대학교 교양 헬스수업이 신체구성 및 체력요인에 미치는 영향

이한용,문진석,김국진 남서울대학교 2005 남서울대학교 논문집 Vol.11 No.1

The purpose of this study was to examine how body composition and the basic physical strength had changed during one semester after taking a general physical education class for 12 periods, to which 130 students (86 male and 44 female) studying at N. Univ. in Chon An City, Chung-nam province, applied. The programs of the class were accompanied by weight training and aerobic exercise. To test the effect of the health class, the body composition was measured by the body fat percentage and the weight. and the basic physical strength was checked by the muscular strength, instantaneous reactionary force, and the flexibility. The conclusions are as follows: First, of the body composition, the male students' weight seemed to be reduced to 2.43kg and the female students' weight to 2.28kg in average, and the body fat percentage of the male students seemed to be reduced to 1.76% and that of the female students to 1.90% in average through general physical education, which showed significant difference statistically Second, for both male students and female students, the basic physical strength, such as the muscular strength, instantaneous reactionary force, and the flexibility, had been improved through the general physical education, which showed significant difference in the statistic. Third, It was revealed that prior to the course, the differences between the male students and the female students in the body composition and the basic physical strength still remained the same after the course.

TiAIN 코팅 평 엔드밀의 성능평가에 관한 기초 연구

유중학,국정한,김문기 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.5

The purpose of this study is an evaluation of flat end mills to develop appropriate tools for the high speed machining. First of all, several flat end mills which are produced by different markers are selected to analyze the performances of the tools. Experimental works are also executed to measure cutting force, tool wear and surface roughness for different cutting conditions. And then the results are compared and analyzed for developing optimal cutting tool in the high speed condition.

^(99m)TC Phytate 간스캔에 있어서 정량적 간외섭취율의 임상적 의의

김병수,문태용,김건일,남상화,한국상 부산의대 1991 부산의대잡지 - 부산대학교 의과대학 Vol.31 No.2

고등학생들의 음란물 접촉실태 및 관련요인

윤분희,정문숙,한창현,어윤국 慶山大學校 保健福祉硏究所 2002 保健福祉硏究 Vol.7 No.-

본 연구는 성에 민감한 청소년들의 음란물 접촉 실태를 알아보기 위하여 1998년 11월 30일부터 12월 30일까지 경상남도 J시 소재 고등학교 2학년 학생 732명을 대상으로 설문 조사 분석한 결과는 다음과 같다. 음란물 접촉실태는 대상자가 가장 많이 접촉하는 음란물은 성인용 비디오(76.9%)이었고 성인용 만화(70.1%), 성인용 주간지(55.9%), 음란 컴퓨터 프로그램(51.2%), 포로노 비디오(50.3%), 포로노 잡지(34.4%) 및 포로노 사진집(28.1%) 순이었다. 인문계 학생이 가장 많이 접촉하는 음란물은 성인용 만화이었고, 실업계 학생은 성인용 비디오였으며 남학생이 여학생보다, 실업계 학생이 인문계 학생보다 음란물 접촉 경험이 더 많았다.(p<0.01) 음란물 접촉 시 특성을 보면 대부분 학생이 "중학교"때 처음 접촉했으며 접촉경로응 "친구를 통해서"가 가장 많았고, 접촉이유는 "호기심 때문에"가 가장 많았다. 제반 변수들에 따른 음란물 접촉과의 연관성을 알아본 결과 자위행위, 성 경험, 이성교제, 학생성적, 흡연, 음주는 모든 음란물의 접촉과 상관성이 있는 것으로 나타났다.(p<0.01) 음란물 접촉 유무를 종속변수로 하여 다중 로지스틱 분석을 한 결과는 남자일수록, 자위행위를 할수록, 학교 성적이 낮을수록, 담배를 피울수록, 술을 마실수록, 외향성일수록 음란물을 보는 경험이 더 많았다.(p<0.01) 이상 결과들을 볼 때, 청소년들을 음란물로부터 보호하기 위해서는 성적충동을 올바르게 표출하고 승화할 수 있도록 개개인의 취향에 맞는 운동이나 취미활동을 권장하고 이를 개발할 수 있도록 도와주어야 할 것이며 유해환경에 대한 규제를 강화하여 학생들이 살고 잇는 사회의 성문화 정화에 모두 관심을 가져야겠다. This study was conducted to examine the sex-sensitive adolescents' actual condition of contact with lecherous things from November 11th to December 20th, 1998 with 732 high school sophomores in Chinju, Kyungsangnam-do. And the results are as follows. According to the actual condition of contact with lecherous things the most lecherous thing subject group came into contact was adult videos(76.9%) and adults cartoons(70.1%), adults magazines(55.9%), lecherous computer programs(51.2%), porn videos(50.3%), porn magazines(34.4%) and porn photo collections(28.1%) in highest order. The most lecherous thing academic high school students came into contact was adults cartoons and that of business high school students was adults videos and contact experiences to it of male students and business school students were higher than those of female students and academic school students respectively(p<0.01%). In view of students' characteristics of contact with lecherous things, most students made first contact with them in their middle school years and from their friends curiosity. In the result of study of relevance to the contact with lecherous things due to all sorts of variables, it shows that masturbations, sex experiences, intersexual acquaintances, school records, smoking and drinking are related to the all contacts with lecherous things(p<0.01). In the result of Multiple Logistic Analysis with the presence of contact with lecherous things as subordinate variable, the more they are men, doing masturbations, the person with bad school records, smoking, drinking and extroversive the more they are inclined to contact with lecherous things(p<0.01). To protect adolescents from the access to lecherous things, in view of above results, we have to encourage and help adolescents to enjoy and develop sports or hobbies of their own to express and purify their sexual impulses right. And we also have to concern the purification of sexual culture of the society in which students live by strengthening our regulatory systems for unsound circumstances.

Gas Chromatography를 이용한 Aspergillus niger KCCM 32005의 Myrcene 대사산물에 대한 연구

金京禮,崔文禎,李尙駿,朴炯國,金正漢 성균관대학교 약학연구소 1991 成均藥硏論文集 Vol.3 No.1

Abstract-After biotransformation of myrcene with Aspergillus niger KCCM 32005, its neutral metabolites were isolated from the conversion broths and analyzed by GC and GC/MS. Myrcene was converted into various terpenoids. Among them the five compounds, which were considered to be important as flavor, were identified as follows; terpinen-4-ol. α-terpineol, trans-carveol, cis-carveol, and carvone. Higher production was accomplished when the amount of myrcene was kept at lower but steady concentration by portion-wise introduction to the culture broth.

Cationic Liposome-Mediated p53 Gene Therapy in Liver Cancers: Result of Basic and Clinical Study

Moon,Young Ho,Kim,Byung Koo,Shim,Hyung Jin,Uhm,Tae Han,Cha,Sung Jae,Moon,Chul So,Moon,Woo-Chul,Kwak,Byung Kook,Gi,Young Jin,Lim,Hyun Mook,Yoo,Nam Sook,Lee,Chang Joon 가톨릭중앙의료원 가톨릭암센터 1998 암심포지움 Vol.- No.2

p53 is a prototype tumor suppressor gene, which plays key roles in regulation of cell cycle progression, apoptosis, DNA repair and maintenance of genomic stability. Experimental stydy study on p53 gene therapy for cancer have been widely tried and Success of adenovirus or retrovirus-mediated p53 gene therapy have been reported in patients with lung cancer and cancer of the head and neck. However, viral vector-mediated gene therapy may have demerits to be widely applied in human cancers. We herein have designed a cationic liposome-mediated p53 gene therapy and have studied its antitumor efficacy and safety in vitro, in vivo and in human patients with advanced liver cancers. We constructed and prepared a complex of plamid vector carrying cDNA of human wild type(WT) p53, cationic liposome (HECH : DOPE) and cationic polymer (polylysine) in sterile and endotoxin-free condition depending on the guideline of FDA and used this complex for in vitro and in vivo transfer oi WT p53 gene. In vitro administration of p53 gene to a variety of human cancer cells with point mutation or deletion of p53 in DNA dose of 1㎍ per ?? cells induced high level expression of WT p53 and p21/WAF1 as demonstrated by RT-PCR-Southern blot and Western blot, apoptosis as demonstrated by DNA electrophoresis, and significant decrease of viable cell numbers by 70.4 to 98.5%, whereas, administration of p53 gene in same condition to human cancer cells with WT p53 didn't induce either apoptosis or significant decrease of viable cell numbers. In vivo antitumor efficacy of p53 gene transfer was initially analyzed in sc,ip, subrenal capsular and intrahepatic xenograft model of human cancers with deletion of p53. Local, ip, or iv administration of p53 gene in DNA dose of 100㎍ daily for 5 to 10 days induced expression of WT p53 and p21 in tumor tissues, significant decrease of tumor volume (by 62.0 to 99.5%)and/or incidence of tumors, and complete suppression of metastasis. Intravenous administration of p53 gene in DNA dose of up to 12 mg/kg to rats didn't induce significant acute or sub-acute toxicity as demonstrated by survival body weight, laboratory studies, and histologic analysis of vital organs. Trans-hepatic arterial administration of p53 in DNA dose of 0.5 to 5 mg per kg induced expression of human WT p53 in rabbits liver and/or lung and didn't induce significant hepatic toxicity or systemic toxicity. Trans-hepatic arterial administration of p53 gene in DNA dose of 1 mg per kg induced significant decrease of tumor incidence (to 40%) and volume (to 0.4% of control) and suppression of metastasis of rabbits liver VX2 carcinoma which carry point mutation of p53. These results suggested that our cationic polyliposome-mediated p53 gene trasfer might be a promising treatment modality for human cancers which carry mutation of p53. Based on the results of basic research, we carried out a pilot study to investigate antitumor efficacy and safety of cationic liposome-mediated p53 gene therapy in patients with liver cancer. Patients whth advanced, primary (N=12) or metastatic (N=4) liver cancer who had failed conventional therapy underwent p53 gene therapy, of whom 12 showed mutation of p53. Patients with advanced liver cirrhosis or metastasis were also included in the study. Fifteen patients with advanced liver cancer who underwent hepatic angiography alone served as control. p53 gene was administered in complex with HECH : DOPE : PLL into common hepatic artery in DNA dose of 10 to 30 mg every 3 to 4 weeks for 2 to 8 times (mean 4 times). Of 16 patients who underwent p53 gene therapy, 6 showed partial response, 4 minimal response and 3 stable disease. High level expression of WT p53 or p21 were found in tumor tissues of hepatovectin1 administered patients. After p53 gene therapy, 11 of 16 patients developed transient fever and chill, but none developed transient fever and chill, but none developed grade 4 toxicity or deterioration of liver function. Of 16 patients who underwent p53 gene therapy, 7 were alive on 1 year follow up and 9 died from metastatic cancer or liver cirrhosis-related complications. in contrast, none of control group survived for 1 year. These results suggest that cationic liposome-mediated p53 gene trasfer via hepatic artery may become a promising therapeutic modality for advanced liver cancer which carry mutation of p53 gene. Our studies strongly suggest that our cationic liposome-mediated p53 gene therapy may be a promising treatment modality for human cancers which carry mutation of p53 gene and failed by conventional therapies. Further stydies are necessary on the actual benefit of this experimental study and effective systemic delivery method of p53 gene.

Protective Effect of Carvacrol on Acute Alcohol-Induced Liver Disease Model in Mice

Moon Han Chang,Bo Byeol Hwang,Ji Eun Moon,Eun Hee Jo,Min Kook Lee,Seoyoon Lee,Suk Hee Lee,Hanvit Cha,Jin Hyup Lee 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10

Case Reports : A case of pedunculated hepatic hemangioma mimicking submucosal tumor of the stomach

( Han Kook Moon ),( Hyoung Su Kim ),( Gyeong Mi Heo ),( Woon Geon Shin ),( Kyung Ho Kim ),( Myoung Kuk Jang ),( Jin Heon Lee ),( Hak Yang Kim ),( Doo Jin Kim ),( Seong Jin Cho ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.1

Hepatic hemangioma is the most common benign tumor of the liver. Most such hemangiomas are small, asymptomatic, and have an excellent prognosis. Giant hepatic hemangioma has been reported in the literature, but the exophytic and pedunculated forms of hepatic hemangioma are rare. A 56-year-old woman was referred to our hospital under the suspicion of having a gastric submucosal tumor. Abdominal computer tomography (CT) scans showed a pedunculated mass from the left lateral segment of the liver into the gastric fundus, exhibiting the atypical CT findings of hepatic hemangioma. We therefore decided to perform laparoscopic resection based on the symptoms, relatively large diameter, inability to exclude malignancy, and risk of rupture of the exophytic lesion. The pathology indicated it to be a cavernous hemangioma of the liver. Herein we report a case of pedunculated hepatic hemangioma mimicking a submucosal tumor of the stomach due to extrinsic compression of the gastric fundus.

폐흡충증과 연관된 급성 호산구성 전격성 심근염 1예

문한국 ( Han Kook Moon ),박대균 ( Dae Gyun Park ),김성은 ( Sung Eun Kim ),윤덕형 ( Duk Hyung Yoon ),이준희 ( Jun Hee Lee ),한규록 ( Kyoo Rok Han ),오동진 ( Dong Jin Oh ) 대한내과학회 2008 대한내과학회지 Vol.74 No.4

전격성 심근염은 급성기에 높은 사망률을 보이나 약물치료나 기계적 순환 보조장치로 회복되기만 하면 급성 심근염 환자에 비해 장기 생존률은 좋은 것으로 알려져 있다. 현재까지 국내에서 기생충 질환에 의한 과민반응에 기인하여 양호한 경과를 보였던 호산구성 심질환은 보고 되었으나 폐 흡충증과 연관되어 호산구수가 증가하고 증상 시작 2일만에 혈압저하, 호흡곤란등 울혈성 심부전 경과를 보이는 급성 호산구성 전격성 심근염을 국내에서는 처음으로 경험하여 문헌고찰과 함께 보고하는 바이다. Fulminant myocarditis is characterized by critical illness at presentation. However, if affected patients recover with pharmacologic therapy and mechanical circulatory support, they may have a better long-term prognosis than patients with other forms of myocarditis. A 31-year-old man was admitted due to chest pain associated with dyspnea. Electrocardiogram showed ST-segment elevation in all leads except for aVR and aVL. Non-sustained ventricular tachycardia developed 12 hours after admission. The echocardiography showed diffuse hypokinesia, concentric edematous thickening of the left ventricular wall, and pericardial effusion. Serum cardiac enzymes and absolute eosinophil count were elevated. Since the ELISA (Enzyme-Linked Immunosorbent Assay) against Paragonimus westermani was positive, the patient was treated with praziquantel for 2 days. Eosinophil count normalized after 10 days, with conversion to negativity on ELISA after 4 weeks. We concluded that his myocarditis was probably caused by allergic reaction secondary to Paragonimus westermani infection.(Korean J Med 74:451-456, 2008)

Solution-Processed Aluminum-Zirconium Oxide as a Gate Dielectric for InGaZnO Thin Film Transistors

Han Jeong Hun,Lee So Young,Kim Hyo Eun,Jeon Jae-Hong,Park KeeChan,Moon Kook Chul,Im Hwarim,Kim Yong-Sang 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1

This study presents a solution-processed aluminum-zirconium oxide (AlZrOx) dielectric for amorphous indium-gallium-zinc oxide (a-IGZO) thin-flm transistors (TFTs). Solution-processed AlZrOx thin flms exhibit overall improved dielectric properties, such as leakage current characteristics of 1.10× 10–8 A/cm2 at 0.5 MV/cm and high dielectric constants of approximately 9.1 by combining the advantages of aluminum oxide (AlOx) and zirconium oxide (ZrOx). Solution-processed IGZO TFTs using the AlZrOx flm as a gate insulator layer exhibited a threshold voltage of 0.64 V, feld-efect mobility of 3.06 cm2 /V s, and a subthreshold slope of 0.26 V/dec. In addition, the IGZO TFTs with the AlZrOx flms exhibited a higher on/of current ratio of 1.05× 106 than devices with the AlOx and ZrOx gate insulator layers. The improvement of device properties is mainly attributed to the interface properties. The IGZO TFTs with the AlZrOx gate insulator exhibited the lowest interface trap density of 2.07× 1012 cm−2 eV−1, compared to the devices with the AlOx and ZrOx gate insulators of 3.30× 1012 and 5.06× 1012 cm−2 eV−1, respectively, because of the smooth surface roughness and reduced residual hydroxyl groups in the flms. The IGZO TFTs with the AlZrOx gate insulator also improved hysteresis characteristics with the hysteresis window of 0.17 V. This study presents a signifcant step toward developing low-cost, low-power-consumption, and high-performance oxide electronic device.