http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
갑상선결절에서 Sodium/Iodide Symporter의 발현과 Thallium-201 갑상선 스캔의 연관성
안준협,나민아,김상수,공옥녀,석주원,이창훈,이창원,김인주,김용기 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.2
Background: The sodium/iodide symporter(NIS) has an important role in the diagnosis and treatment of well differentiated thyroid carcinoma. The relationship between the uptake of thallium- 201 scan(201Tl scan) and the expression of sodium/iodide symporter(hNIS) was studied in thyroid nodules. Methods: Patients that had undergone operations for thyroid nodules, and who received a 201Tl scan before their operations, were investigated. Anti-NIS antibodies were used to analyze the presence and distribution of the hNIS protein by immunohistochemical staining of their thyroid tissues.Results: Forty-four patients(papillary carcinoma; 18, follicular adenoma; 11, adenomatous goiter; 14, nonspecific thyroiditis; 1) 30 with no immunoreactivity and 14 with a positive reaction to the anti-NIS antibody, were included. The NIS negative patients(12/30) had no 201Tl uptake, but all others were positive on 201Tl scan, and the NIS-positive patients(13/14) had positive 201Tl uptake, with 1 negative on 201Tl scan, with significant difference(p=0.035). Of the 18 patients with a papillary thyroid carcinoma, the NIS negative patients(2/10) had no 201Tl uptake and the others were positive on 201Tl scan, but without significant difference. NIS positive patients(1/8) with a papillary thyroid carcinoma had no 201Tl uptake, and the others were positive on 201Tl scan, but without significant difference. Whether the results of NIS staining and 201Tl scan were positive or not did not affect the responses of radioactive iodine therapy in our study. Conclusion: These results suggest that thallium-201 uptake may be correlated with hNIS expression in thyroid nodules
비스포스포네이트가 인간 양수유래 중간엽 줄기세포로부터 조골세포의 분화에 미치는 영향
안준협 ( Joon Hyop An ),안병민 ( Byeong Min An ),최태영 ( Tae Young Choi ),김상국 ( Sang Gook Kim ),문화숙 ( Hwa Sook Moon ),주보선 ( Bo Sun Joo ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.3
Objective: It has been known that amniotic fluid (AF) is rich source of mesenchymal stem cells (MSCs). Bisphosphonates are widely used in clinical treatment of various metabolic bone diseases and their primary action is the inhibition of osteoclastic bone resorption. However, litter is known about whether bisphosphonates affect the differentiation into osteoblast, especially from AF-derived MSCs (AFMSCs). Therefore, the purpose of this study is to investigate whether these bisphosphonates influence in the process of AFMSCs differentiation into osteoblast. Methods: AF samples were obtained by second trimester amniocentesis for fetal karyotyping from 6 pregnant women. Cells were treated with various concentration (0, 10-10, 10-8, 10-6 M) of zoledronate and alendronate and analyzed over 21 days of culture. Differentiation into osteoblast was determined by cell staining and RT-PCR for alkaline phosphatase (ALP). Results: It was observed that AFMSCs could differentiate into osteoblast. Alendronate had more potent effect than zoledronate in osteoblastic differentiation. ALP expression was increased with increasing concentration of zoledronate and it was highest in 10-8 M alendronate. However, no effect of bisphosphonates was found in 14 days of culture. Conclusion: This study shows that AFMSCs can be differentiated into osteoblast. The induction of these differentiation following bisphosphonate treatment was appear to be drug type-, dose-, and culture time-dependent. However, further studies are needed to conclude a consistent outcome for the effects of bisphosphonate on differentiation potential of AFMSCs.