Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.

Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate

Xiang Wei,Peng Yongbo,Zeng Hongliang,Yu Chunping,Zhang Qun,Liu Biao,Liu Jiahao,Hu Xing,Wei Wensu,Deng Minhua,Wang Ning,Liu Xuewen,Xie Jianfei,Hou Weibin,Tang Jin,Long Zhi,Wang Long,Liu Jianye 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Gemcitabine (GEM) is one of the first-line chemotherapies for bladder cancer (BC), but the GEMs cannot recognize cancer cells and have a low long-term response rate and high recurrence rate with side effects during the treatment of BC. Targeted transport of GEMs to mediate cytotoxicity to tumor and avoid the systemic side effects remains a challenge in the treatment of BC.Based on a firstly confirmed biomarker in BC-protein tyrosine kinase 7 (PTK7), which is overexpressed on the cell membrane surface in BC cells, a novel targeting system protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized using a specific PTK7 aptamer and GEM through auto-synthesis method to deliver GEM against BC. In addition, the antitumor effects and safety evaluation of PTK7-GEMs was assessed with a series of in vitro and in vivo assays.PTK7-GEMs can specifically bind and enter to BC cells dependent on the expression levels of PTK7 and via the macropinocytosis pathway, which induced cytotoxicity after GEM cleavage from PTK7-GEMs respond to the intracellular phosphatase. Moreover, PTK7-GEMs showed stronger anti-tumor efficacy and excellent biosafety in three types of tumor xenograft mice models.These results demonstrated that PTK7-GEMs is a successful targeted aptamer-drug conjugates strategy (APDCs) to treat BC, which will provide new directions for the precision treatment of BC in the field of biomarker-oriented tumor targeted therapy.

MALICIOUS URL RECOGNITION AND DETECTION USING ATTENTION-BASED CNN-LSTM

( Yongfang Peng ),( Shengwei Tian ),( Long Yu ),( Yalong Lv ),( Ruijin Wang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.11

A malicious Uniform Resource Locator (URL) recognition and detection method based on the combination of Attention mechanism with Convolutional Neural Network and Long Short-Term Memory Network (Attention-Based CNN-LSTM), is proposed. Firstly, the WHOIS check method is used to extract and filter features, including the URL texture information, the URL string statistical information of attributes and the WHOIS information, and the features are subsequently encoded and pre-processed followed by inputting them to the constructed Convolutional Neural Network (CNN) convolution layer to extract local features. Secondly, in accordance with the weights from the Attention mechanism, the generated local features are input into the Long-Short Term Memory (LSTM) model, and subsequently pooled to calculate the global features of the URLs. Finally, the URLs are detected and classified by the SoftMax function using global features. The results demonstrate that compared with the existing methods, the Attention-based CNN-LSTM mechanism has higher accuracy for malicious URL detection.

Changes in Markers of Liver Function in HCV 1b Patients with Compensated Cirrhosis Treated with Ombitasvir/Paritaprevir/ Ritonavir plus Dasabuvir with Ribavirin

( Jeong Heo ),( Yan Luo ),( Wan-long Chuang ),( Jidong Jia ),( Kwang-hyub Han ),( Ming-lung Yu ),( Hong Tang ),( Young-suk Lim ),( Cheng-yuan Peng ),( Min Xu ),( Maorong Wang ),( Bo Fu ),( Niloufar Mo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Patients chronically infected with HCV are at risk of developing extrahepatic manifestations of HCV as well as progressing to compensated or decompensated cirrhosis and HCC. Although current treatments have high rates of SVR, relatively little is known about possible regression of liver fibrosis after achieving an SVR. The ONYX-II trial examined the efficacy and safety of ombitasvir/paritaprevir/ritonavir plus dasabuvir + ribavirin (RBV) in Asian patients with HCV genotype 1b infection and compensated cirrhosis. Here we report changes in key markers of liver fibrosis and function. Methods: Patients with chronic HCV GT1b infection and compensated cirrhosis were enrolled in China, South Korea and Taiwan and received 12 weeks of OBV/PTV/r (25 mg/150 mg/100 mg once daily) and DSV (250 mg twice daily) with weight-based RBV. The primary objective of ONYX-II was to assess efficacy (SVR12) and safety of the regimen. Changes in markers of liver fibrosis and function between baseline (BL) and post-treatment week (PTW) 12 are presented. Results: Overall, 104 patients were enrolled and treated in ONYX-II. All patients (104/104, 100%) achieved SVR12. BL and PTW12 data for FibroTest score, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, albumin, platelet count and alpha fetoprotein (AFP) are shown in Table 1. All selected parameters showed numerical improvements between BL and PTW12. Mean ALT and AST levels returned to within normal range and FibroTest scores demonstrated a numerical improvement, suggesting improvement in liver status. The complete set of data between BL and PTW12 will be presented for these parameters and other liver composite parameters at the conference. Conclusions: Measurement of key liver function markers during the ONYX-II trial showed a numerical improvement within 12 weeks of completion of treatment in HCV GT1b-infected patients with compensated cirrhosis. Further follow-up of these patients will determine the long-term durability of these changes.

Robust H∞ Model Reference Tracking Control for Networked Control Systems with Communication Constraints

Yu-Long Wang,Guang-Hong Yang 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.6

This paper studies the problem of H∞ model reference tracking control for continuous time networked control systems (NCSs) with communication constraints. By using the continuous Jensen inequality, linear matrix inequality (LMI)-based H∞ model reference tracking controller design for nominal NCSs with controller-to-actuator communication constraints is presented, and a new method is proposed to design H∞ model reference tracking controllers for NCSs with both controller-to-actuator and sensor-to- controller communication constraints. The results are also extended to NCSs with norm-bounded parameter uncertainties. The merits of the proposed methods lie in their less computational complexity and less conservatism, which are achieved by adopting continuous Jensen inequality and proposing new controller design methods, respectively. The simulation results illustrate the effectiveness of the proposed H∞ model reference tracking controller design for NCSs with communication constraints.

天安艦"事件與中朝關系變化

강용범 ( Long Fan Jiang ) , 왕우 ( Yu Wang ) 朝鮮大學校 統一問題硏究所 2010 統一 問題 硏究 Vol.25 No.2

Strong turbulence occurred in Korean Peninsula after "Cheonan Warship Event". President Announcement by UNSC seemed to have ceased the event, but actually caused more political and military struggles among some Northeast Asian countries. ROK, the USA and Japan strengthened the control over DPRK, and the USA, by means of a series of joint military maneuvers, tried to establish Asian-Pacific Military Alliance to control China and edge the Sino-USA relationship to military conflict. At the same time, there has been more frequent interaction between Sino-DPRK leaders and economic cooperation and strategic communication after "Cheonan Warship Event". How to strengthen the relationship among ROK, the USA and Japan and how to develop Sino-DPRK relations will affect the geo-politics of Northeast Asia. `천안함` 사건이 발생한 후 조선반도 정세에는 큰 파장이 일어났다. 비록 유엔안보리에서 "의장성명"을 발표하여 표면상에서 이 사건이 한단락 매듭지어진 듯 했으나 동북아 주요 국가 간에 이 사건을 에워싼 정치, 군사 논쟁은 날로 격렬해졌다. 한미일은 북한에 대한 제재를 강화하였을 뿐만 아니라 미국은 일련의 연합군사연습을 통해 `아시아-태평양군사연맹`을 결성하여 중국을 견제하고 나아가 중미 양국 관계를 "군사대항"의 변두리에 밀어부치려 시도하였다. 더불어 `천안함`사건 후 북중 양국 고위층의 움직임이 빈번해지고 경제무역 합작과 전략 접촉이 더욱 밀접해졌다. 한미일 3각동맹관계가 어떻게 강화되고 북중 양국 관계가 어떻게 발전하겠는가는 동북아 지정학관계에 중요한 영향을 미치게 될 것이다.

AWGN과 AWAN채널의 비교분석

왕위롱(Yu-Long Wang),주언경(Eon-Kyeong Joo) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6

Using power lines to high-speed and reliable data transmission communication, the erecting of dedicated communication lines can be eliminated. However, due to the complex network structure and load characteristics, ordinary AWGN channel can’t be used to conduct simulation analysis. The paper conducts brief introduction on the principles of power line communications(PLC). As for the impulse noise existed in power line channels, AWANis used to represent the noise in power line channels. It also analyzes the differences and connections between AWAN and AWGN, and provides reference to the design of power line communication system.

AWGN 과 AWAN 채널의 비교분석

왕위롱(Yu Long Wang),주언경(Eon Kyeong Joo) 한국통신학회 2016 한국통신학회 학술대회논문집 Vol.2016 No.6

Benchtop fabrication of three-dimensional reconfigurable microfluidic devices from paper-polymer composite.

Han, Yu Long,Wang, Wenqi,Hu, Jie,Huang, Guoyou,Wang, Shuqi,Lee, Won Gu,Lu, Tian Jian,Xu, Feng Royal Society of Chemistry 2013 Lab on a chip Vol.13 No.24

<P>We presented a benchtop technique that can fabricate reconfigurable, three-dimensional (3D) microfluidic devices made from a soft paper-polymer composite. This fabrication approach can produce microchannels at a minimal width of 100 μm and can be used to prototype 3D microfluidic devices by simple bending and stretching. The entire fabrication process can be finished in 2 hours on a laboratory bench without the need for special equipment involved in lithography. Various functional microfluidic devices (e.g., droplet generator and reconfigurable electronic circuit) were prepared using this paper-polymer hybrid microfluidic system. The developed method can be applied in a wide range of standard applications and emerging technologies such as liquid-phase electronics.</P>

Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA

Chunping Yu,Yi Zhang,Ning Wang,Wensu Wei,Ke Cao,Qun Zhang,Peiying Ma,Dan Xie,Pei Wu,Biao Liu,Jiahao Liu,Wei Xiang,Xing Hu,Xuewen Liu,Jianfei Xie,Jin Tang,Zhi Long,Long Wang,Hongliang Zeng,Jianye Liu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1

Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-adherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.