http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
만성 B형 활동성 간염환자에서 HBeAg과 임상양상에 따른 간조직내 B형 간염 바이러스 Core 항원의 발현양상
문희용(Hee Yong Moon),박상진(Sang Jin Park),한광협(Kwang Hyub Han),오승희(Seung Hee Oh),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),박인서(In Suh Park),박찬일(Chan Il Park) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.4
N/A Background/Aims: The expression of hepatitis H virus core antigen(HBcAg) in the liver reflects the state of viral replication and may influence the immune response of the host. Methods: We investigated the intrahepatic expression of HBcAg using immunohistochemistry in patients with biopsy proven chronic active hepatitis B(CAH-B) according to HBeAg status and clinical patterns. Results: The intrahepatic expression of cytoplasmic HBcAg(cHBcAg) in patients with CAH-B was significantly higher in the group of HBeAg positive than negative(p0.05). In patients with HBeAg negative CAH-B, the intrahepatic expression of cHBcAg was relatively higher in the group of sustained ALT elevation during follow-up than persistent normal ALT, but statistical signifi- cance was not observed. The pattern of intrahepatic expression of cHBcAg can be different in patients with CAH-B according to the timing of the liver biopsy and the level of transaminase following the liver biopsy. Conclusions: The intrahepatic expression of cHBcAg in patients with CAH-B was different according to the timing of liver biopsy and the level of transaminase following the liver biopsy as well as HBeAg status. (Korean J Gastroenterol 1996;28: 520 - 529)
원발성 간암환자의 간염 바이러스 감염유형에 따른 임상양상 및 예후
한광협(Kwang Hyub Han),문희용(Hee Yong Moon),김범수(Bum Soo Kim),백용한(Yong Han Paik),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park) 대한내과학회 2001 대한내과학회지 Vol.60 No.1
Background : Hepatocellular carcinoma(HCC) is one of the important causes of cancer-related mortality and morbidity in East Asia, including Korea. Most of the hepatocellular carcinoma in Korea are associated with hepatitis B and C virus infection. The clinical characteristics and prognosis of the patients with HCC were evaluated in relation to the type of hepatitis virus. Methods : A retrospective analysis of the clinical data and survival rate was done in 603 patients(M:F=4.9:1, mean age; 54.2 years) who were admitted to Yonsei medical center from April, 1991 through April, 1994. Results : Among 603 patients, tests for HBsAg and anti-HCV was done simultaneously in 455 patients. Out of the 455 HCC patients, 303 patients (66.6%) were classified as Group B(HBsAg+ve, anti-HCV-ve), 102 patients (22.4%) were classified as Group C (HBsAg-ve, anti-HCV+ve), 45 patients (9.9%) were classified as Group non-BC (HBsAg-ve, anti-HCV-ve), and 5 patients (1.1%) were classified as Group BC (HBsAg+ve, anti-HCV+ve). The mean age of the patients in Group C was older than that of Group B (64.9 vs. 51.3 yr) (p<0.05). Liver cirrhosis was frequently noticed in Group C than Group B (84.3 vs. 68.0%) (p<0.05). The number of the patients whose serum FP level was elevated (>400 ng/mL) was significantly higher in Group B than in Group C (70.0 vs. 52.0%)(p<0.05). According to the gross type, nodular type was more common in Group C than in Group B(72.0 vs. 38.1%) (p<0.01). The incidence of portal vein thrombosis was significantly lower in Group C compared with that in Group B (16.7 vs. 31.4%)(p<0.05). The number of the patients whose tumor size of less than 5 cm was significantly higher in Group C than in Group B (35.3 vs. 17.8%) (p<0.05). Using multivariant analysis, independent prognostic factors were found to be Child grading, FP level, size of the tumor, gross type, and the type of hepatitis virus. The cumulative survival rate of 1, 2, and 3 year in each Group was 31.5%, 17.5%, and 10.8%, respectively in Group B, and 55.7%, 30.2%, and 21.6%, respectively in Group C. The median duration of survival of Group B was significantly shorter than that of Group C(5.0 vs. 13 months)(p<0.05). Conclusion : About 90 % of HCC was associated with hepatitis B or C viral infection in Korea. Hepatitis B virus associated HCC had poorer prognosis compared with hepatitis C virus associated HCC in Korea.(Korean J Med 60:22-31, 2001)
성인에서 반복적인 복부통증을 유발한 Meckel 게실염에 의한 복막유착
김영수(Young Soo Kim),신용운(Yong Woon shin),문희용(Hee Yong Moon),김명식(Myong Sik Kim),권계숙(Kye Sook Kwon),방제소(Jei So Bang),조현근(Hyeon Geun Cho),김범수(Pum Soo Kim),김준미(Joon Mee Kim) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.6
Meckel,s diverticulum is generally acknowledged to be the most prevalent congenital anomaly of the gastrointestinal tract. In the autopsy series, the incidence ranged from 0.5 to 2 percent. The preoperative diagnosis of Meckels divemiculum is difficult, especially in the adult, because of the lesions ability to masquerade as one of a variety of much more common abdominal pathologies. The diagnostic accuracy may be affected by the age of the patient and by complications of diverticulum. The complications that may result include ulcer bleeding, intestinal obstruction, perforation, diverticulitis, stone, and neoplasm. The ways a Meckels diverticulum can cause bowel obstruction are different. Recently we experienced a case of Meckels diverticulitis causing intlammatory reaction and adhesion with the abdominal wall and causing recurrent abdominal pain and obstruction in a 22-year-old woman. Therefore, we present this case with a brief review of the related literature. (Korean J Gastroenterol 1997; 30:826-830)
박상진(Sang Jin Park),전재윤(Chae Yoon Chon),신현승(Hyun Seung Shin),문희용(Hee Yong Moon),한광협(Kwang Hyub Han),문영명(Yung Myung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park),박찬일(Chan Il Park) 대한내과학회 1993 대한내과학회지 Vol.45 No.6
Primary hepatic angiosarcoma is an extremely rare tumor. It is associated with chronic exposure to thor- otrast, vinyl chloride, arsenic, radium and possibly cop- per and with chronic idiopathic hemochromatosis. However, there are no known causes in about 40% of these patients. Although 40% of patients have hepatic fibrosis or cirrhosis at autopsy, the nature of the association between chronic liver disease and hepatic angiosarcoma is unknown. Only 3% of patients with hepatic angiosarcoma can live longer than 2years. A 44-year-old man was admitted due to right upper quadrant pain. He had no history of exposure to vinyl chloride, thorotrast, or arsenic. Abdominal CT scan showed multiple variable sized low density lesions with tortuous contrast enhancement from the periphery of the tumor in the right lobe of the liver. On the 2nd hospital day, hemoperitoneum was developed and emergency selective angiograpy was performed. In seletive angiography. the vascular puddling and stretching of the hepatic artery due to the enlarged tumor was shown on the right lobe of the liver from early arterial to late venous phase. In spite of double spring coil embolization and conservative care, the patient died. The patient was confirmed to have primary hepatic angiosarcoma by blind liver biopsy. We report a patient of primary hepatic angiosarcoma who came to the hospital because of right upper quad- rant pain and died of spontaneous rupture of the tumor with hemoperitoneum.
김태일(Tae Il Kim),박효진(Hyo Jin Park),문희용(Hee Yong Moon),송시영(Si Young Song),김귀언(Gui En Kim),조남훈(Nam Hoon Cho),박인서(In Suh Park) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
N/A Background/Aims: The adverse effects of radiation on the bowel after radiotherapy of aMomino- pelvic malignancy have been well described, and its chronic late form is progressive and poor in prognosis. Because of the close proximity to the pelvic organ and relative immobility, the rectum is the most common site of late radiation injury. In this study, we report the characteristics of late radiaton induced proctitis. Methods: The 28 patients with newly developed hematochezia at least 6 months after radiotherapy due to cervical cancer were reviewed from November 1993 to November 1994. Predisposing factors and clinical characteristics were examined. Sigmoidoscopy and endoscopic biopsy were performed, and symptom score, degree of sigmoidoscopic findings, and pathologic score were examined. Results: The peak incidence of hematochezia occurred after a latent period of 9 months from irradiation, and the mean latent period was 11.5 2.4 months(3 72 months). Of the previousely known predisposing factors, obesity and previous operation were most frequent, but they are not associated with the severity of chronic radiation proctitis. However, in patients with more than two predisposing factors, the severer degree of sigmoidoscopic findings was noted, compared witb patients with no predisposing factor. Age and the stage of malignancy were not associated with severity of chronic radiation proctitis. The mean total external and internal radiation dose was 8289138 cGy(6,600 10,300 cGy), and the total rectal radiation dose was 7,213 223(4,794-9,252 cGy), but we found no association between radiation dose and severity of radiation proctitis. And no reliable correlation was found in symptom score, degree of sigmoidosco- pic findings, and pathologic score, except between symptom score and pathologic score. Treatment was done with sucralfate enema, systemic steroid and sucralfate enema, etc., and its results are being followed up. The operation(transverse loop colostomy, low anterior resection, transverse end colostomy) were performed in 3 cases due to rectovaginal fistula and intractable hematochezia, and relapse was developed in 1 case. Conclusions: Chronic radiation proctitis was the progressive disease with a )ong latent period as in other studies, and there was no association between radiation dose and severity of disease, but previousely known predisposing factors were involved in the severer disease state. In the grade system of the disease severity, reliable correlation was found only between symptom score and pathologic score, but not with sigmoidoscopic findings, so we think that a more reliable grade system and more investigation for treatment and prevention of this progressive disease are needed. (Korean J Gastroenterol 1996;28: 28-35)
Sjo¨gren 증후군 환자 3예에서의 식도 운동 검사 소견
김범수,박효진,이수곤,서정기,문희용,문병수,박인서 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
저자들은 Sjo¨gren 증후군 환자 3예에서 식도체부의 수축력 저하 및 타액분비의 감소로 인한 산청소능의 저하 소견을 관찰할 수 있었기에 문헌고찰과 함께 보고하는 바이다. A number of factors protect the esophagus from acid-mediated injury. Among these, acid clearance from the esophagus appears to play a central role. Sjogren's syndrome is an autoimmune exocrinopathy that primarily affects the salivary glands but also involve almost any other part of the gut. The most distressing manifestation of Sjogren's syndrome is xerostomia secondary to destruction of the salivary glands. Another major problem is dysphagia due to the lack of saliva as well as esophageal dysmotility. We performed esophageal motility tests in three cases of Sjo¨gren's syndrome and found that patients with Sjo¨gren's syndrome had an esophageal dysmotility, an abnormal 24-hour esophageal pH, and delayed esophageal acid clearance.