대장 용종절제술을 시행한 환자에서 조기 대장암의 예측 인자

유정래,송현주,범종욱,나수영,부선진,최은광,조유경,김흥업,송병철,현창림,김조헌 대한장연구학회 2013 Intestinal Research Vol.11 No.3

목적: 대장암은 국내에서 암 발생률 3위, 암 사망률 4위를 차지한다. 최근 대장내시경 검진과 대장 용종절제술로 인해 대장암의 발생률과 사망률이 감소하고 있다. 이번 연구는 대장 용종절제술 후 진행성 선종, 점막암, 점막하층암을 분석하여 조기 대장암을 예측할 수 있는 인자들이 있는지를 평가하고자 하였다. 방법: 2003년 8월부터 2012년 6월까지 제주대학병원에서 대장 용종절제술을 시행받은 총 1,001명의 환자 기록을 분석하였다. 결과: 대상 환자의 용종은 비진행성 선종 460명(50.1%), 진행성 선종 409명(44.5%), 점막암 38명(4.0%), 그리고 점막하층암 12명(1.4%)에서 관찰되었다. 평균 용종의 크기는 조기 대장암에서 유의하게 증가되어 있었고 (12.2 mm vs . 15.3 mm, P <0.01), 당뇨병을 가지고 있는 환자가 증가되어 있었다(13.1% vs . 25.0%, P =0.04). 또한 용종의 해부학적 위치는 원위부에 위치할수록 조기 대장암의 분포가 증가되어 있었다(39.3% vs . 52.0%, P=0.05). 다변량 회귀분석을 통해서 조기 대장암의 위험인자를 분석한 결과 당뇨병(odds ratio [OR], 2.10;95% confidence interval [CI], 1.07-4.33; P <0.01), 용종의 크기(>15 mm; OR, 4.49; 95% CI, 2.40-8.38; P <0.001), 원위부 위치(OR,2.59; 95% CI, 1.33-5.05; P <0.01)가 위험 요인으로 확인되었다. 점막하층암의 환자에서 5명은 추가적인 수술을 시행하였고 암성조직은발견되지 않았다. 결론: 대장 용종절제술을 시행한 환자에서 조기 대장암의 예측인자는 크기가 15 mm 이상, 용종이 원위부에 분포하거나 당뇨병을 동반한 경우였다. Background/Aims: Colorectal cancer is the third most common cancer and the fourth leading cause of cancer death in Korea. Colonoscopic screening with removal of adenomas is an effective strategy for reducing the incidence and mortality of colorectal cancer. This study was conducted to investigate predictable factors of early colorectal cancer (ECC) in patients with advanced adenoma (AA), tumor in situ (Tis), and submucosal (SM) cancer diagnosed after colonoscopic polypectomy. Methods: Between August 2003 and June 2012, a total of 1,001 patients who underwent colonoscopic polypectomy in Jeju National University Hospital were enrolled in this study. Results: Patients were classified into four groups; non-AA, AA, Tis, and SM cancer. Compared to the AA group, the ECC group (n=50) had large adenoma size (12.2±5.9 mm vs. 15.3±6.5 mm, P<0.01), distal location (39.3% vs. 52.0%, P=0.05) and diabetes mellitus (13.1% vs. 25.0%, P=0.04). However, age, sex, body mass index, the mean number of polyps, and morphological features (polypoid vs. nonpolypoid lesions) were not significantly different between the AA and ECC groups. In multivariate analysis, adenoma size >15 mm (odds ratio [OR], 4.49; 95% confidence interval [CI] 2.40-8.38), distal location (OR, 2.59; 95% CI, 1.33-5.05), and diabetes mellitus (OR, 2.10; 95% CI, 1.07-4.43) were significantly associated with ECC. Of the 12 patients with SM cancer, 5 underwent additional operations and had no remnant carcinoma. Conclusions: Predictable factors of ECC after colonoscopic polypectomy may be adenoma size >15 mm, distal location and diabetes mellitus. (Intest Res 2013;11:169-177)

고배속 광 디스크 드라이브의 고속 직접 검색 제어

유정래,정명진 제어로봇시스템학회 1998 제어로봇시스템학회 합동학술대회 논문집 Vol.1998 No.3

FPGA를 이용한 실시간 영상 워핑 구현

유정래,이은상,도태용 대한임베디드공학회 2014 대한임베디드공학회논문지 Vol.9 No.6

As a kind of 2D spatial coordinate transform, image warping is a basic image processing technique utilized in various applications. Though image warping algorithm is composed of relatively simple operations such as memory accesses and computations of weighted average, real-time implementations on embedded vision systems suffer from limited computational power because the simple operations are iterated as many times as the number of pixels. This paper presents a real-time implementation of a look-up table(LUT)-based image warping using an FPGA. In order to ensure sufficient data transfer rate from memories storing mapping LUT and image data, appropriate memory devices are selected by analyzing memory access patterns in an LUT-based image warping using backward mapping. In addition, hardware structure of a parallel and pipelined architecture is proposed for fast computation of bilinear interpolation using fixed-point operations. Accuracy of the implemented hardware is verified using a synthesized test image, and an application to real-time lens distortion correction is exemplified.

Serum Vitamin D Status and Its Relationship to Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

유정래,이상아,Jae-Geun Lee,Gil Myeong Seong,Seong Joo Ko,고관표,공미희,Keun-Young Park,김병준,임동미,이대호 전남대학교 의과학연구소 2012 전남의대학술지 Vol.48 No.2

The potential relationship between vitamin D (VitD) status and metabolic control in patients with type 2 diabetes mellitus (T2DM) warrants further study. We aimed to evaluate the relationship between the serum 25-hydroxyvitamin D [25(OH)D] level and various parameters in patients with T2DM. We analyzed retrospectively data from 276 Korean patients with T2DM whose serum 25(OH)D level was measured in our hospital. Nondiabetic healthy subjects who visited the hospital for health screening were selected as the control group (Non-DM, n=160). Compared with control subjects,patients with T2DM had a lower serum 25(OH)D level (15.4±0.5 vs. 12.9±0.4 ng/ml,p<0.01). Eleven percent of T2DM patients were VitD “insufficient” (20-29 ng/ml) and 87% of the patients were VitD “deficient” (<20 ng/ml). The serum 25(OH)D level was significantly related to serum fibrinogen, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), ferritin, the urine albumin creatinine ratio, and hemoglobin A1C (HbA1C). In a multivariate logistic regression analysis, high levels of HbA1C, TG, and LDL-C were independently associated with VitD deficiency in T2DM patients. The results of the present study show that the majority of Koreans with T2DM are VitD deficient,and the serum 25(OH)D level in patients with T2DM is related to lipid and glucose parameters. Further studies are required of the relationship of VitD with fibrinogen and other related parameters.

광디스크 드라이브를 위한 대물렌즈의 중립위치 보정

유정래 서울産業大學校 2005 논문집 Vol.54 No.3

Optical axis misalignment, which represents the position deviation of the objective lens from the optical axis, is an inevitable assembly error in an optical pick-up. Since the laser power intensity varies with respect to the distance from the optical axis, the misalignment leads to variation of the laser spot power intensity, which is one of the critical factors increasing data bit-error-rate in optical disc drives. In this paper, an auto-adjustment scheme for optical axis alignment is proposed to eliminate the undesirable variation of the laser spot power intensity in optical disc drives. An envelope of the data signal is extracted and utilized to detect the optical axis misalignment. Then an adjustment input is added to the driving input of the tracking actuator to shift the objective lens to the optical axis. Finally, the feasibility is verified by a series of experiments.

광디스크 드라이브 트랙 추종 제어 시스템을 위한 외란 관측기의 QFT 설계

유정래 서울産業大學校 2005 논문집 Vol.54 No.3

In For track-following control in optical disk drive, a compensator should be designed to satisfy disturbance attenuation property, overall system stability, and so on. In order to ease the compensator design procedure by reducing trial and errors, a disturbance observer is added on to a conventional single loop track-following control system, which may cause control input saturation due to excessive loop gain. Because the track-following control system is conditionally stable, control input saturation leads to actual reduction of loop gain whereby the system becomes unstable. To preserve the overall stability during transient response, where control input saturation possibly occurs, the circle criterion based on the pull-in condition is utilized to check the stability under control input saturation. The constraints from the circle criterion and robust stability condition are converted into frequency domain bounds, which are represented on a Nichols chart. Then a design method using quantitative feedback theory (QFT) is applied to satisfy the constraints shown on the Nichols chart. To show the feasibility, some experiments are conducted, and the results are presented.

On-Line Trajectory Generation for an Active Head-Eye System

유정래 서울産業大學校 2005 논문집 Vol.54 No.3

In robotic research field, vision system is one of the most powerful sensing devices. Recently, active vision system has been spotlighted, because it can solve some problems that exist in conventional passive vision systems. In order to utilize the advantages, active head-eye systems have been constructed. In this paper, an on-line trajectory generation method is presented. Basically, it adopts the weighted least norm method that was proposed in the redundant joint manipulator field. The weighting matrix is chosen in consideration of maximum joint angular velocities. For proof of feasibility, the method is applied to an active head-eye system and the result is presented.

Seroprevalence of Severe Fever with Thrombocytopenia Syndrome in the Agricultural Population of Jeju Island, Korea, 2015–2017

유정래,허상택,김미연,송성욱,부지환,이근화 대한감염학회 2019 Infection and Chemotherapy Vol.51 No.4

Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne zoonotic disease that is caused by the SFTS virus (SFTSV), and exhibits an overall mortality rate of approximately 20.0% in Korea. Most cases of this disease have been reported in Korea, East China, and Japan, and it mostly affects outdoor workers and farmers. This study aimed to investigate the seroprevalence of SFTSV among healthy farmers on Jeju Island, Korea. Materials and Methods: In this prospective cross-sectional study, we analyzed 421 blood samples obtained from 254 farmers (mean age, 59.9 years; 68.9% male) to determine the seroprevalence of SFTSV in 16 rural areas of the Jeju Special Self-Governing Province over a period of 3 years (January 2015–December 2017). We used an enzyme-linked immunosorbent assay to detect immunoglobulin (Ig) G antibodies against SFTSV in the collected samples. Results: The seroprevalence of the SFTSV IgG among farmers on Jeju Island was observed to be 2.4%. One subject showed seropositivity over the entire 3-year study period. The areas with the highest SFTSV IgG seropositivity rates were Seonheul-ri in Jocheon-eup, followed by Namwon-eup. Fruit farmers were at a higher risk of exposure to SFTSV than other farmers. Conclusion: The seroprevalence of SFTSV in the healthy agricultural population of Jeju Island was not high. However, personal hygiene management should be implemented for the agricultural population in the endemic areas. Surveillance of mild or asymptomatic infections is required in the endemic regions.

Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome

유정래,김선형,김영리,이근화,오원섭,허상택 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.4

Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not been established. Herein, we introduced the therapeutic plasma exchange (TPE) in SFTS patients in a tertiary hospital between 2013 and 2015. Methods: TPE was performed in patients with rapidly progressing SFTS. Clinical, laboratory, and virological parameters were compared before and after TPE. Results: Among 27 confirmed SFTS patients, two patients were treated with TPE and ribavirin combination in May 2013, then, 14 patients with rapidly progressing SFTS patients were treated with only TPE from June 2013 to September 2015: their median age was 58 years (interquartile range, 50 to 70) and eight (57.1%) were male. Body temperature, pressure-adjusted heart rate, white blood cell and platelet counts, coagulation profile, serum creatinine, and multiple organ dysfunction score improved immediately after TPE. In addition, the mean cyclic threshold value of real-time reverse transcriptase polymerase chain reaction for SFTS virus after TPE (mean ± standard deviation, 31.3 ± 2.9) was significantly higher than that before TPE (26.5 ± 2.9; p < 0.001), indicating that serum viral loads decreased after TPE. Finally, 13 of 14 TPE-treated patients (92.8%) recovered from rapidly progressing SFTS without sequelae. Conclusions: SFTS patients treated with TPE showed improvements in clinical, laboratory, and virological parameters. These results suggest that TPE would be a therapeutic modality as rescue therapy in patients with rapidly progressing SFTS.

중증열성혈소판감소증후군(SFTS) 환자에 대한 고찰: 현재까지 연구된 치료법을 중점으로

유정래,허상택 대한수혈학회 2018 大韓輸血學會誌 Vol.29 No.2

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease that is caused by the genus phlebovirus in the family Bunyaviridae. The syndrome is characterized by fever, gastrointestinal symptoms, neutropenia, and thrombocytopenia. The number of reported cases and deaths in endemic areas, such as China and Japan, has increased each year. Since the first SFTS patient was identified in 2013, the number of cases have also been increasing every year in South Korea and the disease is posing a great public health concern. The number of patients is increasing and there is a high mortality rate, but there is no established treatment that has proven to be effective. The purpose of this review was to elucidate the various treatment modalities, such as plasma exchange, antiviral agents, e.g. ribavirin, high-dose steroids, and interferon.