뇌손상 후 인지기능장애에 대한 메칠페니데이트의 효과-이중맹검 위약대조 연구-

김연희,나승용,신용일,서정환 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.4

Fosfomycin의 항균효과 및 capillary electrophoresis에 의한 측정법에 관한 연구

윤효인,박승춘,이규승,권진욱,조준형,신광순,김무열,허강준,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

Fosfomycin, a low molecular antibiotic, is to be easily synthesized, therefore to be possibly used in veterinary sectors due to econimic reasons. In this study, we determined the antibacterial activities of fosfomycin against some domestic animal-origin pathogens, and its combined effects with some important antibacterials available. We also compared detection methods of fosfomycin from various measuring instruments. The results obtained through this experiment were as follows: 1. Antibacterial activities of fosfomycin against the pathogens used in this experiment were appeared fairly low. We found the antobacterial activities depanded on the kinds of media and the addition of some material thereins, which suggests the importance of appropriate medium so as to judge the antibacterial activity of fosfomycin. 2. Fosfomycin showed varying antibacterial effects in combination with other antibacterials, which should be taken into consideration when combining other antobacterials especially in the clinical settings. Of the combined antivacterials, fosfomycin had synergistic effects in combination with amoxicillin but antagonistic effects with oxytetracyline. 3. Conventional detection methods using HPLC, GC and spectrophotometer were not appropriate to measure fosfomycin. Capillary electrophoresis by the way of the indirect ultraviolet detection method was good enough to detect fosfomycin in the range of expected concentration in tissues, with the limit of quantitation (LOQ) of 1.25 ㎍/㎖. We recommend the eletrophoresis method could be used to detect fosfomycin, thereby being able to set the optimal dosage for animals and providing the measures in relation with the residual concentration in the meat.

토끼에서 enrofloxacin과 enrofloxacin acetate의 比較藥物動態學

윤효인,박승춘,김창식,김민규,최기섭,신광순,박종일,조준형,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

This study was designed to examine the in vitro antibacterial activities and pharmacokinetics of enrofloxacin acetate (ENFXA) and enrofloxacin (ENFX). Two enrofloxacins had wide spectrum antibacterial activities against Gram positive and negative bacteria, and mycoplasma, showing potent antibacterial activities with low MICs (0.05-3.33 ㎍/㎖ for Gram positives, 0.002 ㎍/㎖ for Gram negatives and 0.02 ㎍/㎖ for mycoplasma). In order to investigate the profiles of two formulations of enrofloxacin we studied comparative pharmacokinetics of them in rabbits. Five rabbits were given 5 ㎎/㎏ body weight of each enrofloxacin formulation intravenously (i.v.) and orally (p.o.) in a cross-over study. Pharmacokinetic parameters of both formulations were calculated by the use of PCNONLIN, a computer program. Their bioavailibility in rabbits, the means of the area under the curve (AUC). After oral administration of each formulation in rabbits, the mean elimination half-lives (t_1/2,ke) were 3.25h (ENFX) and 4.32 h (ENFXA), and mean AUC 4.27 ㎍·h/㎖ (ENFX) and 6.21 ㎍·h/㎖ (ENFXA). Both enrofloxacin formulations seemed to have good tissue distribution and penetration as indicated by large volume of distribution: 4.76 1/㎏ for ENFX and 7.23 1/㎏ for ENFXA. With the results obtained in this study, ENFXA could be used in place of ENFX in rabbits.

學校體育評價의 諸 問題

愼承允 師範大學 體育硏究所 1989 서울大學校 體育硏究所論集 Vol.10 No.1

The purpose of this study was to investigate the measurement and evaluation problems in physical education. The subject of this study was 199 teachers. The research method was questionnaire method. The questionnaire was developed by research himself. The data which subjects responded exactly were analyzed by using SPSS Pc+ in Hyundai personal computer. The results and conclusions were as follows: 1. 35.4% of subjects responded to 3∼4 hours per semester about the question of measurement time per semester. 2. 62.2% of subjects responded to 1 time per semester about the question of written test. 3. 42.6% of subjects responded to 2 times per semester about the question of motor test. 4. 80.3% of subjects responded to text about the question of the content of written test. 5. 70.6% of subjects responded to 7:3 about the question of the ratio between motor test and written test. 6. 58.3% of subjects responded to 1 time about the question of needed time of motor test. 7. 63.6% of subjects responded to motor domain about the question of the factors of evaluation. 8. 77.7% of subjects responded to criterion-referenced test about the question of the preference of evaluation method. 9. 48.5% of subjects responded to yes about the question of knowledge of statistical technique. 10. 54.9% of subjects responded to yes about the question of a need of statistical technique.

체육평가와 준거지향검사

신승윤,김종택 師範大學 體育硏究所 1993 서울大學校 體育硏究所論集 Vol.14 No.1

This study examined the characteristics of criterion-referenced test and reviewd the method of setting criterion in the area of physical education. 1. Characteristics of criterion-referenced test. Criterion-referenced test was made to evaluate what a learner could perform or could not. Norm-referenced test explains motor performance of learner in relation to that of the other learner. Variance is the essential element in differentiating criterion-referenced test and norm-referenced test. Norm-referenced test needs the heterogeneity between groups to improve the reliability of test, but criterion-referenced test does not need it. The reliability of criterion-referenced test is based on the consistency of classification, and the reliability of norm-referenced test is affected by the relative position of each score. 2. Problem of criterion-referenced test. Accoarding to the reviews of Meskauskas(1976), Millman(1974), and Glass(1978), the most important problems in utilizing the criterion are as follow; First, the criterion is determined on the base of arbitrariness. Second, the influence of misclassification is severe. 3. Validity Several terms for test validity are used, and they are content validity, criterion validity, and construct validity(AERA/ARA/NCME joint committee, 1985). These terms are the same as those used for norm-referenced test. The meaning of the terms have no difference between criterion-referenced test and norm-referenced test. The only differenced is in the method identifying in validity due to the different goals of the test. 4. Reliability The reliability of test depends on the consistency in providing informations of test results for the subjects. The reliability of criterion-referenced test can be improved by the consistent predictive of performance in the area The reliability of mastery test means the consistent classification between master and nonmaster. 5. Setting-standard Many scholars attempted to make the method of setting-standard(Glass, 1978; Meskauskas, 1976; Zieky & Livingeton, 1977). These studies can be classified into judgment, empirical, mixing of the two. In the area of physical education, the model of judgment is frequently used for motor performance test, and the mixed model for motor skill test. In the mixed model, there are criterion-groups model, borderline-group models, contrasting-groups models, and sequential probability ratio test.

오래달리기 기록의 거리간 동등화 방안

신승윤 龍仁大學校 1998 용인대학교 논문집 Vol.15 No.-

The purpose of this study was to find a method for comparing records from different types of distance run and walk. Currently many kinds of physical fitness test batteries have been developed and used in several countries including Korea. Although a distance run and walk item is usually included in those batteries, each has employed different types of test method. Thus it has been practically very difficult to compare the records from those different distance run and walk test methods. This study attempts to fond a way to compare them. Six hundreds boys and girls of 13,14 and 15 years old were tested. In each age/sex group one hundred subjects were assigned. The run and walk distances were 1,000m, 1,200m, and 1,609m(1mile) for boys and 800m, 1,200m, and 1,609m(1mile) for girls. The test items of 800m and 1,000m were those in Korea Student Physical Fitness Test Battery, 1,200m was Korea Physical Fitness Test Battery, and 1,609m(1mile) was the internationally used run and walk distance. Single group design was applied and thus each age/sex group conducted the three tests. The interval between tests was two weeks. Records were equated according to age and sex by using the equipercentile equating method. The table shows the records which were equated according to the percentile.

돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학

윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.

다카야스 동맥염과 동반된 초점성 분절성 사구체경화증 1예

강신명,송영수,김주성,윤수영,이루다,최규헌,조승연,이호영,한대석,정현주' 대한신장학회 2000 대한신장학회잡지 Vol.19 No.5

치료저항 정신분열병환자에서 Clozapine의 효과 및 안전성

지익성,김영희,신석철,왕성근,신윤오,이선우,김정란 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

In order to assess the efficacy and safety of clozapine, 50 in-patients with treatment-resistanat schizophrenia were evaluated using PANSS(Positive and Negative Symptome Scale for Schizophrenia), CGI(Clinical Global Impression), AMS(Abnormal Involuntary Movement Scale), Adverse Event-Somatic Symptoms, Neurological Rating Scale for EPS before and during treatment. Mean daily dosage of clozapine was 344.15±123.43mg at 12th week. A clinically significant improvement in positive, negative, and general psychopathology was noted as early as week 2 through 12 week. The tolerability of clozapine was generally found to be good. Drowsiness/sleepiness, Hypersalivation, and Constipation were the most common side effects. There was no neutropenia, and 3 patients suffered from seizures. These results suggest that clozapine is worth considering for the treatment-resistant patients

Wolff-Parkinson-White증후군의 임상상 및 전기생리학적 소견

안신기,이문형,장양수,오동진,최인석,하종원,임세중,김병옥,정남식,심원흠,조승연,김성순 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9