관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

현대 건축의 유목적 표현특성에 관한 연구

이화순,김기철,이영수 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)

The purpose of this study was to analyze the characteristics of 'Nomadism' throuth the understanding and the interpretation of the contemporary nomadic life. The citizens in modern times lead a nomadic life on the move rather than settle down in a place, and this pattern of life is going with increasing speed keeping in step with the development of the internet. From this point of view, this theoretical investigation on the relationship of the architectural analyses and their applications through nomadic thought as a new paradigm is to establish the basis of architecture in the capacity of the main value system in our new generation and to explore the new notion of architectural space.

다성분계 천연가스 하이드레이트 제조 및 특성 분석

이영철,조병학,백영순,모용기 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

메탄을 포함한 천연가스 하이드레이트의 상평형 조건을 관찰하였으며, 제조시 반응시간에 따른 천연가스 주요 성분들의 초기 농도 재비 농도변화에 대한 하이드레이트 생성 거동을 관찰하였다. 하이드레이트 제조 중에 천연가스의 성분들이 서로 다른 농도변화를 나타내고 제조된 하이드레이트를 해리시켰을 때도 가스 성분들의 서로 다른 해리 속도에 의해 성분들의 농도가 변화되었다. 천연가스 하이드레이트 제조시 유도지체시간은 다성분계이므로 짧은 시간에서 관찰되었다. 온도가 276.65K이고 교반속도가 600rpm 일 때 반응 압력이 4 MPa에서 7 MPa로 증가할수록 생성속도는 증가하였고, 가스저쟝량은 압력이 4MPadldhl에는 거의 유사하였다. 또한 압력이 6MPa이고 교반 속도가 600rpm 일때 반응온도가 274.15K에서 283.15K까지 증가할수록 생성속도와 가스저장량은 감소하였다. 그리고 온도가 274.65K이고 압력이 6 MPa일때 교반속도가 300rpm에서 600rpm으로 증가하면, 생성속도와 가스저장량은 증가하였다. A phase equilibrium of natural gas hydrate including methane is observed by visual cell in the manufacture of the natural gas hydrate the phenomena of a hydrate formation on the change of the gas concentration in comparison with initial concentration is observed for the reaction time. The concentration of components of natural gas is changed during the reaction and the concentration of components is changed by each decomposing rates of gases during the decomposition of hydrate. The induction delay time of natural gas hydrate formation is shorter than that of methane hydrate formation due to multiple components. The hydrate growth rate increases with increasing reaction pressure(4 MPa to 7 MPa) and gas storage ability is constant for the reaction pressure except 4 MPa at 276.65K and 600rpm. The hydrate growth rate and gas storage ability decreases with increasing reaction temperature(274.15K to 283.15K) at 6 MPa and 600rpm. Hydrate growth rate and gas storage ability increases with increasing stirring rate(300 to 600rpm) at 6MPa and 276.65K.

치수유래 구심성 신경섬유의 삼차신경 감각핵군에서의 연접특성

배용철,이은희,최민기,홍수형,김현정,남순현,김영진 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.2

일차연접부위에서 악안면 영역에서 유래하는 유해자극의 전달 및 처리기전을 이해하고자 horseradish pe개xidase를 치수지배 구심성 신경섬유를 표식한 후 연수후각에서 미세구조 및 연절 양상을 분석하여 다음과 같은 결과를 얻었다. 표식종말은 소수의 큰 치밀소포가 관찰되는 종말 (S형) 및 다수의 치밀소포를 함유하는 종말 (LDCV형)등 2종류로 분류할 수 있었다. S형 및 LDCV형 표식종말의 연접양식은 유사하였으며, 다수의 표식종말이 1개 혹은 2개의 neurofile과 연접을 이루어 대단히 단순한 연접양상을 보였다. 표식종말은 가지돌기체 보다는 다수의 가지돌기가시와 연접을 이루는 빈도가 높았다. 표식종말이 세포체 및 이에 인접한 근심부 가지돌기와 연접하는 경우는 드물었으며, 소수의 표식종말에서 p-ending과 연접하는 경우를 보였다. 표식종말의 체적, 표면적, 사립체의 체적, neurofile과 접하는 면적, 활성부위의 면적, 단위표식종말당 연접소포의 수 및 연접소포의 밀도등은 넓은 범위의 계측치를 나타내었으며, 이는 5명 및 LDCV형 표식종말 사이에 유의한 차이가 없었다. 이상의 결과로 미루어보아 연수후각에서 치수유래 구심성 신경섬유 종말의 연접양식은 고유의 특징을 보이며 이는 신경회로의 기능과 밀접한 상관관계를 가지는 것으로 판단되었다. Little is known about processing mechanism of pain sensation of the oral cavity at the 1st synapse of trigeminal sensory nuclei. Serial ultrathin sections of tooth pulp afferent terminals, identified by the transganglionic transport of 1% wheatgerm agglutinin conjugated horseradish peroxidase, were investigated wih electron microscope. Quantitative ultrastructural analysis was performed on digitizing tablet connected to Macintoshi personal computer (software: NIH Image 1.60, NIH, Bethesda, MD). Labeled boutons could be classified into two types by the shapes of containing vesicles : S bouton which contained mainly spherical vesicles (Dia. 45-55 nm) and few large dense cored vesicles (Dia. 80-120nm), and LDCV bouton, which contained spherical vesicles as well as large number of large dense coredd vesicles. Most of the parameters on the ultrastruotural characteristic and synaptic organization of labeled boutons were similar between S and LDCV boutons, except shapes of containing vesicles. Majority of the labeled boutons showed simple synaptic arrangement. The labeled bouton were frequency presynaptic to dendritic spine, and to a lesser extent, dendritic shaft. They rarely synapsed with soma and adjacent proximal dendrite. A small proportion of labeled boutons made synaptic contacts with presynaptic pleomorphic vesicless containing endings and synaptic triad. Morphometric parameters of labeled boutons including volume and surface area, total apposed area, mitochondrial volume, active zone area, vesicle number and density showed wide variation and theme were not significantly different between S and LDCV boutons. The present study revealed characteristic features on ultrastructure and synaptic connection of pulpal afferents which may involved in transmission of oral pain sensation.

투기종목 선수들의 무산소성 역치의 특성

조현철,송순천,김춘경,김의영,안용규,이규석,김학렬 龍仁大學校 體育科學硏究所 1991 體育科學硏究論叢 Vol.1 No.1

The purpose of the present study is to determine the levels of maximal oxygen uptake and anaerobic threshold of boxing players(n=23), ken-do players(n=18), Judo players(n=12), T.D.K players(n=18). Treadmill test was used to measure maximal state and anaerobic threshold of metabolic variables. Treadmill exercises protocol was 2-min incremental test from an initial work load of 0MPH(grade : 0%) to all-out by step of 1.0MPH(grade : 2%). The results of measurement was as follows : 1. Absolute(1/min) and relative(ml/kg/min) maximal oxygen uptake was highest(5.08l/min, 65.01 ml/kg/min) in Judo layers, followed in order by the T.D.K players (4.37l/min, 64.74 ml/kg/min), Boxing players(4.18) l/min, 63.19 ml/kg/min) and ken-do players(3.81l/min, 58.65 ml/kg/min). It is not significant difference in the relative maximal oxygen uptake, but is significant difference between group in the absolute maximal oxygen uptake(p<0.001) 2. AT-VO₂(l/min) and AT-VO₂(ml/kg/min) in the anaerobic threshold was highest (3.71 l/min, 47.28 ml/kg/min) in Judo players, followed in order by the T.K.D players(3.29 l/min, 48.75 ml/kg/min), boxing players(2.90 l/min, 43.91 ml/kg/min) and ken-do players(2.82 l/min, 43.52 ml/kg/min). It is not significant difference in the AT-V02(ml/kg/min), but is significant difference between group in the AT-V02(l/min). (p<0.001) 3. %HRmax and %V 02max in the anaerobic threshold was not significant difference between group.

방사선 조사가 배양된 조골세포의 apoptosis와 세포주기의 변화 및 석회화 결절 형성에 미치는 영향에 관한 연구

이영미,최항문,허민석,이삼선,최순철,박태원 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3

Purpose : The study was aimed to detect the induction of apoptosis, cell cycle arrest and calcified nodule formation after irradiation on primarily cultured osteoblasts. Materials and Methods : Using rat calvarial osteoblasts, the effects of irradiation on apoptosis, cell cycle arrest, and calcified nodule formation were studied. The single irradiation of 10 and 20 Gy was done with 5.38 Gy/min dose rate using the 137Cs cell irradiator at 4th and 14th day of culture. Apoptosis induction and cell cycle arrest were assayed by the flowcytomtry at 1,2,3, and 4 days after irradiation. The formation of calcified nodules was observed by alizarin red staining at 1,3,10,14 days after irradiation at 4th day of culture, and at 1,4,5 days after irradiation at 14th day of culture. Results : Apoptosis was not induced by 10 or 20 Gy independent of irradiation and culture period. Irradiation did not induced Gl arrest in post-irradiated ostedblasts. After irradiation at 4th-day of culture, G2 arrest was induced but it was not statistically significant after irradiation at 14th-day of culture. In the case of irradiated cells at 4th day of culture, calcified nodules were not formed and at 14th-day of culture after irradiation, calcified nodule formation did not affected. Conclusion : Taken together, these results suggest that Irradiation at the dose of 10-20 Gy would not affect apoptosis induction of osteoblasts. Cell cycle and calcified nodule formation were influenced by the level of differentiation of osteblasts. (Korean J Oral Maxillofac Radiol 2000; 30: 189-198)

수용성 고분자물질-단백질 접합체의 합성 및 응용

용철순,손영택 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-

Since the advent of recombinant DNA technology coupled with other biotechnology a variety of therapeutically effective proteins and peptides have been extensively invesitigated and many of them are now on clinical trial. They, however, suffer from some problems such as immunogenicity, antigenicity, instability and short half-life in circulation due to their proteinous natures. These draw-backs can be overcome successfully by conjugating proteins and peptides with hydrophilic polymers such as polyethylene glycol (PEG), albumin or dextran. The resulting soluble conjugates showed reduced antigenicity and immunogenicity, increased circulatory half-life, enhanced stability against proteolytic degradation. Comparing with the unmodified proteins and peptides, the therapeutic potential of conjugates is greatly enhanced. Clinical applications of these conjugates have shown promising results for the future use.

세포성 면역 알고리즘을 이용한 AGV의 주행제어

이영진,손주한,조현철,이권순 동아대학교 정보기술연구소 2000 情報通信硏究所論文誌 Vol.8 No.1

In this paper, cell-mediated immune algorithm(CMIA) controller was proposed and applied for the autonomous guided vehicle(AGV) driving. It was based on specific immune response of the biological immune system which is the cell-mediated immunity. To verify the performance of the designed CMIA controller, some experiments were performed for the control of steering and speed of AGV. And then the displacement and speed tracking error of the AGV was mainly investigated. As a result, the capability of realization and reliableness were proved by comparing the response characteristics of the classical controller with the proposed CMIA controller

食用油脂類에 對한 免疫生物學的 硏究

朴炳哲,文宰奎,朴榮吉,金杏順,安年衡,金度勳,金正勳,安榮根,李相根,鮮于演 圓光大學校 1990 論文集 Vol.24 No.2

食用油脂는 健康維持에 必須的인 營養素이다. 그러나 食用油脂는 脂肪을 構成하는 脂肪酸의 種類와 攝取하는 量에 따라 健康을 保衛하는 必須的인 食品의 成分이 되기도 하고 有害한 影響을 끼칠 수도 있어서 脂質代謝와 關連된 疾病 뿐만아니라 老化를 促進하고, 乳房癌, 大腸癌等의 癌發生과도 關連된 것으로 밝혀져 있다. 本 硏究는 우리生活環境에서 食用으로 接할 수 있는 10種의 油脂에 對한 免疫生物學的인 活性에서 究明한 結果 對照群인 참기름食餌群에 比해 올리브유食用群은 全般的으로 體液性 및 細胞性免疫을 有意性있게 增加시켰으나, 大食細胞의 活性과 末梢循環白血球數는 有意性없는 減少를 보였고, 動物性 油脂인 牛脂食餌群과 植物性 油脂인 옥수수기름食餌群, 들기름食餌群, 米糠油食餌群, 大豆油食餌群, 菜種油食餌群 및 고추씨기름食餌群에서는 全般的으로 體液性 및 細胞性免疫, 大食細胞의 活性 및 末梢循環白血球數를 有意性있게 減少시켰다. This study was performed to investigate the effects of edible oils and fats on the immunobiological responses in ICR male mice. Ten groups of experimental diets, such as sesame oil diet, beef tallow diet, lard oil diet, olive oil diet, corn oil diet, perilla oil diet, rice polishing oil diet, soybeen oil diet, rape seed oil diet, and red pepper seed oil diet were fed adlibitum to the ICR male mice for 27 days. The results of this study were summarized as followings. 1. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes in sesame oil group were increased. However, the increasing rate of body weight and the weight retios of spleen and thymus to body were generally decreased. 2. Hemagglutination titer(HA) and rosette forming cell(RFC) of the beef tallow group and the lard group were significantly lower than the sesame oil group(P<0.01), but the lard group significantly increased Arthus reaction and delayed type hypersensitivity(DTH)(P<0.01). 3. Arthus reaction, DTH, and RFC of the olive oil group were significantly higher than the sesame oil group(P<0.01). 4. DTH of the corn oil group was significantly higher than the sesame oil group(P<0.01) whereas phagochyte activity was significantly lower(P<0.01). But no statistically significant differences were found between the two groups in the humoral immune response. 5. HA, PFC, DTH, RFC, phagocyte activity, and number of leukocytes of the perilla oil group and the rice polishing oil group were significantly lower than the sesame oil group(P<0.01). 6. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes of the soybeen oil group, the rape seed oil group, and the red pepper oil group were significantly lower than the sesame oil group(P<0.01).

韓國人 標準體格과 健康度判定을 위한 標準體重에 關한 硏究

朴東哲,朴淳永,柳東俊 慶熙大學校 1988 論文集 Vol.17 No.-

The purpose of this study is to identify the physical growth in Korean. The subjects of this study include both of male and female, who are attending elementary school, middle school, high school, college in middle and large cities and rural areas. The total number of subjects was 144, 583 persons, including 76,402 persons of male and 68,181 persons of female. The researcher measured the physical status of the male and female-in terms of body height, body weight, chest-girth, sitting height-through cross-sectional method. On the basis of the results, calculated the standard values of each body structure, the physical and nutritional indices, fatness and estimate the standard body weight, under-and over weight, the weight of malnutrition and obesity in accordance with age, sex and body height for decision of health level. These surveys and measurements took for 18 months from 1 September, 1986 to 30 April, 1988, and the data from thess surveys were analyzed through computer. The results are as follows. 1. Body Measurements 1) Body height(㎝) In the growth condition of body height, rapid growth has been observed among male in the ages 7-15 and among female 7-13, Growth in terms of body height turned out to be slower among higher ages by both sexes, and the average body height of full-grown Korean youth(20-24 age group) was 170.6±7.1㎝ for male and 159.9±6.3㎝ for female. The maximum growth age and annual increment of body height were 10-11 years old and 6.73㎝ per year for female and 11-12 years old and 6.8㎝ for male. These data show a fact that the female starts to grow earlier than the male by about one year. The age of crossover between the sexes come around 9.5-11.5 years of age, whereupon female outgrows male. 2) Body weight(㎏) Rapid growth, in terms of body weight, which was represented by a straight line on a growth, curve was observed among the both sexes of 7-15 years of age and growth turned out to be slower among higher ages by both sexes. The average body weight of full-grown Korean youth(20-24 age group) was 63.8±6.8㎏ for male and 52.95±6.0㎏ for female. The maximum growth age and annual increment of body weight were 12-13 years old and 6.0㎏ per year for male and 10-11 years old and 5.6㎏ for female. Those data show a fact that the female starts to grow earlier than the male by about two year. The age of crossover between the sexes come around 9.5-12.5 years of age, whereupon female outgrows male. 3) Chest-girth(㎝) Rapid growth, in terms of chest-girth, which was represented by a straight line on a growth curve was observed among the 7-14 years of age for female. The average chest-girth of full-grown Korean youth(20-204 age group) was 89.64±5.86㎝ for male and 83.60±5.38㎝ for female. The age of crossover between the sexes came around 10-13.5 years of age, whereupon female outgrows male. 4) Sitting height(㎝) Rapid growth, in terms of sitting height, which was represented by a straight line on a growth curve was observed among 7-15 years of age for male and 7-14 years of age for female. The average sitting height of full-grown Korean youth(20-24 age group) was 89.64±5.86㎝ for male and 83.60±5.38㎝ for female. The maximum growth age and annual increment of sitting height were 12-13 years old and 3.7㎝ per year for male and 9-10 years old and 4.0㎝ for female. These data show a fact that the female starts to grow earlier than the male by about three years. The age of crossover between the sexes came around 9.5-12.5 years of age, whereupon female outgrows male. 2. Physical and Nutritional Indices 1) Relative body weight Rapid growth, in terms of relative body weight, which was represented by a straight line on a growth curve was observed among the both sexes of 7-16 years of age and the age of crossover between the sexes come around 7-12.5 years of age. 2) Relative chest-girth The status of narrow relative chest-girth were observed at ages 7-14 by males and at 7-12 by the females, which were found to be normal relative chest-girth thereafter with advancing ages. The age of crossover between the sexes come around 7-16 years of age. 3) Relative sitting height The largest values of relative sitting height were obtained with both sexes aged 7, which were found to be declining rather slowly thereafter with advancing ages. Female's index exceeds the male one before 17 years of age and the largest index is limited in 52 to 54. 4) Ro¨hrer index Ro¨hrer index displayed more rich value in case of female than male and in the adolescent period, the level of fullness is lower than after the completion of development. 5) Kaup index In both sexes, Kaup index increased in accordance with advancing ages. The index comes to under 2.02 from 7 to 14 years old in case of male and from 7 to 13 years old in case of female. So the growth of longitudinal axis seemed to be more poor than the one of vertical axis. The index increases beyond 2.0 in case of male of after 15 years old and 14 years old for female. 6) Vervaeck index The values of Vervaeck index were obtained with in the range of 68-91 for male and 71-86 for female, and the index increases in accordance with advancing ages. 7) Pelidisi index The values of Pelidisi index were obtained with in the range of 92.97 in cases of both sexes and index increases in accordance with advancing ages. 3. The fat amount through the method of measurement of physical body. In 7 years of age group, the amount of body fat of male was 3.77±1.25㎏ and that of female was 9.49±2.24㎏. The amount in creased with age to reach for male in 20-24 age group an average 11.39±2.8㎏ and for female 14.81±2.12㎏. In 7 years of age group, the body fat(%) of male was 15.35±5.14% and that of female was 18.01±2.87%, The body fat(%) increased with age to reach for male in 20-24 age group an average 17.63±2.67% and 4.85±4.47% for female. In cases of male, the body fat(%) of 8-13 age group indicated normal range but the other age group indicated higher range. In cases of female, the body fat(%) of below 10 age group indicites lower range and over 11 age group indicates normal range. 4. The standard body weight of the Koreans 1) The standard body weight of Korean youth In case of 7 years age group, correlation coefficient of r=+0.572(P<0.001) between body height and body weight was found in a male group of 2,358 subjects and r=+0.353(p<0.001) was found in female group of 2,461 subjects, from which respective linear regression equation of body weight and body height was established for male and female as follow: For male; Y(B.W.㎏)=0.4059×(B.H,㎝)-26.1 (Sy.x=±3.7) Female; Y(B.W,㎏)=0.1471×(B.H,㎝)+6.3(Sy.x=±5.4) Similar regression equations of body weight and height were found all age groups from 7 to 19 years old and listed in table 18. 2) Standard body weight of Koreans A correlation coefficient of r=±0.320(P<0.001) between body height and body weight was found in a 20-24 age male group of 7,659 subjects and r=+0.301(P<0.001) in a 20-24 female group of 6,693 subjects, from which respective linear regression equation of body weight and height was established for male and female as follows; For male: Y(B.W,㎏)=0.3063×(B.H,㎝)+11.6 (Sy.x±6.4) Female: Y(B.W,㎏)=0.2856×(B.H,㎝)+7.3 (Sy.x±5.7) The standard body weight, under-and over-weight, weight of malnutrition and obestiy of Koreans calculated and listed in table 19-a and 19-b.