자락발관법(刺絡拔罐法)을 병행한 한방치료로 호전된 대상포진 후 신경통환자 치험 1례

김태연,김현정,김창환,Kim, Tae-Yeon,Kim, Hyun-Jung,Kim, Chang-Hwan 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.3

Objective : This study reports the effect of oriental medicine with depletion and cupping therapy on post-herpetic neuralgia(PHN) 1 case. Methods : We experienced one case of PHN treated by oriental medical treatment with depletion and cupping therapy. To evaluate the effectiveness of this treatment, we used the Visual Analogue Scale(VAS). Result : After the treatment the grade of VAS was decreased and clinical symptoms were improved. Conclusion : Oriental medicine with depletion and cupping therapy can be available for relieving symptoms related with PHN.

특발성(特發性) 동안신경마비(動眼神經麻痺)로 진단된 안검하수(眼瞼下垂) 환자 치험 1례

김태연,김현정,이창원,김창환,Kim, Tae-Yeon,Kim, Hyun-Jung,Lee, Chang-Won,Kim, Chang-Hwan 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.3

Objective : This study reports the effect of korean medicine on ptosis patient 1 case diagnosed as idiopathic oculomoter nerve palsy. Methods : We experienced one case of ptosis diagnosed as idiopathic oculomoter nerve palsy treated with herbal medicine and acupuncture. Ptosis and associated symptoms had been estimated with difference of both eye's interpalpebral fissure and VAS(Visual Analogue Scale). Result : After the treatment, symptoms were decreased and almost disappeared. In this case, difference of both eye's interpalpebral fissure decreased from 6mm to 1mm in a month. Conclusion : This study suggests that korean medicine is effective on ptosis diagnosed as idiopathic oculomoter nerve palsy.

클라우드 컴퓨팅에서 u-Fitness 기반 운동 관리를 위한 소유자의 프라이버시를 보장하는 프로토콜

김태연,조기환,최은복,Kim, Tae-yeon,Cho, Ki-hwan,Choi, Eun-Bok 한국스마트미디어학회 2017 스마트미디어저널 Vol.6 No.3

u-fitness 기반 운동관리와 관련된 민감한 신체 정보의 양이 폭발적으로 증가하고 있기 때문에 클라우드 서비스의 활용에 대한 관심이 날로 증가하고 있다. 그러나 클라우드 서버는 자신의 서버에 저장된 정보에 불법적으로 접근할 수 있으며, 누가 그 정보의 소유자인지를 알아낼 수 있고, 스토리지에 저장된 정보 간의 연관성을 불법적으로 추론할 수 있다. 또한 클라우드 서버는 저장된 정보에 대해 수정, 삭제 같은 소유자의 정당한 연산 요청에 대해 불이행할 수 있으며, 자체의 오작동으로 인해 정보를 분실하거나 손상시킬 수 있다. 따라서 우리는 클라우드 서버를 전적으로 신뢰할 수 없기 때문에 클라우드 서버를 사용하기 위해서는 위와 같은 문제들을 해결해야 한다. 우리는 클라우드 컴퓨팅 환경에서 u-Fitness 기반 운동관리를 위한 소유자의 프라이버시를 보장하는 프로토콜을 제안한다. 그리고 제안한 구조가 실제 환경에서 적용 가능함을 보안 분석과 성능 분석을 통해 보인다. There is growing interest in the use of cloud services these days because the amount of sensitive physical information related to u-fitness-based exercise management increase in explosive. However, it is possible to illegally access information stored in a cloud server, and to find out who owns the information, even, to illegally deduce an association among the information stored in its memory. The cloud server may also intentionally pass over the owner's legitimate operation requests such as modification and deletion of stored information, and may lose or damage information due to its malfunction. So, it is strongly required to solve the above problems because we can not trust the cloud server entirely. In this paper, we propose a protocol to preserve the privacy of the owner for u-Fitness-based exercise management in a cloud computing environment. And we show that our proposed architecture is applicable in real environment through security analysis and performance analysis.

MOCVD-grown Ga₂O₃ 이종 구조의 열전도도 계측

김태연,김지현,이종구,김형윤,박지현,전대우,조정완,Hoe Woong Kim,Seung Hyun Cho,Yoon Young Kim 대한기계학회 2024 대한기계학회 춘추학술대회 Vol.2024 No.4

Silybin Synergizes with Wnt3a in Activation of the Wnt/${\beta}$-catenin Signaling Pathway through Stabilization of Intracellular ${\beta}$-Catenin Protein

김태연,오상택,Kim, Tae-Yeoun,Oh, Sang-Taek The Korean Society for Microbiology and Biotechnol 2012 한국미생물·생명공학회지 Vol.40 No.1

Wnt/${\beta}$-catenin 신호전달체계는 세포의 분화와 증식, 기관의 발생과 조절을 담당하는 중요한 세포내 신호전달체계이다. 발생과정에서 Wnt/${\beta}$-catenin 신호전달체계의 작용이 지방세포로의 분화를 억제하고 조골세포와 신경세포로의 분화는 촉진한다는 많은 연구들이 보고되어 있으며, 현재 Wnt/${\beta}$-catenin 신호전달체계의 조절을 통한 여러 질병의 치료와 예방에 대한 관심이 대두되고 있다. 본 연구에서는 세포를 기반으로 한 초고속 저분자 스크리닝 시스템을 이용하여 Wnt의 상승제인 silybin을 발굴하였다. silybin은 Wnt가 존재 않을 경우에는 ${\beta}$-catenin 단백질의 수준에 영향을 미치지 않지만 Wnt가 존재할 경우, mRNA 발현양의 변화 없이 세포질내의 ${\beta}$-catenin 단백질의 수준을 증가시킨다. 또한 silybin에 의해 증가된 ${\beta}$-catenin으로 인해 지방세포분화에 중요한 전사인자라고 알려진 PPAR-${\gamma}$와 C/EBP-${\alpha}$의 발현을 억제한다. 따라서 이 연구에서는 silybin이 세포질내 ${\beta}$-catenin 단백질의 수준을 증가시킴으로써 Wnt/${\beta}$-catenin 신호전달체계를 활성한다는 사실을 제시하였다. The Wnt/${\beta}$-catenin signaling pathway regulates diverse developmental processes and adult tissue homeostasis. Inappropriate regulation of this pathway has been associated with human diseases, such as cancers, osteoporosis, and Alzheimer's disease. Using a cell-based chemical screening with natural compounds, we discovered silybin, a plant flavonoid isolated from the Silybum marianum, which activated the Wnt/${\beta}$-catenin signaling pathway in a synergy with Wnt3a-conditioned medium (Wnt3a-CM). In the presence of Wnt3a-CM, silybin up-regulated ${\beta}$-catenin response transcription (CRT) in HEK293-FL reporter cells and 3T3-L1 preadipocytes through stabilization of intracellular ${\beta}$-catenin protein. Silybin and Wnt3a-CM synergistically reduced expression of important adipocyte marker genes including peroxisome-proliferator-activated $receptor{\gamma}$ ($PPAR{\gamma}$) and CAATT enhancer-binding protein ${\alpha}$ (C/$EBP{\alpha}$) in 3T3-L1 preadipocytes, accompanied by the activation of Wnt/${\beta}$-catenin signaling pathway. Taken together, our findings indicate that silybin is a small-molecule synergist of the Wnt/${\beta}$-catenin signaling pathway and can be used as a controllable reagent for investigating biological processes that involve the Wnt/${\beta}$-catenin signaling pathway.

위임과 보안 성질을 통한 OSI망과 TCP/IP 인터네트의 통합관리

김태연,서재현,노봉남,Kim, Tae-Yeon,Seo, Jae-Hyeon,No, Bong-Nam 한국정보처리학회 1995 정보처리논문지 Vol.2 No.6

To integrate both the OSI network and the TCP/IP internet, the application gateway that have the powerful and flexible paradigms has been used, but due to the micro-managements of the gateway produce the high costs and the long delay of communication in the case of emergency. The mechanism that maps the access control policies between two domains using the different security policies is needed. These problems are caused by integrating both domains with the different standards. In this paper, the application gateway that delegating to an agent the powerful and flexible services of the CMIP as well as the management functions were proposed. A proposed algorithm that delegates he management script to an gateway safely by capitalizing on the Diffie-Hellman's distribution method, and presents the security mechanism mediating the security policies for guaranteeing the secure communication between two domains using the different security policies. OSI 망과 TCP/OP 인터네트를 통합 관리하기 위해서 강력하고 융통성이 있는 패러 다임인 응용 게이트웨어가 사용되고 있지만 게이트웨어의 미시 관리 (micro management) 로 응급 상황에서 통신 지연과 시용이 증가하여 성능이 저하된다. 또한 서로 다른 방안 정책을 사용하는두 영역간에 접근 제어 정책을 사상하는 메카니즘이 필요하다. 이러한 문제는 서로 다른 표준으로 구성된 두 영역을 통합하는 데서 야기된다. 본 논문에서는 CMIP의 강력하고 융통성이 있는 서비스뿐만 아니라 관리 기능을 위임할 수 있는 응용 게이트웨어를 설계하였다. Diffie-Hellman의 키 분배 방식을 기반으로 하여 관리 서비스와 기능을 안전하게 전달하는 알고리즘을 정의하고 서로 다른 보안 정책을 사용하는 두 영역간에 안전한 통신이 보장될 수 있도록 보안 정책을 조정하는 메카니즘을 제시하였다.

한국개화기의 외인관(2)

김태연,Kim, Tae-Yeon 대한건축사협회 1989 建築士 Vol.1989 No.6

Surgical Strategy for Primary Colorectal Carcinoma and Synchronous Pulmonary Metastasis Resection

김태연,조종호,최용수,김홍관,Jhingook Kim,심영목 대한심장혈관흉부외과학회 2022 Journal of Chest Surgery (J Chest Surg) Vol.55 No.1

Background: The surgical strategy for single-stage resection of primary colorectal cancer (CRC) and synchronous pulmonary metastases remains a matter of debate. Methods: Perioperative data of patients who underwent single-stage resection of pri- mary CRC and synchronous pulmonary metastases were compared to those of patients who underwent 2-stage resections. The demographic data, number of metastases, type of pulmonary and colorectal resections, operation time, blood loss, postoperative com- plications, morbidities, mortality, medical costs, and length of hospital stay were analyzed. Results: Twenty-two patients underwent single-stage resection of primary CRC and pul- monary metastases, while 27 patients underwent 2-stage resection. Tumor size and the number of pulmonary metastases were not significantly different between the 2 groups. The extent of pulmonary metastasectomy and abdominal procedures were similar in both groups, as was the thoracic surgical approach (video-assisted thoracic surgery vs. thoracotomy). However, open laparotomy was performed more frequently in the 2-stage group than in the single-stage group (p=0.045), which also had a longer total anesthetic time (p=0.013). The operation time, medical costs, estimated blood loss, complication rates, and severity were similar in both groups, but the length of hospital stay was shorter in the sin- gle-stage group (p<0.001). Conclusion: Single-stage colorectal and pulmonary resection shortened the overall hos- pital stay, with no significant changes in operation time, medical costs, hospital mortality, and morbidity. Therefore, single-stage resection could be a good surgical strategy in se- lected patients.

자외선으로 유도된 피부손상에 대한 한의학계의 연구동향

김태연,성현경,Kim, Taeyeon,Sung, Hyunkyung 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.2

Objective : In order to establish the scientific research methods to prove the effects of korean traditional medicine about ultraviolet induced skin damage, we investigated the research on ultraviolet induced skin damage in the korean traditional medicine field. Method : We searched the papers about ultraviolet induced skin damage published in the journals of korean traditional medicine. The searching end date was on June 29, 2015. Results : Thirty papers about ultraviolet induced skin damage were found. Twenty nine papers were experimental research, and one paper was clinical research. Sixty-three percent of papers were written the years after 2011. Fifty-seven percent of papers were published in the korean journal of oriental physiology & pathology and the journal of korean oriental medical ophthalmology & otolaryngology & dermatology. Main outcome measures of experimental research were anti-wrinkle effects, anti-oxidant capacity, anti-apoptosis effects, whitening effects and anti-inflammatory effects. Conclusion : We need more systematic research in order to prove the effects of korean traditional medicine, and use extensively.

한방병원에 입원한 두위 현훈 환자의 임상 분석

김태연,김기태,고흥,Kim, Tae-Yeon,Kim, Gi-Tae,Go, Heung 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.3

Background : Vertigo is a very common complaint in clinical practice. The number of patients who complain of vertigo has been increasing due to rapid growth of the elderly population. This study was designed to review the clinical features and success of oriental medical treatment of positional vertigo. Methods : This observation was made on 70 subjects diagnosed with positional vertigo. They were hospitalized in the Semyung University Oriental Medicine Hospital. Results : The results were as follows 1. Female patients (82.9%) were more than male patients. The most common age group was 8th decade and the patients rapidly increased after the 5th decade of age. 2. The most common past history of positional vertigo was hypertension, the second was cerebral infarction, and the third was hyperlipidemia. 3. In the oriental medicine diagnosis, phlegm-dampness syndrome (痰濕交阻 眩暈) was the most common disease (92.9%), and in western medicine, BPPV was the most (82.9%). 4. In herbal medication, Banhabaekchulchunma-tang gami (45.7%) was the most commonly used, the second being Taeksa-tang (30%). 5. The vertigo score of 94.3% patients improved and none got worse. 6. In general characteristics, men over 64 years improved best. Past history had no effect on the improvement of vertigo. 7. The sooner patients visited hospital after onset, the shorter hospitalization time was. Conclusions : Vertigo attacks patients well in advanced age, with various causative diseases. Oriental medical treatments have considerable effects on positional vertigo, especially treated with Banhabaekchulchunma-tang gami and Taeksa-tang.