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Bee Venom 및 Melittin 약침액(藥鍼液)이 신경아세포종(神經芽細胞腫)의 세포사(細胞死)에 미치는 영향(影響)
강동철,정태영,서정철,임성철,한상원,Kang, Dong-cheol,Jung, Tae-young,Seo, Jung-chul,Leem, Seong-cheol,Han, Sang-won 대한침구의학회 2003 대한침구의학회지 Vol.20 No.2
Objective : This study was designed to analyze the effects of bee venom and melittin on cell death in neuroblastoma cell line. Methods : MTT assay, morphologic method, DNA fragmentation, flow cytometry, immunocytochemistry analysis, RT-PCR and Western blot were performed. Results : The obtained results are summarized as follows: 1. The MTT assay demonstrated that neuroblastoma cell viability was significantly inhibitted dose-dependently by treatment with bee venom and melittin in comparison with control. 2. Cell culture demonstrated that control group proliferated highestly at he 5th day in comparison with the 4th day in bee venom and melittin group. And in bee venom and melitti group cell proliferation decreased 2.5 times than control group. 3. The morphologic study demonstrated that neuroblastoma cell showed apoptosis after treatment with bee venom and melittin for 6 hours using microscope. 4. The Flow cytometry demonstrated that apoptosis of neuroblastoma cell treated with bee venom and melittin was related with stop of cell cycle in stage of $G_0/G_1$. 5 .DNA fragmenation demonstrated that neuroblastoma cell treated with bee venom and melittin showed DNA ladder below 1 Kbp. 6. Immunocytochemistry assay demonstrated that Fos and MAPK which are related with cancer were down-regulated by treatment with bee venom and melittin. 7. RT-PCR analysis demonstrated that Fos and MAPK mRNA were transcripted. Fos was down-regulated form treatment with $5{\mu}g/ml$ bee venom and MAPK was down-regulated form $1{\mu}g/ml$ bee venom. 8. Western blot demonstrated that Fos was down-regulated from $1{\mu}g/ml$ bee venom whereas MAPK was expressed by $1{\mu}g/ml$ bee venom but down-regulated by $10{\mu}g/ml$ bee venom. Conclusions : We found that some cancer related genes ware down-regulated by treatment with bee venom and melittin. Further study is needed for investigating the anti-cancer effect of bee venom and melittin.
Rainbow Power Therapy의 경항통에 대한 효과
서정철,서보명,김성웅,이경민,윤종석,이세연,김경운,이윤경,임성철,정태영,황재옥,한상원,Seo, Jung-Chul,Seo, Bo-Myung,Kim, Sung-Woong,Lee, Kyung-Min,Yun, Jong-Seok,Lee, Sea-Youn,Kim, Kyung-Woon,Lee, Yoon-Kyung,Lim, Seong-Chul,Jung, Tae-Young 경락경혈학회 2004 대한침구의학회지 Vol.21 No.2
Objective : This study was designed to estimate the effects of Rainbow Power therapy on neck pain patients by using Visual Analogue Scale(VAS) and pressure algometer. Methods : Rainbow Power therapy group consisted of 18 patients and acupuncture therapy group consisted of 7 patients. The degree of improvement of neck pain was evaluated by VAS and pain pressure threshold(at the points of Jianjing GB21 and Jianwaishu SI14) before treatment, before 3rd treatment and before 5th treatment. Rainbow Power therapy was performed at the points of Jianjing GB21, Zhongfu LU1, Yangxi LI5, Ganshu BL18, Weishu BL21 and Shenshu, BL23. Each points were stimulated with RP-UM103(Rainbow Power therapy instrument) for 20 seconds. The points of acupuncture therapy were Jeonggeun, Jeongjong, Sangbaekn and Hegu LI4 and acupuncture was maintained for 15 minutes. After above therapy dry cupping was performed at the points of Jianjing GB21, Jianwaishu SI14, Gaohuang BL43, Tianzong, SI11 and Bingfeng SI12 for 5 minutes. Results : There was no significant difference between the two groups in VAS, pain threshold of Jianjing GB21 and Jianwaishu SI14 following treatment. In the two groups VAS was significantly decreased. In Rainbow Power therapy group the pain threshold of the two points was significantly increased. But there was no significant increase in acupuncture therapy groups about the pain threshold of Jianwaishu SI14. Conclusions : The effectiveness of Rainbow Power therapy on neck pain was shown through VAS and pressure algometer. These imply that Rainbow Power therapy may be useful for neck pain. Further study is needed about Rainbow Power therapy.
거자법(巨刺法)위주의 침치료(鍼治療)가 뇌졸중(腦卒中) 환자(환자)의 기능 회복에 미치는 영향(影響)
서정철,정병식,윤형석,조성규,김윤미,김종인,이윤호,Seo, Jung-Chul,Cheong, Byung-Shik,Yun, Hyong-Seok,Cho, Seong-Gyu,Kim, Youn-Mi,Kim, Jong-In,Lee, Yun-Ho 대한침구의학회 2001 대한침구의학회지 Vol.18 No.3
Objective : In order to study the effect of contralateral acupuncture on recovery of motor disorders in stroke patients a clinical study was performed. Methods : Thirteen patients with poststroke-hemiplegia were randomized into two groups. Six patients(test group) treated with contralateral acupuncture. The other seven patients(control group) treated with ipsilateral acupuncture. The activity of daily living was measured with a modified barthel index(MBI). The therapy was performed one a day for 3 weeks. Results : In terms of improvement of activity of daily living, the test group showed statistically meningful increase after 1 week treatment. but the control group showed statistically meningful increase after 2 weeks(p<0.05). In terms of score of MBI, the groups showed no statistically meningful difference after 3 week treatment. Conclusions : These results support that contralateral acupuncture therapy has almost same effectness compared with ipsilateral acupuncture therapy in improvement of the activity of daily living of poststroke-hemiplegic patients.
서정철,임성철,정태영,신동훈,김민정,한상원,Seo, Jung-chul,Lim, Seong-chul,Jung, Tae-young,Shin, Dong-hoon,Kim, Min-jung,Han, Sang-won The Korean AcupunctureMoxibustion Medicine Society 2004 대한침구의학회지 Vol.21 No.2
목적 : 본 연구는 Interleukin 10 (IL10) 유전자 다형성이 구안와사의 발병과 관련이 있는지 알아보기 위해 수행되었다. 대상: 대구한의대학교부속 한방병원에 내원한 구안와사 환자 62명과 종합건진센터에 내원한 구안와사 기왕력이 없는 건강인 104명을 대상으로 하였다 방법 : 각 그룹에서 개개인마다 DNA를 분리 정제한 후 Taq polymerase로 증폭하여 한천 겔에서 전기영동을 하여 PCR 산물을 확인하였다. PCR 산물은 Pyrosequendng 과정을 통하여 IL10의 유전형이 자동으로 판정되었다. 결과 : A/A, A/C의 두가지 유전자형이 검출되었으며 구안와사군과 대조군 사이에 유의성 있는 차이가 발견되지는 않았다(p=0.052). 또한 개별 allele 빈도에 있어서도 구안와사군과 건강인 사이에 통계적인 유의성이 나타나지 않았다(p=0.064). 결론 : 이상의 결과를 통하여 IL10 유전자 다형성은 구안와사의 발병과는 관련성이 없는 것으로 사려된다. 그러나 더 많은 구안와사 환자를 대상으로 IL10 유전자와의 연관성에 대한 후속 연구가 필요하다고 하겠다.
일제치하(日帝治下)부터 1970년대까지의 한국(韓國) 침구학사(鍼灸學史)에 대한 고찰
서정철,남상수,안병철,Seo, Jung-Chul,Nam, Sang-Soo,Ahn, Byung-Cheol 대한침구의학회 2001 대한침구의학회지 Vol.18 No.4
Objective ; This Study was carried out to review the history of acupuncture & moxibustion in Korea under the control of imperialized Japan and to compare the history among Korea, China and Japan. Results ; Under the control of imperialized Japan the science of acupuncture & moxibustion in Korea has experienced the dark ages because of the momentary disordered medical laws made by Japan. As we compare the history of acupuncture & moxibustion among Korea, China and Japan, Korea was simple but systemic, China was complicate but complex and Japan was nearly surgical. Conclusion ; The science of acupuncture & moxibustion of Korea was mostly advanced in the late Chosun and did not just imitate that of China and has advanced uniquely.
서정철(Jung-Chul Seo),김경민(Kyong-Min Kim),현동훈(Dong-hoon Hyun) 한국생산제조학회 2011 한국생산제조시스템학회 학술발표대회 논문집 Vol.2011 No.4
적분구, 분광복사도계 등을 이용하여 램프 형태의 백색 LED에서 주입 전류에 따른 분광복사선속을 측정하였다. 주입 전류에 따라서 형광체의 발광 스펙트럼, 광 효율, 연색지수, 색온도 등이 강하게 의존하였다. 이와 같은 현상은 백색 LED의 수명 단축 및 파손과 형광체의 광 특성이 밀접한 관련성이 있음을 나타낸다.
서정철,임강현,한상원,Seo, Jung-Chul,Leem, Kang-Hyun,Han, Sang-Won 대한약침학회 2003 Journal of pharmacopuncture Vol.6 No.1
Bee venom has been clinically used to control the pain of inflammation disease etc. in general. Although the effect of bee venom herbal acupuncture has been reported, its mechanism has not been fully elucidated yet. Free radical metabolism seems to occupy a remarkably common position in the mechanisms of inflammation and ageing related disease. Oxidative damage to DNA, lipids, proteins and other molecules may contribute to the development inflammation disease. NO or DPPH is one of the free radicals and a mediator in inflammation diseases. The objective of this study is to investigate the scavenging effect of bee venom herbal acupuncture against NO and DPPH. The followings are the summary of the results: (1) There is no significant scavenging effect of bee venom herbal acupuncture on NO in BVS and BVP group. (2) There is a significant scavenging effect of bee venom herbal acupuncture on DPPH in BVS-1 and BVP-1 group. These results suggest that bee venom herbal acupuncture can be used for inflammation diseases such as rheumatoid arthritis. This study would provide important basic data on the possibility of the clinical treatment of bee venom herbal acupuncture. Further studies are required to investigate the antioxidative effects of it.