漢方藥劑의 品質評價와 藥效에 關한 硏究(第6報) : 元柴胡및 竹柴胡 水性엑스의 中樞抑制作用에 對하여 Central Depressive Action of Bupleurum Falcatum and Bupleurum Longiradiotum

徐成勳,洪南斗,權昌鎬,金壽億 慶熙大學校 1988 論文集 Vol.17 No.-

The effects of the aqueous extracts of Bupleurun falcatum and Bupleurum longiradiotum on the central nervous depressive action were studied by the behaviroral pharmacological method. The roots of Bupleuri radix was extracted with distilled water for 8 hours. Effect of extracts were tested by spontaneous movement activity using photoelectric method, openfield method, sloped plate method, rotarrod method and extension of hypnosis time induced with sodium phenobarbital and pentobarbital sodium, and defense against convulsive action induced with strychnine, picrotoxine and electric shock seizure in mice and rats. Extracts was found to pharmacologically expect above various action similar to these of diazepam but action of samples weaker than that of diazepame. Extracts of Bupleurum longiradiotum was definitely superior to the Bupleurum extracts in the central nervousderpressive action.

퇴행성 슬관절염에 대한 제통단의 안정성과 효능 임상연구

서병관,류성룡,강중원,안경애,이상훈,최도영,김건식,이두익,이윤호,이재동 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : In order to investigate the efficacy and safety of the newly developed herbal medicine Jetongdan, a placebo-controlled randomized clinical trial of patients with osteoarthriotis of the knee was undertaken. Methods : Data were obtained from 80 patients with OA of the knee. After the enrollment, they were asked to answer a disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index) and analyzed with the erythrocyte sedimentation rate (ESR) in order to evaluate the efficacy of Jetongdan, and analyzed for aspartate transaminase (AST) level, alanine transminase (ALT) level, blood urea mitrogen (BUN) level, and creatinine (Cr) level in order to evaluate the safety of Jetongdan. Results : The liver function and renal function did not deteriorate after treatment with Jetongdan. Composite WOMAC score and physical function subscale was improved, but pain subscale, stiffness subscale, and ESR were not improved by Jetongdan. This was possibly because the baseline characteristics of the two groups were not homogenized after randomization. Conclusions : Jetongdan could be a promising treatment option for osteoarthritis of the knee. Further study in a larger population with appropriate severity grades is recommended.

Polyaaccharide 類의 固形分斯體에 의한 藥物 傳達體系의 開發

서성훈,김길수,김동현,이승진,장미경 경희대학교 약학대학 1994 慶熙藥大論文集 Vol.22 No.

퇴행성 슬관절염 환자의 증상 중증도 지표와 DITI의 상관성 연구

서병관,류성룡,강중원,안경애,이재동,최도영,김건식,이두익,이윤호,이상훈 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : To investigate the applicability of thermography as severity measurement in the patients with osteoarthritis (OA) of the knee. Methods : Data were obtained from 80 patiens with OA of the knee. They were asked to answer two disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index, Lequesne's Functional Index (LFI)), one generic instrument (Korean Health Assessment Questionnaire (KHAQ)), VAS in order to assess the severity of disease, quality of life, degree of pain and taken thermography in standardized environment. Results : The thermal difference between ipsilateral side and contralaterla side of lateral aspect of knee was correlated with that of medial aspect of knee, and the thermal difference of anterior thigh was correlated with that of lateral, medial aspect of knee and patella region. Age, duration of disease, duration of morning stiffness, sex, crepitus, and painful side of knee were not correlated with the thermal differences of each region. LFI, WOMAC, WOMAC pain subscale, WOMAC stiffness subscale, WOMAC physical function, KHAQ,, VAS were not correlated with the thermal differences of each region. Conclusion : Further study on the thermography on OA of the knee in population with appropriate severity grade and the standardization of analysis of thermographic data were recommended.

폴리에스터 흡음재가 조합된 다공판 시스템의 흡음성능에 관한 연구

서성원,황윤,이동훈 서울産業大學校 2002 논문집 Vol.53 No.1

The sound absorption coefficients for perforated plate systems containing several compartments with airspaces and polyester absorbing materials are estimated using the transfer matrix method developed in the previous paper. The absorption coefficients from transfer matrix method agree well with the values measured by the two-microphone impedance tube method for various combinations of perforated plates, airspaces or absorbing materials. Based on these results. a guidance for the design of perforated plate systems combined with airspaces and absorbing materials is discussed in detail.

漢方藥의 成分 및 藥效에 關한 硏究(第4報) : 매자나무 엑기스의 行動藥理學的 硏究 Behavioral Pharmacology of Berberis koreana Pilibin

徐成勳,金壽億 慶熙大學校 1985 論文集 Vol.14 No.-

The behavioral effects of Berberis korean Pilibin extracts which is used to insomnia, neurose and nervous prostration were compared with those of diazepam and chloropromazine as a comparison durg in mice and rate. Effect of Berberis korean Pilibin extracts on the central nervous depressive action were tested by spontaneous movement activity using photoelectrical method, smoked paper method, open field method, sloped plate method and extension of hypnosis time induced with sodium phenoborbital and sodium pentoborbital, and defense against convulsive action induced with picrotoxin and strychnine. Berberis korean Pilibin extracts was found to pharmacollgically expect above various action similar to those of diazepam and chloropromazine but action of sample weaker than that of diazepam and chloropromazine. Aquar extracts was definitely superior to the alcohal extracts in the central nervous depressive action.

제통단이 퇴행성 슬관절염 환자의 삶의 질에 미치는 영향

서병관,류성룡,강중원,우현수,이상훈,이재동,최도영,김건식,이두익,이윤호 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : to evaluate the effects of Jetongdan, the newly developed herbal medicine, on the quality of life in patients with osteoarthritis of knee Methods : Placebo-controlled, randomized clinical trial on the 80 patients with osteoarthritis of the knee was fulfilled. After enrollment, they took medication as they enrolled. And they were asked to answer the questionnaires (Korean Health Assessment Questionnaire (KHAQ), Lequesne's functional index (LF1), visual analogue scale (VAS)) and analysed with the erythrocyte sedimentation rate (ESR) at baseline, after 4 weeks and 8 weeks of medication. Results : Total KHAQ score, some categories of KHAQ like hygiene, activities were significantly improved after 8 weeks of medication. And the change of the KHAQ score was significantly correlated with the change of VAS. But LFI, VAS, ESR level was not significantly improved, and it was considered because of the short medication period and small size of study population. Conclusion : In conclusion, Jetongdan could improve the health-related quality of life in patients with osteoarthritis of knee. Further study in the large population, in long period were recommended.

퇴행성 슬관절염 환자 평가 설문도구의 내적 신뢰도, 상관성에 관한 연구

류성룡,안경애,서병관,강중원,이상훈,이재동,최도영,김건식,이두익,이윤호 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : The aim of this study is to evaluate internal reliability and correlation among assessment instruments of knee OA. Methods : Data were obtained from 85 patients with knee OA. They were asked to answer VAS pain scale, two disease-specific questionnaires (WOMAC and LFI) and one instrument about health-related quality(KHAQ). Reliability was assessed using cronbach's alpha. Correlation was assessed by examining the pearson's correlation coefficients. Results : Cronbach's alpha of all Index except WOMAC stiffness subscale(.6679) exceeded the value of 0.70. A good correlation was obtained between WOMAC Subscale (especially Pain Subscale) and LFI (.726<cronbach's alpha<.791). Also, Correlation between KHAQ and two disease-specific questionnaires (WOMAC and LFI) was good(.612<cronbach's alpha<.662). Conclusions : All used instruments have good internal reliability. also, There are good correlation among them. The treatment of knee OA must be focused on health related quality. For this, we should use proper assessment instruments.

새로운 무기 응집제 개발에 따른 특성

최성우,우성훈,윤철종,곽명화,서향미,박승조 동아대학교 환경문제연구소 2000 硏究報告 Vol.23 No.1

This study has carried out the coagulation tests for tannery wastewater including high-level suspended solids and organic matters to determine the optimum pH and coagulant dosage and to characterize several coagulants for coagulation. In case of optimum pH range test, we know that multi-coagulants are not only cost-effective but also applicable from acidic pH range to alkaline pH range widely, while single-coagulant are useful in limited pH range. Removal efficiency for using of the multi-coagulants appeared more efficient than that of single-coagulant. Especially, sulfates(alum-ferric sulfate : AFS & alum-magnesium sulfate : AMS) are more effective than chlorides (alum-ferric chloride : AFC & alum-magnesium chloride AMC). In comparison of residual turbidity related to settling time between alum and alum-ferric sulfate-magnesium sulfate(AFM), it took to 40 minutes using of alum but 5 minutes using of alum-ferric sulfate-magnesium sulfate(AFM) until constant residual turbidity are reached.

정상 성인에 경구 투여한 Cefixime 두 정제의 생물학적 동등성 비교

강진양,서성훈,이경태,문창훈,강진한,이동건,최정현,신완식 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.4

목적 : 식품의약안전청 고시 제 1998-86호(1998. 8.26) "생물학적 동등성 시험 기준"에 의하여 섹심 캅셀(시험약, 한국유나이트제약)과 슈프락스 캅셀(대조약, 동아제약)의 생물학적 동등성을 비교 검토하였다. 방법 : 2×2 라틴 방격법에 따라 건강한 성인 남성 지원자 20명에게 cefixime 100㎎씩 경구투여하였다. 약제투여 후 12시간까지 일정간격으로 채혈하였고 각 피험자들의 혈중약물농도 데이터로부터 구한 Area under the concentration (AUC), C_(max), T_(max) 등의 생체이용률 파라미터에 대해 통계학적으로 고찰하여 두 제제간의 생물학적 동등성을 평가하였다. 결과 : AUC, C_(max), T_(max)에 대한 평균값의 차가 각각 1.26%, 3.73%, 6.21%로서 모두 대조약의 20% 이내에 들어 생물학적 동등성 판정기준의 전제조건을 만족하였다. 분산분석 결과 AUC, C_(max), T_(max)의 각 비교 항목에 있어서 모두 유의수준 α=0.05의 군/순서효과 검정에서 F비가 F 분석표의 한계값보다 작아 교차시험이 제대로 이루어졌음을 확인할 수 있었으며, AUC, C_(max), T_(max) 각 비교항목에 있어서 유의수준 α=0.05에서 대조약에 대한 최소검출차(Δ)가 각각 17.74%, 17.05%, 15.67%로 모두 20% 이내이었으며, 검출력(1-β)도 모두 0.8 이상으로 나타나 생물학적 동등성 판정기준을 만족시켰다. 또 AUC, C_(max), T_(max) 각 비교항목에 있어서 대조약에 대한 생체이용률 차이의 신뢰한계(δ)가 ±20% 이내이어야 한다는 생물학적 동등성 판정기준을 모두 만족시켰다. 결론 : 이상의 실험결과로 시험약은 대조약에 대하여 생물학적 동등성 평가항목인 AUC, C_(max), T_(max)에서 모두 판정기준을 만족시켜 시험약은 대조약과 생물학적으로 동등하다고 사료된다. Background : The study was designed to compare the bioeqivalence between the test (CEXIME®. United Korea. Co., Ltd) and control (SUPRAX®. Dong-a Pharm. Co.. Ltd) capsules of cefixime. Methods : Twenty. healthy, male volunteers completed the study Each subject ingested single dose (100 ㎍) of the control and test drugs in 2?2 crossover design with a week drug-free interval between the doses. Blood samples were collected serially up to 12 hours and plasma concentrations of cefixime were measured by high-performance liquid chromatography with UV detection. A non-compartmental approach was used for analysis of the concentration-time data. Results : The area under the curve (AUC), the maximum concentration of drug (C_(max)). and time to reach C_(max)(T_(max)) did not show any significant difference between the two preparations by ANOVA. The mean differences of AUC, C_(max), and T_(max) were within 20% of the control drug, those were 1.26%. 3.73%. and 6.21%. respectively. The confidence limits of three parameters were satisfied the bioeqivalence criteria. Conclusion : These results suggest that the test drug was bioequivalent with the control drug.