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폐실질내의 주변형 결절로 나타난 소세포성 폐암의 CT 소견
이태희,최요원,전석철,서흥석,함창곡,박충기 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.2
We evaluated CT findings of the small cell carninoma, which presented as a solitary pulmonary nodule at the periphery of the lung parenchyma. Of pathologically-proven 45 patients with small cell carcinoma, 10 patients was included in this study, who had a solitary, peripheral lung nodule at distal portion of the subsegmental bronchus. We retrospectively reviewed clinical data and CT findings including size, location, margin, enhancement pattern, lymph node enlargement, metastasis. Peripheral small cell carcinomas were 22.2%(10/45). All masses had well-defined margin and lobulated margin was seen in 7 patients. Mean diameter was 3.8cm (2.5-7.0cm). Enhancement pattern were homogeneous in 3 cases and inhomogeneous in seven. Calcification or air-bronchogram was not present, and focal cavitation was seen in one case. In five, only lung mass was present, and lung mass with lymph node enlargement was seen in one. distant metastasis without lymph node enlargement was noted on two patients and another two patients showed lymph node enlargement and distant metastasis. Peripheral small cell carcinoma is not rare(22.2%). Most frequent CT finding is a well-defined, lobulated mass with inhomogeneous enhancement, these findings would be helpful in differentiating small cell carcinoma from other neuroendocrine tumors when differentiataion is difficult cytologically.
Mutations of <i>ADAMTS9</i> Cause Nephronophthisis-Related Ciliopathy
Choi, Yo Jun,Halbritter, Jan,Braun, Daniela A.,Schueler, Markus,Schapiro, David,Rim, John Hoon,Nandadasa, Sumeda,Choi, Won-il,Widmeier, Eugen,Shril, Shirlee,Kö,rber, Friederike,Sethi, Sidharth K. Elsevier 2019 American journal of human genetics Vol.104 No.1
<P>Nephronophthisis-related ciliopathies (NPHP-RCs) are a group of inherited diseases that are associated with defects in primary cilium structure and function. To identify genes mutated in NPHP-RC, we performed homozygosity mapping and whole-exome sequencing for >100 individuals, some of whom were single affected individuals born to consanguineous parents and some of whom were siblings of indexes who were also affected by NPHP-RC. We then performed high-throughput exon sequencing in a worldwide cohort of 800 additional families affected by NPHP-RC. We identified two <I>ADAMTS9</I> mutations (c.4575_4576del [p.Gln1525Hisfs<SUP>∗</SUP>60] and c.194C>G [p.Thr65Arg]) that appear to cause NPHP-RC. Although ADAMTS9 is known to be a secreted extracellular metalloproteinase, we found that ADAMTS9 localized near the basal bodies of primary cilia in the cytoplasm. Heterologously expressed wild-type ADAMTS9, in contrast to mutant proteins detected in individuals with NPHP-RC, localized to the vicinity of the basal body. Loss of ADAMTS9 resulted in shortened cilia and defective sonic hedgehog signaling. Knockout of <I>Adamts9</I> in IMCD3 cells, followed by spheroid induction, resulted in defective lumen formation, which was rescued by an overexpression of wild-type, but not of mutant, ADAMTS9. Knockdown of <I>adamts9</I> in zebrafish recapitulated NPHP-RC phenotypes, including renal cysts and hydrocephalus. These findings suggest that the identified mutations in <I>ADAMTS9</I> cause NPHP-RC and that ADAMTS9 is required for the formation and function of primary cilia.</P>
Carbon dioxide Fischer-Tropsch synthesis: A new path to carbon-neutral fuels
Choi, Yo Han,Jang, Youn Jeong,Park, Hunmin,Kim, Won Young,Lee, Young Hye,Choi, Sun Hee,Lee, Jae Sung Elsevier BV 2017 Applied Catalysis B Vol.202 No.-
<P><B>Abstract</B></P> <P>Paradigm of climate change mitigation technologies is shifting from carbon capture and storage (CCS) to carbon capture and utilization (CCU). Here we propose a new path to CCU – direct CO<SUB>2</SUB> conversion to liquid transportation fuels by reacting with renewable hydrogen produced by solar water splitting. The highly promising and CO<SUB>2</SUB>-neutral CCU system is possible by our discovery of a new catalyst that produces liquid hydrocarbon (C<SUB>5+</SUB>) selectivity of ∼65% and greatly suppressed CH<SUB>4</SUB> formation to 2–3%, which represents an unprecedented selectivity pattern for direct catalytic CO<SUB>2</SUB> hydrogenation and is very similar to that of conventional CO-based Fischer-Tropsch (FT) synthesis. The catalyst was prepared by reduction of delafossite-CuFeO<SUB>2</SUB> and <I>in-situ</I> carburization to Hägg carbide (χ-Fe<SUB>5</SUB>C<SUB>2</SUB>), the active phase for heavy hydrocarbon formation. The reference catalysts derived from bare Fe<SUB>2</SUB>O<SUB>3</SUB>, CuO-Fe<SUB>2</SUB>O<SUB>3</SUB> mixture, and spinel CuFe<SUB>2</SUB>O<SUB>4</SUB> are much less active and produce mainly light hydrocarbons, highlighting the critical role of delafossite-CuFeO<SUB>2</SUB> as the catalyst precursor. The new catalyst breaks through the limitation of CO<SUB>2</SUB>-based FT synthesis and will open the avenue for new opportunity for carbon recycling into valuable liquid fuels at the similar conditions to industrially practiced CO-FT synthesis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CO<SUB>2</SUB> conversion to liquid fuels by reacting with renewable hydrogen. </LI> <LI> Reduced CuFeO<SUB>2</SUB> catalyst produces C<SUB>5+</SUB> hydrocarbons of ∼65% and CH<SUB>4</SUB> of only 2–3%. </LI> <LI> The catalyst allows facile <I>in-situ</I> carburization to Hägg carbide active for C<SUB>5+</SUB> formation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
주용원 ( Yong Won Joo ),손창남 ( Chang Nam Son ),정경희 ( Kyong Hee Jung ),박혜정 ( Hae Jeong Park ),김상헌 ( Sang Heon Kim ),김태형 ( Tae Hyung Kim ),손장원 ( Jang Won Sohn ),윤호주 ( Ho Joo Yoon ),최요원 ( Yo Won Choi ),정원상 ( 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.3
A chronic expanding hematoma (CEH) in the thorax is a rare and specific condition of chronic empyema. CEHs in the thorax are often associated with tuberculosis and/or previous surgical procedures. While the incidental detection of a pleural mass and dyspnea are common clinical manifestations, a few cases present with hemoptysis. We encountered a case of CEH in the thorax. This case is unique in that it developed without a prior history of tuberculosis or surgery and presented with massive hemoptysis accompanied by bronchopleural fistula. We report the third case of CEH in the thorax in Korea with a summary of the clinical characteristics of previous cases. (Tuberc Respir Dis 2008;65:216-221)
呂鐵鉉,鄭元陽,片茂實,崔在時 연세대학교 자연과학연구소 1979 學術論文集 Vol.3 No.-
황산수소칼슘(KHSO_4) 포화용액으로부터 증발법으로 KHSO_4 단결정을 최적조건에서 생성시킨다. 11.25×10^6 렌트겐의 방사선(r-선)조사로 생긴 단결정의 방사선손상은 몇개의 상자성 중심을 형성한다. 그 결정들의 전자스핀공명 스펙트라를 상온에서 X-띠 전자스핀공명 분석기로 얻는다. 상자성종들의 전자스핀공명(ESR) 피-크들은 무등방성을 보이지만 g=2.003인 Gauss형 등방성 피-크가 생기는 것은 SO_3^-기 때문이다. 회전축 이외 제삼의 축과 자장간에 이루는 여러 각도에서 모든 상자성종들의 g-값들은 그종들의 무등방성 피-크들과 SO_3^-기의 등방성 피-크간의 거리로부터 구할 수 있다. 결정내에 성성된 기들의 주 g-값은 g^2을 Θ에 대하여 도시한 곡선으로부터 계산하였다. 모든 상자성종들은 대응되는 특성 주-값들로부터 확인되고 결정의 결함구조는 또한 이들 종으로 고찰된다. Single crystals of Potassium Hydrogen Sulfate(KHSO_4) have been grown from the saturated solution by the evaporation method at the optimum conditions. Radiation damages in the single crystal caused by r-irradiation of 11.25×10^6 Rentgen have given rise to several paramagnetic centers. Electron spin resonance(ESR) spectra of the crystals are obtained with the X-band EPR spectrometer at room temperature. The ESR peaks of the paramagnetic species are found to be anisotropic but an isotropic peak of Gaussian shape at g=2.0036 is assigned to SO_3 radical. The g-values of all the species at various angles between the other axis besides the rotating axes and the magnetic field are obtained from the distances between anisotropic peaks of the species and the isotropic peak of SO_3^- radical. The principal g-values of the trapped radicals are calculated from the plots of g^2 vs.Θ. All the species are identified with the corresponding principal g-values and the defect structure of the KHSO_4 crystal is also discussed in terms of the species.
Orotic Acid Induces Hypertension Associated with Impaired Endothelial Nitric Oxide Synthesis
Choi, You-Jin,Yoon, Yujin,Lee, Kang-Yo,Kang, Yun-Pyo,Lim, Dong Kyu,Kwon, Sung Won,Kang, Keon-Wook,Lee, Seung-Mi,Lee, Byung-Hoon ACADEMIC PRESS 2015 TOXICOLOGICAL SCIENCES Vol.144 No.2
<P>Orotic acid (OA) is an intermediate of pyrimidine nucleotide biosynthesis. Hereditary deficiencies in some enzymes associated with pyrimidine synthesis or the urea cycle induce OA accumulation, resulting in orotic aciduria. A link between patients with orotic aciduria and hypertension has been reported; however, the molecular mechanisms remain elusive. In this study, to elucidate the role of OA in vascular insulin resistance, we investigated whether OA induced endothelial dysfunction and hypertension. OA inhibited insulin- or metformin-stimulated nitric oxide (NO) production and endothelial NO synthase (eNOS) phosphorylation in human umbilical vein endothelial cells. A decreased insulin response by OA was mediated by impairment of the insulin-stimulated phosphoinositide 3-kinase (PI3K)-protein kinase B (PKB/Akt) signaling pathway in cells overexpressing the p110-PI3K catalytic subunit. Impaired effects of metformin on eNOS phosphorylation and NO production were reversed in cells transfected with constitutively active AMP-activated protein kinase. Moreover, experimental induction of orotic aciduria in rats caused insulin resistance, measured as a 125% increase in the homeostasis model assessment, and hypertension, measured as a 25% increase in systolic blood pressure. OA increased the plasma concentration of endothelin-1 by 201% and significantly inhibited insulin- or metformin-induced vasodilation. A compromised insulin or metformin response on the Akt/eNOS and AMP-activated protein kinase/eNOS pathway was observed in aortic rings of OA-fed rats. Taken together, we showed that OA induces endothelial dysfunction by contributing to vascular and systemic insulin resistance that affects insulin- or metformin-induced NO production, leading to the development of hypertension.</P>