MMPI에 依한 少年院生의 性格에 關한 硏究

姜達三,申石澈 충남대학교 의과대학 지역사회의학연구소 1976 충남의대잡지 Vol.3 No.1

The author has attempted to study the personality problems of the adolescence of boy's camp by utilizing the Minnesota Multiphasic Personality Inventory(MMPI). One hundred and twenty male adolescents of boy's camp, and one thousand and two hundred normal male students aged between 13 through 19 were selected at random for this study. T-score, anxiety index, internalized ratio, active hostility index, and passive aggressive index based on T-score of the MMPI are summarized as follow. 1) In the T-score of the clinical scales, the T-score of the scales in the boy's camp group is comparatively higher than that in the normal student group. In the normal student group, the psychotic and behavioral disorder scales in the younger group is higher in comparison with that in the elder group. The result of the MMPI indicates higher value of standard deviation in the normal student group, and highest value in the elder group. 2) The value of anxiety index is higher in the boy's camp group than in the normal student group. In the normal student group, the elder group has higher value than the younger group. There shows higher value of the standard deviation in the normal student group, and highest value in the elder group. 3) The value of internalized ratio is higher in the normal student group, and it was discovered that the elder the group is the higher the value. The higher value of the standard deviation in the normal student group was discovered and so was in the elder student group. 4) The value of the active hostility index is higher in the boy's camp group, and the same is true in the test of the younger group in the normal student group. There shows a higher value of the standard deviation in the normal student group, and also highest in the elder student group. 5) The value of the passive aggressive index is higher in the normal student, and is particularly highest in the elder student group. there shows a highest value of the standard deviation in the boy's camp group, and also higher in the younger group of the normal student.

Morphology-Controlled Synthesis of Rhodium Nanoparticles for Cancer Phototherapy

Kang, Seounghun,Shin, Woojun,Choi, Myung-Ho,Ahn, Minchul,Kim, Young-Kwan,Kim, Seongchan,Min, Dal-Hee,Jang, Hongje American Chemical Society 2018 ACS NANO Vol.12 No.7

<P>Rhodium nanoparticles are promising transition metal nanocatalysts for electrochemical and synthetic organic chemistry applications. However, notwithstanding their potential, to date, Rh nanoparticles have not been utilized for biological applications; there has been no cytotoxicity study of Rh reported in the literature. In this regard, the absence of a facile and controllable synthetic strategy of Rh nanostructures with various sizes and morphologies might be responsible for the lack of progress in this field. Herein, we have developed a synthetic strategy for Rh nanostructures with controllable morphology through an inverse-directional galvanic replacement reaction. Three types of Rh-based nanostructures-nanoshells, nanoframes, and porous nanoplates-were successfully synthesized. A plausible synthetic mechanism based on thermodynamic considerations has also been proposed. The cytotoxicity, surface functionalization, and photothermal therapeutic effect of manufactured Rh nanostructures were systematically investigated to reveal their potential for <I>in vitro</I> and <I>in vivo</I> biological applications. Considering the comparable behavior of porous Rh nanoplates to that of gold nanostructures that are widely used in nanomedicine, the present study introduces Rh-based nanostructures into the field of biological research.</P> [FIG OMISSION]</BR>

Crystal structure of Hop2–Mnd1 and mechanistic insights into its role in meiotic recombination

Kang, Hyun-Ah,Shin, Ho-Chul,Kalantzi, Alexandra-Styliani,Toseland, Christopher P.,Kim, Hyun-Min,Gruber, Stephan,Peraro, Matteo Dal,Oh, Byung-Ha Oxford University Press 2015 Nucleic acids research Vol.43 No.7

<P>In meiotic DNA recombination, the Hop2−Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism. Here, the crystal structure of Hop2−Mnd1 reveals that it forms a curved rod-like structure consisting of three leucine zippers and two kinked junctions. One end of the rod is linked to two juxtaposed winged-helix domains, and the other end is capped by extra α-helices to form a helical bundle-like structure. Deletion analysis shows that the helical bundle-like structure is sufficient for interacting with the Dmc1-ssDNA nucleofilament, and molecular modeling suggests that the curved rod could be accommodated into the helical groove of the nucleofilament. Remarkably, the winged-helix domains are juxtaposed at fixed relative orientation, and their binding to DNA is likely to perturb the base pairing according to molecular simulations. These findings allow us to propose a model explaining how Hop2−Mnd1 juxtaposes Dmc1-bound ssDNA with distorted recipient double-stranded DNA and thus facilitates strand invasion.</P>

Local Expression of and Effect of Melatonin on Expression of PLP-A Gene in the Rat Placenta

Shin Chang-Sook,Lee Chae-Kwan,Kang Han-Seung,Kim Haekwon,Yoon Yong-Dal,Moon Deog-Hwan,Kang Sung-Goo 한국발생생물학회 2001 발생과 생식 Vol.5 No.2

포유동물의 혈중 프로락틴 농도는 일주기와 연주기의 변화를 나타내며 송과체에서 분비되는 멜라토닌이 조절인자로 관여한다. 인위적인 송과체의 기능 억제는 혈중 프로락틴 농도를 증가시킨다. 임신 후반기에 태반에서는 수종의 프로락틴군 호르몬들이 분비되어 태반기능 및 배아발생에 중요한 역할을 한다. 그러나 이들 호르몬 유전자들의 발현 조절기작과 조절 인자들에 관한 연구 결과는 미비하다. 본 연구에서는 RT-PCR과, in situ hybridization 방법으로 Seasonal changes and circadian rhythm of plasma prolactin(PRL) concentration in mammals are mediated by melatonin. Pinealectomy or denervation of the pineal gland produces an increase in plasma PRL level. In the rat placenta several members of the PRL family gene are expressed during the late pregnancy. However, the full spectrum of their expression mechanisms and regulatory factors are not elucidated yet. Present study aimed to investigate the local expression of the melatonin receptor la(Me ) gene and the effect of melatonin on expression of prolactin-like protein A(PLP-A), a member of the PRL-family gene in the rat placenta. According to the RT-PCR, northern blot and in situ hybridization experiments, Me gene was locally expressed in the rat placenta, Me mRNA was localized mainly in the placental junctional and labyrinth zones. Interestingly, junctional zone of the placenta showed strong expression of Me at daytime(16:00) than at nighttime(22:00). Melatonin agonist, chlorornelatonin decreased the PLP-A mRNA levels in the rat placenta. These results suggest that melatonin coupled with Me , may act as a regulation factor that mediates the expression of the PLP-A gene in the rat placenta.

헌혈자와 비헌혈자의 헌혈에 대한 지식, 태도 및 동기에 대한 비교

신재학,사공준,김석범,김창윤,강복수,정종학,송달효 영남대학교 의과대학 1989 Yeungnam University Journal of Medicine Vol.6 No.2

일부 가두 및 단체 헌혈자와 헌혈 미경험자들의 헌혈에 대한 태도, 지식 및 동기 등을 비교조사하기 위해 1989년 3월1일부터 3월 31일까지 대구적십자 혈액원 소속 가두헌혈차를 방문하여 헌혈한 사람과 동기관에서 실시한 단체헌혈캠페인의 헌혈자 622명과 가두 헌혈차를 방문하여 헌혈을 거부하였거나 단체헌혈캠페인에서 거부한 322명을 대상으로 자기기입식 설문서를 이용하여 조사분석하여 다음과 같은 결과를 얻었다. 헌혈자군은 남자가 84.1%, 여자 15.9%였고 비헌혈자군은 남자 73.6%, 여자 26.4%였고 16-24세군이 헌혈자군 63.2%, 비헌혈자군 72.7%를 차지하였다. 그외 교육정도, 직업분포, 종교, 가구당 월수입, 결혼상태 및 건강상태의 분포도 헌혈자군과 비헌혈자군이 유사하였다. 헌혈에 관한 정보습득 매체는 TV가 헌혈자군 75.2%, 비헌혈자군 78.9%로 가장 많았고, 헌혈차직원, 라디오, 신문 순이었다. 잡지를 통한 정보습득이 헌혈자군에서 유의하게 많았다(p<0.05). 헌혈자군의 70.6%, 비헌혈자군의 58.1%가 헌혈을 권유받은 적이 있다고 대답했으며(p<0.01), 권유의 근원은 두군 모두에서 친구가 가장 많았고 헌혈차직원이 그 다음이었다. 헌혈 및 혈액에 관한 지식측정 문항 중 정답률이 가장 높은 것은 "혈액의 생성 및 소멸"에 관한 것이었으며 오답률이 가장 높았던 문항은 "수혈을 통한 암전파 가능"이었다. 헌혈자군의 평균정답률은 62.6%였고 비헌혈자군은 54.1%로 뚜렷한 차이가 있었다(p<0.01). 그리고 교육수준이 높을수록 정답률도 높아지는 경향이었다. 헌혈에 대한 태도측정 문항중에서 "혈액에 대한 느낌", "수혈을 가정한 혈액선택" 및 "혈액부족상황에 대한 견해"가 헌혈자군과 비헌혈자군 사이에 태도의 차이가 있었다(p<0.05) 헌혈자군과 비헌혈자군에서 헌혈의 가장 큰 동기는 "예치성 동기"였고 그 다음이 "인도주의적 이유"이었다. 헌혈에 응하지 않은 이유의 분포는 헌혈자군과 비헌혈자군 모두에서 "주사침공포", "헌혈차나 혈액원 방문이 두렵다" 그리고 " 현혈이 건강이나 활동에 지장" 등의 순으로 중요한 이유였다. 이상의 소견으로 보아 헌혈에 대한 홍보 및 계몽활동시 잡지를 이용하는 방안이 더욱 고려 되어야겠으며 홍보내용은 위의 지식측정문항중 오답률이 높은 것과 헌혈에 응하지 않은 이유중 잘못 인식하고 있는 부분에 대해 중점적으로 다뤄져야겠으며 각종 두려움에 관한 문제를 해결하기 위해서 다회 헌혈자의 비중을 높여야겠다. This study was conducted to compare the date on knowledge, attitude and motivation toward blood donation between donors and nondonors. The study population included 622 donors and 322 nondonors who visited the mobile blood donation car of Taegu Red Cross Blood Center and participated the group appointed blood donation campaign managed by the center from March 1 to March 31, 1989. The donors and nondonors were questioned above mentioned items with a formulated questionnaire. Among the general characteristics of the subjects in the study, male predominace (84.1% in donors and 73.6% in nondonors) in young age group(16-24 years)was the outstanding feature. As a medium of information about blood donation, "television" was playing a dominant role(donors ; 75.2%, nondonors ; 78.9%), while "magazine" played more important roles among donors. Of the donors, 70.6% and ofthe nondonors, 58.1% replieb that they had ever been induced to donate blood(p<0.01). Major inducers were friend and personnel of mobile blood donation vehicle. On the measuring of knowledge level, the average rates of correct answer was higher in donors(62.6%) than in nondonors(54.1%) (p<0.01). Higher the education level was presented, higher the knowledge level(p<0.05). There have been noticeable difference between donors and nondonors in blood replying the questionnaire set to measure their attitude toward blood donation, especially in the items such as "impression toward blood", "selection of transfusion blood source" and "view on the situation of blood shortage." The major motivation toward blood donation of the groups were "possible future need" and "altruism or humanitarian interest." The major reasons for not donation blood in both groups were " fear of the needle" and "dread to visit to mobile car or center."

Enhanced Controlled Transdermal Delivery of Hydrochlorothiazide from an Ethylene-vinyl Acetate Matrix

( Dal Keun Kim ),( Jung Chan Park ),( Ik Hyun Chang ),( Chung Kang ),( Sang Rok Ryu ),( Sang Chul Shin ) 한국약제학회 2010 Journal of Pharmaceutical Investigation Vol.40 No.3

만성 간염 , 간경변 및 간세포암 조직에서의 암유전자 발현 동태

신동호,박성수,강경원,이동후,유병무,이중달,노임환,권기운 대한소화기학회 1992 대한소화기학회지 Vol.24 No.3

Liver cell replication is known to invlove a sequential activation of proto-oneogenes including c-myc and e-Ha-ras. These positive regulations of proliferative signal are thought to be counter- balanced by growth-constraining tumor suppressor genes. During the genesis of liver cell carcinoma both the qualitative and the quantitative changes in growth promoting proto-oncogenes were elucidated in animal models. And also mutational inactivation bf suppressor genes such as p53 liberates the cell from the negative regulation, resulting in deregulated growth. Since there is strong corrleation between persistence of hepatitis B virus infection and the development of hepatocellular carcinoma, we attempted to investigate the dynamic changes of proto-oncogenes and tumor suppressor gene in HBV DNA positive lliver tissues among 8 chronic persistent hepatitis, 9 chronic active hepatitis, 12 liver cirrhosis, and 13 hepatocellular carcinomas, employing in situ hybridization and immunohistochemistry. Comparing to chronie hepatitis and liver cirrhosis, c-myc overexpression was heterogeneously distributed in hepatocellular carcinoma, Intensity of c-Ha-ras expressions was strong in hepatocellular carcinomas, liver cirrhosis, chranic active hepatitis, and chronic persistent hepatitis in orders. Whereas wild type of p53 was immunohistochemically detectable in all of the cases investigated, mutant gene deleted 9 amino acids adjacent to carboxyl terminal revealed in 37.5% of chronic persistent hepatitis, 33.3% of chronic active hepatitis or liver cirrhosis, and 46.2% of hepatocelluar carcinomas, respectively. In conclusion, these data support that enhanced expressian of positive growth promoting proto-oncogenes is related with regeneration of the liver and progression of tumor cell growth. And the various mutant genes of tumor suppressor might be emerged during the persistent replication of hepatocytes in HBV DNA positive chronic liver diseases, in cooperation with proto-oncogenes, eventually resulting in development of hepatocellular carcinoma. This means, in turn, that HBV-related chronic liver diseases retained a malignant potential.

Local Expression of $Mel_{la}$ and Effect of Melatonin on Expression of PLP-A Gene in the Rat Placenta

Shin, Chang-Sook,Lee, Chae-Kwan,Kang, Han-Seung,Kim, Haekwon,Yoon, Yong-Dal,Moon, Deog-Hwan,Kang, Sung-Goo The Korean Society of Developmental Biology 2001 발생과 생식 Vol.5 No.2

포유동물의 혈중 프로락틴 농도는 일주기와 연주기의 변화를 나타내며 송과체에서 분비되는 멜라토닌이 조절인자로 관여한다. 인위적인 송과체의 기능 억제는 혈중 프로락틴 농도를 증가시킨다. 임신 후반기에 태반에서는 수종의 프로락틴군 호르몬들이 분비되어 태반기능 및 배아발생에 중요한 역할을 한다. 그러나 이들 호르몬 유전자들의 발현 조절기작과 조절 인자들에 관한 연구 결과는 미비하다. 본 연구에서는 RT-PCR과, in situ hybridization 방법으로 흰쥐의 태반에서 Me $l_{la}$ 유전자의 발현을 확인하였다. 발현되는 주요 세포는 junctional zone과 labyrinth zone의 spongiotrophoblast 세포와 trophoblast giant세포였다. 특이한 것은junctional zone의 Me $l_{la}$ 유전자의 발현이 밤시간(22:00)에 비하여 낮시간(16:00)에 높게 조사되었다. 그리고 멜라토닌 수용체 agonist인 chloromelatonin은 PLP-A 유전자의 발현을 억제하였다. 이러한 결과들로 보아 흰쥐의 태반에서 Me $l_{la}$ 유전자가 발현되며, 멜라토닌에 의해 유도되는 Me $l_{la}$ 의 활성화는 PLP-A유전자의 발현에 중요한 조절인자로 작용할 것이다. Seasonal changes and circadian rhythm of plasma prolactin(PRL) concentration in mammals are mediated by melatonin. Pinealectomy or denervation of the pineal gland produces an increase in plasma PRL level. In the rat placenta several members of the PRL family gene are expressed during the late pregnancy. However, the full spectrum of their expression mechanisms and regulatory factors are not elucidated yet. Present study aimed to investigate the local expression of the melatonin receptor la(Me $l_{la}$ ) gene and the effect of melatonin on expression of prolactin-like protein A(PLP-A), a member of the PRL-family gene in the rat placenta. According to the RT-PCR, northern blot and in situ hybridization experiments, Me $l_{la}$ gene was locally expressed in the rat placenta, Me $l_{la}$ mRNA was localized mainly in the placental junctional and labyrinth zones. Interestingly, junctional zone of the placenta showed strong expression of Me $l_{la}$ at daytime(16:00) than at nighttime(22:00). Melatonin agonist, chlorornelatonin decreased the PLP-A mRNA levels in the rat placenta. These results suggest that melatonin coupled with Me $l_{la}$ , may act as a regulation factor that mediates the expression of the PLP-A gene in the rat placenta.

Revisiting of Pd Nanoparticles in Cancer Treatment: All-Round Excellence of Porous Pd Nanoplates in Gene-Thermo Combinational Therapy

Kang, Seounghun,Shin, Woojun,Kang, Kyunglee,Choi, Myung-Ho,Kim, Young-Jin,Kim, Young-Kwan,Min, Dal-Hee,Jang, Hongje American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.16

<P>Gold nanomaterials are commonly used in biomedical applications owing to their excellent biocompatibility and unique physicochemical and optical properties, whereas Pd nanomaterials are mainly used as catalysts. Here, we re-examined the possible applications of Pd nanomaterials. Reducing agent-assisted excessive galvanic replacement-mediated porous Au nanoplates, porous Pt nanoplates, and porous Pd nanoplate synthesis enabled us to compare the properties and efficiency of nanoplates composed of three metal elements (Au, Pt, and Pd). According to our analytical results, porous Pd nanoplates exhibited exceptional all-round excellence in photothermal conversion, therapeutic gene loading/releasing, cytotoxicity, and in vitro combination cancer treatment. We believe that this discovery broadens the potential applications of metal nanomaterials, with an emphasis on more efficient biomedical applications in limited conventional fields.</P> [FIG OMISSION]</BR>

피트니스센터 이용자들의 스포츠상해 원인에 대한 사례연구

강은석(Kang, Eun-Suk),신중달(Shin, Joong-Dal) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.6

This study tries to show the findings of case studies of sport-related injuries in fitness centers whose popularity is ever-increasing, especially regarding the causes of such injuries, a field that lacks in-depth researches. As for the research methods, I made visits to three fitness centers, giving questionnaires to 100 members of the centers who have had sport-related injuries, which asks about why such injuries, under what circumstances, occurred, along with which parts of the body were hurt and how they treated them. I also conduced interviews with expert groups who work as professional trainers to add up the validity of this research"s findings. The research findings were summarized into the three like the below, other than the factor that most of the injuries could have been prevented with due diligence being paid to the sport scenes. First, subjects lack the knowledge and technologies without due process of education about the knowledge and technologies. Second, they repeatedly forget the significance of trainers" education by doing indiscreet behaviors. Third, some of them are overly motivated to engage in the sports even though they are not physically prepared well. Apart from the main concern of this study, it is mentioned that there are some legal matters between fitness trainers and users in regards to the injuries. I hope this study will contribute to enhancing the awareness of how the sports injuries can be dangerous among the users and of how to prevent such injuries among the trainers.