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면역생쥐에서 Ehrlich Carcinoma의 피하이식에 대한 충수돌기 임파조직의 반응에 대한 연구
홍재흥,박희설,송훈석 최신의학사 1972 最新醫學 Vol.15 No.10
Littman et al. (1968) reported that a high level of immunity of a long duration against Ehrlich carcinoma was produced in CFA white Swiss mice by UV-irradiated homologous Ehrlich carcinoma ascites tumor cell and suggested that the immunity produced by irradiated, killed tumor cell vaccine was primarily cell mediated. Lee and Kim (1972) reported that from the result of an autoradiographic observation the proliferation of small round cells around the tumor mass was distinct. Kang & Kim (1972) and Koh & Kim (1972) also reported that in the immune mice proliferation of large lymphoid cells in the thymus-dependent area of the spleen and the axillar lymph nodes was prominent. Recently Parey (1968) postulated that stem cells originating in hemopoietic tissue and differentiating into immunoglobulin and antibody-producing cells could develop and function normally without being directly or indirectly influenced by the thymus gland, whereas this differentiation occurred under the influence of lymphoepithelial tissues of the intestine, especially appendix. We made an attempt to observe autoradiogaphically the response of the appendiceal lymphoid tissue of the immune mice following subaxillar transplantation of Ehrlich carcinoma. The results were as follows: In the immune mice proliferation of large lymphoid cells in the appendiceal lymphoid tissue was prominent 5 days after the subaxillar transplantation of Ehrlich carcinoma.
전종민,최태림,이보람,서주현,송훈석,정혜림,양수연,박준영,김은정,김병기,양영헌 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.4
Streptomyces spp. have been isolated from different environmental niches and are known to exhibit diversity in secondary metabolism. They have complex regulation system to control secondary metabolism, however it is difficult to prioritize the importance of specific regulator among the thousands of global or cluster-situated genes that may regulate secondary metabolism in different Streptomyces strains. Here we suggest a simple homologybased selection method to find out important regulators by comparing seven Streptomyces strains finding highly homologous regulators in various Streptomyces strains and showed highly homologous 11 regulators containing four well known regulators such as BldM, IclR, WhiD and NdgR. Among various regulators, we showed a putative transcriptional regulator in Streptomyces coelicolor A3(2), SCO1463 playing a pivotal role in growth, antibiotic production (actinorhodin[ACT] and undecylprodigiosin [RED] production), and production/utilization of organic acids such as propionate and succinate by making comparisons between the deletion mutant and the wild type strain. Although high homology in various strains does not always mean the importance of a gene, we suggested a criterion on which regulator should be studied first and which would be more important among more than one thousand regulators.
박준영,박예림,최태림,김현중,송훈석,한영훈,이선미,박솔이,이혜수,Shashi Kant Bhatia,Ranjit Gurav,양영헌 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.12
γ-Aminobutyric acid (GABA), an important fine chemical in pharmacotherapy and food industries, is used as a novel material in the nylon industry and has attracted attention for its potential application in large scale production. Search for new genes and strains, development of efficient reaction systems, such as fermentation and bioconversion, and use of cheap starting material like monosodium glutamate (MSG) can make GABA production using less expensive bulk chemicals possible. Therefore, in this study, we constructed a recombinant Escherichia coli whole-cell system for GABA production that expressed glutamate decarboxylase (GAD) from Lactobacillus brevis and used MSG as the starting material. We also optimized the reaction conditions for MSG to GABA conversion, such as citrate buffer concentration, pyridoxal 5'-phosphate concentration, temperature, MSG concentration, and cell density (OD600). The optimized whole-cell system converted MSG to GABA via seven repetitive cycles resulting in an average conversion rate of 86% (71.7mM/h) within 42 h.