가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화

김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.

Identification of a sensitive urinary biomarker, selenium-binding protein 1, for early detection of acute kidney injury

Kim, Kyeong Seok,Yang, Hun Yong,Song, Hosup,Kang, Ye Rim,Kwon, JiHoon,An, JiHye,Son, Ji Yeon,Kwack, Seung Jun,Kim, Young-Mi,Bae, Ok-Nam,Ahn, Mee-Young,Lee, Jaewon,Yoon, Sungpil,Lee, Byung μ,Kim, Hyung TAYLOR & FRANCIS 2017 Journal of Toxicology and Environmental Health Vol.80 No.9

<P>Acute kidney injury (AKI) is associated with increased mortality rate in patients but clinically available biomarkers for disease detection are currently not available. Recently, a new biomarker, selenium-binding protein 1 (SBP1), was identified for detection of nephrotoxicity using proteomic analysis. The aim of this study was to assess the sensitivity of urinary SBP1 levels as an early detection of AKI using animal models such as cisplatin or ischemia/reperfusion (I/R). Sprague-Dawley rats were injected with cisplatin (6 mg/kg, once i.p.) and sacrificed at 1, 3, or 5 days after treatment. Ischemia was achieved by bilaterally occluding both kidneys with a microvascular clamp for 45 min and verified visually by a change in tissue color. After post-reperfusion, urine samples were collected at 9, 24, and 48 hr intervals. Urinary excretion of protein-based biomarkers was measured by Western blot analysis. In cisplatin-treated rats, mild histopathologic alterations were noted at day 1 which became severe at day 3. Blood urea nitrogen (BUN) and serum creatinine (SCr) levels were significantly increased at day 3. Levels of urinary excretion of SBP1, neutrophil gelatinase-associated lipocalin (NGAL), and a tissue inhibitor of metalloproteinase-1 (TIMP-1) were markedly elevated at day 3 and 5 following drug treatment. In the vehicle-treated I/R group, serum levels of BUN and SCr and AST activity were significantly increased compared to sham. Urinary excretion of SBP1 and NGAL rose markedly following I/R. The urinary levels of SBP1, NGAL, TIMP-1, and KIM-1 proteins excreted by AKI patients and normal subjects were compared. Among these proteins, a marked rise in SBP1 was observed in urine of patients with AKI compared to normal subjects. Based upon receiver-operator curves (ROC), SBP1 displayed a higher area under the curve (AUC) scores than levels of SCr, BUN, total protein, and glucose. In particular, SBP1 protein was readily detected in small amounts of urine without purification. Data thus indicate that urinary excretion of SBP1 may be useful as a reliable biomarker for early diagnosis of AKI in patients.</P>

Thermal Expansion Behavior of Thermally Expandable Microspheres Prepared by Suspension Polymerization Using P(AN-MMA-MAA) Core/Shell

Hyun Tae Kim,Ashok Kumar Jaladi,Yong Jin Lee,Duk Keun An 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.2

Thermally expandable microspheres (TEMs) have widespread industrial applications. In this study, high heat resistant and largely expandable TEMs have been synthesized by suspension polymerization. Microspheres were prepared with acrylonitrile (AN) as the main monomer. Initial thermomechanical analysis of TEMs containing AN and methyl acrylate (MA) showed good thermal expansion, leading to the investigation of the polymerization using various monomers at variable weight ratios. TEMs with co-polymer AN, methyl methacrylate (MMA), and methacrylic acid (MAA) were investigated for the first time. They displayed wider heating range and larger expansion rate than the microspheres with MA monomer. The effect of varying amounts of monomer ratios on the thermal expansion behavior is discussed.

표재성 방광암에서 Bacillus Calmette-Guerin 방광 내 주입요법 : 장기적 추적결과 Long-term Follow up Results

김용웅,왕세환,육승모,한동석,노안식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

To evaluated the results of long-term follow up of superficial bladder cancer patients who were treated with transurethral resection and intravesical BCG therapy. Between April 1989 and December 1997, 65 patients with superficial bladder cancer were treated with TUR-B(Transurethral resection of bladder tumor) and intravesical BCG instillation, and follow-up was performed for 5 years longer, and the mean follow-up duration was 82 months. Of 65 patients, pathologic stage were Ta in 17 cases and T1 in 48 cases and grade were G Ⅰ in 22 cases, G Ⅱ in 35 cases and G Ⅲ in 8 cases. The tumor recurred in 22(33.8%) at the median of 21.8 months and the tumor progressed in 9(13.8%) at the median of 20.8 months. Most of the recurrences and progression were within 3 year(838 and 77%). Progression is more likely in higher grade(G Ⅱ, G Ⅲ) and higher stage(T1). The complete response rate after first and second courses of BCG therapy were 53% and 73% and the 5 and 10 year disease specific survival rates were 89.5 and 78% respectively. The complete response rate after first and second courses of BCG therapywere 53% and 73%. Most of recurrences and progressions were within 3 years of the BCG therapy, but some cases occured after 5 years. Therefore, close long-term follow up is needed.

대동맥 이첨판과 승모판 이탈증을 동반한 대동맥 판하부 협착 1예

김용화,장경식,양태영,임영국,안기완,홍순표 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Discrete subaortic stenosis is a rare cardiac disorder especially in Orientals which occupies eight to ten percent of aortic stenosis, It occurs mainly before age of eighteen and accompanies with aortic valve abnormalities such as aortic stenosis, supravalvrlar stenosis, bicuspid valve and muscular hypertrophic subaortic stenosis, and other cardiac abnormalities such as ventricular septal defect, pulmonary stenosis and coarctation of aorta. There is no report of discrete subaortic stenosis accompanied with mitral valve prolapse. The major complications of discrete subaortic stenosis are aortic insufficiency, and subacute bacterial endocarditis. We report a case of asymptomatic nineteen-year-old male of discrete subaotic stenosis with bicuspid aortic valve and mitral valve prolapse, which is comfirmed by two-dimensional and Doppler echocardiography including transesophaigeal echocardiography.

順天大學 母後山 演習林의 山林資源에 關한 硏究(Ⅰ)

安鍾萬,金容煥,張漢晟 順天大學校 1983 論文集 Vol.2 No.1

順天大學 松光 演習林에 分布되어 있는 木本植物의 種類를 調査한 結果 다음과 같다. 1. 演習林에 分布되어 있는 木本植物은 51科92屬126種22變種으로 總 148種임을 알수 있었다. 2. 天然林에는 참나무類가 群集되어 있었다. 3. 特히 히어리가 群落을 形成하고 있었다. Suncheon National College Forest is located Seungjy-Gun in Cheonnam Do: more specifically located 34°59′30″-35°20′30″N, 127°10′15″-127°12′30″E. The forest covers are an area of 165. 59ha. This investigation was accomplished one month and the results obtained were as follows: 1. The grown in the College Forested of 51 families, 92 geners, 126 species, 22 varieties, so that the totaling were 148 texa. 2. There were Quercus association in the forest. 3. Among the 4 blocks (Jelte Valley) were cooupied with Corylopsis coreana Nakai, and the part of the other block were occupied with osk.

개불과 넙치의 혼합 사육시 성장과 사육환경의 변화

김용구,박일웅,안윤근,배애란,최상덕 國立麗水大學校 環境問題硏究所 2004 環境硏究論文集 Vol.6 No.-

This present study was conducted to determine the effects of sea water quality and sediment quality on growth and body composition in poly culture system, Paralichthys olivaceus and Urechis unicinctus. The seawater temperature of the experimental groups was ranges of 17.1~23.8℃, the lowest in 0 day and the highest in 70 day. The concentration of COD was 1.2~1.6㎎/ℓ, DIN 6.19~28.89㎎/ℓ in the D group. Mean IL concentration was 5.42~5.07% and it was maximum in 0 day and relatively minimum 70day. The concentration of AVS was 0.36~0.22㎎/g-dry, COD 4.36~4.08㎎/g-dry in the D group. Growth and feed intake of fish were affected by diets and feeding frequencies(P<0.05). There were differences at all experimental groups especially C group and control group but A, B group and C, D group were not difference. The lowest increased body weight was observed 4.7g in the D experimental group and the highest experimental group was observed 8.6g in the C group.

부산지역에서 고려수지요법의 인식과 이용실태

안성향,김강련,이용환 고신대학교보건과학연구소 2003 보건과학연구소보 Vol.13 No.-

The purpose of this study is to examine current recognitions and applications of Koryo Hand Therapy that is now prevailed in this nation. For the purpose, the author made a questionnaire survey to 227 people who experienced the therapy and 179 having no experience of the therapy. The surveyed subjects were all residents of Busan. The survey results showed that Koryo Hand Therapy was most frequently used by people in 5th dedicate or over. Those who experienced the therapy had more recognition and expectations about the treatment than those who didn't expehence it. Such recognition and expectations were most influenced by the age level. Families and relatives were a main source of information about Koryo Hand Therapy. Most of the subjects referred themselves to the therapy in accordance with recommnendations by others around them. In most cases, the therapy was applied in combination with hospital treatment. Most of the subjects used Koryo Hand Therapy 2 or 3 times a week for not longer than 3 months, especially the therapy with acupunctures. Most of people surveyed here used only one of the ways of fhe treatment. The study subjects were very sadsfied with therapeutic and preventive effects of the therapy. Most of them intended to receive the treatment again and recommend it to others. No side effect was recognized as the strongest point of Koryo Hand Therapy. In conclusion, those who experienced Koryo Hand Therapy had more recognition and expectation and more positive attitudes about the therapy. Thus Koryo Hand Therapy needs to be actively informed and more easily approached by people.

중·고 하키지도자의 지도유형에 따른 선수만족과의 관계

안용덕,김종이,이승준,신명건 朝鮮大學校 스포츠科學硏究所 2007 스포츠科學硏究 Vol.18 No.-

유도결합 플라즈마를 이용한 PZT 박막 식각특성에 관한 연구

안태현,김창일,서용진,장의구 중앙대학교 기술과학연구소 1999 기술과학연구소 논문집 Vol.29 No.-

졸-겔 법을 통해 PZT 박막을 2500 Å을 정착하였고 열처리를 통해 페로브스카이트 상을 얻었다. ICP 장비를 이용하여 Ar(20)/??/?? 가스 조합에 따른 플라즈마에서 기판 온도를 변화시키면서 PZT식각을 수행하였다. 가스 조건으로는 Ar/??:20/80, 기판온도는 80℃, 소오스 파워 500 W, dc 바이어스 전압은 -300 V, 반응로 압력 200 mTorr에서 PZT대 TR과 Pt의 식각 선택비는 각각 0.9, 3.9를 각각 얻었고, PZT 식각속도는 2450 A/min을 얻었다. ?? 가스는 상온에서 응결하므로 공정 반응로까지 이어지는 가스관에 정온 코일을 감아주기 때문에 가판온도을 올리기 전에 이미 데워져 있기 때문으로 여겨진다. 그러나 식각속도는 증가하였다. 이는 B와 BCl의 라디칼이 O와 결합하여?? 그리고/또는 ??의 휘발생 물질을 생성하여 metallic Pb, Zr, Ti가 표면으로 많이 노출되어 Cl 라디칼과 결합이 용이하기 때문에 식각속도가 증가한다고 판단된다. 또한 /?? 가스조건과 80°이상의 식각 프로파일을 얻었다. In this study, PZT etching was performed using plannar inductively coupled Ar(20)/??/?? plasma. The etch rate of PZT film was 2450 Å/min at Ar/?? gas mixing ratio and substrate temperature of 80℃. As increasing content of ??, the selectivities of PZT to Pr and PR increase linearly, and are directly proportional to substrate temperature in less than amount of 50% ??. However, at the condition over 50% ??, the etch rate of PZT have no dependence on the substrate temperature. The selectivities of PZT to Pt and PR were 3.9 and 0.9, respectively at the Ar(20)/??(80) gas mixing ratio and the substrate temperature of 80℃. X-ray photoelectron spectroscopy (XPS) analysis for film composition of etched PZT surface was utilized. The chemical bond of PbO is broken by ion bombardment and Cl radical, and the peak of metal Pb in a Pb 4f narrow can begins to appear upon etching. As increasing additive ?? content, the relative content of oxygen decreases rapidly, in contrast with etch rate of PZT thin film. So, we thought content of oxygen decreases rapidly, in contrast with etch rate of PZT thin film. So, we thought content of oxygen decreases rapidly, in contrast with etch rate of PZT thin film increased because abundant B and BCl radicals made volatile oxy-compound such as ?? and/or ?? bond. To understand etching mechanism, Langmuir probe and optical emission spectroscopy (OES) analysis were utilized for plasma diagnostic.