위해서 실험연구를 수행하였다.본 연구에서 면외 휨 성능실험은 접합부에서 정착부 수직철근이 인발되면서 파괴되었고, 면내 전단성능실험은 기초부에서의 휨 균열이 발생하여 파괴되었으며, 이론식과의 비교결과 최대 내력이 실험값/이론값의 결과가 면외 휨성능실험은 96%, 면내 전단성능실험은 82%의 값을 나타내었다. This paper describes an experimental study on the mechanical characteristic and behavior of a structure that has a joint between the reinforced concrete (RC) member and steel plate concrete (SC) member. An out-of-plane flexural test on an L-type test specimen and in-plane shear test on an I-type test specimen were carried out by means of repeated cyclic loading until their failure. Based on the results, the former showed pull-out failure mode of anchored vertical bars while the latter exhibited flexural failure mode of the basement member. These results reveal that the maximum capacity of the specimens is 96% and 82%, respectively, compared with the theoretical value.

RC 슬래브와 SC 벽 접합부의 전단마찰 거동에 관한 실험연구

이경진,황경민,김우범,Lee, Kyung Jin,Hwang, Kyeong Min,Kim, Woo Bum 한국강구조학회 2013 韓國鋼構造學會 論文集 Vol.25 No.6

본 연구에서는 RC 구조 슬래브와 SC 구조 전단벽이 만나는 접합부의 거동특성을 파악하고 RC구조 슬래브-SC구조 전단벽 이질접합부의 전단마찰내력을 평가하고 KEPIC SNG의 접합면 소요전단강도 기준의 안전율을 평가하기 위해 실험연구를 수행하였다. 연구결과, 접합면의 전단마찰내력은 약 300kN으로 나타났고, 변위가 증가할수록 철근의 내력분담이 증가하게 되며, 상부철근보다는 하부철근의 전단내력 분담율이 높은 것으로 나타났다. 하부철근을 구성한 경우에는 하부철근이 없는 실험체에 비해 40% 이상 전단내력이 증가하는 것으로 나타났다. In this study, the structure behavior of RC slab and SC shear wall connection was investigated. Also experimental study was performed to evaluate the factor of safety of demand shear connection strength in KEPIC SNG Standard. As a result, shear friction strength of connection was known about 300kN and shear strength of rebar increased according to the displacement increase. With the installment of the lower rebars, 40% shear strength increased compared to the non-rebar specimen.

철근 콘크리트 구조와 강판 콘크리트 구조(Steel Plate Concrete) 이질접합부를 가진 보의 휨 하중 특성에 관한 실험연구

이경진,함경원,박동수,김우범,Lee, Kyung-Jin,Hahm, Kyung-Won,Park, Dong-Soo,Kim, Woo-Bum 한국강구조학회 2010 韓國鋼構造學會 論文集 Vol.22 No.5

본 연구는 철근콘크리트 구조와 강판 콘크리트 구조가 혼합되어 이질접합부가 있는 보형 구조물의 역학적 특성을 평가하기 위하여 수행하였다. 강판콘크리트 구조는 현재 국내와 일본, 미국 등에서 연구가 진행되고 있고, 대규모 산업설비에서 철근콘크리트 구조의 대안으로 실험연구가 수행되고 있다. 본 연구에서는 대규모 철근콘크리트 구조물에 강판 콘크리트 구조를 적용할 경우를 가정하여 보 형태의 구조물에 강판 콘크리트 구조와 철근 콘크리트 구조를 적용하여 이질접합부를 만들고, 면외하중을 파괴 시까지 가력하여 이질접합부를 가진 보형실험체의 휨 내력 및 구조특성을 평가하기 위하여 실험연구를 수행하였다. This paper describes the experimental study on the mechanical characteristics of a steel plate-reinforced concrete joint. As an alternative reinforced concrete structure, the SC modular construction method is widely used and studied in the field ofindustrial facility field. However, the structure characteristics of RC and SC joint are not yet studied completely. In this paper, the beam-type construction joint of RC and SC walls was made to simulate the application of SC module to the large RC structure. Also, an out-of-plane loading was applied to the test specimen in order to evaluate flexural strength and structural properties of the beam-type RC-SC joint.