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테트라히드로디시크로펜타디엔의 아다만탄으로의 전위반응에 대한 금속희토류교환 제올라이트 촉매의 활성과 선택성
趙容錫,姜判祚 西原大學校 基礎科學硏究所 1992 基礎科學硏究論叢 Vol.6 No.-
Bifunctional catalysts metals on supported on Y zeolite exchanged by rare-earth ion (RE*), have high catalystic activity for the synthesis of adamantane from tetrahydrocyclopentadiene(TCD) in the presence of hydrogen and hydrogen chloride. These catalysts were prepared by the impregnation of metal salts with RE-Y zeolite. Their activity was measured by the batch reactor system. The TCD conversion consists of two reactions, the rearrangement of TCD to adamantane and hydrocracking to ring opening products(C??H?? isomer). No tarry materials were produced in the TCD conversion over bifunctional catalysts in the presence of hydrogen. The activity of metals supported on RE-Y for hydrocracking of TCD varied in proportion to the %d character of the metals. While for the rearrangement, it was independent of the %d character of the metals. In the case of a binary system of platinium and Rhenium the maximum activity for both reaction was observed at Re/(re+Pt) = 0.24. Furthermore poisoning by atomic sulfure on a bifunctional catalyst, the activity for the hydrocracking of TCD was depressed.
急性骨髓性 白血症에서의 試驗管內 集落細胞 形成에 관한 연구
고석만,조덕연,박철신,강원권,김민범,김삼용,노흥규 忠南大學校 癌共同硏究所 1991 癌共同硏究所 硏究誌 Vol.1 No.1
To evaluate the in vitro granulocyte-macrophage colony formation in acute myeloblastic leukemia and the prognostic implications of these results, the author performed the in vitro agar culture of bone marrow cells in 10 patients with acute myeloblastic leukemia (AML) and 5 control subjects. Culture medium was composed of 20% fetal calf serum(FCS), 50% Iscove's medium, 0.3% agar, 10% colony stimulation factor (CSF), and 2×105 cells/ml. Human placental conditioned medium (HPCM) and phytohemagglutinin-leukocyte conditioned medium (PHA-LCM) were used as colony stimulating factor. Colony counting was done on 7th day of culture. Colony was defined as containg 20 or more cells, and cluster was defined as containing 3 - 19 cells. The results were as followings, 1. In control subjects, the number of clusters formed was 3-47/2×10^(5) cells (20±19)and that of colonies was 5-24/2×10^(5) cells (14±9) when stimulated with HPCM. When stimulated with PHA-LCM, the number of clusters formed 5-39/2×10^(5) cells(18±16) and that of colonies was 6-13/2×10^(5) cells (9±3). 2. In AML patients, 3 groups were recognized according to pattern of colony formation : 1) non-forming 2) cluster forming 3) both cluster and colony forming. Of 10 cases, 5 cases were 'non-forming', 2 cases were 'cluster forming'; and 3cases wer cluster and 'colony forming'; 3. All 5 cases 'non-forming' cases, one of 2 cases of 'cluster forming'; and none of 3 cases of 'cluster and colony forming' achieved complete remission. So, there was significant difference in remission rate in the different growth types. These results suggest that granulopoiesis in AML patients is impaired and the pattern of in vitro CFU-L(colony forming unit-leukemia) formation has prognostic significance.
조해용,정석영,김명한,조창용,이제훈,서정 한국레이저가공학회 2001 한국레이저가공학회지 Vol.4 No.1
Simulation on the electron beam welding of Al 2219 alloy was carried out by using commercial FEM code MARC, which encounters moving heat sources. Due to axisymmetry of geometry, a half of the cylinder was simulated. A coupled thermo-mechanical analysis was carried out and subroutine for heat flux was substituted in the program. The material properties such as specific heat, heat transfer coefficient and thermal expansion coefficient were given as a function of temperature and the latent heat associated with a given temperature range is considered. As a result, the proper beam power is 60kVX60mA and welding speed is 1~1.5 m/min. The residual stress in the heat-affected zone as well as the fusion zone does not increase. It is necessary to use jigs for preventing distortion of cylinder and improving weld quality.
急性骨髓性 白血病에서의 試驗管內 集落細胞 形成에 관한 연구
고석만,조덕연,박철신,강원권,김민범,김삼용,노흥규 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
To evaluate the in vitro granulocyte-macrophage colony formation in acute myfloblastic leukemia and the prognostic implications of these results, the author performed the in vitro agar culture of bone marrow cells in 10 patients with acute myeloblastic leukemia (AML) and 5 control subjects. Culture medium was composed of 20% fetal calf serum(FCS), 50% Iscove's medium, 0.3% agar, 10% colony stimulation factor (CSF), and 2 × 10 exp (5) cells/ml. Human placental conditioned medium (HPCM) and phytohemagglutinin-leukocyte conditioned medium (PHA-LCM) were used as colony stimulating factor. Colony counting was done on 7th day of culture. Colony was defi ned as containg 20 or more cells, and cluster was defined as containing 3-19 cells. The results were as followings, 1. In control subjects, the number of clusters formed was 3-47/2 × 10 exp (5) cells (20±19)and that of colonies was 5-24/2 × 10 exp (5) cells (14±9) when stimulated with HPCM. When stimulated with PHA-LCM, the number of clusters formed 5-39/2 × 10 exp (5) cells(18±16) and that of colonies was 6-13/2 × 10 exp (5) cells (9±3). 2. In AML patients, 3 groups were recognized according to pattern of colony formation: 1) non-forming 2) cluster forming 3) both cluster and colony forming. Of 10 cases, 5 cases Were `non-forming', 2 cases were `cluster forming'; and 3cases wer cluster and `colony forming'; 3. All 5 cases 'non-forming' cases, one of 2 cases of `cluster forming'; and none of 3 cases of `cluster and colony forming' achieved complete remission. So, there was significa nt difference in remission rate in the different growth types. These results suggest that granulopoiesis in AML patients is impaired and the pattern of in vitro CFU-L(colony forming unit-leukemia) formation has prognostic significance.
Jo Yong Suk 대한결핵및호흡기학회 2022 Tuberculosis and Respiratory Diseases Vol.85 No.2
There is a considerable number of individuals who exhibit features of both asthma and chronic obstructive pulmonary disease (COPD), defined as asthma-COPD overlap (ACO). Many studies have reported that these patients have a greater burden of symptoms, including cough and dyspnea, and experience more exacerbations and hospitalizations than those with non-ACO COPD or asthma. Although diagnostic criteria for ACO have not yet been clearly established, their clinical significance remains to be determined. As interest in ACO grows, related studies have been conducted in South Korea as well. The present review summarizes ACO-related studies in South Korea to better understand Korean ACO patients and guide further research. Several cohort studies of asthma and COPD and population-based studies for ACO were reviewed and the key results from demographics, clinical features, lung function, biomarkers, treatment, and prognosis were summarized.
( Yong Suk Jo ),( Chang Hoon Lee ),( Sun Mi Choi ),( Jin Woo Lee ),( Young Sik Park ),( Sang Min Lee ),( Jae Joon Yim ),( Chul Gyu Yoo ),( Young Whan Kim ),( Sung Koo Han ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Multiple comorbidities related to chronic obstructive pulmonary disease (COPD) make it a difficult disease to treat. The relationship between these comorbidities and COPD has not been fully investigated. We aimed to determine whether COPD was independently associated with various comorbidities. Methods: This was a cross-sectional study, which used data from the Korean National Health and Nutrition Examination Survey (KNHANES) V conducted between 2010 and 2012. Survey design analysis was employed to determine the association between COPD and 15 comorbidities. A COPD patient was defined as a smoker with forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0.7 and comorbidities were defined based on objective laboratory findings and questionnaires. Results: Of a total of 9488 patient who underwent spirometry, 744 (7.84%) COPD cases and 3313 non-COPD controls were included in the analyses. Although the prevalence rates of the majority of the comorbidities were high among the COPD patients, only hypertension (adjusted odds ratio [aOR], 1.63; 95% CI, 1.13-2.33 in Stage 1 COPD group; aOR, 1.92; 95% CI, 1.36-2.72 in Stage 2-4 COPD group) and a history of pulmonary tuberculosis (aOR, 3.38; 95% CI, 1.90-5.99 in Stage 2-4 COPD group) were independently associated with COPD after adjustment for age, smoking status, and confounders. Conclusions: Only hypertension and a history of pulmonary tuberculosis were independently associated with COPD after adjustment for confounders among 15 comorbidities. The results suggest that majority of COPD patients might have similar risk factors with its comorbidities, including age and smoking status.
( Yong Suk Jo ),( Hye Yun Park ),( Sun Hye Shin ),( Deog Kyeom Kim ),( Sang-heon Kim ),( Tae Rim Shin ),( Ki-Suck Jung ),( Kwang Ha Yoo ),( Ki-eun Hwang ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Inhaled corticosteroids (ICS) remain widely overused in clinical practice, even among patients with chronic obstructive pulmonary disease (COPD) who are less symptomatic and at low risk of future exacerbations. As most clinical trials have been performed in more symptomatic and higher-risk patients, evidence regarding treatment in patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) group A COPD are limited. We assessed the distribution of inhaler treatment and sought to investigate the association between ICS use and future exacerbation in this GOLD group A COPD patients. Methods Patients with GOLD group A COPD who received maintenance inhalers were identified from a multicenter, prospective cohort in the South Korea. Patients were categorized as group A when they had less symptom (mMRC 0-1 and CAT < 10) and did not experience severe exacerbation in the previous year. Development of moderate or severe exacerbation during 1-year followup was analyzed according to the baseline inhaler treatment. Results In 286 patients with GOLD group A COPD, mono-bronchodilator (37.8%), dual-bronchodilator (29.0%), triple therapy (17.5%) and ICS/long-acting beta-2 agonist (15.4%) were used (Figure 1). Compared to patients without ICS-containing inhaler (N = 191), those using ICS (N = 95) were more dyspneic, more likely to have asthma history, lower lung function, and bronchodilator response. During 1-year follow-up, moderate or severe exacerbations occurred in 66 of 286 (23.1%) patients. In multivariable logistic regression analysis, ICS-containing inhaler use was not associated with the development of exacerbation (Table 1). Even in subgroup with high probability of asthma-COPD overlap, this association was not significant. Conclusion Although about one third of patients with GOLD group A COPD was using ICS-containing inhalers, use of ICS was not associated with the reduction of future development of exacerbation.