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김선희 ( Seon Hee Kim ),김영학 ( Young Hak Kim ),조유숙 ( You Sook Cho ),김찬 ( Chan Kim ),최승원 ( Seung Won Choi ),유빈 ( Bin Yoo ),이명종 ( Myoung Chong Lee ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.2
Sjogren`s syndrome is a heterogenous autoimmune disease characterized by progressive destruction of the exocrine glands and accompanied by a variety of autoimmune phenomena. Sjogren`s syndrome patients can develop symptoms of ocular and oral dryness as well as extraglandular complications including central and peripheral nervous system disease. Sometimes neuropathy precedes the diagnosis of Sjogren`s syndrome. Adie`s syndrome is characterized by tonic pupil and the absence of tendon reflex. Sweating abnormality and chronic peripheral polyneuropathy can also be present. We report a case of primary Sjogren`s syndrome preceded by Adie`s syndrome with peripheral neuropathy. A 26-year-old woman was admitted for photophobia and paresthesia. On examination. her pupils were anisocoric and did not react to light but constricted promptly to pilocarpin. Sensation decreased on her left side of body and deep tendon reflexes were absent. Biopsy of minor salivary gland demonstrated infiltration by lymphocyte consistent with Sjogren`s syndrome, but Schirmer test was negative. So she was diagnosed as Adie`s syndrome with peripheral neuropathy. Five month later she complained of dry eye and dizziness. Rose bengal staining was positive. Sjogren`s syndrome was diagnosed and she was discharged with local therapy for the sicca symptoms.
심정연,변원철,홍정수,문희범,홍수종 ( Jung Yeon Shim,Won Chul Byun,Jeong Soo Hong,Hee Bom Moon,Soo Jong Hong ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Objective .' To evaluate the basophil histamine releasability in response to IgE- and non- IgE-mediated stimuli in children with atopic asthma. Met: Basophil histamine releasability was measured in Dermatophagoides farinae (D. farinae) -sensitive atopic asthmatics, D.farinae -sensitive healthy atopics, non-atopic asthmatics, and healthy non-atopics. Basophils were stimulated with D.farinae, goat antihuman IgE antibody, formyl-Met-Leu-Phe(fMLP), and Calcium ionophore A23187. Histamine was measured by automated fluorometric technique. Results '. Sponianeous histamine release was higher in atopic asthmatics compared to healthy non-atopics. Histamine release by D.farinae and by anti-IgE antibody was higher in atopic asthmatics compared to the other groups. There was no difference in histamine release by fMLP among all groups. Histamine release by Calcium ionophore was higher in healthy atopics and non-atopic asthmatics compared to healthy non-atopics. The atopics showed correlation between histamine release by D.farinae, by anti-IgE antibody and total serum IgE levels. Conclusions '. Spontaneous and IgE-mediated histamine release were related to the presence of both atopy and asthma, whereas non-IgE mediated histamine release was different depending on the stimuli.
조유숙,임윤정,김성호,이재천,임미경,유빈,문희범 ( You Sook Cho,Yeun Jeong Lim,Jae Cheon Lee,Seoung Ho Kim,Mi Kyoung Lim,Bin Yoo,Hee Bom Moon ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backgroand: Oral allergy syndrome(OAS) is composed of it,ching sense and edema in oral cavity, lips, throat, pharynx, and larynx following eating some fresh fruits or vegetables. It has been known that most of patients with OAS are allergic to pollens. Common epitopes were found among pollens, fruits and vegetables. Although OAS is a common farm of food allergy in adults, this is the first epidemiologic study of OAS in Korea. Muterial and metkod: One hundred and fifty one patients who showed positive skin reaction to pollens were telephone-interviewed. Investigation of the prevalence and clinical manifestations of OAS was possible in 81 patients. Result: The prevalence of OAS among these patients was 34.6% (28/81). OAS was found in 24(48%) out of 50 patients sensitized to tree pollens, whereas 4(13%) of 31 grass or weed pol- len-sensitized paients had OAS. Most common causative food was apple and all of 17 apple- OAS patients were sensitized to tree pollens. Peach was the second common food and 14 of 15 peach-OAS patients were sensitized to tree pollens. Besides oral symptoms, rhinitis, asthma, diarrhea, nausea, vomiting or generalized urticaria were accompanied in half of the OAS patients (14/28). Some patients showed OAS to some unique Korean foods such as dropwort, taro and Aster. Conclasion.' OAS was very common in pollen-sensitized patients. Larger epidemiologic studies are needed to find unique Korean foods and their antigensm causing OAS.