위식도접합부선암의 임상병리학적 특성

김한수,정오,박영규,김동의,류성엽,김영진,Kim, Han-Su,Jeong, Oh,Park, Young-Kyu,Kim, Dong-Yi,Ryu, Seong-Yeop,Kim, Young-Jin 대한위암학회 2008 대한위암학회지 Vol.8 No.4

목적: 위식도접합부선암의 임상병리학적 특성은 서구와 아시아 간의 많은 차이를 보인다고 알려져 있다. 그러나, 한국의 경우 위식도접합부선암의 유병율이 매우 낮고 이에 대한 연구 또한 부족하다. 따라서 저자들은 우식도접합부선암의 Siewert 분류에 따른 임상병리학적 특성을 조사하여 서구와 다른 국내 위식도접합부선암의 특성을 연구하고자 하였다. 대상 및 방법: 2004년 5월부터 2008년 2월까지 본원에서 위암으로 수술을 시행 받은 환자들을 대상으로 수술소견 및 병리 사진을 토대로 Siewert 분류법에 따라 위식도접합부선암을 분류하고, 의무기록을 바탕으로 환자들의 임상병리학적 특성들을 조사하였다. 결과: 위식도접합부선암은 전체 1,778예 중 70예(3.9%)였다. Siewert 1형은 3예(4.3%)로 매우 드물었으며, 2형과 3형이 각각 30예(42.8%) 37예(52.8%)였다. 2형이 3형에 비하여 평균연령이 높았으나(64세 vs 59세, P=0.049), 남녀비에는 차이가 없었다. 2형과 3형간에 Barrett 식도의 발현 정도나 Lauren 분류의 차이는 없었으나, 저분화암의 빈도는 3형에서 유의하게 높았다(P=0.045). 68예(97.1%)에서 근치적 절제가 시행되었으며, 각 아형간에 TNM 병기의 차이는 없었다. 결론: 국내의 위식도접합부선암은 매우 드물며 특히 1형의 유병율이 매우 낮다. 본 연구에서 서구의 보고와 부분적으로 일치하지 않는 병리학적 특성을 보였다. 향후 보다 많은 환자들을 대상으로 한국인의 위식도접합부선암의 특성을 연구할 필요가 있다. Purpose: Siewert's classification of adenocarcinoma of the esophagogastric junction (AEG) has been widely adopted, but there is a wide discrepancy of the clinicopathological features of AEG of the Asian patients as compared to that of the Western patients. The aim of this study was to investigate the clinicopathological characteristics of AEG according to the Siewert classification. Materials and Methods: Among the patients who underwent surgery for gastric carcinoma in our institution between May 2004 and February 2008, the AEG patients were selected based on their operation records and the photographs according to Siewert's classification. Results: There were 70 AEG patients (3.9%) among the total of 1,778 patients. There were 3 patients (4.3%) with type I, 30 patients (42.8%) with type II and 37 patients (52.8%) with type III. Curative resection (R0) was achieved in 68 cases (97.1%). No significant differences in gender, stage, Barrett's esophagus and the proximal margin were found between the patients with type II and type III AEG. The patients with type III were younger than the patients with type II (59 vs 64 years, respectively, P=0.049). Well differentiated histology (P=0.045) and the intestinal type (P=0.055) were significantly more frequent in the patients with type II as compared with that in the patients with type III. Conclusion: There was a striking difference of the Asian patients from the Western patients for the incidence of AEG (and especially type I). Some of the differences between type II and type III patients were similar to those of the previous Western studies. A large study is needed to investigate whether these features are typical in the Korean population.

Pb(Z$n_{1/3}$N$b_{2/3}$)$O_3$-Pb(N$i_{1/3}$N$b_{2/3}$)$O_3$-PZT와 PLZT를 경사조성으로 하는 경사기능 압전엑튜에이터의 제조와 물성

김한수,최승철,최진호,Kim, Han-Su,Choe, Seung-Cheol,Choy, Jin-Ho 한국재료학회 1993 한국재료학회지 Vol.3 No.3

4.5 Pb($Zn_{1/3}Nb_{2/3})O_3-40.5Pb(Ni_{1/3}Nb_{2/3})O_3$-55PZT와 PLZT(10/70/30, 11/60/40)를 경사조성으로 하여 경사기능 재료를 제조하였으며, 그 유전 특성과 압전 변형율 특성을 조사하였다. 경사기능재료는 A/B/A의 세층으로 성형하고 소결한 후 한 층을 연마해내어 제작하였다. 닥터블레이드용 슬립에는 acrylic계 유기 결합제가 34-36wt% 혼합되었으며, 건조 후 균열이 없는 양호한 thick film을 제조하였다. $1250^{\circ}C$, 2시간의 소성에 의해 경사기능화된 시편은 Nb와 La등의 조성 차이에 의한 구배를 이루었으며, 구배영역은 약 30${\mu}$m 정도였다. 경사기능재료에서 유전상수나 큐리온도롸 같은 유전특성은 조합한 조성층의 특성들사이의 값을 나타내었다. 인가 전압에 따른 변형율 특성은 단일 조성의 시편보다 현저하게 증가하였다. 실제로 경사기능 압전엑튜에이터를 제조한 결과 약 3${\mu}$m/100V 정도의 변위향을 나타내었다. Functionally Gradient Materials(FGM) of 4.5Pb($Ni_{1/3}Nb_{2/3})O_3$-55PZT and PLZT(lO/70 /30, 11/60/40) were prepared. Its dielectric and piezoelectric strain properties were investigated. The FGM were pressed into A/B/ A configuration using two kinds of films, one layer(A) was eliminated from FGM by polishing after sintering at $l250^{\circ}C$, 2 hrs. The acrylic binder system was successfully applied for crack free film through doctor blade method. The thickness of gradent layer in FGM was about 30${\mu}$m. Dielectric properties of FGM show the average value of each side layer. The strain-electric field characteristics of FGM were significantly improved comparison with the other single compositions. The prepared FGM piezoelectric actuator shows about 3${\mu}$m/IOOV displacement.

음도 고정 시 강도 변화에 따른 일반인과 성악인 발성의 성대접촉률 변화 특성의 비교

김한수,전용선,정성민,조근경,박은희,Kim, Han-Su,Jeon, Yong-Sun,Chung, Sung-Min,Cho, Kun-Kyung,Park, Eun-Hee 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.1

Background and Objectives : The most important two factors of the voice production are the respiratory function which is the power source of voice and the glottic closure that transform the air flow into sound signals. The purpose of this study was to investigate the differences between trained singers and untrained controls under varying intensity at a constant vocal pitch by simulataneous using the airway interruption method and electroglottography(EGG). Materials and Methods : Under two different intensity condition at a constant vocal pitch(/G/), 20(Male 10, Female 10) trained singers were studied. Mean flow rate(MFR), subglottic pressure(Psub) and intensity were measured with aerodynamic test using the Phonatory function analyzer. Closed quotients(CQ), jitter and shimmer were also investigated by electroglottography using Lx speech studio. These data were compared with that of normal controls. Results : MFR and Psub were increased on high intensity condition in all subject groups but there was no statistically significance. Statistically significant increasing of CQ. were observed in male trained singers on high intensity condition (untrained male : 51.31${\pm}$3.70%, trained male :55.52${\pm}$6.07%, p=.039). Shimmer percent, one of the phonatory stability parameters, was also decreased statistically in all subject groups(p<.001). Conclusion : The trained singers' phonation was more efficient than untrained singers. The result means that the trained singers can increase the loudness with little changing of mean flow rate, subglottic pressure but more increasing of glottic closed quotients.

국제학술회의 참관기 - 제46차 미국 정형외과연구학회 연례학술대회

김한수,Kim, Han-Su 한국과학기술단체총연합회 2000 과학과 기술 Vol.33 No.5

지난 3월 12일부터 나흘간 미국 올란도 오렌지카운티에서 열린 미국 정형외과연구학회 연례학술대회는 25개국에서 1천8백여명이 참석하여 1천1백여편의 논문이 발표되었다. 정형외과의 모든 기초연구 분야의 논문들이 발표되는 이 학술대회에서 필자는 악성골종양에 항암제의 효과를 높이기 위한 방법의 하나로 항암제를 뼈의 약성종양수술에 흔히 사용되는 골시멘트에 혼합하여 약성종양세포 성장이 억제되는 내용의 논문을 발표했다.

외래치료실에서의 근위축성 측삭경화증 환자(ALS)의 전신마취 하치과 치료시 마취관리

김한수,이숙영,최은혜,김승오,Kim, Han-Su,Lee, Suk-Yung,Choi, Eun-Hye,Kim, Seung-Oh 대한치과마취과학회 2013 Journal of Dental Anesthesia and Pain Medicine Vol.13 No.4

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the degeneration of upper and lower motor neurons. The disorder causes muscle weakness and atrophy in airway muscles including pharyngeal, laryngeal and other respiratory muscles. The response to muscle realxant is also altered in patients with ALS. Because of the inherent muscle weakness and associated respiratory insufficiency, particular attentions are needed in anesthetic management of ALS patients. We used proper doses of inhalation anesthetics and opioids under EEG-entropy (electroencephalography-entropy)-monitoring without the use of muscle realxants in the anesthetic management of a patient with ALS. The patient early recovered and was discharged on the same day without any respiratory complications.

가뭄 정보 전문기관 「국가가뭄정보분석센터」의 설립배경 및 역할

김한수,Kim, Han-Su 한국방재학회 2016 한국방재학회지 Vol.16 No.2

외래 시행 성대주입술을 위한 마취 방법

김한수,Kim, Han Su 대한후두음성언어의학회 2020 대한후두음성언어의학회지 Vol.31 No.2

Vocal fold injections are usually performed with a patient wake in an office under local anesthesia. For comfortable and safe office-based procedures, thorough anesthesia and premedication should be provided to the following three regions; nasal cavity, oropharynx, and larynx. Topical lidocaine is most widely used anesthetics on office based procedure. Lidocaine has a low to intermediate potency, 45 minutes to 60 minutes' duration of action, and onset of sufficient anesthesia within 90 seconds of topical administration. Tetracaine, prilocaine, ropivacaine, and bupivacaine also have been used in the office-based procedures. Nasal decongestant, oxymetazoline, is also used for widening nasal cavity by constriction of nasal mucosa. The amount of topical and local anesthetics used in vocal fold injection rarely exceeds toxic doses. The physician should know proper anesthesia techniques and must be familiar with the safe dose and complication of all anesthetics used.

척수손상 수준에 따른 외상성 척수손상환자의 합병증 발생양상

김한수,이용덕,박윤기,서태수,허춘복,Kim, Han-Su,Lee, Yong-Deok,Park, Yun-Gi,Seo, Tae-Su,Heo, Chun-Bok 대한물리치료사협회 1992 대한물리치료사협회지 Vol.13 No.2

2014년~2015년 가뭄의 평가

김한수,김현식,전근일,강신욱,Kim, Han-Su,Kim, Hyeon-Sik,Jeon, Geun-Il,Gang, Sin-Uk 한국수자원학회 2016 물과 미래(한국수자원학회지) Vol.49 No.7

최근 물정보화 동향과 MyWater 기술 SW 커뮤니티 운영

김한수,Kim, Han-Su 한국수자원학회 2016 물과 미래(한국수자원학회지) Vol.49 No.9