단일조사와 분할조사시 마우스 공장 소낭선세포의 방사선효과에 관한 실험적 연구

高秉熙(Byung Hee Koh),咸蒼谷(Chang Kok Hahm),金禎鎭(Jung Jin Kim),朴贊一(Chan Il Park) 대한방사선종양학회 1985 Radiation Oncology Journal Vol.3 No.1

To determine the dose·survival and repair characteristics of the jejunal crypt cells, experimental study was carried out using total 70 mice. Single or split irradiations of 1,100 to 2,200 rad were delivered to whole bodies of C_57 BL mice, using a cesium 137 animal irradiator and those mice were sacrificed after 90 hours. The number of regenerating crypts per jejunal circumference was counted by a jejunal crypt cell assay technique and dose·response curve was measured. The results were as follows : 1. The average number of jejunal crypts per circumference in control group was 140. In a single irradiation group, the number of regenerated jejunal crypts was, 125, 56, 2 in each subgroup of 1,100 rad, 1,400 rad and 1,800 rad respectively. In split irraiation group, it was 105,44,2 in each subgroup of 1,400rad 1,800rad and 2,200rad respectively. 2. Mean lethal dose of mouse jejunal crypt cell was 167 and 169 rad respectively in a single and split irradiation. 3. Repair dose of sublethal damage was 280 rad. 4. Sublethal damage was completely repaired within 4 hours between the split dose of irradiation.

안면골 골절

이현,김철수,이상길,이승로,함창곡,Lee, Hyun,Kim, Chul-Soo,Lee, Sang-Kil,Lee, Seung-Ro,Hahm, Chang-Kok 대한영상의학회 1983 대한영상의학회지 Vol.19 No.4

Tomography has played an important role in diagnosis of facial bone fracture. Nowadays, it still acts as a inevitable process in decision of adequate treatment in patient with facial bone fracture. At the Department of Radiology, Hanyang University Hospital, 74 patients who have facial bone fracture, were observed and analyzed with simple skull films, mainly skull A-P, lateral and Water's view, after comparison with tomographic findings. The results were as follows : 1. Male was in 90.5% incidence. Most frequent age distribution was 21 to 40 years and marked 62.2%. 2. Most frequent cause of trauma was traffic accident as 41 cases and the next one was fall down as 13 cases. Other cause were blunt trauma such as fist, stone, heavy metal etc. and explosion. 3. Clinical symptoms and physical signs were painful swelling, abrasion, ecchymosis and subconjuctival hemorrhage in almost all patient. 4. Fracture distribution was 22 cases in simple fracture and 52 cases in complex fractures which were 26 cases in Tripod fractures, 14 cases in Le Fort fractures and 12 cases in combined complex fractures. 5. The radioligic findings on tomography were opacity of orbit or P.N.S. 87.8%, regional soft tissue swelling 85.1%, displacement of bony fragment 56.8%, abnormal linear density in orbit or P.N.S. 48.6%, bony fragment in orbit or P.N.S. 47.3% change of size of orbit or P.N.S. 40.5%, foreign body in orbit or P.N.S. 16.2%, and others 27.0%. These radiologic findings of simple fracture were less than those of complex fracture. 6. Radiologic findings of facial bone fracture on simple films were analyzed after comparison with tomographs. Detectable possibility of obvious fracture lines such as cortical disruption or separation was 67.6% on simple films. Detectable possibility of other radiologic findings on simple films were displacement of bony fragment 86.7%, abnormal linear density in orbit or P.N.S. 88.6%, bony fragment in orbit or P.N.S. 71.4%, opacity of orbit or P.N.S. 90.8%, change of size or orbit or P.N.S. 96.4%, regional soft tissue swelling 96.2%, foreign boy in orbit or P.N.S. 41.7%. Others such as absence or deformity of infraorbital formen, subcutaneous emphysemal or infraorbital air 40.0%. Therefore tomography is inevitably taken to correct diagnosis of facial bone fracture.

소아 급성 림프구성 백혈병의 치료 중간파 후에 보이는 뇌의 이상 영상 소견

이경주,이승로,박동우,주경빈,김장욱,함창곡,김기중,이항,Lee, Kyung-Joo,Lee, Seung-Rho,Park, Dong-Woo,Joo, Kyung-Bin,Kim, Jang-Wook,Hahm, Chang-Kok,Kim, Ki-Joong,Lee, Hahng 대한영상의학회 2001 대한영상의학회지 Vol.45 No.3

목적: 소아 급성 림프구성 백혈병의 치료 중간과 후에 발생될 수 있는 뇌의 영상 이상을 알아보고자 하였다. 대상과 방법: 소아 급성 림프구성 백혈병 환자 중 최근 10년간 백혈병의 중추 신경계 재발에 대한 예방적 치료를 받고, 진단 당시 뇌에 대한 컴퓨터 단층 촬영으로 기본 영상 검사를 시행한 후, 중추신경계 증상 유무와 상관없이 1회 이상추적 검사를 한 30명(남아 여아 = 19 : 11, 평균 연령 64개월)을 대상으로 하였다. 이중 뇌에 이상 영상 소견을 보인 경우는 영상 이상의 종류. 치료 방법 . 연관된 중추 신경계 증상. 최초의 진단일 에서 뇌에 이상 영상이 발견될 때까지의 기간 등을 후향적으로 분석하였다 결과: 30명중 15명(50%; 남아 여아 = 9 6, 평균 연령 77개월)에서 뇌 이상 영상 소견이 보였는데 뇌 위축이 9예, 뇌 경색이 4예. 뇌 출혈이 1예, 무기질 침착성 미세혈관병증이 2예, 백질 연화증이 3예였다. 뇌 위축이 있었던 9명 중 4명에서는 다른 영상 이상이 동반되었는데, 백질 연화증 2예, 경색 1예. 미세혈관병증이 1예였다. 뇌척수액에서 백혈병 세포가 발견된 1명을 제외한 14명은 동일한 치료를 받았다. 중추 신경계 증상은 6명에서 있었다. 뇌 이상 영상이 있었던 15명에서 이상 영상이 발견될 때까지의 기간은 1개월에서 4년까지였다. 뇌 위축을 보인 1명을 제외한 14명에서 이상 영상 소견이 치료 종결 후에도 남아 있었다. 결론: 소아 급성 림프구성 백혈병 치료중간과 후에 다양한 뇌 이상 영상이 나타나고 장기간 지속되므로. 급성 림프구성 백혈병 환자들의 뇌 이상을 평가하기 위해 추적 검사가 필요하리라 생각된다 Purpose: We evaluated the imaging abnormalities of the brain observed during and after treatment of acute childhood Iymphoblastic leukemia. Materials and Methods: The study group consisted of 30patients (male: female = 19:11; mean age, 64months) with acute childhood Iymphoblastic leukemia during the precious ten-year period who had undergone prophylaxis of the central nervous system. Irrespective of the CNS symptoms, base-line study of the brain involving CT and follow-up CT or MRI was undertaken more than once. We retrospectively evaluated the imaging findings, methods of treatment, associated CNS symptoms, and the interval between diagnosis and the time at which brain abnormalities were revealed by imaging studies. Results: In 15(50% ; male female =9:6 ; mean age,77months) of 30 patients, brain abnormalities that included brain atrophy (n = 9), cerebral infarctions (n=4), intracranial hemorrhage (n = 11, mineralizing microangiopathy (n =2), and periventricular leukomalacia (n= 3) were seen on follow-up CT or MR images. In four of nine patients with brain atrophy, imaging abnormalities such as periventricular leukomalacia(n = 2), infarction (n= 1) and microangiopathy (n= 1) were demonstrated. Fourteen of the 15 patients underwent similar treatment; the one excluded had leukemic cells in the CSF. Six patients had CNS symptoms. In the 15 patients with abnormal brain imaging findings, the interval between diagnosis and the demonstration of brain abnormalities was between one month and four years. After the cessation of treatment, imaging abnormalities remained in all patients except one with brain atrophy Conclusion: Various imaging abnormalities of the brain may be seen during and after the treatment of acute childhood Iymphoblastic leukemia and persist for a long time. In children with this condition, the assessment of brain abnormalities requires follow-up study of the brain.

급성심근경색증에서의 심장자기공명영상술의 진단 정확도와 심근 생존력 평가: TI-201 심근관류 SPECT와의 비교

김혜선,박동우,김용수,김영선,최요원,전석철,서흥석,함창곡,김순길,안유헌,최윤영,박충기,Kim Hye-seon,Park Dong Woo,Kim Yongsoo,Kim Young-sun,Choi Yo Won,Jeon Seok Chul,Seo Heung Suk,Hahm Chang Kok,Kim Soon Kil,Ahn You hern,Choi Yoon Young,P 대한자기공명의과학회 2003 Investigative Magnetic Resonance Imaging Vol.7 No.2

목적 : 급성심근경색을 진단하는데 있어 심장자기공명영상의 유용성을 알아보고, 생존심근을 평가하는데 있어 Tl-201 심근관류 SPECT와 비교하고자 하였다. 대상 및 방법 : 흉통 및 호흡곤란이 있는 환자 중 심장자기공명영상과 Tl-201 SPECT를 시행한 17명을 후향적으로 조사하였다. 심장자기공명영상에서는 T2강조영상에서 심벽의 고신호 강도 유무, 영화영상에서 심벽 운동, Gd-DTPA 조영 증강 후 좌심실 벽의 관류 결손 및 주입 15분 후의 지연조영증강 유무를 평가하였다. T1-201 SPECT에서는 아데노신 부하 영상과 휴식기 영상을 얻어 관류 결손 유무와 관류 결손시 가역성 여부를 평가하였다. 결과 심장자기공명영상과 T1-201 SPECT 모두 급성심근경색을 진단하는데 통계적으로 의미가 있었고, T2강조영상, T1-201 SPECT, 지연조영증강 및 심벽운동 순으로 연관성이 있는 것으로 나타났고, 관류 결손은 통계적 유의성이 없었다. 생존심근 평가에 있어서는 두 검사간 유의한 차이가 없었으며, T2강조영상과 관류영상에서 T1-201 SPECT와 높은 일치율, 지연조영증강 및 심벽운동은 낮은 일치율을 보였다. 결론 : 심장자기공명영상은 급성심근경색을 진단하는데 매우 유의한 진단율을 보였고, 생존 심근여부의 판단에 있어 SPECT와 높은 일치율을 보였다. 그러나 각 검사별 판독 기준과 방법에서 많은 연구가 필요할 것으로 생각된다. Purpose : To assess the usefulness of cardiac MR imaging (MRI) in the diagnosis of acute myocardial infarction and in the assessment of myocardial viability in comparision with T1-201 SPECT. Materials and Methods : We retrospectively studied 17 patients who complained of chest pain and dyspnea with cardiac MRI . The patients were evaluated for the presence or absence of high signal intensity on T2-weighted image (T2wI), abnormal wall motion on 2D-FIESTA, perfusion defect on Gd-DTPA enhanced T1WI, and delayed myocardial enhancement on 15-minutes delay Gd-DTPA enhanced T1WI. The results were correlated with the images on T1-201 SPECT, taken at rest and stress, through which reversibility of perfusion defect was assessed. Results : Both cardiac MRI and T1-201 SPECT proved to be useful methods for diagnosing acute myocardial infarction. In order of decreasing correspondence, T2WI, T1-201 SPECT, delayed enhancement study, and wall motion images all showed significant statistical correlation with the clinical diagnosis of myocardial infarction. Perfusion MRI, on the other hand, showed no significant statistical difference was found between T1-201 SPECT and cardiac MRI. The results on T2WI showed high accordance with those on Tl-201 SPECT, while delayed myocardial enhancement and wall motion studies showed no agreement with Tl-201 SPECT. Conclusion : Cardiac MRI is useful method for diagnosis of acute myocardiac infarction. With respect to the assessment of myocardial viability, the results obtained on cardiac MRI showed high agreement with those on Tl-201 SPECT. However, further study is necessary at this point for standardization and establishment of the methods for assessing myocardial viability on cardiac MRI.

고실 경화증 : 방사선학적 소견과 수술소견의 비교

문원진,박동우,이승로,성진용,송순영,함창곡,김용수,박충기,태경,Moon, Won-Jin,Park, Dong-Woo,Lee, Seung-Ro,Seong, Jin-Yong,Song, Soon-Young,Hahm, Chang-Kok,Kim, Yong-Soo,Park, Choong-Ki,Tae, Kyung 대한영상의학회 1998 대한영상의학회지 Vol.38 No.2

Purpose: Tympanosclerosis is a common problem causing conductive hearing loss accompanied by chronic otitismedia. The purpose of this study was to evaluate the CT findings of tympanosclerosis, and correlate them with thesurgical findings. Materials and Methods: The CT scans of 17 patients with surgically-proven tympanosclerosis andthose of a control group of 34 patients with nontympanosclerotic chronic otitis media were reviewed. According totheir location, they were assigned to one of three groups; tympanic membrane, epitympanum, or ossicles. Results:Tympanosclerosis was found during surgery to be located in the tympanic membrane (n=11), the epitympanum (n=6), oraround the ossicles(n=8). Calcification of the tympanic membrane, ossicular thickening, narrowing of theepitympanum and calcification of the tympanic cavity occurred to a significant extent, and were more often afeature of tympanosclerosis than of nontympanosclerotic chronic otitis media (p<0.05). As an indicater of tympanicmembrane involvement, sensitivity and specificity of calcification of the tympanic membrane were 73% and 83%,respectively. As an indicator of ossicular involvement, the corresponding figures for ossicular thickening were50% and 93% ; as an indicator of involvement of the tympanic cavity (especially the epitympanum) the figures fornarrowing of the epitympanum and calcification of the tympanic cavity were 50% and 50% (respective sensitivities),and 89% and 93%(respective specificities). Conclusion: Tympanosclerosis usually appears on CT as ossicularthickening, narrowing of the epitympanum, calcification of the tympanic membrane and/or tympanic cavity. CT isvery helpful in evaluating ossicular involvement and determining the appropriate surgical treatment oftympanosclerosis.

전산화 단층촬영술을 이용한 가토 지방간의 정량적 평가에 관한 실험적 연구

박충기,함창곡 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2

For the study of correlation of ct number and fatty content of the liver, total 35 rabbits were used. The rabbits were divided into one control and three experimental groups according to the amount of carbon tetrachloride, administered 1 ml, 2 ml and 3 ml per kg of body weight respectively. The carbon tetrachloride was administered via intragastric route. CT was performed 72 hours following administration of carbon tetrachloride, and immediately prior to CT scan each rabbit was anesthetized by means of IM injection of ketamine and IV injection of succinylcholine to stop motion and respiration. CT numbers were measurd and histological study for the deposition of fat in the liver tissue was done. Also biochemical analysis of lipid in the blood and in the extraction of liver tissue was performed. Comparison of CT number with biochemical and histological data was done. The results were as follows: 1. In each experimental group, the degree of accumulation of fat in the liver was proportional to the amount of carbon tetrachloride. 2. Degree of decreasing CT number was correlated with the increase in the accumulation of fat in the liver. 3. In the control and experimental (1,2,3) groups, when the amount of carbon tetrachloride increased, the amount of total lipid, cholesterol and triglyceride on biochemical analysis of the liver increased. Also increase in the amount of plasma lipids on biochemical analysis and a great degree of increase in accumulation of fat in the liver on histological examination were seen. But no changes in the amounts of phospholipid and protein on biochemical analysis of the liver were noticed. 4. Increase in the amount of total lipid could make a change in the CT number of the liver remakably (r=-0.63). As the amount of cholesterol and triglyceride increased, the CT number of the liver decreased (r=-0.61 and r=-0-.76 respectively). But there was no significant correlation between the amount of protein and phospholipid and the degree of decrease in CT number. 5. Mean values of CT number in normal, grade 1, grade 2, grade 3 and grade 4 according to the degree of histological changes were 67.46±2.24, 58.53±3.06, 49.43±6.81, 39.49±9.69, 20.62±8.04 respectively. The reduction of CT number was correlated with the accumulation of fat on histological examination.

Sturge-Weber 증후군

이승로,전석철,박상규,박영근,함창곡 한양대학교 의과대학 1983 한양의대 학술지 Vol.3 No.2

The authors experienced 2 cases of Sturge-Weber syndrome which showed typical appearance of the disease, clinically and radiologically. Especially, these showed extensive calcification and diffuse cortical atrophy of frontal and parietal lobe, which was known as rarely demonstrated findings. Thus the authors report these cases with emphasis in plain skull and brain C.T. findings with a brief review of the literatures.

지연성 외상성 두개강내 혈종

이승로,주경빈,서흥석,함창곡 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.1

We retrospectively analyzed brain CT findings of 60 cases with delayed traumatic intracranial hematomas. Of all 60 cases, 32 cases were delayed traumatic intracerebral hematomas, 16 were epidural and 12 were subdural hematomas. Delayed traumatic intracranial hematoma were mainly found within 5 days after initial head trauma and more common in patient with hemorrhagic focus on initial CT scan, which was done just after initial head trauma. We could not correlate delayed hematoma with presence, size or location of hematoma seen on initial CT scans. And also formation of delayed hematoma was not correlated with mental status or blood pressure of the patient, examined just after initial head trauma. Further consideration of effect of mannitol or cerol on the formation of delayed hematoma might be necessary.

Mycoplasma Pneumonia의 방사선학적 소견에 대한 연구

이영춘,서흥석,함창곡 한양대학교 의과대학 1988 한양의대 학술지 Vol.8 No.2

The lung is primary site of infection with M. pneumoniae, other sites are the skin, central nervous system, heart, and joint. School-aged children and young adult experienced high attack rate, especially in a defined group or population, such as school and military pupulation. Authors reviewed clinical and radiological features of 34 cases of serologically proven Mycoplasma pneumonia in hospitalized children from January 1986 to January 1988. Male to female ratio was 24:10 (2.4:1) and 61.8% of them were 5 through 8 year old. The clinical symptoms were cough, sputum, sore throat, fever and duration of the symptom before admission was from 6 days to 10 days. The radiologic findings were bronchopneumonic pattern in 14.1%, with lobar in 26.5% and segmental in 14.7%, normal in 11.8%, lobal atelectasis in 2.9%. Mean radiologic resolution period was 8.5% days in bronchopneumonia pattern and 6.8 days in alveolar consolidation. Therefore more rapid resolution was observed in alveolar consolidation than bronchopneumonia. Extrapulmonary manifestations were hematuria, skin rash and hepatomegaly and otitis media.

만성 및 재발성 부비동염의 전산화단층촬영

이영욱,서흥석,함창곡 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.2

Computed tomography (CT) findins were retrospectively analyzed in 182 patients with chronic or recurrent paranasal sinusitis, visiting Koryo General Hospital, from October 1987 to August 1991. The result were as follows: 1. With respect to the distribution of the sinusitis, anterior ethmoid was 168(91%), maxillary was 160(88%), frontal was 102(56%) cases. 2. Computed tomographic findings of the sinusitiw were sinus opacification, mucoperiosteal thickening, mucosal enhancement, air-fluid level, and bony wall thickening. Complications were retencion cysts, mucoceles, and orbital cellulitis. 3. Of the 182 cases, obstruction of the ostiomeatal unit was noted in 175 cases (96%). The causes were inflammatory processes, nasal polyps, concha bullosae, inverting papillomas, paradoxic middle turbiantes, severe septal deviations, and large ethmoidal bulla. 4. Of the 31 cases with past history of changes and uniform and symmetric pansinusitis, 30 cases were diagnosed as allergic sinusitis, slinically. Of the 11 case with nodular mucosal thickening, bony sclerotic change, enhancing soft tissue mass, or calcification, 5 cases were diagnosed as aspergilloses and 1 case as mucormyocsis. Therefore, the authors could ascertain the rhinogenic origin theory and the importance of the ostiomeatal unit obssrutction as the basic cause of the sinusitis. The authors concluded that comuputed tomography isthe best modality for evaluation chronic or recurrent prarnasal sinusitis.