위암과 폐암의 동시성 중복암으로 오인된 폐암의 동시성 단독 위전이

고성애 ( Sung Ae Koh ),이경희 ( Kyung Hee Lee ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.3

Although hematogenous metastasis of cancer to the gastrointestinal track is rare, it sometime has been reported in patients with malignant melanoma and breast cancer. However, it is extremely rare for lung cancer to metastasize to the stomach, not to mention solitary gastric metastasis. Herein, the authors report a case of a 69-year-old man who was initially diagnosed with lung cancer with synchronous primary gastric cancer which proved to be lung cancer with solitary gastric metastasis after the operation. (Korean J Gastroenterol 2014;64:154-157)

박종홍 철학의 형성과정 연구

고성애(Koh, Sung-Ae) 서울대학교 철학사상연구소 2013 철학사상 Vol.48 No.-

박종홍 철학에 대한 기존의 연구에서는 그의 철학사상에만 관심을 가졌지 그러한 철학사상의 형성과정과 배경에 대한 연구는 많지 않다. 본고에서는 박종홍 철학을 본격적으로 검토하기 위한 기초 작업으로서 경성제국대학에 입학하기 전에 형성된 어떤 문제의식이 그를 ‘철학함’으로 이끌어주는지 살펴보고자 하였다. 박종홍이 철학함의 출발점에서 고민하였던 문제는 “우리”와 “민족”이었고 고민을 해결하고자 읽었던 것이 최남선이 간행한 책이었다. 그는 민족의 독립을 위하여 “우리 민족”의 특색을 밝혀보고자 시도하였고 다카야마 쵸규의 저작들을 읽으면서 조선 미술사에 대한 연구를 시작하였다. 하지만 결국 한계를 느끼고 중단되었지만 다시 니시다 기타로의 철학사상을 접하면서 박종홍은 생에 대한 고민과 미적 감정에 대하여 철학적인 고찰을 시도하게 되는데 그 결과 심미적 감정이 우위를 차지해야 된다고 한다. 또한 박종홍은 교직에 종사하면서 과도기의 혼돈을 겪고 있는 현실에 직면하여 전통적인 교육사상 중의 근본정신을 살리고자 고민하면서 퇴계의 경(敬) 사상에 주목하게 되었다. 이는 다카하시 도루의 조선 유학에 대한 연구에서 자극을 받은 지식인들이 점차 학문적인 연구를 진행하였던 당시의 시대적ㆍ학문적 상황과 떨어져서는 논의할 수 없다. Previous research on the philosophy of Park Jong-hong has focused mainly on his thoughts as a whole, omitting the background and formation of his thoughts. ‘Before delving into the full-fledged philosophy of Park, this article examines the problematiks he had in mind before he entered Keijo Imperial University. Two starting points of Park’s philosophy are ‘us’ and ‘people of nation’; in searching for the answers he extensively read the books published by Choi Nam-sun. Park attempted to uncover the unique characteristics of ‘our people’ by reading Takayama Chogyu’s books on the history of Joseon art, with which Park faced limitations. As he turned his attention to the philosophy of Nishida Kitaro, which led him to new philosophical inquiries into life and aesthetic feelings, and eventually to conclude aesthetic feelings must take the pride of place in life. As Park was engaged in teaching, the chaotic reality in the turbulent period made him decide to revive the original spirit of traditional thoughts on education, leading him to Toegye’s philosophy of Gyong (敬, pious attention). It must be taken into account, however, that in Park’s time, elites stimulated Takahashi Toru’s work on Joseon Confucianism, and began serious academic research on national spirits.

혈액종양 ; 국소 연조직 환자의 예후인자 분석

고성애 ( Sung Ae Koh ),이경희 ( Kyung Hee Lee ),김민경 ( Min Kyoung Kim ),현명수 ( Myung Soo Hyun ),신덕섭 ( Duk Seop Shin ),윤상모 ( Sang Mo Yun ),강민규 ( Min Kyu Kang ) 대한내과학회 2011 대한내과학회지 Vol.80 No.4

Background/Aims: We evaluated the independent prognostic factors for overall and disease-free survival in the treatment of soft tissue sarcoma. Methods: Sixty-seven medical records were retrospectively reviewed. All the patients had presented with localized soft tissue sarcoma and had been treated with conservative surgery, followed by additional therapy or surgery. All were treated at the Yeungnam University Hospital between January 2000 and December 2006. Univariate and multivariate analyses were used to evaluate factors affecting overall and disease-free survival. Results: The median age of the study sample was 50 (range, 15~70) years. Twenty patients (30%) had liposarcoma and nine (13%) had leiomyosarcoma. Seventeen patients (25%) had a tumor measuring greater than 10 cm. Nineteen patients (28%) had positive resection margins. The median overall survival was 62.7 months (95% CI: 25.7~99.4) and the median disease-free survival was 36.1 months (95% CI: 17.9~54.2). Factors that significantly affected the median overall survival were a tumor size greater than 10 cm and performance status. Positive resection margins and tumor site were independent prognostic factors associated with disease- free survival. Other factors, such as histopathology, gender, age, and tumor grade, did not have prognostic value. Additionally, the chosen modality of treatment after surgery was not an independent predictor of the median overall or disease-free survival. Conclusions: Tumor size, positive resection margins, tumor site, and performance status were statistically significant independent predictors of poor prognosis. (Korean J Med 2011;80:419-426)

혈액종양 ; 혈액학적인 검사의 이상으로 협진이 의뢰되었던 입원환자의 특징 분석

이하영 ( Ha Young Lee ),고성애 ( Sung Ae Koh ),손세훈 ( Se Hoon Sohn ),김민경 ( Min Kyoung Kim ),이경희 ( Kyung Hee Lee ),현명수 ( Myung Soo Hyun ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5

Background/Aims: Although inpatient hematology consultations have recently increased, the reasons for consultation, as well as the impact of inpatient hematologic consultations, are not clear. Therefore, we assessed patient profiles, the reasons for hematology consultations, and diagnoses at our hospital. Methods: We evaluated 177 consecutive patients with hematology problems seen between March 2004 and February 2005. For each, we assessed the reason for the consultation, patient diagnosis, and outcome. Results: Of 28,854 inpatients in our hospital, 177 (0.6%) required consultations for hematology problems. Of these 177 inpatients, 85 (48%) were male and 92 (52%) were female; their median age was 55 years (range 16-85 years), with the most frequent age group being patients 61-70 years old. Hematology consultations were requested by the neurosurgery (25%), general surgery (11%), internal medicine (10%), neurology (10%), and orthopedics (9%) departments. The most common reasons for consultation were anemia (29%), thrombocytopenia (21%), pancytopenia/bicytopenia (16%), coagulation abnormalities (14%), and thrombocytosis (5%). In one-third of these consultations, the hematologic abnormality was detected after admission and most were resolved successfully. The most common cause of anemia was iron deficiency (43%). Drug-induced thrombocytopenia and pancytopenia were also common (20%), and were thought to be due to anticonvulsants and antibiotics. Bone marrow examination was required in 19 patients (11%). Careful examination detected bleeding of the gastrointestinal tract, or liver or hematologic diseases, such as chronic myeloproliferative disorders, in some of these patients. Conclusions: Although it provides a small cross-sectional survey of the types of patient and problems seen by hematologists during in-patient consultations, this information may help to improve patient care and the quality of hematology consultations. (Korean J Med 76:578-583, 2009)

면역성혈소판감소증을 동반한 사르코이드증

정다은 ( Da Eun Jeong ),김민경 ( Min Kyoung Kim ),고성애 ( Sung Ae Koh ),이경희 ( Kyoung Hee Lee ),최준혁 ( Joon Hyuk Choi ),홍영훈 ( Young Hoon Hong ),조재호 ( Jae Ho Cho ),구은주 ( Eun Ju Goo ),현명수 ( Myung Soo Hyun ) 영남대학교 의과대학 2015 Yeungnam University Journal of Medicine Vol.32 No.1

Sarcoidosis is a systemic disease of unknown cause involving multiple organs and is characterized by noncaseating granuloma. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to the presence of an antibody to the platelet and abnormal platelet production. There is no known pathogenesis that occurs concurrently with ITP and sarcoidosis. However, considering together of 2 known pathogenesis, abnormal immune response triggers either ITP or sarcoidosis. The disease that develops first stimulates secondary disease. After development of secondary disease, they stimulate each other. A few cases of ITP associated with sarcoidosis are well documented in English; however, the disease has rarely been reported in Korea. Here, we report on a case of ITP with sarcoidosis in a 29-year-old man. He suffered from easy bruising. The chest X-ray and the contrast-enhanced computed tomography scan showed bihilar lymphadenopathy and reticulonodular infiltrates. Bone marrow study and fluoroscopy-guided percutaneous needle biopsy were performed and the patient was diagnosed with sarcoidosis and ITP. He was put on 400 mg/kg of intravenous immunoglobulin for 5 days and administered oral steroids and further follow-up will be carried out. He has shown a good response without significant bleeding event. However, administration of more oral steroid and additional follow-up is required than for single disease, whether sarcoidosis or ITP.

심근 및 전신의 연조직을 침범한 Richter 증후군의

구은주 ( Eun Joo Goo ),김민경 ( Min Kyoung Kim ),공은정 ( Eun Jung Kong ),고성애 ( Sung Ae Koh ),구미진 ( Mi Jin Gu ),정지윤 ( Ji Yoon Jung ),현명수 ( Myung Soo Hyun ) 대한내과학회 2016 대한내과학회지 Vol.90 No.2

Richter’s syndrome refers to the development of aggressive lymphoma in a patient with chronic lymphocytic leukemia (CLL). It occurs in about 2% to 10% of patients with CLL. The most frequent manifestation of Richter’s syndrome is diffuse large B cell lymphoma (DLBCL). Extranodal involvement is rare but can occur. The prognosis of Richter’s syndrome is very poor. We herein report a case of a rare presentation of Richter’s syndrome. A 42-year-old man diagnosed with CLL 2 years previously developed nodules on the bilateral thighs and buttocks. A positron emission tomography (PET)-CT scan revealed high fluorodeoxyglucose uptake in multiple lymph nodes, skeletal muscles, and the myocardium. An ultrasonography-guided biopsy confirmed Richter’s syndrome from CLL to DLBCL. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy. After six cycles of chemotherapy, we performed a PET-CT scan that revealed a complete response. However, 3 months later, the syndrome recurred. The patient was undergoing salvage chemotherapy at the time of this writing. (Korean J Med 2016;90:163-168)

눈꺼풀로 전이된 진행성 위암

정지윤 ( Ji Yoon Jung ),구은주 ( Eun Joo Goo ),이재창 ( Jae Chang Lee ),송재이 ( Jay Song ),고성애 ( Sung Ae Koh ),이경희 ( Kyung Hee Lee ),배영경 ( Young Kyung Bae ) 영남대학교 의과대학 2016 Yeungnam University Journal of Medicine Vol.33 No.2

Gastric cancer is the most common cancer in Korean males and can easily spread to distant organs such as the liver, lungs, brain, or bones. However, skin metastasis, particularly of the eye, is rare. Metastatic eyelid cancer is extremely rare; metastases from internal organs have not been reported so far. We recently experienced a patient with metastatic eyelid cancer from adenocarcinoma of the stomach. A 62-year-old female was admitted with a right upper eyelid mass and foreign body sensation. She had a history of stomach cancer of 3 years. She was treated by chemotherapy and radiotherapy for pathologic fracture. After receiving supportive care for 2 years, the mass appeared on her right pupil. Punch-biopsy of the mass was performed and histological examination revealed adenocarcinoma, the same as the initial histological result. We report this case with a review of related literature.

진성 적혈구 증다증 환자에서 발생한 발목뼈 결핵 1 예

고성애,정선영,손세훈,김동근,박성우,허지안,이경희,김민경,현명수 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

Talus tuberculosis is a rare disease, even in an endemic tuberculosis area. In reviews of the worldwide literature, only 18 cases of talus tuberculosis have been reported. Recently, we experienced a case of a 70-year-old polycythemia vera patient with right metatarsopharyngeal joint pain for 2 months duration who was diagnosed with talus tuberculosis with prostate involvement. Tuberculosis should be considered as one of the causes of monoarticulitis, especially in countries, where the disease is endemic. Additionally, we highly recommend taking a biopsy of the site of suspected infection because an early diagnosis is the key to successful treatment.

복막투석복막염 환자에서 발생한 창자벽공기증 1예

정선영,나지훈,최윤정,고성애,조규향,박종원,도준영,윤경우 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

Peritonitis is a serious problem in patients undergoing peritoneal dialysis. Rarely pneumatosis intestinalis can occur as a complication of this infectious process. Pneumatosis intestinalis is a potential life threatening condition with a challenging management. The mortality of peritoneal dialysis patients with pneumatosis intestinalis secondary to mesenteric ischemia is almost 100%. We describe a rare case of pneumatosis intestinalis in a peritoneal dialysis patient who developed Staphylococcus aureus peritonitis which was initially treated with appropriate antibiotics. Since initial response to therapy was not achieved, an abdominal computerized tomography was done which revealed a pneumatosis intestinalis. A laparotomy was performed and small bowel necrosis was seen. A segmented resection with ileostomy, jejunostomy was done. Though surgical treatment was performed, the patient died in 2 weeks after admission. Pneumocystitis intestinalis in peritoneal dialysis peritonitis is a uncommon complication which requires prompt evaluation to rule out mesenteric ischemia as it carries a high mortality and its management will be surgical.