간호사에서 항암제 취급양상과 건강증상

신혜숙,이세훈 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

To evaluate the subjective symptoms among nurses handling anticancer drugs, we investigated symptom prevalence in 487 nurses exposed to anticancer drugs and 242 control nurses, who are working at 14 university hospitals in Korea by self-administered questionnaire. Safety regulations for handling anticancer drugs in these hospitals as well as the level of knowledge on safety rules of them among nurses were also evaluated. The results were as follows: 1. Only 1.5% of nurses used the biological safety cabinet always, 32.7% could not use it during evening time and on holidays, and 65.8% could not use at all since lack of it. When nurses prepared anticancer drugs, they were gloves(49.7%), gown(7.2%), goggle(1.6%), and mask(11.5%). And 46.1% of them answered that they ate and drank in the anticancer drugs preparation room. 2. The level of knowledge on safety rules of anticancer drugs were generally low in both exposed(12.7/17 items) and control(12.7/17 items) group. The questions which nurses answered wrong exceeded fifty percent were : the possibility of exposing to anticancer drugs when they correct their make-ups; and when they handled body fluids of cancer patients. Only 20.3% of the nurses were acknowledged with the hours for the cancer patients' body fluids being considered to be contaminated after receiving chemotherapy. 3. The prevalence of allergic disease was higher in exposed group than in control group. Among 43 symptoms of total, the prevalence of 10 symptoms (nausea, skin rash, itching, chronic throat irritation, tachycardia, alopecia, skin hyper pigmentation, loss of libido, leukopenia, thrombocytopenia) were higher in exposed group than in control group. 4. The prevalence of ten symptoms which showed higher prevalence in exposed group was significantly correlated with eating and drinking in the preparation room for anticancer drugs, the degree of skin contact with anticancer drugs, and the amount of anticancer handling them, and BMI. It was shown that eating and drinking in anticancer drug preparation room, and the amount of handling them, significantly affected the prevalence of 10 symptoms among nurses exposed after stepwise multiple regression analysis. The results of this study suggest that nurses handling anticancer drugs have potential risk of exposure to anticancer drugs, and the preventive measures for the protection of nurses' health be needed by education, and improvement of their working environment.

Hydantoin계 유도체의 COX-2 저해활성

신혜순,박해선,박명숙 德成女子大學校 藥學硏究所 2003 藥學論文誌 Vol.14 No.1

For the selective candidates of COX-2 inhibitors, we designed new NSAIDs which is the hydantoin ring based structure substituted with two planar aromatic ring. Seven O-alkyl a-anilinophenylacetate were synthesized through the base-catalysis hydrolysis of 1,5-diarylhydantoins and O-alkylation of sodium a- anilinophenylacetate with alkyl halides. To evaluate inhibitory effect of COX-2. synthetic hydantoin ring based derivatives were screened with accumulation of prostaglandin by lipopolysaccharide in aspirin-treated murine macropharge cell. Most of these compounds inhibited less than 60% of the prostaglandin E_(2) production at a concentration of 10μg/mL.

Cyclooxygenase-2 저해제로서의 benzothiazine 유도체 합성과 항염작용 평가

신혜순,박명숙,권순경 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1

The antiinflammatory mechanism of NSAIDs is attributed to the reduction of prostaglandin synthesis by the direct inhibition of cyclooxygenase. Inhibition of prostaglandin production in organs such as stomach and kidney can result in gastric lesions, nephrotoxicity and increased bleeding. In this study, newly designed COX-2 inhibitors, synthesized 1,2-benzothiazine derivatives, were screened in vitro for selectivity of COX-1 and COX-2 inhibition properties. Lead compounds in the structure-activity relationship were studied to synthesize new highly selective COX-2 inhibitors. To determine inhibitory effect of COX-2, synthesized 1,2-benzothiazine derivatives were screened with accumulation of prostaglandin by lipopolysaccharide (LPS) in aspirin-treated macrophages and murine macropharge cell. Some of synthesized 1,2-benzothiazine derivatives were shown to be effective as selective COX-2 inhibitory activity. Others exhibited a preferential inhibition of COX-2, although some COX-1 inhibitory activity was still present. As a conclusion, simple monomer derivatives were more active than dimer derivatives. Substitution of halogen (Br, Cl) on the benzothiazine nucleus slightly enhanced inhibition activity.

두경부 암환자의 항암화학요법에 따른 삶의 질 변화

신혜숙,박혜자,박명희,연기순,김훈교,문한림,송혜향 가톨릭대학교 가톨릭대학교 간호대학 호스피스 교육연구소 1999 호스피스논집 Vol.4 No.-

The purpose of this study was to assess the changes in quality of life wish elapse of chemotherapy in head and neck cancer patients. This study was a longitudinal descriptive design. The subjects were 9 patients who had stage III and stage IV head and neck cancer and received neoadjuvant cisplatin and 5-fluorouracil chemotherapy. Linear Analogue Self Assessment Scale (LASA) of the QOL which it includes eleven items(seven physical items appetite, nausea/vomiting, physical well-being, vigor activity, energy, sleepiness, fatigue and four mental items anger, anxiety, depression & vital power) were used to assess the quality of life eleven times(once in the prechemotherapy period and from the 1st day to 10th day postchemotherapy). The means of scores at each time were analyzed by repealed measures of ANOVA and Bonferroni multiple comparison method. The results are as follows : 1. The degree of appetites decreased significantly on the period between third and sixth day compared with that of appetites on the prechemotherapy day (p<0.001). 2. The degree of physical well-being decreased significantly on the period between first and fifth day compared with that of physical well-being on the prechemotherapy day (p<0.001). 3. The degree of nausea/vomiting decreased significantly on the period between first and fourth day compared with that of appetites on the prechemotherapy day (p<0.001). 4. The degree of anger decreased significantly on the second, fourth, eighth and ninth day after chemotherapy compared with that of anger on the prechemotherapy day(p<0.001). 5. The degree of fatigue decreased significantly on the fourth day compared with that of fatigue on the prechemotherapy day(p<0.001). 6. The increment of nausea/vomiting and poor appetite started on the 2.89th day and 3.67th day after chemotherapy, respectively. 7. The increment of sleepiness started on the 2.56th day after chemotherapy. 8. The increment of depression and anxiety started on the 2.33th day and 3.33th day after chemotherapy, respectively. 9. The lowest degrees of nausea/vomiting and poor appetite were 37.00±17.9 % and 28.64±14.94 % after chemotherapy compared with those of nausea/vomiting and poor appetite on the prechemotherapy day, respectively. 10. The lowest degrees of anger and vigor activity were 48.12±28.3 % and 39.83±24.9 % after chemotherapy compared with those of anger and vigor activity on the prechemotherapy day, respectively. 11. The recovery rates of eight items of quality of life (appetite, vigor activity, energy, fatigue, anger, anxiety, depression & vital power) were shown to reach a peak on the tenth day after chemotherapy and be reached to almost 84 % compared with those of quality of life on the prechemotherapy day. 12. The recovery rates of physical well-being and sleepiness were shown to reach to 67.75 % and 95.68 % on the 10th day after chemotherapy compared with those of physical well-belong and sleepiness on the prechemotherapy day. 13. The recovery rates of seven physical items were faster than those of four mental items on the 10th day after chemotherapy. In conclusion, it is suggested that nursing care strategies to improve the quality of life in patients with chemotherapy would be established both physically and mentally, and be extended at least ten days when patients stayed their home after chemotherapy.

한방병원에서 가정의학과 진료 내용 분석

원진숙,신선호,김혜정 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Background: Recently social requirement for collaborated treatment of medical practice with oriental medicine has been increasing. This study is designed to provide the guidance of role of family medicine physician in oriental medicine hospital to help the establishment of interdepartmental cooperation between western and oriental medicines. Methods: Medical records of a total 973 patients administered in Chonju Oriental Medical Hospital of Wonkwang University from January Ito June 30 were reviewed. Data including sex, age distribution, periods of administration, past history, major clinical manifestations, diagnosis, laboratory tests, medications were collected and expressed as a percentage. The classification of Diseases was made according to ICPC. Results: Of 973 patients, sex ratio was 1:1.4 with female predominance and age distribution was highest in fifties and sixties (48%). Past history was dominated in cardiovascular disease (30.1%), postoperative sequele (16.4%) and diabetes (12.2%). Chief complains were ordered in frequency as arthralgia and myalgia (42%), hemiplegia (26%), dysphagia (17%), headache (13.8%), dizziness and vertigo (11.5%). Major diagnoses were cerebrosclerosis (39.7%), HNP (21.4%), cerebral hemorrage (11.2%) and arthritis (8.79%). Diseases of the administered patients were classified as cardiovascular (50.8%), musculoskeletal (31.8%), gastrointestinal (6.2%) and nervous systems. Conclusion: The main categories of the patients who were aided by family medicine physician in oriental medicine hospital were chronic debilitating diseases including cardiovascular disease and diabetes. To establish an effective collaboration of family medicine physicians in oriental medicine hospital, the doctors needed expert skills for treatment of supportive cares of chronic degenerative diseases and their complications.

플라바논의 아자 유도체인 새로운 2,3-디하이드로-2-페닐-4-퀴놀론 유도체의 간편한 합성 : Aza Analogs of Flavanones

박명숙,신혜순 德成女子大學校 藥學硏究所 2003 藥學論文誌 Vol.14 No.1

A series of 2,3-dihydro-2-phynyl-4-quinolones 6a-c have been synthesized using acid-catalyzed one-pot reaction. 2,3-Dihydro-2-phyenylquinolone was synthesized from aniline by condensation with ethyl benzoylacetate followed by a cyclization in toluene. Similarly, the 6-substituted 2,3-dihydro-2-phylquinolones were prepared from the para-substituted aniline. The reaction mechanism of the formation of the final product involves the nucleophilic dehydration and following cyclization between aniline and ethyl benzoylacetate. Nucleophilic dehydration, the condensation was undertaken with p-toluenesulfonic acid at 90-110℃ in toluene for 2-6 hours under the dean-stark apparatus for the ester 3. The ester 3 was continuously converted to the 2-phenylquinolones 6 with dihydrogenation and removal of ethanol. All synthetic process from anilines and ethyl benzoylacetate to 2,3-dihydro-2-phenyl-4-quinolones 6a-c could be carried out in one-pot reaction.

성인교육으로서의 MBTI 전문교육에 대한 인론적 고찰

심혜숙,신영규 한국심리유형학회 2002 심리유형과 인간발달 Vol.9 No.-

본 연구는 심리유형론을 바탕으로 하는 MBTI 전문교육을 성인교육의 관점에서 고찰하고자 하였다. 성인교육에 관해 살펴본 다음, MBTI 교육의 목적, 철학 및 기본전제와 단계, 그리고 지도자의 역할을 성인교육의 관점에서 이론적으로 비교 분석하였다. 그 결과 성인교육의 원리인, 자발성의 원리, 경험의 원리, 다양성의 원리, 실용성의 원리가 MBTI 교육에 적용되고 있음이 논의되었다. 그리고 MBTI 전문교육이 학습목표, 학습계획, 학습자의 욕구진단, 실행과 평가에 있어 학습자가 관여되는 성인교육으로써 실제 진행되고 있음이 밝혀졌다. 따라서 MBTI 전문교육이 정보와 기술 전달의 수동적 주입식 교육이기보다 자기 성장을 지향하는 자기 주도적 성인교육으로 진행되고 있음이 분석되었다. The purpose of this study was to examine the MBTI qualifying education in the context of adult education theory. Thus the MBTI qualifying education was analized in terms of the goal, philosophy, basic beliefs, program structure, facilitator's role and educational steps of the adult education theory. The analysis pointed out that there is no difference between the MBTI qualifying education and adult education in above mentioned areas. Moreover, the results of the comparative analysis showed that the workshop style of program setting, the emphasis on the warming up phase, and the learners' active participation in learning schedule, goal, and evaluation which are the basics of adult learning embed in the MBTI qualifying education. Therefore the literature research shows that the MBTI qualifying education is a self-directed learning adult education which meet the adult need to fulfill the on-going desire for growth.

COX-2 Inhibitors를 위한 새로운 1,2-치환된 피롤리딘 유도체의 합성

박명숙,신혜순 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1

For the development of new COX-2 inhibitor, novel compounds were synthesized through induction an arylsulfony group to 1-position, an arylcarboxamidyl group to 2-position and an aralkyl group to 4-position of L-proline. The 4-aralkyloxy-1-(4-methylphenylsulfonyl)-L-prolines 5a-d were synthesized through N-tosylation, esterification, O-alkyl-(or aryl)ation, base-hydrolysis (deprotection of carboxylic acid) from 4-hydroxy-L-proline. Final 4-aralkyloxy-1-(4-methylphenylsulfonyl)-2-phenylcarboxamidyl-L-prolines 6a-d were synthesized through the condensation of aniline with 5a-d using DCC.

학령전기 아동의 심적 표상 : ASSOCIATION WITH PARENTAL MENTAL REPRESENTATION 부모에 대한 심적 표상과의 관계를 중심으로

이혜란,신의진,이경숙 대한소아ㆍ청소년정신의학회 1999 소아청소년정신의학 Vol.10 No.1

Nifedipine 투여가 선천성 고혈압 쥐의 CYP1A1과 2B1 유도에 미치는 영향

홍영숙,김형래,박혜영,배영숙,박상신 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.3

Cytochrome P-450(CYP) enzymes are important in catalyzing the hiotransffrmation on manyendogeneous compounds and xenobiotics, including drugs and carcinogens. In the presentstudy, effect of nifedipine a voltage dependent calcium channel blocker on the induction ofCYP1A1 and 2B1 was investigated. Change of CYP1A1 and 2B1 activities were measuredby using specific enzyme activities and Western blot analysis. CYP1A1, as quantified by ethoxyresorufin-0-deethylase activity and Western blot with monoclonal antibody 1-7-1, increasedin liver microsome of nifedipine-treated spontaneous hypertensive rat(SHR. 30mg/kg.b.w, twicea day for 3days) but not in kidney microsome. CYP2B1, as quantified by benzyloxyresorufin-O-dealkylase activity and Western blot wit]1 monoclonal antibody 2-66-3, markedly increasedin liver microsome of nifedipine-treated SHR but slightly in kidney microsome. The resultsdemonstrate that nifedipine is a potent inducer of CYP2B1 in SHR.