Ca^(2+)-ATPase에 대한 Steroid Hormone의 영향

정병선 부산의대 1983 부산의대잡지 - 부산대학교 의과대학 Vol.23 No.2

링 앞 휘돌아 물구나무서기 동작의 운동학적 분석

류지선,정남주,강병의 韓國體育大學校附屬 體育科學硏究所 1997 韓國體育大學校附屬 體育科學硏究所論文集 Vol.16 No.1

The purpose of this study is to examine the kinematical factors of Felge upward with straight arms to handstand motion, and to grope for the better Felge motion or dismount motion using the Felge motion on the Rings. As the subjects, six gymnasts(KOR 2, JPN 2, CHN 2) who participated in the 1997 Pusan East Asian Games(men's team competition Ⅰ). Two S-VHS video cameras were used for the data collection. The Direct Linear Transformation(DLT) technique was employed to obtain 3-D position coordinates of 30 control object points and 18 landmarks. A cubic spline function was used for smoothing and differentiation. And the following conclusions were drawn; 1. Down swing phase : It indicated that the longer vertical and horizontal displacement of CM were the smaller in vertical position of CM after the first handstand. Also it showed that the large extension of shoulder and hip joint resulted in the fast downward velocity at the Beating. 2. Beating swing phase : It indicated that the factors influencing the angular velocity of shoulder and hip joints and the horizontal velocity of the CM were the large downward vertical velocity during downswing phase, and the hip angle and position at the Beating. 3. Felge swing phase : It indicated that the large upward velocity and the small angular velocity of the shoulder and hip joints and the small horizontal velocity of the CM have the advantage of performing the last handstand motion.

O^(-)₂생산 NADPH oxidase의 활성화에 대한 연구

한창섭,정병선 부산의대 1988 부산의대잡지 - 부산대학교 의과대학 Vol.28 No.2

환기정도에 따른 수술실용 신발 종류가 수술실 오염에 미치는 영향 : How to Choose Suitable Shoes?

남경동,정혜선,박영신,원진희,주미자,성화신,이지혜,이병희,조경숙,배재춘 한국의료QA학회 2000 한국의료질향상학회지 Vol.7 No.1

Background : Various types of protective footwear have been used to minimize bacterial contamination in operating rooms. In recent years, debate has arisen concerning the need for use of such protective footwear. This study was designed to provide useful data about choosing shoes most suitable for the surgical environment. Methods : Between November, 1999 and January, 2000, we performed this experimental study by comparing effect of three types of shoes (i.e., disposable shoescover, operating room-restricted shoes, and ordinary shoes) on bacterial contamination of operating rooms equipped with two different ventilation systems (i.e., high air-change, low air-change) respectively. Data were collected during two-hour sham operations in which subjects and their activities were strictly standardized. Bacterial flora were sampled from the study area floor and air colony-counts were measured. Results : In experiments involving high air-change ventilation system, there was a significant difference of floor contamination between three types of shoes, but no difference of air contamination. Under low air-change system, there was a significant difference of both floor and air contamination between three types of shoes. Conclusion : The results show that protective footwear would be unnecessary in the operating room with high air-change ventilation system, but it is important to choose suitable shoes carefully under low air-change system. Therefore, the use of outdoor shoes can be considered under high air-change system, but it would seem sensible to apply their first use in less bloody operations at the day surgery center or out-patient department to prevent transfer of body fluid into the outside environment.

신합성 물질인 Protein kinase A 억제제, H-87의 MDR1 유전자 발현의 조절

박주인,김선희,정병선 부산대학교 유전공학연구소 1992 분자생물학 연구보 Vol.8 No.-

In this study, we examined the effect of H-87, specific inhibitor of protein kinase A, on in vitro sensitivities of mouse leukemia cell line P388 resistant to several antitumor agents. H-87 significantly potentiated the cytotoxic effects of ADM, VCR and VBL on P388 cells resistant to these antitumor agents. Thus we examined the mechanism of overcoming multidrug resistance by H-87. In northern blot analysis, H-87-treated resistant P388 cell lines showed less MDR1 gene expression than untreated control cells. As a result of CAT assay, the expression of MDRI promoter was inhibited by H-87 in a concentration-dependent manner. To compare the effect of H-87 with that of staurosporine(PKC inhibitor), we examined the effect of staurosporine on in vitro sensitivities of mouse leukemia cell line resistant to several antitumor agents. The expression of MDR1 gene in multidrug resistant P388 cells was decreased by staurosporine. The activity of MDR1 promoter was increased by TPA(PKC activator) and forskolin(adenylate cyclase activator). Therefore, we speculate that PKA and PKC may play important roles in the regulation of MDRI gene expression.

JPEG에서 필터를 이용한 압축률 개선에 관한 연구

申仁澈,金成鍾,鄭炳善 단국대학교 1995 論文集 Vol.29 No.-

Recently the application of the digital image processing has been increased with technical advances in digital computers. It is necessary to compress the digital image data in order to store and transmit it with real time. It is possible to redisplay the relatively exact image and decrease bandwidth of transmission path with the reduced information by compression. JPEG in ISO and CCITT defines the standard compression and restoration algorithm for grayscale and color still image. In this paper, we propose a method of decreasing higher frequency component and increasing spatial redundancy in image, and the compression ratio. In order to decrease higher frequency components of the images, various filters were used in the preprocessing. Compression ratio and processing time were compared. Results shows the enhanced compression ratio without damage of image quality by using filter in JPEG.

선반 기어박스의 기어열 - 축계 진동 해석 및 저감에 관한 연구

최영휴,박선균,배병태,정택수,김청수 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

In this study, torsional and lateral vibrations of a gear box transmission system were analyzed theoretically using some mathematical models and examined to determine the causes of its excessive vibrations. As the results, it was found there exist possibility of resonance between gear mesh frequencies and lateral vibration mode of the transmission shaft during the third shifting mode operation. In order to avoid this resonance, we proposed changing the arrangement of gears on the transmission shaft. The measured vibration levels of the improved gear box were dramatically reduced. These results may be helpful to design a machine tool gear box with low noise and vibration.

NC선반 기어박스의 기어열 : 축계 진동해석 Spindle System for an NC Lathe Gear Box

최영휴,박선균,배병태,정택수,김청수 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-

In this study, two mathematical models are first constructed to analyze vibration characteristics of a gear train - spindle system of an NC lathe gear box. One is a lumped parameter model which is used for calculating natural frequencies of the torsional vibration, the other is a finite element model for analyzing lateral vibration and critical speeds of the spindle system. In addition, this study examines some possible resonance conditions such as gear mesh frequencies, IX shaft rpm frequencies over whole operating speed range, and so on. The results may be helpful to design a machine tool gear box with low noise and vibration.

Phosphorylation modulators에 의한 항암제 다제내성 유전자의 발현 조절

김선희,곽남희,강치덕,정병선 부산대학교 유전공학연구소 1995 분자생물학 연구보 Vol.11 No.-

암을 치료함에 있어서 항암제에 대한 다제내성(MDR)의 획득이 중대한 장애로서 지적되고 있으며, MDR 현상은 MDRI 유전자의 과잉 발현에 의한 것으로 알려져 있다. MDRI promoter 활성이 mutated ras 또는 raf-1 발현에 의하여 증강되는 현상을 좀 더 명확히 하기 위하여 암 환자의 조직검체를 사용하여 RNA slot-blot 분석법으로 MDRI 유전자의 발현과 이들 암 유전자의 발현과의 관련성을 조사하였다. 3개의 대장암 검체에서 이들 암유전자의 높은 발현과 함께 MDRI gene도 높은 발현을 나타내었다. Raf-1에 의한 MDRI promoter의 최대 활성 증강을 나타내는 DNA 배열은 이 promoter 영역내의 HSE 영역과 일치하며, 또한 이 promoter에 작용하는 regulatory clement가 has70 promoter와 매우 유사하여 heat-induced(42℃) p432-CAT 발현에 있어 protein phosphatase inhibitor의 효과를 조사하였다. Okadaic acid나 calyculin은 농도 의존적으로 heat-induced p432-CAT의 발현을 증강시켰다. 또한 p56-CAT 발현이 forskolin에 의한 증강 또는 H-87에 의한 감소를 나타내어 이러한 현상은 MDRI promoter내의 CRE 유사 배열이 기능을 나타내는 것으로 사료되어 MDRI promoter가 has70 promoter와 유사하게 조절되며, Raf-1 발현에 의한 MDRI promoter의 활성화는 MDRI promoter내에 존재하는 HSE와 관련됨을 시사하였다. Multidrug resistance(MDR) poses a serious clinical problem in chemotherapy of cancer. MDR results from overexpression of the MDRI gene which encodes a drug-efflux pump called P-glycoprotein. To confirm our observation that the expression of mutated ras or raf-1 gene increased MDRI promoter activity, it was examined whether MDRI gene expression were correlated with the expression of these oncogenes in clinical tumor samples using RNA slot-blot analysis. These oncogenes were correlated with the expression of MDRI gene in 3 colon tumor samples. Since DNA sequence exhibiting maximum activation of MDRI promoter by Raf-1 is associated with heat shock element of MDRI promoter region, and regulatory element contained in MDRI promoter is very similar to that of hsp70 promoter. The effects of okadaic acid or calyculin on the heat-induced(42℃) expression of p432-CAT were determined. Okadaic acid or calyculin A potentiated the heat-induced expression of p432-CAT in dose-dependent manner. In addition, stimulation or inhibition of p56-CAT expression by forskolin or H-87, respectively suggests functional operation of CRE element in MDRI promoter. It is suggested that the regulation of MDRI promoter activity is very similar to that of hap70 promoter.

cis-platin에 의한 급성구토예방의 Dexamethasone의 4가지 정주량의 비교

김원,강지은,서영선,이동민,서정균,신병철,정기영,박유환,정춘해 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

B5-hydroxytryptamine _3수용체(5-HT_3) 길항제와 dexamethasone의 동시투여가 cis-platin에 의한 급성 구토를 막는데 가장 효과적이다. 그러나 현재까지 가장 적절한 정주dexamethasone의 용량이 알려져 있지 않았다. 이에 dexamethasone의 4가지 다른 용량을 투여하여 그 효과를 비교하였다. 환자는 임의 추출되어 cis-platin 투여 45분전에 15분 동안 정주로 각각 dexamethasone 5, 10, 15, 20 mg을 투여 받았다. cis-platin 투여 30분전에는 ondansetron 8 mg이 부가하여 정주 되었다. 1999년 3월부터 2000년 2월까지 54명의 환자가 연구에 등록되어졌고 53명의 환자가 연구 대상으로 실험에 4군 (dexamethasone 5 mg 13명, 10 mg 14명, 15 mg 13명, 20 mg 13명)으로 나뉘어 평가 되어졌다. 급성구토와 구역질의 완전한 예방은 dexamethasone 5 mg을 투여 받은 환자에서 각각 69.2%, 60.9%, dexamethasone 10 mg을 투여 환자에서 69.1%, 61%, dexamethasone 15 mg 투여 환자에서 78.5%, 66.9%, dexamethasone 20 mg을 투여 환자에서 83.2%, 71.0%로 나타났다. 구토로부터 완전한 예방은 dexamethasone 20 mg을 투여 환자에서 5, 10 mg을 투여 환자와 비교하여 높았고, dexamethasone 15 mg을 투여 군에 비교하여서는 약간 우수한 효과만 있었다. 구역질으로부터의 완전한 예방도 월등한 것은 아닐지라도 20 mg을 받은 환자에서 높았다. 항 구토 치료는 특별한 불편 없이 조절되었고, 부작용의 발생에서 4가지그룹간에는 커다란 차이가 발견되지 않았다. Dexamethasone의 20 mg 정주양이 cis-platin으로 인한 급성구토를 예방하는데 가장 효과적인 예방량으로 사료되어진다. Background and objective: A 5-hydroxytryptamine _3(5-HT_3) receptor antagonist plus dexamethasone is the most efficacious antiemetic prophylactic treatment for the prevention of cis-platin induced acute emesis, but the optimal intraveous (Ⅳ) dose of dexamethasone is unknown. This prompted us to perform a randomized, double-blind, dose-finding study that compared four different doses of dexamethasone. Materials and Methods: Patients were randomized to receive dexamethasone, either 5, 10, 15, 20 mg, administered by 15-minute Ⅳ infusion 45 minutes before cis-platin. Ondansetron 8 mg was added to dexamethasone and was administered Ⅳ 30 minutes before cis-platin. From March 1999 to February 2000, 54 patients were enrolled onto the study and 53 were assessable according to the intention-to-treat principle (13 patients received 5 mg; 14 patients, 10 mg; 13 patients, 15 mg and 13 patients, 20 mg of dexamethasone). Results: Complete protection from acute vomiting and nausea was achieved by 69.2% and 60.9% of patients, respectively, who received 5 mg of dexamethasone, by 69.1% and 61.0% of those who received 10 mg, by 78.5% and 66.9% of those who received 15 mg, and by 83.2% and 71.0% of those who received 20 mg of dexamethasone. Complete protection from vomiting was significantly superior in patients who received 20 mg compared with those who received 5 and 10 mg of dexamethasone (P<05) and was superior, but not significantly, compared with those who received 15mg. Complete protection from nausea was superior, but not significantly, in patients who received 20 mg of dekamethasone. Multifactorial analysis confirmed these results. Antiemetic treatment was well tolerated, and no significant difference was found among the four groups in the incidence of adverse events. Conclusion: A 20mg single Ⅳ dose of dexamethasone should be considered the most efficacious prophylactic dose for the prevention of ois-platin induced acute amesis in treatment of cancer.