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광합성 세균 P-99 가 분비하는 항생물질의 구조 및 항암역가에 관한 연구
하지홍,오일웅 경북대학교 유전공학연구소 1992 遺傳工學硏究所報 Vol.7 No.1
The unidentified antibiotic P-99, produced by purple nonsulfur photosynthetic bacteria was selected by antimicrobial activity and reemergency. The compound was isolated from culture broth by solvent extraction followed by silica gel column chromatography. The compound was partially characterized and shown to be chiefly biologically active against gram-positive bacteria and melanoma cell line of SK-MEL-2.
하지홍,이성은,탁연빈,김종봉 한국축산학회 1998 한국축산학회지 Vol.40 No.6
The prototypes of physical characteristics in the breeds of Korean Native dog were reviewed. Sapsaree and Jindo dog were medium sized, but Sapsaree was 5 ㎏ heavier and 6 cm higher than Jindo dog on the average. The dominant coat color of Jindo dog and Chejudo dog was white or yellow, but that of Sapsaree was black or yellow. Sapsaree showed higher degree of variation in the tone of main color than Jindo dog. Most of the medium sized dog breeds in the Far East Asia had erect ears, upward tails and short coat. Jindo dog and Chejudo dog showed those characteristics of them, while Sapsaree had dropped ears and long coat. Appearance frequency of dew claw in Jindo dog and Chejudo dog was different from that in Sapsaree, the former was 4% and the latter was 18.3%. Fluctuations of blood cell number and blood protein contents were reviewed by different conditional variations such as age, sex and coat color in Jindo dog and Sapsaree. Blood types in DEA (dog erythrocyte antigen) system of the dog breeds showed extreme values that were different from the values of the European dogs. Phylogenetic relationships of the Asian dog breeds were compared by using the blood protein polymorphism. Jindo dog, Chejudo dog and Sapsaree showed close relationships among them.
하지홍,김경석,이성은 한국축산학회 1999 한국축산학회지 Vol.41 No.6
To investigate the genetic diversity and structure of Korean native dog populations, blood protein polymorphism, mtDNA sequence variation and microsatellite loci of them were analyzed. Blood protein polymorphism analysis was found to be useful for the understanding of genetic structure of the populations. However, the analysis of mtDNA sequence variation could not be used for the purpose. Microsatellite loci analysis showed the high values of heterozygosity and low values of genetic distances of Korean dog populations which were different from those of the Japanese and European dogs. Heterozygosity and average values of allele number of Jindo-dog, Akita dog and Grey hound were as follows ; 0.7 and 6.11 of Jindo-dog, 0.56 and 3.88 of Akita dog, 0.36 and 3.3 of Grey hound.
하지홍,김경석 한국축산학회 1998 한국축산학회지 Vol.40 No.6
The origin of Korean Native dog was studied by investigating the phylogenic relationships of Asian breed dogs. Polymorphic frequencies of 5 blood proteins of the breed, Hb(haemoglobin), Gmo(ganglioside monoxygenase). Es-2(esterase-2). Poa-2(post- albumin-3) and Ptf(pretransferrin) revealed that Sahalin and Eskimo dogs were the closest relatives to Korean native dogs. Polymorphic microsatellite loci analysis of 11 Asian native dogs also attested the same phylogenetic relationship of blood protein. Korean native dogs. Sapsaree. Jindo dog and Chejudo dog, formed a blood group and showed a close relationship with the Eskimo and Sahalin dogs. It was concluded that Korean native dogs were originated from the dogs of Northern part of Far East Asia from which Eskimo dog and Sahalin dog were also originated in the prehistoric age.
동양견 8품종의 RAPD - Marker 에 의한 유연관계 분석
하지홍,정하원,김경석 한국유전학회 1997 Genes & Genomics Vol.19 No.2
Randomly amplified polymorphic DNA (RAPD) was exploited as a genetic marker to assess the level of genetic variation among Asian 8 dog breeds. To obtain distinct band patterns, we tested 50 RAPD primers in an initial screening with PCR by using dog blood DNA. Of those, 17 primers showed clear polymorphic band patterns among dog breeds that corresponded to products of PCR that ranged in length from 0.3 to 1.5 kb, while the others produced identical band patterns or no band at all. 231 bands of the amplified DNA bands were generated by the 17 primers and 73 (31.6%) of 231 bands showed polymorphism. Dissimilarity coefficients among the 8 Asian dog breeds which were estimated by using the UPGMA method were ranged from 0.072 to 0.236. In the genetic relationships based on UPGMA dendrogram, Asian 8 dog breeds were classified into four groups, A group (Shiba), B group (Pug, Pekingese), C group (Sapsaree, Jin-do dog, Akita Inu and Tosa) and D group (Japanese Chin). According to this study, RAPD seems to be a valuable tool for phylogenic analysis of dog breeds.
미토콘드리아 DNA 의 RFLP 분석에 의한 삽사리 혈연 연구
하지홍,홍성용,이상욱 한국유전학회 1995 Genes & Genomics Vol.17 No.1
Analysis of mtDNA RFLP for the Korean dog breeds, Sapsaree, Jindo dog and Heterogeneous aboriginal dog (HAD) showed 7 different genotype which were made by 5 restriction enzymes. Four of them were found in the Sapsaree population. Three genotypes of Sapsaree were also found in Jindo dog and HAD, and one genotype in the Sapsaree population only. The genotypes of the Korean dog breeds had low nucleotide divergency among them was determined to be 0.176% which showed that all the Korean native dogs had a close maternal relationship. Molecular weight of Sapsaree mtDNA was also determined to be 16kb from the results of restriction map.
DNA Intercalating Agent 인 Ethidium Bromide 의 유전적 영향
하지홍,이세영,백형석,박찬규 한국유전학회 1980 Genes & Genomics Vol.2 No.1
The genetic effects of ethidium bromide on Salmonella typhimurium and Aspergillus nidulans were studied. Ethidium bromide was only weakly mutagenic on Salmonella typhimurium directly but upon the activation by the rat liver microsomal enzymes became highly mutagenic on the frameshift mutant of Salmonella typhimurium. Ethidium bromide was not mutagenic on Aspergillus nidulans directly or with the rat liver microsomal enzymes. However, it induced mitotic recombinations in the fungi in high frequencies.
하지홍,정운복,이상로,탁연빈,김종봉 대구효성가톨릭대학교 자연과학연구소 1991 基礎科學硏究論集 Vol.1991 No.1
The Sapsaree is a nearly extincted Korean native dog whose historic habitat has included much of the Southeastern Korea. The only existing population of Sapsaree consists of 50 dogs living in the small area of Kyung-San Goon in Kyung-Pook Province. Field observations of the population indicated the presence of two distinct morphological phenotypes that are divided into Blue- and Yellow-Sapsaree. A RFLP (Restriction Fragment Length Polymorphism) analysis using pV 47-2 probe and Sapsaree DNA indicated the existence of two distint genetic stocks concordant with the morphological phenotypes.