엔로플록사신 액제의 닭유래 병원세균에 대한 시험관내 항균효과 시험

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study the antimicrobial spectrum and sensitivity of a liquid formulation of enrofloxacin against the major six pathogenic bacteria isolated from the diseased poultry in Korea were evaluated in comparison with ciprfloxacin (CFX), gentamicin (GM) and penicillin (PC). A liquid form of enrofloxacin, a test material and ciprofloxacin showed at least 83% antibacterial activity against all of six test pathogenic microorganisms at the fixed concentration of 10 ㎍/㎖. Gentamicin and penicillin revealed much lower antibacterial activity at the same condition. We evaluated the liquid form of enrofloxacin as having widespread antibacterial spectrum against poultry infections. The liquid form of enrofloxacin showed potent antibacterial activity, with the MIC range being 0.12∼2 ㎍/㎖ against Gram positives, 0.06∼2 ㎍/㎖ against Gram negatives and 0.5∼2 ㎍/㎖ against Mycoplasma spp. These values were equivalent to or somewhat higher than those of ciprofloxacin, but much lower than those of gentamicn and penicillin. This new liquid form of enrofloxacin would find its way in application of mixing with drinking water for the prevention and treatment of diverse infections in chickens.

엔로플록사신 액제의 닭 호흡기 및 소화기 감염증에 대한 예방 및 치료효과

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

We evaluated the efficacy of the liquid form of enrofloxacin against poultry respiratory and digestive infections, the major problems in the poultry industry, from diverse diagnosis viewpoints. Results obtained through this study were as follows: 1. The liquid form of enrofloxacin showed good acceptability to poultry owing to no abhorrence to the drug by chickens, which indicated its suitability for mixing in drinking water. 2. The application of the enrofloxacin formulation improved the productivity of the chicken farm to a great extent by lowering the death toll of chicken raised in the farm. 3. The use of the drug shortened the days to the market, and increased the body weight at the time of marketing. 4. Preventive and therapeutic effects of the liquid enrofloxacin were observed higher than ampicillin, a major antibiotic used in poultry farming. From above results, the liquid form of enrofloxacin would find its use for the prevention and treatment of digestive and respiratory infections, let alone the growth promotion and feed efficiency, especially in the chicken farming practice.

分割方法에 의한 斜張橋의 構造解析

朴春赫,梁承鉉 全北大學校 附設 都市및環境硏究所 1989 都市 및 環境硏究 Vol.4 No.-

This paper deal with structural analysis of Cable-stayed Bridges by Block Method. The Block Method were analyzed by Displacement Method which divides some structure from the total structure. As a numerical example, this structural analysis applies to cable-stayed Bridge which consits of two-span continuous beam and one towers attached four cables. The make a comparison between resultant values of numerical calculation by structural analysis into block method and resultant value were analyzed to total structures by Finite Element Method in order for validity of this paper to verify clearly. This structural analysis method can be decreased memory volume of computer.

사지발생 중 표피성장인자-수용체 표현과 Etretinate와의 상관성

김승민,김강련,박선화,전용혁 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

동일한 국제예후지표(International Prognostic Index)를 나타내는 미만성 대형 B-세포 림프종에서 Bcl-2와 p16의 임상적 중요성

박상은,박수진,곽승근,박남숙,천재민,윤환중,조덕연,김삼용,김진만 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

In Korea, malignant lymphoma is a common cancer, comprising about 2.7% of all malignant neoplasm. Diffuse large B cell lymphoma is the most common lymphoma, representing about 50% of all Non-Hodgkin's lymphoma. Diffuse large B-cell lymphoma is usually considered as heterogeneous group of neoplasms rather than a single clinicopathological entity. Clinical prognostic systems, including the International Prognostic Index (IPI), although useful to assess overall prognosis, embrace patients with heterogeneous prognoses. But International Prognostic Index scoring system is not sufficiently predict the prognosis. It is likely that the prognostic assessment of patients with diffuse large B-cell lymphomamight be improved by using biological features. Bcl-2 protein and p16 protein expression is recognized as useful biologic markers predicting the prognosis of patients with diffuse large B-cell lymphoma. To determine the clinical significance and prognostic value of bcl-2 and p16 proteins expression patterns, we studied 18 patients with de novo DLBL, whose archival pathology specimen were available for immunohistochemistry studies, atChungnam National University Hospital from September 1992 to December 2000. Archival specimens from each patient were immunostained with respective antibodies for bcl-2, p16. The results are as follows; 1) The median age was 54(rage : 37-69). There were 12 male patients(66.7%) and 6 female patients(33.3%) The 'B' symptom was abscentin all patients. The stages were as follows : Ⅰ, 2 patient(11.1%), Ⅱ, 10 patient(55.6%), Ⅲ, 4patient(22.2%) and Ⅳ, 2patient(11.1%). 3 patients(16.8%) had the elevated LDH level, 14 patients(77.8%) had the normal LDH level and 1 patients(5.6%) was not identified the LDH level. 2 patients(11.1%) had the bulky disease and 16 patients(88.7%) had no bulky diease. The distribution of ECOG status were O, 2 patients(11.1%c), 1, 14patients(77.8%) and 2, 2patients(11.1%). 2) Theimmunohistochemistry results are as follows bcl-2:+,10 patients(55.6%), bcl-2:-, 8patinets(44.4%), p16:+,3 patients(16.7%), p16:-, 15patients(83.3%) 3) After a median follow UP durations of 67 months, the median survival time was 57 months with a rage of 7-100+ months. 5-years overall survival rates was 44% by Kaplan-Meier method. 4) Reduced overall survival was demonstrated in the patients who expressed bcl-2 protein(P=0.0174). 5-year overall survivial rate was 12%(bcl-2 expression) versus 88%(no bcl-2 expression) 5) Among diffuse large B-cell lymphoma patients with IPI score 0-1, reduced overall survival was demonstrated with bcl-2 expression(P=0.023). 5-year overall survival rate was 18%(bcl-2 expression group) versus 100%(no bcl-2 expressiongroup) 6) Median survival durtation of diffuse large B-cell lymphoma patients negative for p16 expression was 57 months whereas p16 postive patients' median survival duration was not reached(P=0.4478). In diffuse large B-cell lymphoma patients with identical IPI scores, bcl-2 expression had additional prognostic value.

반도체 공정에서의 기상 세정장비 개발에 관한 연구

박헌휘,이춘수,최승우,함승주 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

저압 기상 영역에서 Anhydrous HF 가스와 Methanol vapor를 사용하는 산화막 식각공정을 수행하기 위하여 (1) 반응기 부피의 최소화, (2) 공정압력의 최소화, (3) 고순도 알루미나 Reactor 적용, (4) Cluster화의 개념을 적용한 VPC 장치를 제작하였다.Wafer의 온도, HF의 분압 및 Working Pressure 등의 공정변수에 따른 Oxide Wafer의 식각특성의 변화를 확인하였다 또한 Etch Uniformity를 향상시키기 위하여 Shower Head의 구조를 변경시켜서 실험하였으며, CFD Simulation을 이용하여 Reactor 내에서의 HF gas 및 Methanol vapor의 분율을 예측하였다.

殺蟲性 O,O-Diethylphenylphosphate 誘導體의 形態와 反應性에 關한 分子軌道論的 硏究

朴勝熙,成洛道,明平根,全容求,李天培 충남대학교 약학대학 의약품개발연구소 1985 藥學論文集 Vol.1 No.-

Molecular orbital theoretical study on the stability of conformations and chemical reactivity of 0,0-diethyphenylphosphate derivatives were carried out by EHT and CNDO/2 molecular orbital calculation method. The results shown that the dipole moment(μ) and total energies of the θ=90° conformer were μ=3.185D & E_t=-162.6479(au) and also that of the θ=0° conformer were μ=5.596D & E_t=-162.4013(au), respectively. Therefore, the values of μ & E_t of the θ=90° conformer were much smaller than that of the θ=0° conformer. The form with angle of rotation θ=90° of phenyl ring was shown to be most stable and this was interpreted in terms of electrostatic and steric effect. O,O-diethylphenylphosphate derivatives are predicted to increase both charge and orbital controlled SN_2 reactivity of the electron withdrawing substituent reduces the HOMO & LUMO energy, while the electron withdrawing substituent due to increase in positive charge of phosphorus atom of phosphate molecule.

METRx™ 기구를 이용한 후방 경추부 추궁추간공 제거술의 예비 결과

박형천,윤승환,박종운,하윤,현동근,김은영,박현선,임대철 대한척추신경외과학회 2004 Neurospine Vol.1 No.1

Objectives: Posterior cervical microscopic laminoforaminotomy has been a preferred procedure for a posterolateral cervical disc or foraminal stenosis. However, neckpain from wide skin incision and muscle injury are some of disadvantages. The authors performed cervical microscopic laminoforaminotomy with METRx™ tubular dilator system and were compared the results with classical cervical microscopic foraminotomy. Methods: Six patients underwent posterior cervical microscopic laminoforaminotomy using the METRx™ during 6 months. We have selected 10 patients from our institution as a comparison group. Preoperative and postoperative pain score composed of the radicular and neck component was examined and disability score also recorded. Diameters and lengths of laminoforaminotomy on the postoperative CT also were compared with two methods Results: Postoperative pain scores to the radiculopathies were not different but postoperative pain scores to the neckpain on the follow up periods were significantly different. The average vertical and transverse diameters of the laminoforaminotomy defect on the postoperative CT scans were not different between two groups. Average hospital stay of the classical methods was 8.8±7.5 days comparison with 4.5±0.54days of new procedure. Conclusions: Posterior cervical microscopic laminoforaminotomy with METRx™ systems seems to provide similar decompression and clinical results as classical methods compared to classical methods and shows superior results for postoperative neckpain and hospital stays.

콘크리트 교량 및 강교의 상시감시 시스템에 관한 연구(Ⅰ)

박승범,홍석주,이봉춘 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

The construction of large scale civil and building structures which form the base of social economy has been grown greatly. As the increasing of aged and deteriorated structure, it is necessary to evaluate the safety of those structures. The deterioration, safety evaluation repair and rehabilitation are important problems in the construction area that every country faces. This paper presents the general information on how to conduct a data analysis of long-term monitoring system and evaluate the characteristics of surveying methods.

체육 서비스조직의 리더십유형과 직무만족 및 조직유효성 간의 관계

천길영,남궁완,최병학,박효찬,홍승달,정석현 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The purpose of the study was to examine the relationship among style of leadership, job satisfaction, and efficacy of sport service organization. In order to achive this purpose three reaserch questions were established. Participants for this study were 300 of 23-50 overaged public workers. Of participations valid data were 279. They completed a modified inventory of the style of leadership, job satisfaction and efficacy of sport service organization. More details, style of leadership Scale modified by Ahn(2000), job satisfaction by Ahn (2000) and efficacy of sport service organization by Kim(2001) were using after remodifing scale to investigate the purpose of this study. Results were analysed in quantitative approaches. Data were collected through self-administered survey. The most three meaningful results of the study were as follows; First, there was influenced to relationship between style of leadership and job satisfaction. Second, there was influenced to relationship between style of leadership and efficacy of sport service organization. Third, there was influenced to relationship among style of leadership, job satisfaction, and efficacy of sport service organization.