한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

Cholelithiasis complicated with biliary sludge and urolithiasis in a dog

Seung-gon Lee,Dong-gun Kim,Joon-seok Lee,Ho-hyun Kwak,Hyun-sook Nam,Heung-myong Woo*, In-Chul Park**, Changbaig Hyun1,In-chul Park,Chang-baig Hyun 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.3

A 10-year-old intact female Miniature Schnauzer dog was referred with the primary complaint of persistentanorexia, remittent fever, vomiting and abdominal pain. Hemogram suggested a chronic inflammatory disease. Serumbiochemistry showed moderate hepatobiliary cellular damage with severe cholestasis. Abdominal radiography andultrasonography revealed hepatomegaly, choleliths and sludges in gall bladder and small stones in urinary bladder. Basedcholecystectomy and cystectomy, choleliths and uroliths were removed from gall bladder and urinary bladder,respectively. The clinical condition was dramatically improved after surgery.

음식물류폐기물 공공 자원화시설 운영에 관한 연구 (Ⅱ)

홍용표ㆍ김웅용ㆍ신현곤(Yong Pyo HongㆍUng Yong KimㆍHyun Gon Shin) 유기성자원학회 2016 유기물자원화 Vol.24 No.1

본 연구는 음식물류폐기물 공공 자원화 시설 운영의 문제점과 제도 개선방안을 위하여 실시하였다. 현재 운영중인 음식물류 폐기물의 가동율 현황과 자원화 시설의 확충 계획에 대한 분석을 통해 시설의 무분별한 신규건설로 인한 국가의 예산이 낭비되지 않도록 그 대안을 제시하였으며, 그 결과는 다음과 같다. 공공 자원화시설 신규 확충보다는 기존 민간 자원화시설을 활용하여 예산을 절약하고 음식물류 폐기물의 안정적인 처리는 물론 자원순환을 촉진시킬 수 있는 정책전환이 필요하다. 음식물류 폐기물을 친환경적인 방법으로 안정적으로 처리하기 위해서는 제도개선이 필요하며, 이를 위해 민간 자원화시설 가동률 저하를 줄일 수 있는 준공영제 도입이 필요하다. 또한, 공공 자원화시설의 검증된 기술과 경제성 확보 방안 마련이 필요하다. This study is conducted to find out the problems of the public food waste recycling facility operation and its improvement. In order to save the national budget by analyzing plans to expand including operation rate for the food waste recycling facility, the alternative ways are suggested. The result can be as follows: Policy switch is required not only to save budget and stable disposal of food waste but also to promote resource recycling rather than expanding public facilities. In order to change the policy for stable and eco-friendly disposal of food waste, it is necessary to adopt semipublic system that prevent the decline of the rate of operation of private resource recycling facility. Furthermore, it is required to prepare both qualified technologies of public resource recycling and the ways of profitability secure.

웨이블렛 변환을 이용한 정전 탐침 자료 분석 알고리즘 개발

김곤호,김대경,황순모,김용현 한양대학교 이학기술연구소 1999 이학기술연구지 Vol.1 No.-

ECR 식각 플라즈마에서 정전 Langmuir 탐침으로 얻은 자료의 해석을 위하여 Dauberchies 웨이블렛과 이중 직교 웨이블렛 변환을 이용한 새로운 알고리즘을 개발하였다. 이 알고리즘을 이용한 자료해석 방식에서는 해석자의 선택적 입력 값을 최소로 하고 자료의 잡음제거시 일반적으로 사용하고 있는 평균을 기초로 하는 통계적인 방법을 사용하지 않았다. 본 알고리즘에서는 Dauberchies 웨이블렛을 이용하여 자료의 저주파 성분만을 추출함으로 포화 이온 및 전자 전류성분을 변환 자료에서 직접 구하였다. 또한, 원시 자료의 1차 미분자료에 대한 이중 직교 웨이블레서 변환을 이용하여 플라즈마 전위를 직접 구할 수 있어 웨이블렛 변환을 거치는 과정에서 플라즈마 전자온도를 구하는 영역이 일관성 있게 정의되었다. 전자분포 모델은 ECR 플라즈마의 특징인 hot과 bulk의 두 가지 온도를 가지는 bi-Maxwallian 분포로 가정하고 Martquardt 방법을 사용한 비선형 fitting 방법으로 두 가지 전자 온도를 구하였다. 포화 이온 및 전자 전류 곡선의 플라즈마 전위에 해당하는 전류 값으로부터 플라즈마 이온 및 전자 밀도를 얻었으며 임의의 자료에 대한 알고리즘의 정확성 검사 결과 90%이상의 정확도를 보였다. A new algorithm for automating the analysis of Langmuir-probe traces taken from the ECR magnetized plasma is developed through the Daubechies wavelet and the bi-orthogonal wavelet transformations. This approach minimizes the operator-specified inputs and provides de-noised data without using the statistical method based on the averaging techniques. In this algorithm, the electron and ion current lines are obtained from the low frequency information of the Daubechies wavelet processed data. From the bi-orthogonal wavelet transform for the differentiated data, the plasma potential can be clearly determined. The region for obtaining the electron temperature can be systematically chosen from these processed data without operator-specified inputs. The electrons are modeled by a bi-Maxwellian distribution with hot and cold temperatures and nonlienar fitting method (a Martquardt method) is used to determine the electron temperatures from this region. Ion and electron plasma densities are obtained from the ion and the electron current at the plasma potential, respectively. The evaluation results by using the artificially generated data shows over 90% accuracy.

Estradiol-17β를 처리한 흰쥐 자궁에 있어서 Clomiphene이 세포내 수용체, DNA 및 cAMP 농도에 미치는 영향

김곤섭,고복현 동국대학교 경주대학 1989 論文集 Vol.8 No.-

These experiments were carried out to investigate the study on the interaction of estradiol receptor and cAMP level of clomiphene in immature rat uterus. The results obtained were summarized as follow : 1. The binding affinity of clomiphene to estradiol receptor in uterine cytosol was lower than that of estradiol-17β. clomiphene inhibited the replenishment of the receptor to cystol in uterus(P<0.01). 2. DNA level in uterus was increased at 48 hours after estradiol-17β or clomiphene injection(P<0.01) 3. cAMP level in uterus was increased at 48 hours after estradiol-17β or clomiphene injection(P<0.01)

포틀랜드 시멘트 페이스트와 몰탈의 특성에 미치는 실리카 흄 및 왕겨재의 영향

김석곤,신현택 慶尙大學校生産技術硏究所 1990 生産技術硏究所論文集 Vol.6 No.-

The effects of the silica fume and rice husk ash on the physical, chemical, and mechanical properties of portland cement mortars and pastes have been studied. When silica fume was added to partland cement with 3,6,9,12wt%, overall compressive strength strength was increased because the added silica fume was reacted with free lime resulting in the formation of new C-S-H phases. Among these, the cement mortars containing 9 wt.%, silica fume shows the highest compressive strength. On the other hand, the addition of rice husk ash to partland cement was not seemed to be much effective on compressive strength due to the larger particle size than silica fume.

양방향 PWM Sepic/Zeta 컨버터 설계

김현곤,이동희 경성대학교 공학기술연구소 2012 공학기술연구지 Vol.18 No.-

본 논문에서는 전력 용량 10kW급의 새로운 양방향 PWM Sepic/Zeta 회로를 사용한 컨버터를 제안한다. 이 회로를 설계하고, 이 컨버터의 설계가 동작 가능한지에 Matlab의 Simulink를 사용하여 시뮬레이션 하였다.

아날로그 방식을 이용한 광케이블의 선로유지 보수를 위한 광전화기 설계 및 제작에 관한 연구

김충관,최현용,소성진,김영곤,김종빈 조선대학교 전자정보통신연구소 2000 電子情報通信硏究所論文誌 Vol.3 No.1

본 논문에서는 fiber optical field test 에서의 통신과 파이버설치, 시험, 유지/보수 및 손실측정에 사용되는 광전화기를 설계 하고자 한다. 본 장비는 음성을 광신호로 변조하여 파이버로 내보내어 설치자/시험자/수리자 등이 상대방과 통신할 수 있도록 한다. 이번에 설계한 광전화기는 FM 변/복조 방식을 이용한 아날로그 양방향 광전화기로써, 마이크로폰을 통해 입력되는 음성신호를 광신호로 변환하고 이를 다시 FM변조한 후 신호를 파이버로 전송한다. 그리고 Photo Diode를 통해 수신된 광신호는 FM 복조기를 통해 아날로그 신호로 복조한 후 적절한 이득으로 취하여 스피커로 전송되고 전송된 신호는 스피커를 통해 사람이 들을 수 있는 소리로 바뀌게 된다. 단일 파이버(Single Optical Fiber)를 통한 쌍방향 동시 통화는 13㎛의 LED를 사용하여 FM 변조 방식을 채용하므로 가능하였다. In this paper, The Optical Talk Set is an design for communication in fiber optical field test and other applications(fiber installation, examination, maintenance/restoration and fiber identification) It launches voice modulated optical signal into fiber and makes the installer/examiner/restorer etc Designed optical talk set is analog full duplex and provides FM for data(de)modulation. The device sends an optical signal which is FM modulated by the voice signal from the microphone And then received form the Photo Diode optical signal is amplified and sent to the ear-phone Single fiber, full duplex operation is available using the FM modulation of 13 ㎛ LED optical signal

10주간의 행동요법이 비만 초등학생의 혈중지질 성분에 미치는 영향

김현준,김태운,박태곤,박찬호,예정복 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this study was to verify the effect of behavioral modification therapy among elementary students by comparing and analysing serum lipid between the experimental group and the control group on obese children. For this study, 44 obese children(boys: above 25% of % fat, girls: above 30% of % fat) between 11 and 12 years old S elementary school in Busan city were engaged in and were divided into two groups, each group consisting twenty two children an experimental group for behavioral modification therapy and a control group without any kind of obesity management program......

불소적용시 법랑질과 상아질에서 불화칼슘형성의 차이에 관한 실험적 연구

김재곤,권선자,윤현두,안수현,백병주 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

The purpose of this study was to compare the amount of calcium fluoride deposited on the enamel and dentin surface and to obtain information on the morphological change and crystallographic details of mineral deposition after 12,000ppm APF application in vitro. The bovine enamel and dentin blocks were randomly assigned to eight groups according to artificial caries lesion formation and difference of fluoride application time. The fluoride concentration and morphological characteristics on the treated enamel and dentin surface were investigated by using fluoride quantitative analysis and SEM. The powdered enamel and dentin of the intact bovine incisors were prepared for the X-ray diffraction analysis. The following results were obtained. 1. The amounts of KOH-soluble fluoride on the carious enamel and dentin surface after 24h APF application were higher than after only 5min APF application(P<0.05), but in the case of the sound enamel and dentin surface were similar after 5min and 24h application (P>0.05). The fluoride content was highly increased in the carious dentin as compared with sound dentin after APF application(P<0.05). 2. The caruous enamel surface after APF application, the demineralized enamel surface were recovered a more dense enamel surface and precipitation of crystal was observed a distintive surface layer of spherical globules of about 1 m diameter. In the case of the fluorided carious dentin surface, precipitation of calcium fluoride-like material was deposited both inside the dentinal tubules as well as in the intertubular regions. 3. The crystallographic structure of powdered enamel and dentin after 24h APF application had large crystallities of apatite and CaF2 diffraction peaks in the enamel as compared with dentin. The diffraction data collected from the 27.50-29.50(2) angular range of the powdered enamel, the (105) apatite, (225) apatite and (111) CaF2 peaks of the enamel crystallities were detected after 24h APF application.