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Structure-Activity Relationship Study of Asiatic Acid Derivatives for New Wound Healing Agent
정병선 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.7
Ten semi-synthetic derivatives of asiatic acid were prepared and their wound healing effects were evaluated by employing a tensile strength assay and a wound area assay. Among them, ethoxymethyl 2-oxo-3,23-isopropylidene-asiatate (12) showed the strongest and the fastest wound healing activity. Furthermore, it left the smallest scar after healing.
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Modification of C2 Functional Group on Asiatic Acid and the Evaluation of Hepatoprotective Effects
정병선,Mi Kyeong Lee,Young Choong Kim,이응석 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
For the development of novel hepatoprotective agents, C2 functional group on asiatic acid was modified, and evaluated for their hepatoprotective effects. Among prepared compounds, compounds 10 and 14 showed better hepatoprotective effects compared to silymarin.
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鄭炳璇 세종대학교 1985 세종대학 논문집 Vol.12 No.이공
Red pepper has greatly influenced our food life since it was first introduced in Korea in the seventeenth century. As a nutritious seasoning it gives a distinctive flavor and color to food and preserves food effectively. People use red pepper in making typical Korean foods Kimchi and Kochujang which form our unique food culture. This study will show the introduction of red pepper, its uses as a food and medicine, proverbs about it, and its production and consumption revealed in old and modern documents.
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放射線을 利用하는 食品 保藏에 關한 硏究 : Ⅲ. Preservation of the Dried Laver Ⅲ. 乾海苔 保藏에 關하여
鄭炳璇 釜山水産大學校 1963 釜山水産大學 硏究報告 Vol.5 No.1
Proximate composition, some enzymes were examined and also the posibility of application of γ-Rays for preservation of the laver was tested. Proximate composition, such as crude protein, crnde fat, free Amino Acid-N correlated well with the quality of the dried laver. Catalase, peroxidase and also possibly lipase might cause the deteriolation of the dried laver. Application of γ-Rays radiation upon the laver will be a good means of preservation of the laver without any discoloration, Change of flavor, or less of nutrients.
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농촌지역 우울증 고위험군에서 만성 의학적 질환과 우울증상 : 1년 추적관찰 연구
정병선,이동윤,최재원,오희옥,강경희,이선숙,김봉조,이철순,이소진,서지영,이영지,차보석,박철수 대한생물치료정신의학회 2019 생물치료정신의학 Vol.25 No.3
Objectives:This study investigated the effects of chronic medical diseases on depressive symptoms in individuals at high risk for depression living in rural areas, over a 1-year period. Methods:A community-based longitudinal study was conducted; 67 participants aged 18-79 years residing in rural areas were included. In the first survey, all participants completed a self-report questionnaire battery. An interview was also conducted to obtain data on demographic variables and current or past chronic medical diseases. In the first survey, participants with the Center for Epidemiologic Studies Depression scale(CES-D) scores of 16 or higher were categorized as being at high risk for depression; the same assessments were carried out 1 year later in a follow-up survey. Multiple regression analysis was performed to determine the association of chronic medical diseases with 1-year follow-up depressive symptoms in the high-risk group. Results:In model 1, which controlled for sociodemographic variables, the number of chronic medical diseases ( p =0.026), baseline severity of depressive symptoms( p =0.002), and presence of diabetes( p =0.039) were significantly associated with the follow-up CES-D scores. In model 2, which further adjusted for Alcohol Use Disorder Identification Test and Beck Anxiety Inventory scores, the number of chronic medical diseases( p =0.036), baseline severity of depressive symptoms( p =0.017), and prevalence of diabetes( p =0.037) were also significantly associated with the follow-up CES-D scores. Conclusion:This study suggests that the number of chronic medical diseases, prevalence of diabetes, and severity of depressive symptoms are significantly associated with 1-year follow-up depressive symptoms in individuals at high risk for depression.
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정병선,김혁 한국유교학회 2015 유교사상문화연구 Vol. No.
This paper explores the social and economic implications of the Profit and Loss Hexagrams(損益卦) in the Zhou’s Book of Changes(周易). This study hopes to find the way of applying the wisdom of Zhou’s Book of Changes to the social and economic problems of these days. Generally, the profit and loss concepts are regarded that loss be avoided and the profit be pursued based on the meaning of profit and loss. However the Profit and Loss Hexagrams in the Zhou’s Book of Changes reveal the secret of the rising and fall aspects of each situation. The Book of Changes says that the yin(陰) includes the yang(陽) in the inner part and that the yang also includes the yin. Likewise, the Loss Hexagram includes the meaning of profit and the Profit Hexagram includes the meaning of loss. We now encounter the social and economic problems of conflict arising from the free market and economic structure such as unemployment, welfare, distribution of wealth, etc. The wisdom of the Profit and Loss Hexagrams, as a kind of economic ethical criterion show the way to solve the social conflict problems by considering the meaning of Loss-down and Profit-up(損下益上) and Profit-down and Loss-up(損上益下). Also the Profit and Loss Dao(損益道) which pursues the ceaseless rebalancing virtue of Shizhong(時中) would be applied to the government policy to restore social equity and the business management. 본 연구의 목적은 『周易』의 損卦와 益卦가 내포하고 있는 경제적 含意를 밝혀내어 이를 현실의 경제 문제에 적용하는 방법을 모색하는 데 있다. 금전만능주의에 물든 자본주의 경제체제에서 損益은 가장 민감한 개념이요 용어라 할 수 있다. 일반적으로 損益의 개념에는 利害得失이 반영되어 損은 害로운 것이므로 피해야 하는 것이고 益은 利로운 것이므로 취해야 하는 것이라는 가치개념과 선택의식이 포함되어 있다. 그러나 덜어내고 보탬의 相補的 관계를 밝히고 있는 『周易』의 損·益卦에는 이런 表皮的인 의미를 넘어 盈虛消息의 변화와 순환원리가 내재되어 있다. 利害禍福의 道理이자 治國의 원리인 損益之道는 儒家의 정치, 윤리 사상을 반영하고 있다. 儒敎哲學에서 ‘經世濟民’은 국가와 사회를 바르게 경영하고 백성을 구제하는 정치·경제·사회·문화의 모든 방면에 걸친 구체적 실천 과제와 원리를 의미한다. 儒敎를 정치의 근본으로 삼은 조선시대의 經世家들은 損下益上, 損上益下로 요약할 수 있는 損·益卦의 원리를 현실의 경제문제를 해결하는 패러다임으로 활용했다. 자유 시장 경제체제의 弊害인 과도한 私的 이윤추구, 富의 集中 현상 등으로 경제적 불균형이 심화되면서 현대 사회는 고용과 복지, 분배 등의 영역에서 여러 가지 문제를 露呈하고 있다. 특히, 세계 금융 위기 이후 불황에 따른 富의 양극화가 급속도로 진행되고 사회적 대립과 갈등은 증폭되어 사회공동체의 존립과 삶의 질을 위협받는 지경에 이르렀다. 그러나 손실은 무조건 회피하고 이익만을 추구하려는 인간의 집착과 욕망을 조절하는데 실패한 기존의 경제이론은 신자유주의 시장경제의 문제점을 극복하지 못하고 있다. 이런 상황에서 互惠와 相生을 根幹으로 하는 損下益上, 損上益下의 원리는 현대사회의 갈등을 解消할 수 있는 지혜를 제시한다. 또한, 時中으로 조화와 균형을 추구하는 損益之道는 복잡하게 변화하는 경제 환경에서 사회적 형평(social equity)을 회복할 수 있는 국가의 경제정책은 물론 기업 경영에도 적용할 수 있을 것이다.
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