악성 흑색종의 임상적 고찰

진한식,이상헌,신극선,이영호 大韓成形外科學會 1977 Archives of Plastic Surgery Vol.4 No.2

Malignant melanoma is a very malignant tumor arising from melanocytes or its antecedents. Because of the black pigment, this disease has been referred to as "black cancer" The first written account of melanotic lesion is attributed to Hippocrates on fifth century before Christ. In 1836, Carswell first used the term melanoma to designate these pigmented malignant neoplasm. Since discussion of the pathology of tumor and suggestion of the method of treatment was reported by W.S. Handley, many papers were reported about various method of treatment for malignant melanoma. In 1969, W.H. Clark's report showed the Histogenesis and biologic behavior of primary human malignant melanoma and propesed leveling of omicroinvasion of melanoma. Authors reviewed the patients with malignant melanoma who were admitted and treated in Yonsei University Medical center during a period between 1965 to 1976 and evaluated clinical patterns, management and histologic patterns. There had been 30 cases of malignant melanoma in that period. The following results were obtained; 1) Males were affected about 1.1 times more than females. 2) The most frequent age group was fifth decade. Mean age was about 45 yrs. More than 60% of cases are over 40 yrs of age. 3) Most frequent site was head and neck(40%), and next was lower extremity (36.6%). 4) Melanoma occurred on lower extremity was more common under 50 yrs of age. 5) Size of tumor was most common over 4cm in diameter(26.7%). As increase of tumor size, longer duration of symptoms and more frequent metastasis were noted. 6) As increase of tumor size, metastasis of regional lymph node and remote organ was more frequently occurred and depth of microinvasion of tumor cell by Clark's level was more deepened. 7) As increase of depth of microinvasion by Clark's level frequent modular type of malignant melanoma was reported. 8) Treatment of malignant melanoma was almostly inadquate except clinical stage 1 malignant melanoma.

DISCOVERY OF AN X-RAY-EMITTING CONTACT BINARY SYSTEM 2MASS J11201034−2201340

Hu, Chin-Ping,Yang, Ting-Chang,Chou, Yi,Liu, L.,Qian, S.-B.,Hui, C. Y.,Kong, Albert K. H.,Lin, L. C. C.,Tam, P. H. T.,Li, K. L.,Ngeow, Chow-Choong,Chen, W. P.,Ip, Wing-Huen American Astronomical Society 2016 The Astronomical journal Vol.151 No.6

<P>We report the detection of orbital modulation, a model solution, and the X-ray properties of a newly discovered contact binary, Two Micron All Sky Survey (2MASS) J11201034-2201340. We serendipitously found this X-ray point source outside the error ellipse when searching for possible X-ray counterparts of 7-ray millisecond pulsars among the unidentified objects detected by the Fermi Gamma-ray Space Telescope. The optical counterpart of the X-ray source (unrelated to the 7-ray source) was then identified using archival databases. The long-term Catalina Real-Time Transient Survey detected a precise signal with a period of P = 0.28876208 (56) days. A follow-up observation made by the Super Light Telescope of Lulin Observatory revealed the binary nature of the object. Utilizing archived photometric data of multi-band surveys, we construct the spectral energy distribution (SED), which is well fit by a K2V spectral template. The fitting result of the orbital profile using the Wilson Devinney code suggests that 2MASS J11201034-2201340 is a short-period A-type contact binary and the more massive component has a cool spot. The X-ray emission was first noted in observations made by Swift, and then further confirmed and characterized by an XMM-Newton observation. The X-ray spectrum can be described by a power law or thermal Bremsstrahlung. Unfortunately, we could not observe significant X-ray orbital modulation. Finally, according to the SED, this system is estimated to be 690 pc from Earth with a calculated X-ray intensity of (0.7 - 1.5) x 10(30) erg s(-1), which is in the expected range of an X-ray emitting contact binary.</P>

심전도 파형 분석 프로그램 개발

이상세,고석남,임승관,정호춘,진달복,이문영,박병림 원광대학교 생체공학연구소 2000 원광인체과학회지 Vol.4 No.1

Easy check system for cardiac function war developed for computer user in this study. EKG amplifier was designed to remove a common noise and muscle noise. EKG pattern, and calculated real time heart rate and probability if arrhythmia were displayed in personal computer. This system would be an effective tool for checking cardiac function in everyone using computer

햄·소시지제품에 대한 소비자 의식 및 구매 실태

조수현,박범영,진구복,유영모,채현석,안종남,이종문,윤상기 한국동물자원과학회 2003 한국축산학회지 Vol.45 No.2

본 설문조사는 국내 육가공제품의 시장에 대한 소비자 의식과 구매형태를 파악하고 시장확대를 위한 기본방안 구축을 위하여 10월부터 12개월까지 3개월 조사한 결과이다. 육가공제품의 구입횟수는 월 1∼2회로 구입하는 소비자가 40.73%로 가장 많았고 그 다음이 주 1∼2회 구입하는 것(28.07%)으로 나타났다. 햄과 소시지를 구분할 수 있는지에 대한 질문에 구분한다가 86.75%로 나타난 반면 구분하지 못한다가 13.25%로 나타났다. 햄과 소시지를 구분하지 못하는 소비자들은 그 이유로서 두 제품의 고기 함량 및 첨가내용물들이 비슷하여서라는 응답이 47.19%로 가장 많았다. 햄과 소시지를 구입할 때 가장 중요하게 고려하는 사항은 회사명(brand name)인 것으로 나타났으며(32.76%) 원료육의 종류(16.53%), 유통기한(16.38%) 및 원료육 생산지(16.23%)인 것으로 나타났다. 햄 또는 소시지 구입시 제품설명 표시내용을 읽느냐는 질문에 응답자들 중 72.25%가 그렇다고 응답한 반면 27.25%는 읽지 않는다고 응답하였다. 소비자들은 햄과 소시지 구입시 불만사항으로 소비자들이 제품내에 고기보다는 결착제를 비롯한 다른 첨가제들이 많아서 고기맛을 거의 느낄 수 없다고 응답하였으며(47.65%), 외관 및 내용물이 비슷한 제품이 너무 많다고 응답한 소비자 및 맛이 없다고 응답한 소비자가 각각 27.70%, 11.62%인 것으로 나타났다. 햄 및 소시지 제품에 대한 요구사항으로 고기 함량이 높은 제품을 생산하기를 원한다고 응답한 소비자가 64.04%였다. 햄과 소시지 제품 판매시 품질에 따른 가격차등제 실시에 대하여 찬성한다고 응답한 소비자가 83.54%인 것으로 나타나 현재 많은 소비자들이 햄과 소시지 제품의 품질에 따른 가격차등제 실시를 원하는 것으로 나타났다. 우리나라도 품질에 따른 등급 기준 설정과 품질별 가격차등제 실시를 통하여 육가공 제품시장의 확대가 가능할 것으로 판단되며 이는 국내돈육의 비선호부위의 소비촉진도 가능할 것이다. Consumer survey(n=1,343) was carried out to investigate the consumer's perception, purchase behavior and demand on the processed meat products. Most consumers purchased the ham and sausage products once a month (40.73%). Consumers(47.19%) didn't distinguish between ham and sausage products due to the similarity of meat contents and additives in products. Consumers(72.75%) considered the product label when they purchased whereas 27.25% of consumers were not interested in the product label. Consumers(47.65%) were not satisfied with ham and sausage products because there were too much additives other than meat, there were many similar processed products in kinds and appearance(27.70%) and they could hardly detect meat taste(11.62%). Consumers demanded to produce the ham and sausage products which contain high meat contents(64.04%). Consumers were favored with establishment of the price differential system depending on the quality based on meat contents in the product(83.54%). In conclusion, the establishment of the price differential system depending on quality as well as the quality grading system for processed meat products is needed not only to increase the processed meat market but also increase the pork consumption especially for non-preferred pork portions.

요도하열을 동반한 남성반음양 1례 보고

진한식,유재덕,신극선,오석준 大韓成形外科學會 1979 Archives of Plastic Surgery Vol.6 No.1

Male hermaphroditism may be defined as a process of incomplete masculinization of the internal or external genital organs or both in subjects with male gonads and male sex chromatic distribution. In the differential diagnosis of genital ambiguity, the important points include history, physical examination. sex chromatin pattern, and determination of the urinary steriod excretion pattern, and also, of help in selected cases are endoscopy, X-ray contrast studies, laparotomy with gonadal biopsy and chromosomal analysis. Cases of male hermaphroditism with ambiguous external genitals can be devided into those with absence of breast development which are usually called PPSH(Pseudovaginal Perineoscrotal Hypospadia) and those with breast development which are usually called incomplete or partial testicular feminization. The former is characterized by a phallus of intermediate size and a perineal urethral meatus, and blindly ending "vagina" which may poen either into the urethra or the perineum. A labia majora-like cleft scrotum frequently contains normally developed testes, and Wolffian-duct derivatives show normal male differentiation. Masculinization at puberty results in masculine body build, axillary, facial and pubic hair, and deepening of the vioce. Breast development is minimal or absent. We have experienced recently a case of male hermaphroditism which was concerned to be a PPSH with the characteristics of external genitals, sex-chromatin pattern(sex-chromatin mass positive), chromosome study(karyotype 46XY) urinary steriod excretion (17-KS; normal value), laparoscopy(no Mullerian-duct structure), IVP (normal), and gonadal biopsy (atrophy of seminiferous tubule and decreased spermatogensis). Extragenital malformations were not detected and he was of normal intelligence. His sex was assigned male, and treatment consists of urethroplasty and resection of urogenital sinus.

논의 물질순환 모니터링

박승우,윤광식,진영민,이변우 서울大學校 農業生命科學大學 農業開發硏究所 1997 서울대농학연구지 Vol.22 No.1

Photoallergic Dermatitis due to 8-Methoxypsoralen

Choi, H. J Korean Dermatological Association 1998 Annals of Dermatology Vol.10 No.3

비양자성 용매 속에서 트리플루오로에틸클로라이드와 알칼리금속을 이용한 트리플루오로에탄올의 합성

김경환,이현주,김훈식,김홍곤,진종식 한국공업화학회 2002 응용화학 Vol.6 No.2

Preparation of 2,2,2-trifluoroethanol from 1,1,1-trifluoroethylchloride with alkali-metals in aprotic polar solvents has been studied. Effects of alkali-metals and solvents on the 2,2,2-trifluoroethanol yield as well as the reaction mechanism were investigated. 2,2,2-trifluoroethanol was produced at high temperatures between 150℃ and 250℃. CH_3COOK produced better yields than KOH, and the co-solvent system of v -butyrolactone and ionic liquid [BMIM]^+BF_4^- produced remarkably improved results.

식염 및 지방을 함유한 분쇄돈육의 이화학적 성상 및 최종가열온도 측정을 위한 근장단백질의 이용

강상미,진구복,조수현,이종문 한국동물자원과학회 2004 한국축산학회지 Vol.46 No.1

Processed meats, such as a ground meat and hamburger patty, are required to ensure that no pathogens remain in the final products. However, there was no rapid method available to verify that the recommended end-point cooking temperature(EPT) was reached. Thus, the objective of this study was to rapidly determine EPT of ground pork hams using sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE), based on the disappearance of sarcoplasmic proteins after cooking. Fresh pork hams were added two levels of salt(0, 2%) and fat(15, 25%) combinations, and stored in refrigerator overnight, and cooked to internal cooking temperatures of 64℃ to 74℃ with 2℃ increments. Cooked pork hams were measured cooking loss(CL, %), protein solubility(PS) and SDS-PAGE. CL(%) was reduced with the addition of 2% salt, as compared to the control, regardless of fat contents. It was also increased with increasing cooking temperature. Protein solubility was affected by the cooking temperature, resulting in reduced PS up to 64℃(P<0.05), but remained constant higher than 68℃. In SDS-PAGE analysis, protein bands with the molecular weights of 36 and 66 kDa were affected by the addition of salt and fat combinations, regardless of treatments. These protein fractions were decreased gradually with increased cooking temperatures up to 68℃~70℃ and might be good indicators for the determination of EPT in ground pork hams.

내시경적 초음파촬영술로 위치가 확인된 인슐린종 1 예

김기수,박성우,이기업,이인철,진재용,이철환,강재영,김해련,한덕종 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.2

Insulinomas are tumors that, in more than 90% or cases, are both single and benign, so the potential for surgical cure is very high. But, their localization is somewhat difficult, as they are small in size and located deep in pancreatic parenchyma. Because success of operation is depentdent on the localization rather than the surgical techniques, the availability of good licalization technique is mandatory. Recently, endoscopic ultrasonography(EUS) has been reported to be a very sensitive and specific test for the localization of insulinomas. We report a case of insulinoma that was localized successfully by EUS, after failure in localization by abdominal ultrasonography, abdominal CT, selective angiography, and even by transhepatic portal vein sampling. (J Kor Soc Endocrinol 8:197~202, 1993)