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몇 가지 전이금속, Ni(II), Cu(II) 및 Zn(II) 3,6-bis(2'-pyridyl)pyridazine 착 화합물들의 세포 독성효과
권병목,이정옥,최상운,성낙도,Kwon, Byung-Mok,Lee, Chong-Ock,Choi, Sang-Un,Sung, Nack-Do 한국응용생명화학회 2006 Applied Biological Chemistry (Appl Biol Chem) Vol.49 No.1
6종의 인체 암(폐암, 피부암, 결장암, 자궁암, 선암 및 뇌암)과 그의 17가지 세포주들에 대한 리간드 화합물 3,6-bis(2'-pyridyl)pyridazine(1) 과 3,6-bi s(6'-methyl-2'-pyridyl)pyridazine(2) 그리고 그들의 전이금속(Ni(II), Cu(II) 및 Zn(II)) 착 화합물들 $(3{\sim}6)$ 세포독성을 각각 측정하였다. 그 결과, 특히 Cu(II) 착 화합물, bis-[3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-$k^2N^2,N^3$]chlorocopper(II)perchlorate (4)는 뇌암(SNB-19)과 결장암(SW-62) 세포주에 대하여 제1세대 항암제인 Cis-platin보다 높은 세포독성을 나타내었다. A series of cytotoxic activities $(ED_{50})$ in vitro against six human cancers (lung cancer, uterine cancer, skin cancer, brain cancer, colon cancer and adenocarcinoma) and their seventeen cell lines of 3,6-bis(2'-pyridyl)pyridazine, 1, 3,6-bis-(6'-methyl-2'-pyridyl)pyridazine, 2 and their transition metal, Ni(II), Cu(II) and Zn(II) complexes, $3{\sim}6$ were measured. Particularly, the results revealed that the cytotoxic activities against the brain cancer cell line (SNB-19) and the colon cancer cell line (SW62) of bis- [3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-$k^2N^2,N^3$]chlorocopper(II)perchlorate, 4 were shown to be higher than that of the first generation anticancer agent, Cis-platin.
그늘쑥(Artemisia sylvatica Max.)으로부터 분리된 FPTase 저해활성 물질들의 구조적인 특성과 biogenic pathway의 배향성
권병목,성낙도,Kwon, Byung-Mok,Sung, Nack-Do 한국응용생명화학회 2002 한국농화학회지 Vol.45 No.4
Characteristic stereostructures of farnesyl protein transferase (FPTase) inhibition materials isolated from Artemisia sylvatica and regioselectivity of biogenic Diels-Alder reactions between dehydromatricarin molecules A and B were examined quantitatively. Results revealed that the major reaction of frontier molecular orbital (FMO) interaction proceeds through charge-control reaction between LUMO of A16, dienophile and HOMO of B1, diene, and the isolated 8-acetylarteminolide and artanomaloide were minor products. FPTase inhibition activity and hydrophobicity of 8-acetylarteminolide were $pI_{50}=3.75$ and logP=2.62, respectively. FPTase inhibition activity of 8-acetylarteminolide was higher than those of artanomaloide and dehydromatricarin. 그늘쑥(Artemisia sylvatica Max.)으로부터 분리된 sesquiterpene lactone계 화합물들의 구조적인 특성과 FPTase 저해활성을 나타내는 dehydromatricarin A, B 분자들 사이 biogenic Diels-Alder 반응의 경계분자 궤도함수 (FMO)상호작용에 대한 배향성을 검토하였다. 그 결과, 주 생성물이 얻어지는 반응은 B1(diene)의 HOMO와 A16(dienophile)의 LUMO간 hard-hard한 charge-control 반응이었다. 그리고 AO계수 분극간의 상호작용에 따른 배향성은 분리된 8-acetylarteminolide와 artanomaloide들이 모두 biogenic Diels-Alder 반응의 부 생성물들임을 시사하였다. 또한, 8-acetyl-arteminolide의 FPTase 저해활성($pI_{50}=3.75$ 및 logP=2.62)은 큰 반면에 artanomaloide 및 dehydromatricarin은 작았다.
그늘쑥(Artemisia sylvatica Max.)으로부터 분리된 FPTase 저해활성 물질들의 구조적인 특성과 biogenic pathway의 배향성
성낙도 ( Nack Do Sung ),권병목 ( Byung Mok Kwon ) 한국응용생명화학회 2002 Applied Biological Chemistry (Appl Biol Chem) Vol.45 No.4
Characteristic stereostructures of famesyl protein transferase(FPTase) inhibition matcrials isolated from Artemisia sylvatica and regioselectivity of biogenic Diels-Alder reactions between dehydromatricarin molecules A and B were examined quantitatively. Results revealed that the major reaction of frontief molecular orbital(FMO) interaction proceeds through charge-control reaction between LUMO of A16, dienophile and HOMO of B1, diene, and the isolated 8-acetylarteminolide and artanomaloide were minor products. FPTase inhibition activity and hydrophobicity of 8-acetylarteminolide were pI_50=3.75 and logp=2.62, respectively. FPTase inhibition activity of 8-acetylarteminolide was higher than those of artanomaloide and dehydromatricarin.
홍화 ( Carthamus tinctorius L. ) 로부터 활성물질의 분리
백남인,김융희,안은미,방면호,남지연,권병목 ( Nam In Baek,Yung Hee Kim,Eun Mi Ahn,Myun Ho Bang,Ji Youn Nam,Byung Mok Kwon ) 한국응용생명화학회 1998 Applied Biological Chemistry (Appl Biol Chem) Vol.41 No.2
The MeOH extracts obtained from the flower petals of Carthamus tinctorius were solvent-fractionated with EtOAc, n-BuOH, and H₂O, successively. From the n-BuOH exact 2 flavonoid compounds were isolated through the repeated silica gel column chromatographies. From not only the results of physico-chemical data including HMBC but also the adaptation of acid hydrolysis, the chemical structures of the compounds were determined as 3-Ο-[β-D-glucopyranosyl (1→2) β-D-glucopyranosyl] kaempferol and 3-Ο-[α-L-rhamnopyranosyl (1→6) β-D-glucopyranosyl] kaempferol. The compounds exhibited IC_(50) values in Grab2-Shc activity to be 43 and 47 ㎍/㎖, respectively.
식용 식물자원으로부터 활성물질의 탐색-V. -상추(Lactuca sativa L.)의 ACAT 억제 Diterpenoid, Phytol-
장태오,방면호,송명종,홍윤희,김지영,정대균,배동근,권병목,김영국,이현선,김인호,백남인,Jang, Tae-O,Bang, Myun-Ho,Song, Myoung-Chong,Hong, Yoon-Hee,Kim, Ji-Young,Chung, Dae-Kyun,Pai, Tong-Kun,Kwon, Byung-Mok,Kim, Young-Kuk,Lee, Hyun-Sun,Kim 한국응용생명화학회 2003 한국농화학회지 Vol.46 No.1
인공핵산 분해효소로서 몇 가지 유기금속 화합물들의 생물활성
성낙도(Nack-Do Sung),김대황(Dae-Whang Kim),권병목(Byung-Mok Kwon),김태영(Tae-Young Kim),서일환(Il-Hwan Suh) 한국농약과학회 2000 농약과학회지 Vol.4 No.1
A series of transition metal complexes of 3,6-bis(6'-methyl-2'-pyridyl)pyridazine (L¹) and 3,6-bis(2'-pyridyl)pyridazine (L²) as artificial nuclease, 1~8 were synthesized. After determining of X-ray crystal structure, hydrolysis rate constants of phosphates, as DNA model compound and biological activities were confirmed. L²-Zn(Ⅱ) complex, 8 was shown the best hydrolysis rate constant. The L²-Ni(Ⅱ) complex, 5 and L²-Co(Ⅱ) complex, 6 showed the highest herbicidal activity against scr (Scriptus Juncoids) with excellent tolerance to rice, ORY (Oryzae sativa L.). And the L¹-Co(Ⅱ) complex, 2, L¹-Zn(Ⅱ) complex, 4 and ligand (L¹ & L²) displayed above 90% fungicidal activity against MAG (Magnaporthe grisea).
몇 가지 전이금속, Ni(II) 및 Zn(II) 3,6-bis(2'-pyridyl)pyridazine 착 화합물들의 세포 독성효과
권병목,이정옥,최상운,성낙도 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
A series of cytotoxic activities (ED_(50)) in vitro against six human cancers (lung cancer, uterine cancer, skin cancer, brain cancer, colon cancer and adenocarcinoma) and their seventeen cell lines of 3,6-bis(2'-pyridyl)pyridazine, 1, 3,6-bis-(6'-methyl-2'-pyridyl)pyridazine, 2 and their transition metal, Ni(II), Cu(II) and Zn(II) complexes, 3~6 were measured. Particularly, the results revealed that the cytotoxic activities against the brain cancer cell line (SNB-19) and the colon cancer cell line (SW62) of bis-[3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-k^(2)N^(2),N^(3)]chlorocopper(II)perchlorate, 4 were shown to be higher than that of the first generation anticancer agent, Cis-platin. 6종의 인체 암(폐암, 피부암, 결장암, 자궁암, 선암 및 뇌암)과 그의 17가지 세포주들에 대한 리간드 화합물 3,6-bis(2'pyridyl)pyridazine(1)과 3,6-bis(6'-methyl-2'-pyridyl)pyridazine(2) 그리고 그들의 전이금속(Ni(II), Cu(II) 및 Zn(II)) 착 화합물들 (3~6)의 세포독성을 각각 측정하였다. 그 결과, 특히 Cu(II) 착화합물, bis-[3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-k^(2)N^(2),N^(3)]chlorocopper(II)perchlorate (4)는 뇌암(SNB-19)과 결장암(SW-62) 세포주에 대하여 제1세대 항암제인 Cis-platin보다 높은 세포독성을 나타내었다.
자생 식물로부터 Cyclin - dependent Kinase 4/Cyclin D1 저해물질의 탐색
안병태,유시용,김미란,하지홍,성낙도,권병목,정하원 한국농화학회 2000 Applied Biological Chemistry (Appl Biol Chem) Vol.43 No.3
To search CDK4/Cyclin D1 enzyme inhibition materials, methanol extracts of native eighty seven plant species in thirty seven families were screened in vitro for their inhibiting activities against CDK4/Cyclin D1 enzyme which are control to the normal cell division cycle in human body. Extracts of Paeonia suffruticosa, Saurus chinensis, Sanguisorba officinalis and Celastrus orbiculatus among them significantly inhibited above fifty percent (in 5 ㎍/㎖) against CDK4/ Cyclin D1 enzyme. Especially, the extracts of P. suffruticosaa and S. officinalis showed moderately strong inhibition. Also, cryptotanshinone was identified as active compound from a extracts of Salvia mitiorrhiza by spectroscopic analyses including 2D NMR experiments.