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원지(遠志)가 뇌혈류 저하에 의한 흰쥐 뇌조직의 산화적 손상과 해마신경세포 자연사에 미치는 영향
구용모 ( Yong-mo Koo ),곽희준 ( Hee-jun Kwak ),권만재 ( Man-jae Kwon ),송민철 ( Mincheol Song ),이지승 ( Ji-seung Lee ),신정원 ( Jung-won Shin ),손낙원 ( Nak-won Sohn ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.1
Objectives : Polygalae Radix (POL) has an ameliorating effect on learning and memory impairment caused by cerebral hypoperfusion. In regard to POL``s action mechanism, this study was carried out to investigate the effects of POL on oxidative damage and neuronal apoptosis induced by cerebral hypoperfusion in rats.Methods : The cerebral hypoperfusion was induced by permanent bilateral common carotid artery occlusion(pBCAO) in Sprague-Dawley rats. POL was administered orally once a day (130 mg/kg of water-extract) for 28days starting at 4 weeks after the pBCAO. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in the brain tissue were measured using ELISA method. Expressions of 4-hydroxynonenal (4HNE) and 8-hydroxy-2``- deoxyguanosine (8-OHdG) were observed using immunohistochemistry. In addition, neuronal apoptosis was evaluated with Cresyl violet staining, TUNEL labeling, and immunohistochemistry against Bax and caspase-3.Results : POL treatment significantly increased SOD activities and significantly reduced MDA levels in the cerebral cortex. The up-regulations of 4HNE and 8-OHdG expression caused by pBCAO in the CA1 of hippocampus were significantly attenuated by POL treatment. POL treatment also restored the reduction of CA1 thickness and CA1 neurons caused by pBCAO and significantly attenuated the apoptotic markers including TUNEL-positive cells, Bax, and caspase-3 expression in the CA1 of hippocampus. Conclusions : The results show that POL attenuated the oxidative damage in brain tissue and neuronal apoptosis in the hippocampus caused by the cerebral hypoperfusion. It suggests that POL can be a beneficial medicinal herb to treat the brain diseases related to cerebral hypoperfusion.
폴리우레탄 발포기 부품 이종재 마찰용접의 품질 평가에 관한 연구
양용모(Yong-Mo Yang) 한국기계가공학회 2012 한국기계가공학회지 Vol.11 No.6
Dissimilar material friction welding such as STD11 and SCM440, we are considering of such things as strength and tenacity of welding interface, which consist of friction welding rotation frequency, friction heating pressure, upset forging-pressure, friction heating time, and upset forging-pressure time. From the study, obtaining the interrelationship between welding condition and quality(toughness, tenacity), we can set the best range of welding condition. while performing acoustic emission examination for the nondestructive evaluation, we can deduce the interrelationship among total acoustic emission counts, friction welding variable, and quality during friction welding, which can solve the manufacturing difficulty and enhance the economic value.