Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

법랑질 접착에 대한 습윤 효과

고근호,조영곤,진철희,유상훈,김종욱,박병철,기영재,최희영,김종진 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.3

This study evaluated the microleakage and interfacial gap between enamel and composite resin under the dry and wet condition of the enamel surface, V shaped class 5 cavities were prepared on the occlusal portion of extracted human molars. Samples were divided into three groups: D group (air dry for 10-15s), BD group (blot dry with moist cotton pellet), and DR group (air dry for 10-15s and rewet with Aqua-Prep F for 20s). Cavities were filled using Aelitefil composite resin after applied One-Step. Microleakage was tested by 2% methylene blue dye solution and the data were statistically analysed by Kruskal-Wallis test and Mann-Whitney test. Also Enamel-resin interface was observed under SEM. Group BD showed statistically lower microleakage than group D (p〈0.05). but there was no statistically significant difference between group BD and DR (p)0.05). At the enamel-resin interface, group D showed the gap of 2 ㎛ thickness, but group BD and DR showed close adaptation. In conclusion, the use of blot dry and rewetting agent (Aqua-Prep F) resulted in decreased microleakage and improved adhesion between enamel and resin when using One-Step.

청소년의 인터넷 중독 정도에 따른 정신과적 공존질환 및 행동 양상에 관한 연구

이준영(June-Young Lee),박이진(E-Jin Park),조근호(Keun-Ho Joe),채숙희(Suk-Hi Chai),김성벽(Sung-Byuk Kim),이창욱(Chang-Uk Lee),김대진(Dai-Jin Kim) 한국중독정신의학회 2010 중독정신의학 Vol.14 No.1

Objectives:This study aimed to clarify the differences in psychiatric comorbidities and, behavioral patterns correlating with the severity of Internet addiction in adolescents. Methods:We assessed 321 adolescents recruited from an Internet rescue school, psychiatric outpatients, and 4 schools in Seoul and Gyeonggido. We divided them into a non-addicted group, a potential-risk group, and a high-risk group according to Young’s Internet Addiction Test (IAT). We evaluated their psychiatric comorbidities and behavioral patterns via psychiatric clinical interview, the Children’s Depression Inventory (CDI), the State-Trait Anxiety Inventory (STAI), and a self-report questionnaire about behavioral pat-terns. Results:There were significant differences in CDI and STAI scores among the 3 groups. The IAT, CDI, and STAI scores correlated positively with each other. There were differences in psychiatric comorbidity distributions between the potential-risk and high-risk groups, but only “other mood disorder” showed a significant difference. There were also significant differences in behavioral patterns among the 3 groups. Conclusion:This study suggests that there are psychiatric comorbidity and behavioral pat-tern differences according to Internet addiction severity in adolescents. We expect further studies will reveal more profound understandings of these relationships.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

20년전과 비교한 한국청년의 미소 변화에 관한 연구

범승균,정지혜,김태영,이경은,동진근 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: Teeth are generally exposed when people smiling. Moreover, the exposed teeth and soft tissue when smiling becomes an important guideline for esthetically prosthetic restoration. This research is to compare and find out differences of Korean young men's smile living in presence and twenty years ago. Materials and methods: Subjects, 100 young men (50 male and 50 female), were required about several aspects; normally developed physical condition, no psychological or genetic disorders, a fine face with no loss of teeth, no experience in orthodontic or prosthetic treatment, relatively normal occlusion, aged between 20 - 29. The photos of the subject at rest position and front face when fully smiled were taken three times. 100 photos (50 male and 50 female) were chosen at random from the 240 university students' smile photos taken by Yoon and his colleagues in 1991. By Hulsey's method of measuring smile, several factors; the change of upper lip curvature, the change of the relation between the upper lip and teeth, parallelism between Mx. incisor and lower lip, contact relation between Mx. incisor and lower lip and teeth displayed in a smile, were measured and analyzed. Meanwhile, ten dentists assessed aesthetic evaluation about men and women's smile for twice and recorded and compared smile score. The -test (P<.05) was used to compare the measured value. The difference of smile score was analyzed by t-test (P<.05). Results: The smile score calculated in 2011 (60.22) was higher than that of 1991 (52.80). Among five measurement categories, the noticeable difference was distinguished from two factors; the change of upper lip curvature and contact relation between Mx. incisor and lower lip. Conclusion: The Korean young men's smile has been considerably improved for twenty years. And it is found that the change of upper lip curvature plays an important role, that is, the smile formed with an ascended labial commissure has been increased significantly. 연구 목적: 일반적으로 치아는 미소 지을 때 가장 많이 노출되며, 미소 시에 나타나는 치아와 연조직과의 관계 등은 심미적인 보철 수복에 있어서 중요한 지침이 된다. 본 연구는 20년 전 한국 청년들의 미소와 현재 한국 청년들의 미소를 비교하여 그 차이를 알아보고자 하였다. 연구 재료 및 방법: 신체적인 발육 상태가 정상적이고 전신적 또는 유전적 질환이 없으며, 안모가 양호하고 치아의 결손이 없으며 교정 및 보철치료를 받은 경험이 없고, 교합상태가 비교적 정상적인 20 - 29세 사이의 청년 100명(남자 50명, 여자 50명)을 대상으로, Cephalometer에 사용되는 두부 고정 장치를 사용하여 피검자의 F-H plane이 지면에 평행하도록 한 후, 35 mm 카메라(400D. Cannon, Japan), 120 mm 렌즈 그리고 삼각대를 사용하여 피검자의 midsagittal plane에 카메라 렌즈의 중심을 맞추고 상악 중절치 절단과 렌즈와의 거리를 930 mm로 하여 안정위 및 full smile 시의 안모 정면 사진을 3회씩 촬영하였다. 1991년 윤 등이 촬영한 대학생 240명 중 무작위로 선택한 100명(남자 50명, 여 자 50명)의 미소사진과 함께 개인용 컴퓨터 및 V-ceph 6.0 프로그램을 이용하고 Hulsey의 미소 계측 방법을 참고로 하여, 상순의 형태, 상순과 치아와의 관계, 하순과 상악 전치 절단연과의 평행 관계, 하순과 상악 전치 절단연과의 접촉 관계, 미소시 나타나는 치아 등을 계측하고 분석하였다. 한편 치과의사 10인이 남,녀 각 2회씩 미소에 대한 미적 평가를 시행하여 미소평점을 기록하고 비교하였다. 결과: 지난 20년간 한국 청년의 미소가 크게 향상되었으며 이러한 변화는 주로 상순의 형태가 영향을 준 것을 알 수 있었다. 즉 입꼬리가 위로 올라가는 형태의 미소가 괄목할 만한 증가를 보인 반면 입 꼬리가 아래로 처지는 형태의 미소는 현저한 감소를 보였다. 결론: 지난 20년간 한국 청년의 미소가 크게 향상되었는데 이러한 변화는 주로 상순의 형태가 영향을 준 것으로 나타났다.

지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

반품콘크리트의 재활용에 관한 실험적 연구

진치섭,최영근,박현재 부산대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.59 No.-

본 연구의 목적은 현장에서 반품되는 콘크리트를 신선하게 유지하여 다음날 사용할 수 있도록 재활용하는 데 있다. 본 연구에서는 반품콘크리트에 지연제를 첨가하여 시멘트의 수화작용을 일시적으로 정지시켜 콘크리트를 신선한 채로 장시간 보존한 후 다음날 활성화제를 첨가하여 보통의 콘크리트와 동일하게 사용 가능한 방법을 제시하였다. 슬럼프 값이 19.8cm인 보통콘크리트에, 3시간 후에 지연제를 첨가했을 때의 슬럼프 값은 22cm, 다음날 활성화제와 유동화제를 첨가한 후에는 19.2cm의 슬럼프 값을 얻었다. 활성화된 반품콘크리트의 응결시간이 보통콘크리트의 응결시간보다 길어지는 결과를 얻을 수 있었다. 또, 활성화된 반품콘크리트와 보통콘크리트의 압축강도 및 인장강도, 휨강도는 거의 같은 것으로 나타났다 To use concrete returned from job sites, the method to remain the fresh properties of the returned concrete for a long time was studied by stopping cement hydration temporarily and adding an activator to the concrete next day to reuse in the same manner as an ordinary concrete. When the slump value of an ordinary concrete was 19.2 cm, the slump value of 22cm was obtained by adding a retarder after 3 hours, next day after adding an activator and a superplasticzer, the slump value of 18.2cm was obtained. The setting time of returned concrete reactivated was in retard compared with ordinary concrete. The reactivated concrete and ordinary concrete exhibits almost equal compressive strength, tensile strength, and flexural strength.

돈육의 저장중 이화학적 성질에 미치는 토코페롤 급여효과

진상근,김일석,송영민,하경희,이성대,김회윤 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.1

비육후기 돼지 사료에 첨가되는 우지 함량 중 2%를 들깨유로 대체 급여한 돈육(T1), T1처리구에 비타민 E 250ppm 첨가 급여한 돈육(T2), 우지함량 중 2%를 오징어유로 대체 급여한 돈육(T3), T3에 비타민 E 250ppm 첨가 급여한 돈육(T4)을 1±1℃에서 28일간 저장하면서 육질특성을 조사한 결과는 다음과 같다. 저장기간에 따라 육색 L^*과 b^*값, 지방색 b^*값 및 drip loss는 증가하였다. 총단백질추출성과 보수력은 14일까지 증가 후 감소하였으며, 염용성 단백질추출성 및 지방색 L^*값은 감소하였다. 근절길이에서는 저장기간에 따라 T3구는 감소하였다. 총단백질추출성은 T1보다는 T2가 낮은 반면 T3보다는 T4가 높았다. 염용성단백질추출성은 비타민 E 첨가구들이(T2, T4) 첨가하지 않은 구들(T1, T3)에 비하여 높았으며, drip loss와 육색 a^*값은 비타민 첨가구들이 첨가하지 않은 구들에 비해 낮게 나타났다. 보수력은 T1보다는 T2가 낮은 반면 T3보다는 T4가 높았다. 지방색 L^*값은 저장 1일째는 비타민을 첨가한 처리구들이 첨가하지 않은 처리구들에 비해 높았으나, 저장 28일째에는 낮게 나타났고, b^*값은 비타민을 첨가한 처리구들이 낮게 나타나 비타민 첨가구가 drip loss, 육색과 염용성단백질 추출성에서 좋은 효과를 나타내었다. The quality of pork meat was determined as following treatments. The meat samples were obtained from pigs which had been fed finishing pig diets containing 2% perillar seed oil in beef tallow(T1), 250ppm vitamin E in T1(T2), 2% squid oil substituted of beef tallow(T3), 250ppm vitamin E in T3(T4). During storage period, meat color L^*, b^* value, fat color b^* value and drip loss were increased. The extraction amount of total protein and water holding capacity were increased until 14 days after then were decrease. The extraction amount of salt soluble protein and fat color L^* value were decreased and sarcomere length were decrease in T2 as well. T1 was higher than T2 in the extraction amount of total protein and its of T4 was higher than T3. The extraction amount of salt soluble protein of the T2 and T4 was higher than that of T1 and T3. The drip loss and the a^* value of meat color were lower in vitamin treated one than non treated one. On water holding capacity. T1 was higher than T2 and T3 was lower than T4. The L^* value of fat in vitamin treated ones was shown higher than that of non treated ones on day 1, however, it and the b^* value of the meat were low on day 28.

MPEG-2를 위한 시공간 상관성을 이용한 빠른 움직임 추정 알고리즘

진성일,이근영 成均館大學校 科學技術硏究所 1996 論文集 Vol.47 No.2

최근에 동영상 압축 기술은 시간축에서 중복성을 제거하는 움직임 보상 기법이 많이 이용되고 이중에 특히 블록 정합 알고리즘이 많이 이용된다. 본 논문에서는 시간축에서와 공간축에서의 상관성을 이용하여 계산량을 줄이는 빠른 움직임 추정 알고리즘을 제안한다.

산삼 배양액 급여가 돈육의 이화학적 특성에 미치는 영향

진상근,김일석,송영민,허선진,박기훈,정기종,김동훈,노정만 진주산업대학교 산업과학기술연구소 2006 산업과학기술연구소보 Vol.- No.13

Berkshire를 이용하여 70일간 산삼 배양액 급여 시 육의 이화학적 특성에 미치는 영향은 다음과 같다. 산삼 배양액의 급여에 의해 육의 수분, 조단백, 조지방, 회분, pH, 가열감량, 콜레스테롤 함량, 육색, 조직감의 응집성과 검성, 포화지방산 및 불포화지방산의 비율은 차이를 보이지 않았다. 보수력, 지방색 L^(*)값, 지방산 중 linoleic acid(18:2), arachidonic acid(20:4), 필수지방산의 함량, 아미노산 중 threonine, glutamic acid, valine, isoleucine, leucine, histidine, lysine 및 총아미노산 함량은 산삼 배양액의 급여에 의해 감소하였다. 전단가, 조직감의 표면경도, 경도, 씹힘성, 지방산 중 stearic acid(18:0), oleic acid(18:1) 함량, 아미노산 중 serine, glycine, cystine, methionine, tyrosine 및 phenylalanine의 함량은 산삼 배양액의 급여에 의해 증가하였다. 본 연구결과를 종합하면 산삼 배양액의 급여는 돈육의 경도를 증가시키는 효과 외에 뚜렷한 이화학적인 차이를 나타내지 않았다. 이러한 이유는 급여된 산삼 배양액 내에 함유된 생리활성 물질의 함량이 낮고, 급여수준이 낮은 결과로 사료되어진다. A total of 60 pigs (Berkshire) were used to investigate the effect of dietary artificial culture medium of wild ginsengs (CMG) on physico-chemical characteristics of pork. About 60 kg pigs were randomly alloted into one of two experimental diet groups (C:commercial diet feed; T:commercial diet + 1 L CMG per day for 70days). Pigs were slaughtered at approximately 110 kg live weight, and chemical composition and physico-chemical characteristics were measured in pork loin. Moisture, crude protein, crude fat and ash were not significantly different by dietary artificial culture medium of wild ginsengs. Water-holding capacity was decreased by dietary artificial culture medium of wild ginsengs, while shear force was increased. However, pH, cooking loss and cholesterol contents were not significantly different between two different treatments. In color, L^(*) of fat was decreased by dietary artificial culture medium of wild ginsengs. Brittleness, hardness and chewiness were increased in dietary artificial culture medium of wild ginsengs group. In fatty acid, stearic acid (18:0) and oleic acid (18:1) were higher in dietary artificial culture medium of wild ginsengs group, whereas linoleic acid (18:2) and arachidonic acid (20:4) were higher in control group. In amino acid, serine, glycine, cystine, methionine, tyrosine and phenylalanine were higher in dietary artificial culture medium of wild ginsengs group, whereas threonine, glutamic acid, valine, isoleucine, leucine, histidine and lysine were higher in control group.