인태아 상경신경절 발육에 관한 전자현미경적 연구

김대영,김백윤,윤재룡,Kim, Dae-Young,Kim, Baik-Yoon,Yoon, Jae-Rhyong 한국현미경학회 1998 Applied microscopy Vol.28 No.2

The development of the superior cervical ganglion was studied by electron microscopic method in human fetuses ranging from 40 mm to 260 mm of crown-rump length (10 to 30 weeks of gestational age). At 40 mm fetus, the superior cervical ganglion was composed of clusters of undifferentiated cell, primitive neuroblast, primitive supporting cell, and unmyelinated fibers. At 70mm fetus, the neuroblasts and their processes were ensheated by the bodies or processes of satellite cells. The cytoplasm of the neuroblast contained rough endoplasmic reticulum, mitochondria, Golgi complex, Nissl bodies and dense-cored vesicles. As the neuroblasts grew and differentiated dense-cored vesicles moved away from perikaryal cytoplasm into developing processes. Synaptic contacts between the cholinergic axon and dendrites of postganglionic neuron and a few axosomatic synapses were first observed at 70 mm fetus. At 90 mm fetus the superior cervical ganglion consisted of neuroblasts, satellite cells, granule-containing cells, and unmyelinated nerve fibers. The ganglion cells increased somewhat in numbers and size by 150 mm fetus. Further differentiation resulted in the formation of young ganglion cells, whose cytoplasm was densely filled with cell organelles. During next prenatal stage up to 260 mm fetus, the cytoplasm of the ganglion cells contained except for large pigment granules, all intracytoplasmic structures which were also found in mature superior cervical ganglion. A great number of synaptic contact zones between the cholinergic preganglionic axon and the dendrites of the postganglionic neuron were observed and a few axosomatic synapses were also observed. Two morphological types of the granule-containing cells in the superior cervical ganglion were first identified at 90 mm fetus. Type I granule-containing cell occurred in solitary, whereas type II tended to appeared in clusters near the blood capillaries. Synaptic contacts were first found on the solitary granule-containing cell at 150 mm fetus. Synaptic contacts between the soma of type I granule-containing cells and preganglionic axon termials were observed. In addition, synaptic junctions between the processes of the granule- containing cells and dendrites of postganglionic neuron were also observed from 150 mm fetus onward. In conclusion, superior cervical ganglion cells and granule-containing cells arise from a common undifferentiated cell precursor of neural crest . The granule-containg cells exhibit a local modulatory feedback system in the superior cervical ganglion and nay serve as interneurons between the preganglionic and postganglionic cells.

비부식성 플럭스를 이용한 알루미늄 브레이징용 필러 소재의 저온 성형용 금속 복합 분말 개발

김대영,장하늘,윤대호,신윤호,김성호,최현주,Kim, Dae-Young,Jang, Ha-Neul,Yoon, Dae-Ho,Shin, Yun-Ho,Kim, Seong-Ho,Choi, Hyun-Joo 한국분말재료학회 (*구 분말야금학회) 2019 한국분말재료학회지 (KPMI) Vol.26 No.1

In aluminum brazing processes, corrosive flux, which is used in preventing oxidation, is currently raising environmental concerns because it generates many pollutants such as dioxin. The brazing process involving non-corrosive flux is known to encounter difficulties because the melting temperature of the flux is similar to that of the base material. In this study, a new brazing filler material is developed based on aluminum and non-corrosive flux composite powder. To minimize the interference of consolidation aluminum alloy powder by the flux, the flux is intentionally embedded in the aluminum alloy powder using a mechanical milling process. This study demonstrates that the morphology of the composite powder can be varied according to the mixing process, and this significantly affects the relative density and mechanical properties of the final filler samples.

골수섬유증과 관련된 양측 수부의 괴저성 농피증

김대영,원영호,김성진,이승철,전인기 ( Dae Young Kim,Young Ho Won,Seong Jin Kim,Seung Chul Lee,Inn Ki Chun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

Pyoderma gangrenosum is a rare neutrophilic dermatosis manifesting as painful pustules or bullae, which rapidly become necrotic to produce an ulceration. It is often associated with systemic disease, such as inflammatory bowel disease, rheumatoid arthritis, leukemia, but myelofibrosis is reported rarely for its underlying disease. The most common location is the lower extremities, and the pyoderma gangrenosum also occur infrequently on the hand and face. As in our case, bilateral involvement of the hands are rarely reported. We present a case of pyoderma gangrenosum that had developed on both hands in a 66 year old man who had macrocytic,anemia. A bone marrow biopsy revealed proliferation of fibroblasts and a dense reticulin network consistent with myelofibrosis, the association of which is very rare world wide. (Kor J Dermatol 1997;35(4): 809-813)

바람과 대공간 구조물

김대영,김지영,김상대,Kim, Dae-Young,Kim, Ji-Young,Kim, Sang-Dae 한국공간구조학회 2005 한국공간구조학회지 Vol.5 No.1

HD-270 MLC의 소개 및 유용성평가

김대영,김원택,이화중,이강혁,Kim Dae Young,Kim Won Taek,Lee Hwa Jung,Lee Kang Hyeok 대한방사선치료학회 2003 大韓放射線治療技術學會誌 Vol.15 No.1

I. 목적 MLC의 단점인 조사영역경계의 요동현상이나, 반음영의 크기를 감소시킬 수 있는 HD270 MLC에 관한 소개와 유용성에 대해 평가하였다. II 대상 및 방법 HD-270 MLC는 PRIMUS(Siemens)의 치료테이블(ZXT) 과 다엽콜리메이터(3D MLC)를 leafs면에 수직방향으로 이동시킴으로써 유효반음영과 조사영역 경계의 요동을 감소시킨다. HD-270 MLC의 효율성과 적당한 resolution을 결정하기 위해 field edge angle(Y축과 이루는 각)이 0도에서 75도까지 15도의 간격으로 된 다각형의 field를 만들고 resolution은 5mm, 3mm, 2mm로 각각의 HD-270 group을 만들어 Siemens사 선형가속기(PRIMUS)의 6MV 광자선을 사용하여 solid phantom에서 SAD 100cm, depth 1.5cm으로 X-Omat film(Kodak)에 60MU로 조사하였다. 조사된 film은 Lumiscan75(LUMISYS)로 스캔해서 RIT113(Radiological Imaging Technology Inc. USA)으로 분석하여 유효반음영과 조사영역 경계의 요동의 변화를 측정하였다. 그리고 치료테이블 움직임의 정확성을 테스트하기 위해 테이블 위에 50Kg의 인체모형팬텀을 놓고 0.001inch의 정밀도를 가진 dial gauge로 가로, 세로, 수직의 세 직각방향으로 ${\pm}5mm,\;{\pm}4mm,\;{\pm}3mm,\;{\pm}2mm$단계별로 측정하였다 III. 결과 Resolution과 field edge angle이 증가할수록 유효반음영과 조사영역 경계의 요동현상은 증가하였다. 그리고 지멘스 ZXT 치료테이블움직임의 오차범위는 ${\pm}1mm$ 이내로 양호하였다. IV. 결론 최근 많이 사용되어지고 있는 다엽콜리메이터의 문제점들을 보완 할 수 있는 HD-270 MLC를 사용함으로써 MLC의 임상적용범위를 보다 넓힐 수 있을 것이다. I. Purpose The multileaf collimator(MLC) has many advantages, but use of the MLC increased effective penumbra and isodose undulation in dose distribution compared with that of an alloy block. In this work, we introduced the HD-270 MLC, which can improve the above disadvantages of MLC, and reported its feasibility study. II. Method and Materials The HD-270 MLC is a technique which combines the use of the existing Siemens multileaf collimator(3D MLC) with patient translation perpendicular to the leaf plane. The technique produces a smoothed isodose distribution with the reduced isodose undulation and effective penumbra. To assess the efficacy of the HD-270 technique and determine the appropriate resolution, a polygonal shaped MLC field was made to produce field edge angles from 0 degree to 75 degree with a step of 15 degree. Each HD-270 group was generated according to the allowed resolution, i. e., 5, 3, and 2mm. The experiment was carried out on Primus, a Siemens linear accelerator configured with HD-270 MLC. The total 60 MU of 6 MV photon beam was delivered to X-Omat film(Kodak, USA) at a SAD of 100 cm and 1.5 cm depth in solid water phantom. Exposed films were scanned by Lumiscan75(LUMISYS) and analyzed using RIT113 software(Radiological Imaging Technology Inc., USA). To test the mechanical accuracy of table movement, the transverse, longitudinal, and vertical positions were controlled by a consol with ${\pm}5\;mm,\;{\pm}4\;mm,\;{\pm}3\;mm,\;and\;{\pm}2\;mm$ steps, and then measured using a dial gauge with an accuracy of 0.001 inch. During the experiments, the table loaded with about 50Kg human phantom to simulate the real treatment situation. III. Results The effective penumbra and isodose undulation became larger with increase the resolution and field edge angle. The accuracy of the table movement on each direction is good within the ${\pm}1\;mm$. IV. Conclusion Clinical use of the MLC can be increased by using of the HD-270 MLC which complements to the disadvantages of the MLC.

LCC Analysis to Determine an Appropriate Apartment Rent Rate for HVAC System Renovation Projects

김대영,임형철,Kim, Dae Young,Lim, Hyoung-Chul Korea Society of Industrial Information Systems 2015 한국산업정보학회논문지 Vol.20 No.5

Residential building owners are turning toward renovating their existing buildings to improve old and inefficient HVAC systems. Due to the renovation, much of the added costs will inevitably be passed on to tenants by increasing rent rates. This increment often increases the vacancy rate in the buildings. To balance the interests of both owners and tenants, this paper suggested a method to determine an appropriate rental rate increment for the HVAC system renovation. A case study on residential buildings was conducted to determine a balanced point where the rental rate increment that offsets the amount tenants are willing to pay for the renovation. To calculate all costs incurred by the renovation, life-cycle cost analysis was carried out. Therefore, this paper ultimately provides a threshold value of rental rate increment such that building owners can make a reasonable decision on the HVAC system renovation.

방추세포성 횡문근육종으로 진단된 성대 내 섬유성 종물 1예

김대영,황준하,박인서,임재열,Kim, Dae Young,Hwang, Jun-Ha,Park, In Suh,Lim, Jae-Yol 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Rhabdomyosarcoma is an uncommon type of soft tissue malignant neoplasm characterized by undifferentiated mesodermal tissue. Sarcomas account for approximately 1% of all laryngeal neoplasm and rhabdomyosarcomas are the rarest sarcoma found in the larynx. When the sarcoma involves the larynx, radical surgery such as laryngectomy has been considered. With recent advances of combined therapy, however, it can be treated by conservative surgeries followed by postoperative radiotherapy and/or pulse chemotherapy. With reviews of literature, we report a 47-year-old patient complaining of husky voice and throat discomfort who was finally diagnosed as rhabdomyosarcoma of the vocal fold and successfully treated by laser cordectomy followed by adjuvant chemoradiotherapy.

TBM 디스크 커터의 수명 예측 방법 개발

김대영,에브라힘,정재훈,이재원,지성현,Kim, Dae-Young,Farrokh, Ebrahim,Jung, Jae-Hoon,Lee, Jae-Won,Jee, Sung-Hyun 한국터널지하공간학회 2017 한국터널지하공간학회논문집 Vol.19 No.3

암반용 TBM 공사에서 디스크 커터의 마모도 예측은 설계 및 시공 단계에서 정확한 공사비와 공사기간을 추정하는데 중요한 요소이다. 디스크 커터 마모도 예측에 널리 사용되고 있는 방법으로는 CSM 모델, 노르웨이 NTNU 모델, Gehring 모델이 있으며, 이들 모델은 각각 세르샤 시험, NTNU 시험 결과로부터 도출된 디스크 커터의 마모지수와 수명 지수를 활용하고 있다. 세르샤 시험은 금속 핀을 이용하여 일방향으로 마모를 발생 시키기 때문에 광물 입자크기나 암석의 이방성에 따라 결과의 편차가 큰 것으로 조사되었다(SINTEF, 2013). 한편, NTNU 시험의 경우에 시료 성형을 위한 사전 작업이 필요하기 때문에 수행 완료까지 2~3일의 기간이 소요된다. 본 연구에서는 금속 디스크의 회전과 이와 직교되는 방향으로 이동하면서 양방향 마모를 발생시켜 마모시험 결과의 편차를 줄이고, NTNU 시험 대비 별도의 시료성형이 필요 없어 소요 시간을 1~2시간으로 단축할 수 있는 새로운 디스크 커터 마모도 예측시험과 이를 이용한 마모지수를 제안하였다. 제안된 마모 지수는 동일 암석을 이용한 세르샤 시험과 NTNU 시험결과와 비교하여 높은 상관관계를 갖는 것으로 나타났다. 또한 국내 외 TBM 현장의 암석 시편을 이용하여 시험결과와 현장의 실제 디스크 커터 마모량을 비교 검증하였으며, 95%의 높은 결정계수를 확인하였다. NAT 시험은 신속하게 시험 수행이 가능하고, 시험 결과로부터 제안된 마모지수가 높은 신뢰수준을 보이는 것으로 판단되어 향후 활용도가 높을 것으로 기대한다. Wear prediction of TBM disc cutters is a very important issue for hard rock TBMs as number of cutter head intervention. In this regard, some model such as NTNU, Gehring model, CSM models have been used to predict disc cutter wear and intervention interval. There are some deficiencies in these models. This paper developed a new test method for wear prediction for TBM disc cutter and proposed a new abrasion index. In this regard, different abrasivity indices along with their testing methods are explained. A comparative study is performed to develop the predictability of different cutter life evaluation methods and index. The evaluation of the new methods proposed in this paper shows a very good agreement with the actual cutter life and intervention interval length. The proposed tester and index can be easily used to predict the intervention interval length and cutter wear evaluation in both planning and construction stages of a TBM tunneling project.

Synthesis and Antimicrobial Activity of 7-(1,3-Dihydropyrrolo[3,4-b]pyridin-2-yl)quinolone-3-carboxylic Acid

김대영,정인창,이재욱,윤길중,Kim, Dae Young,Jung, In Chang,Lee, Jae Wook,Yoon, Geal Jung Korean Chemical Society 1998 대한화학회지 Vol.42 No.1

Mo(100) 표면에 $TiO_2$초박막의 성장과 특성

김대영,Kim, Dae Young 대한화학회 1997 대한화학회지 Vol.41 No.5

Ultra-thin $TiO_2$ films are grown on the Mo(100) surface using evaporated Ti metal under ambient $O_2$ pressure. The thickness of the $TiO_2$ film is controlled by the dosing rate of Ti metal over Mo(100) which is determined from the Auger signal changes with dosing time. 30 ML, 5 ML, and 1.6 ML thick films are prepared and used to determine the growth mechanism, the chemical composition, and the surface structure of the films. The growth mechanism of the $TiO_2$ film on Mo(100) is observed to follow the layer-by-layer growth mechanism. The chemical composition of the film is found to be that of bulk $TiO_2$. The surface plane of the film is (001), which facets irreversibly at 1200 K. The LEED pattern obtained from the film can be explained with the faceted surface with {011} planes reconstructed to $(2\sqrt2{\times}\sqrt2)R45^{\circ}$ with respect to the $TiO_2$ (001) surface. The film is somewhat thermally unstable when annealed to 1300 K. The film sputtered with $Ar^+$ ion is also studied by XPS. 초고진공조에서 산소 분압, $1{\times}10^{-6}$ Torr, 하에서 Ti 금속을 Mo(100)에 증발시킴으로써 $TiO_2$ 초박막을 성장시켰다. Ti 금속을 Mo(100) 표면에 증착시킨 시간에 따른 오재(Auger) 봉우리의 크기 변화율을 조사함으로써 Ti 금속의 증발 속도를 알아내고, 그것을 이용하여 $TiO_2$ 박막 성장시 박막의 두께를 조절하였다. 30 ML, 5 ML, 1.6 ML 두께의 $TiO_2$ 박막을 만들어 박막의 성장메카니즘, 박막의 화학적 조성, 박막의 표면 구조를 연구하였다. 박막의 성장 메커니즘은 층별 성장에 가까운 성장 방식인 것으로 설명할 수 있다. 박막의 화학적 조성은 본체 $TiO_2$ 와 동일하였다. 박막의 표면은 (001) 평면이며, 고온 1200 K에서 비가역적으로 부면화(faceging)한다. 박막으로부터 관찰된 저에너지 전자회절 무늬는 $TiO_2$ (001) 표면이 {011} 평면을 가진 부면을 형성하고 각 부면이 다시 $TiO_2$ (001) 평면에 대하여 $(2\sqrt2{\times}\sqrt2)R45^{\circ}$로 재건축한다는 것으로 설명될 수 있다. 박막은 1300 K의 고온에서 얼마간 열적 불안정성을 보인다. $Ar^+$ 이온으로 스퍼터링한 $TiO_2$ 박막에 대하여 XPS를 이용하여 역시 알아보았다.