정맥 주입용 의료 소모품의 2차 감염 방지용 항균 제품 개발

심혜림,조혜영,이혜원,최지훈,이해광,박순용 한국고분자학회 2014 한국고분자학회 학술대회 연구논문 초록집 Vol.2014 No.10

실리카에 고정화된 이온성액체를 촉매로 이용한 알릴글리시딜에테르와 이산화탄소의 부가반응

심혜림(Hye-Lim Shim),이미경(Mi-Kyung Lee),유정인(Jeong-In Yu),박대원(Dae-Won Park) 한국청정기술학회 2008 청정기술 Vol.14 No.3

본 연구에서는 이미다졸륨계의 이온성액체를 실리카에 고정화시킨 촉매를 제조하고, 알릴글리시딜에테르(AGE)와 이산화탄소의 부가반응을 통한 이종 5원환 카보네이트의 합성반응에서 이 촉매의 반응특성을 고찰하였다. 고정화된 이온성액체는 chloropropyl 그룹이 도입된 실리카에 이미다졸이 고정화됨으로써 형성되었다. 제조된 촉매는 XRD, BET, ²?Si MAS-NMR 그리고 SEM 등 다양한 기기분석을 통하여 특성분석을 수행하였다. ²?Si MAS-NMR을 통하여 chloropropyl 그룹이 부과된 실리카 표면에 이온성액체가 잘 형성 되어있었음을 관찰하였다. 고정화된 이온성액체 촉매는 반응온도 80-120℃의 범위에서 AGE의 전환율이 55-67% 이고 생성물의 선택도가 85% 이상으로 우수한 반응성을 나타내었다. 또한 고정화된 이온성액체 촉매는 균일계 촉매인 1-n-butyl-3-methyl imidazolium bromide (BMImBr)보다 더 높은 AGE의 전환율과 생성물의 선택도를 나타내었다. In this study, imidazolium salt ionic liquid on amorphous silica was prepared and its catalytic performance in the cycloaddition of CO₂ with allyl glycidyl ether (AGE) to produce heterocyclic carbonate was investigated. The ionic liquid was generated on chloropropyl functionalized silica through the immobilization of imidazole. The prepared catalyst was characterized using a number of instrumental analysis including XRD, BET, ²?Si MAS-NMR and SEM. ²?Si MAS-NMR showed that the ionic liquid formed adduct with the chloropropyl groups attached to the silica surface. The immobilized ionic liquid showed very good catalytic activity for the cycloaddition of CO₂ with AGE, showing 55-67% of AGE conversion with over 85% of the carbonate selectivity at 80-120℃. Its AGE conversion and selectivity to the carbonate were even higher than the homogeneous analog, 1-n-butyl-3-methyl imidazolium bromide (BMImBr).

Hexanoic acid - crown ether system을 이용한 europium과 yttrium의 용매추출효과의 향상

심대선,한혜림,김세미,김정훈,김영운,정노희,강호철 한국유화학회 2015 한국응용과학기술학회지 Vol.32 No.1

용매추출법에서 희토류 금속을 효과적으로 분리하기 위해 추출제만 사용하는 것이 아니라 crown ether와 같은 첨가제를 이용하는 연구를 하였다. Host-guest 화합물인 macrocyclic ligand는 금 속과 착화물을 형성하는데, 이 때 crown ether의 cavity 크기와 비슷한 크기의 금속 이온들과 안정한 착 화물을 형성한다. 이전 연구에서 europium과 yttrium을 분리하기 위해 여러 사슬 길이의 지방산 추출제 를 이용한 추출실험을 행하였었다. 이를 토대로 분리효율이 좋지 않았던 hexanoic acid에 크기가 다른 crown ether (18-crown-6 ether, 15-crown-5 ether, 12-crown-4 ether)를 첨가하여 분리효과가 증가 하는 것을 연구하였다. hexanoic acid의 농도별로 분리효율을 본 후 가장 분리 효율이 좋은 농도에서 crown ether를 종류와 농도를 다르게 하여 첨가하였다. 그 결과 0.05 M hexanoic acid에서 분리능이 1.72으로 가장 높게 나타났고, crown ether를 첨가하였을 시 분리능이 0.002 M 15-crown-5 ether에서 가장 높게 나왔으며 기존의 분리능보다 2배 이상 더 높았다. 또한 crown ether를 첨가하였을 때 두 금 속이 MLR3·3RH의 형태로 추출되는 것도 확인 할 수 있었다. The synergistic solvent extraction of rare earth elements such as europium and yttrium has been investigated by the extractant with crown ether as an additive. Macrocyclic ligand as host-guest compounds form more stable complexes with metal ions which have the similar size of the cavity of crown ether. In our previous study[14] founded that the extraction used fatty acid of the various alkyl chain length. Based on the results of the previous experiment, the synergistic separation effect of two metals investigated that the hexanoic acid had was the worst extraction effect which added a crown ether such as 18-crown-6 ether, 15-crown-5 ether, and 12-crown-4 ether. In this study, the concentrations of hexanoic acid have showed the separation effect, and then the concentrations and kind of crown ether are performed for synergistic extraction at the hexanoic acid concentration of the highest separation effect. As a results, the separation rate is the highest value of 1.72 at 0.05 M hexanoic acid, and 0.002 M 15-crown-5 ether is the best value in other concentrations and kind of crown ether, it is about twice of using only hexanoic acid. Moreover, the extraction species of two metals has been founded MLR3·3RH form when added the crown ether.

고감도 및 고선택성의 유기인계/카바메이트계 농약 검출용 바이오칩 센서

심혜림 ( Hye Rim Sim ),김수희 ( Su Hee Kim ),이재영 ( Jae Young Lee ),이혜진 ( Hye Jin Lee ) 한국공업화학회 2009 공업화학 Vol.20 No.6

유기농 콩 추출물의 항염증 및 항알레르기 효과

정은경,서은혜,박준호,심혜림,김경희,이병용 한국유기농업학회 2011 韓國有機農業學會誌 Vol.19 No.2

This study was carried out to investigate the biological effects of organic soybean extracts. Cellular and molecular analysis was performed to determine anti-oxidative, anti-inflammatory, anti-apoptotic, and anti-inflammatory effects of soybean extracts. First, we obtained various solvent extracts of soybean such as water, ethanol, and methanol. Molecular and cellular analysis were performed with 0.1 ㎎/ml concentration of each solvent extracts. The results of anti-oxidative, antiinflammatory and anti-apoptotic effects of organic soybean extracts were prominent. However, organic soybean extracts were not observed in anti-allergic effects determined by releasing histamine from rat mast cell line, RBL-2H3. Conclusively, organic soybean suppress inflammatory responses. In addition, organic soybean could be applied as a functional food ingredient for treatment of chronic inflammation, asthma, and atopic dermatitis with enhanced anti-inflammatory activities.

Epidemiological Study of Hereditary Hemolytic Anemia in the Korean Pediatric Population during 1997–2016: a Nationwide Retrospective Cohort Study

심예지,정혜림,신희영,강형진,Jung Yoon Choi,하정옥,이제민,임영탁,양의진,백희조,최형수,유건희,박준은,김성구,김지윤,박은실,임호준,최희원,김순기,이재희,유은선,Park Hyeon Jin,Lee Jun Ah,Park Meerim,강현식,박지경,이나희,박상규,이영호,이성욱,Eun Jin Choi,공섬김,Red Blood Cell Disorder Wo 대한의학회 2020 Journal of Korean medical science Vol.35 No.33

Background: Hereditary hemolytic anemia (HHA) is a rare disease characterized by premature red blood cell (RBC) destruction due to intrinsic RBC defects. The RBC Disorder Working Party of the Korean Society of Hematology established and updated the standard operating procedure for making an accurate diagnosis of HHA since 2007. The aim of this study was to investigate a nationwide epidemiology of Korean HHA. Methods: We collected the data of a newly diagnosed pediatric HHA cohort (2007–2016) and compared this cohort's characteristics with those of a previously surveyed pediatric HHA cohort (1997–2006) in Korea. Each participant's information was retrospectively collected by a questionnaire survey. Results: A total of 369 children with HHA from 38 hospitals distributed in 16 of 17 districts of Korea were investigated. RBC membranopathies, hemoglobinopathies, RBC enzymopathies, and unknown etiologies accounted for 263 (71.3%), 59 (16.0%), 23 (6.2%), and 24 (6.5%) of the cases, respectively. Compared to the cohort from the previous decade, the proportions of hemoglobinopathies and RBC enzymopathies significantly increased (P < 0.001 and P = 0.008, respectively). Twenty-three of the 59 hemoglobinopathy patients had immigrant mothers, mostly from South-East Asia. Conclusion: In Korea, thalassemia traits have increased over the past 10 years, reflecting both increased awareness of this disease and increased international marriages. The enhanced recognition of RBC enzymopathies is due to advances in diagnostic technique; however, 6.5% of HHA patients still do not have a clear diagnosis. It is necessary to improve accessibility of diagnosing HHA.

Hexanoic acid - crown ether system을 이용한 europium과 yttrium의 용매추출효과의 향상

심대선(Dea-Seon Sim),한혜림(Hye-Rim Han),김세미(Se-Mi Kim),김정훈(Jeong-Hoon Kim),김영운(Young-Wun Kim),정노희(Noh-Hee Jeong),강호철(Ho-Cheol Kang) 한국유화학회 2015 한국응용과학기술학회지 Vol.32 No.1

용매추출법에서 희토류 금속을 효과적으로 분리하기 위해 추출제만 사용하는 것이 아니라 crown ether와 같은 첨가제를 이용하는 연구를 하였다. Host-guest 화합물인 macrocyclic ligand는 금속과 착화물을 형성하는데, 이 때 crown ether의 cavity 크기와 비슷한 크기의 금속 이온들과 안정한 착화물을 형성한다. 이전 연구에서 europium과 yttrium을 분리하기 위해 여러 사슬 길이의 지방산 추출제를 이용한 추출실험을 행하였었다. 이를 토대로 분리효율이 좋지 않았던 hexanoic acid에 크기가 다른 crown ether (18-crown-6 ether, 15-crown-5 ether, 12-crown-4 ether)를 첨가하여 분리효과가 증가하는 것을 연구하였다. hexanoic acid의 농도별로 분리효율을 본 후 가장 분리 효율이 좋은 농도에서 crown ether를 종류와 농도를 다르게 하여 첨가하였다. 그 결과 0.05 M hexanoic acid에서 분리능이1.72으로 가장 높게 나타났고, crown ether를 첨가하였을 시 분리능이 0.002 M 15-crown-5 ether에서가장 높게 나왔으며 기존의 분리능보다 2배 이상 더 높았다. 또한 crown ether를 첨가하였을 때 두 금속이 MLR3·3RH의 형태로 추출되는 것도 확인 할 수 있었다. The synergistic solvent extraction of rare earth elements such as europium and yttrium has been investigated by the extractant with crown ether as an additive. Macrocyclic ligand as host-guest compounds form more stable complexes with metal ions which have the similar size of the cavity of crown ether. In our previous study[14] founded that the extraction used fatty acid of the various alkyl chain length. Based on the results of the previous experiment, the synergistic separation effect of two metals investigated that the hexanoic acid had was the worst extraction effect which added a crown ether such as 18-crown-6 ether, 15-crown-5 ether, and 12-crown-4 ether. In this study, the concentrations of hexanoic acid have showed the separation effect, and then the concentrations and kind of crown ether are performed for synergistic extraction at the hexanoic acid concentration of the highest separation effect. As a results, the separation rate is the highest value of 1.72 at 0.05 M hexanoic acid, and 0.002M 15-crown-5 ether is the best value in other concentrations and kind of crown ether, it is about twice of using only hexanoic acid. Moreover, the extraction species of two metals has been founded MLR3·3RH form when added the crown ether.

윤활유첨가제로써 마모억제 성능을 갖는 Dimethacryloyloxy Alkane 유도체에 관한 연구

한혜림 ( Hye-rim Han ),조정은 ( Jung-eun Cho ),심대선 ( Dae-seon Sim ),강충호 ( Chung-ho Kang ),김영운 ( Young-wun Kim ),정노희 ( Noh-hee Jeong ),강호철 ( Ho-cheol Kang ) 한국공업화학회 2016 공업화학 Vol.27 No.6

Zinc dialkyldithiophosphate (ZDDP)와 같이 금속을 포함한 윤활유 첨가제는 값이 싸다는 이점 때문에 널리 사용되고 있으나, 재와 같은 불순물이 발생한다는 단점이 있다. 본 연구에서는 ZDDP를 부분적으로 대체하여 zinc와 같은 금속을 포함하지 않는 구조인 알칸디올로부터 유래하는 bis[3-(dialkyloxyphosphorothionyl) thio-2-methylpropanyloxy] butane(BAP4)을 간편하고 효율적으로 합성하였고, 합성한 BAP4 화합물들에 따른 내 마모 특성을 살펴보았다. 여러 가지 알킬기가 있는 BAP4 화합물들이 4-ball 시험법에 의해 마모 직경(Wear scar diameter, WSD) 값이 측정되었다. BAP4화합물에서 알킬기가 4에서 8로 증가함에 따라 WSD 값은 0.59 mm에서 0.45 mm로 급격히 감소했으나, BAP4의 알킬기가 8에서 14로 증가할 경우 WSD 값은 0.45 mm에서 0.50 mm로 서서히 증가했다. 따라서 BAP4 화합물 중 가장WSD 값이 적게 나타난 것은 B8P4이었다. 윤활기유에 B8P4와 ZDDP를 0.50 wt%로 첨가하여 4-ball 시험을 실시한 결과, B8P4와 ZDDP의 WSD 값은 각각 0.45, 0.54 mm로 측정되었다. 또한, 열 중량 분석기(Thermogravimetric Analyzer, TGA)를 통해 열안정성을 확인하였고, 에너지 분산형 X-선 분광분석기(Energy-Dispersive X-rays Spectroscopy, EDS)로 tribofilm이 제대로 형성되었는지를 측정하였다. Lubricant additives including zinc dialkyldithiophosphate (ZDDP) containing metal have been widely used due to the advantage of very low cost, but they can generate impurities such as ash. In this work, ZDDP containing metals was partially replaced with bis[3-(dialkyloxyphosphorothionyl) thio-2-methylpropanyloxy] butane (BAP4s) which was synthesized conveniently and ef-fectively from alkanediol without any metal components. Also, the wear resistance property of synthesized BAP4s were studied. Wear scar diameter (WSD) values of BAP4s with butyl, octyl, decyl, dodecyl or tetradecyl groups were also measured by four-ball test. As the length of the alkyl group increased from 4 to 8, the WSD value of BAP4s decreased rapidly from 0.59 to 0.45 mm, but from 8 to 14, the value increased very slowly from 0.45 to 0.50 mm. Thus, among all BAP4s, B8P4 having BAP4 with the octyl group, showed the lowest WSD value. Furthermore, the WSD values were measured in a lubricant base oil mixed with a 0.50 percent concentration (w/w) of either BAP4 or ZDDP. The former was 0.55 mm, and the latter was 0.45 mm. The thermal stability and tribofilm formation peroperty were also measured by thermogravimetric analyzer (TGA) and en-ergy-dispersive X-rays spectroscopy (EDS), respectively.

Syntheses and tribologycal properties of diacid derivatives as exteme pressure additives

심대선,한혜림,조정은,김영운,정노희,강호철 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0

Lead naphthenates as well as molybdenum dithiocarbamates (Mo-DTC) and zinc dialkyldithiophosphates (ZDDP) have been extensively used as lubricant additives on all sides. However, those contain heavy metals such as zinc, molybdenum and etc., which are not biodegadable and tend to accumulate in living organisms, causing various diseases and disorders. Because of environmental concern of those, chemicals without heavy metal moiety have been studied in order to replace conventional extreme pressure additives with heavey metal moety. Diacid derivatives with eco-friendly structure have been synthesized and 4-ball wear test of those was carried out.

Tribological characteristics of ashless dicarboxylic acid derivatives containing dialkyl dithiophosphate

심대선,한혜림,조정은,강충호,김영운,정노희,강호철 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1

본 연구에서는 석유유래 화합물을 대체하기 위하여 bio mass유래의 alkane diacid유도체와 dithiophosphate를 이용하여 중금속이 첨가되지 않은 내마모제를 간편하게 합성하였다. 합성한 내마모제의 diacid와 dithiophosphate의 변화에 따른 마모성능의 경향성을 4 ball wear scar test를 이용하여 살펴보았으며, 시중에 판매되는 내마모제인 zinc dialkyl-dithiophosphorus와도 비교하여보았다. 합성한 dicarboxylic acid 유도체 내마모제의 마모성능을 wear scar diameter의 크기를 측정하여 살펴보았다. 비교군으로 사용한 zinc dialkyldithiophosphorus는 첨가 농도가 0.05 % 일 때 0.82 mm인 것에 반해 합성한 내마모제는 0.48 mm로 나타났다. 합성한 내마모제는 0.05 % 이상으로 첨가 시마모성능이 더 이상 증가하지 않았다. 다음으로 dicarboxylic acid의 탄소 길이를 4개에서 11개로 증가시켜 본 결과, wear scar diameter가 0.52 mm에서 0.48 mm로 마모성능이 소폭 상승되는 경향을 나타내었다. 또한 TGA를 통해 열적 특성을 살펴본 결과 90°C에서 열분해가 되는 것을 확인하였고, 이를 통해 극한의 조건이 아니어도 내마모필름을 형성한다는 것을 확인하였다.